@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMQ6: (2017-11-09 )
MKYCQFFSVLALGLSAASCAVTSGLQTYDIPSEGVYKTDLGTTVNVVKISQETLPAIQPAQIDYQRDYASLFKNQQTIYRLSPGDVLSIQLWAYPEIAPPVNNISNEQSVQAYGYPIDQTGYIQFPLVGRYKAAGKTLAQVNRELHSQLARFLKNPDVVVRVVSYEGQRFSVQGSVTKGGQFYLSDQPVSIYTALGMAGGVTTTGDNTYIQLIRNGRTYNLNTIDLEKAGYSLHKLLVQPNDTIYVSTRENQKIYVMGESGKNQALPMRDQGMSLTDALGESLGINPLSGSASRIYVVRTNPNDRTTEIYHLNLMSIGDFGLANQFRLRSNDVVYVDATGLTRWQRIVNQIIPFSNALYNIDRLGQ
Atome Classification :
(20 SA)
--.........10...-...----------..20--------.-......----.30...-.....40.......-.50........----60........70........80.-.---......90........100.......110..-.....120...--....130.......-----------140...-....150..---.-------------.-----...160.......170----........180---..-------...-..190....--.-..200.-.--...----------------..210....-..--------------------------------------------.220........-.230.......240..---------.-.--.--....----250.......260.......270...---.-...280.......290.......300------...---------.---.---.---..------.310.-......320.......330---.-----...-.....340------.------........--------350---..--.......----------------360....-------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
K
Y
C
Q
F
F
S
V
L
A
L
G
L
-
S
A
A
----------
S
C
A
V--------T-SGLQTY----DIPSE
G
-
V
Y
KTDLG
T
T
V
N
V
V
K
-ISQETLPAIQP----
A
Q
I
D
Y
Q
R
D
Y
A
S
L
FKNQ
Q
T
I
Y
R
LS-P---G
D
V
L
S
I
Q
L
W
AYPEIAPPVNNISNEQSVQAYG-YPIDQTG
Y
I
QF--PLVGR
Y
K
AA
G
K
T
L
A
-----------
Q
V
N
R
E
L
-
H
S
Q
L
A
R
F
LK---N-------------P-----
D
V
V
V
R
V
V
SYEG
Q
R
F
-
S
----
V
Q
G
S
VTKG
G
Q
F
---
Y
L-------SDQ-
P
V
S
I
Y
T
ALG--M-AGG
V
T
T-T--GDN----------------
T
Y
I
Q
L
I
RNG-
R
T
--------------------------------------------
Y
N--
L
N
T
I
D
L
E
K-AG
Y
S
L
H
K
L
L
VQP--N
D
---------
T
-
I
--
Y
--
V
S
TR----EN
Q
K
I
Y
V
MGESGKNQALPMRDQGM
S
L
---
T
-
D
A
L
G
E
SLGINPLSGSA
S
R
I
Y
V
V
RT--------NPN---------D---R---
T
---
T
E
------
I
Y
H
L
N
-
L
M
S
IGDFGLA
N
Q
F
R
LRS-----N-----
D
V
V
-
Y
V
DAT
G
--------
L
------
T
R
W
Q
R
I
V
N
--------
Q
-----II--PF
S
N
A
L
Y----------------
N
I
D
RLGQ-------------------
21
Fugue
91.34
27%
-101
- C4 -
-
2W8H
1
?
A:
[8-329]
------------------------------
I
P
G
Q
--------
G
-
L
N
S
L
R
K
----
N
V
V
E
L
P
-
D
S
D
Y
D
L
D
K
L
V
N
V
Y
P
-
M
T
P
G
L
I
D
Q
L
R
P
----
E
P
V
I
A
R
S
N
P
Q
L
D
N
L
L
K
S
Y
E
Y
R
I
G
-
V
---
G
D
V
L
M
V
T
V
W
D
H
P
E
L
T
T
P
A
G
Q
---
Y
R
S
A
S
D
T
G
-
N
W
V
N
S
D
G
T
I
F
Y
--
P
Y
I
G
K
V
Q
V
A
G
K
T
V
S
-----------
Q
V
R
Q
D
I
-
T
S
R
L
T
T
Y
I
E
---
S
-------------
P
-----
Q
V
D
V
S
I
A
A
F
R
S
Q
K
V
-
Y
----
V
T
G
E
V
A
N
S
G
K
Q
---
A
I
-------
T
N
I
-
P
L
T
V
M
D
A
I
N
--
A
-
A
G
G
L
A
A
-
D
--
A
D
W
----------------
R
N
V
V
L
T
H
N
G
-
K
D
--------------------------------------------
T
K
--
I
S
L
Y
A
L
M
Q
-
K
G
D
L
T
Q
N
H
L
L
Y
H
--
G
D
---------
I
-
L
--
F
--
I
P
S
N
----
D
D
L
K
V
F
V
M
G
E
V
G
K
Q
S
T
L
K
M
D
R
S
G
M
T
L
---
A
-
E
A
L
G
N
A
E
G
I
S
Q
E
M
S
D
A
T
G
I
F
V
V
R
Q
--------
L
K
G
---------
D
---
R
TGK
I
---
A
D
------
I
Y
Q
L
N
-
A
Q
D
A
S
A
M
V
L
G
T
E
F
Q
L
C
P
-----
Y
-----
D
I
V
-
Y
V
T
T
A
-------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.82
30%
1
- C4 -
-
2W8H
1
?
A:
[29-326]
-----------------------------------------------------------------
D
L
D
K
L
V
N
V
Y
P
-
M
T
P
G
L
I
D
Q
L
R
P
EPV
I
A
R
S
N
P
Q
L
D
--
N
L
L
K
S
Y
E
--
Y
R
I
G
-
V
---
G
D
V
L
M
V
T
V
W
D
H
P
E
L
T
T
P
A
G
Q
Y
---
R
S
A
S
D
T
G
-
N
W
V
N
S
D
G
T
I
F
Y
--
P
Y
I
G
K
V
Q
V
A
G
K
T
V
S
-----------
Q
V
R
Q
D
I
-
T
S
R
L
T
T
Y
I
E
---
S
-------------
P
-----
Q
V
D
V
S
I
A
A
F
R
S
Q
K
V
-
Y
----
V
T
G
E
V
A
N
S
G
K
Q
---
A
I
-------
T
N
I
-
P
L
T
V
M
D
A
I
N
--
A
-
A
G
G
L
A
A
-
D
--
A
D
W
----------------
R
N
V
V
L
T
H
N
G
-
K
D
--------------------------------------------
T
K
--
I
S
L
Y
A
L
M
Q
-
K
G
D
L
T
Q
N
H
L
L
Y
H
--
G
D
---------
I
-
L
--
F
--
I
P
S
N
----
D
D
L
K
V
F
V
M
G
E
V
G
K
Q
S
T
L
K
M
D
R
S
G
M
T
L
---
A
-
E
A
L
G
N
A
E
G
I
S
Q
E
M
S
D
A
T
G
I
F
V
V
R
Q
--------
L
K
G
---------
D
---
R
---
T
GKI
A
D
------
I
Y
Q
L
N
-
A
Q
D
A
S
A
M
V
L
G
T
E
F
Q
L
C
P
-----
Y
-----
D
I
V
-
Y
V
----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.04
30%
-
- C4 -
-
2W8I
-
?
A:
[45-342]
-----------------------------------------------------------------
D
L
D
K
L
V
N
V
Y
P
-
M
T
P
G
L
I
D
Q
L
R
P
EPVI
A
R
S
N
P
Q
L
D
--
N
L
L
K
S
Y
E
--
Y
R
I
G
-
V
---
G
D
V
L
M
V
T
V
W
D
H
P
E
L
T
T
P
A
G
Q
Y
---
R
S
A
S
D
T
G
-
N
W
V
N
S
D
G
T
I
F
Y
--
P
Y
I
G
K
V
Q
V
A
G
K
T
V
S
-----------
Q
V
R
Q
D
I
-
T
S
R
L
T
T
Y
I
E
---
S
-------------
P
-----
Q
V
D
V
S
I
A
A
F
R
S
Q
K
V
-
Y
----
V
T
G
E
V
A
N
S
G
K
Q
---
A
I
-------
T
N
I
-
P
L
T
V
M
D
A
I
N
--
A
-
A
G
G
L
A
A
-
D
--
A
D
W
----------------
R
N
V
V
L
T
H
N
G
-
K
D
--------------------------------------------
T
K
--
I
S
L
Y
A
L
M
Q
-
K
G
D
L
T
Q
N
H
L
L
Y
H
--
G
D
---------
I
-
L
--
F
--
I
P
S
N
----
D
D
L
K
V
F
V
M
G
E
V
G
K
Q
S
T
L
K
M
D
R
S
G
M
T
L
---
A
-
E
A
L
G
N
A
E
G
I
S
Q
E
M
S
D
A
T
G
I
F
V
V
R
Q
--------
L
K
G
---------
D
---
R
---
T
GKI
A
D
------
I
Y
Q
L
N
-
A
Q
D
A
S
A
M
V
L
G
T
E
F
Q
L
Q
P
-----
Y
-----
D
I
V
-
Y
V
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.74
28%
11
- C4 -
-
2J58
3
?
A:
[26-346]
-----------------------------------------------------------------
D
L
D
K
L
V
N
V
Y
P
-
M
T
P
G
L
I
D
Q
L
R
P
EPV
I
A
R
S
N
P
Q
L
D
--
N
L
L
K
S
Y
E
--
Y
R
I
G
-
V
---
G
D
V
L
M
V
T
V
W
D
H
P
E
L
T
T
P
A
G
Q
Y
---
R
S
A
S
D
T
G
-
N
W
V
N
S
D
G
T
I
F
Y
--
P
Y
I
G
K
V
Q
V
A
G
K
T
V
S
-----------
Q
V
R
Q
D
I
-
T
S
R
L
T
T
Y
I
E
---
S
-------------
P
-----
Q
V
D
V
S
I
A
A
F
R
S
Q
K
V
-
Y
----
V
T
G
E
V
A
N
S
G
K
Q
---
A
I
-------
T
N
I
-
P
L
T
V
M
D
A
I
N
--
A
-
A
G
G
L
A
A
-
D
--
A
D
W
----------------
R
N
V
V
L
T
H
N
G
-
K
D
--------------------------------------------
T
K
--
I
S
L
Y
A
L
M
Q
-
K
G
D
L
T
Q
N
H
L
L
Y
H
--
G
D
---------
I
-
L
--
F
--
I
P
S
N
----
D
D
L
K
V
F
V
M
G
E
V
G
K
Q
S
T
L
K
M
D
R
S
G
M
T
L
---
A
-
E
A
L
G
N
A
E
G
I
S
Q
E
M
S
D
A
T
G
I
F
V
V
R
Q
--------
L
K
G
---------
D
---
R
---
T
GKI
A
D
------
I
Y
Q
L
N
-
A
Q
D
A
S
A
M
V
L
G
T
E
F
Q
L
Q
P
-----
Y
-----
D
I
V
-
Y
V
T
T
A
P
--------
L
------
V
R
W
N
R
V
I
S
--------
Q
-----
L
V
--
P
T
I
S
G
V
H
----------------
D
-------------------------
29
HHSearch
69.43
28%
17
* C4 *
-
2J58
-
?
H:
[26-350]
-----------------------------------------------------------------
D
L
D
K
L
V
N
V
Y
P
-
M
T
P
G
L
I
D
Q
L
R
P
----
E
P
V
I
A
R
S
N
P
Q
L
D
N
L
L
K
S
Y
E
Y
R
I
G
-
V
---
G
D
V
L
M
V
T
V
W
D
H
P
E
L
T
T
P
A
G
Q
---
Y
R
S
A
S
D
T
G
-
N
W
V
N
S
D
G
T
I
F
Y
--
P
Y
I
G
K
V
Q
V
A
G
K
T
V
S
-----------
Q
V
R
Q
D
I
-
T
S
R
L
T
T
Y
I
E
---
S
-------------
P
-----
Q
V
D
V
S
I
A
A
F
R
S
Q
K
V
-
Y
----
V
T
G
E
V
A
N
S
G
K
Q
---
A
I
-------
T
N
I
-
P
L
T
V
M
D
A
I
N
--
A
-
A
G
G
L
A
A
-
D
--
A
D
W
----------------
R
N
V
V
L
T
H
N
G
-
K
D
--------------------------------------------
T
K
--
I
S
L
Y
A
L
M
Q
-
K
G
D
L
T
Q
N
H
L
L
Y
H
--
G
D
---------
I
-
L
--
F
--
I
P
S
N
----
D
D
L
K
V
F
V
M
G
E
V
G
K
Q
S
T
L
K
M
D
R
S
G
M
T
L
---
A
-
E
A
L
G
N
A
E
G
I
S
Q
E
M
S
D
A
T
G
I
F
V
V
R
Q
--------
L
K
G
---------
D
RTG
K
---
I
---
A
D
------
I
Y
Q
L
N
-
A
Q
D
A
S
A
M
V
L
G
T
E
F
Q
L
Q
P
-----
Y
-----
D
I
V
-
Y
V
T
T
A
P
--------
L
------
V
R
W
N
R
V
I
S
--------
Q
-----
L
V
--
P
T
I
S
G
V
H
----------------
D
M
T
E
T
---------------------
24
Fugue
56.36
18%
-69
- C2 -
-
5U5G
4
?
A:
[3-288]
--------
R
V
V
G
F
I
G
L
-
G
R
M
----------
G
Q
A
I
--------
C
-
R
R
L
L
A
S
----
Q
M
P
-------------
V
H
V
H
N
-
R
S
R
E
K
A
D
D
L
I
R
----
Q
G
A
V
W
A
P
D
I
V
A
L
T
R
A
A
R
V
L
F
V
C
T
-
A
---
G
----------------------
S
E
A
V
Q
D
F
Y
-
H
A
P
D
R
G
------------------------------------------
L
L
A
C
L
E
---
V
-------------
G
-----
D
I
V
V
D
L
S
T
I
A
P
E
T
A
E
G
----
L
H
A
A
F
A
Q
Q
G
A
D
---
Y
I
-------
E
-
C
-
P
V
S
G
G
V
E
G
A
--
L
-
A
G
I
L
S
A
-
I
V
S
G
R
P
----------------
E
A
Y
G
L
I
R
P
L
-
L
E
--------------------------------------------
V
F
--
C
A
T
V
T
Y
V
P
-
E
P
G
K
A
Q
R
L
K
I
L
N
--
N
L
---------
A
-
E
--
S
--
I
N
L
A
----
G
A
I
E
V
I
S
Q
G
L
S
Q
G
L
D
L
K
S
M
A
D
V
F
T
S
C
RGR
S
-
A
Y
M
D
V
A
L
G
Y
A
L
S
G
G
A
S
S
N
V
S
-----------------------------------------------
L
G
-
V
R
C
K
-
D
L
E
L
A
R
R
-
R
L
P
Q
-----
D
-----
Q
S
Y
-
P
F
S
T
L
A
--------
M
------
T
T
F
D
T
V
R
Q
--------
A
-----
C
G
--
E
E
S
D
Q
C
Q
----------------
Y
F
S
V
L
S
H
-------------------
23
Fugue
53.24
21%
29
- C2 -
-
4L8N
2
?
A:
[6-457]
-------
N
T
S
I
C
R
L
G
F
-
T
Y
D
ISQSKNWGNN
K
P
V
I
--------
K
-
S
I
I
P
Y
S
----
S
A
E
Q
A
G
-
I
K
K
Y
D
V
I
E
E
I
N
G
V
P
-
V
T
E
V
S
V
D
E
I
P
Q
----
L
L
N
P
A
G
R
N
D
V
L
L
-----
T
I
S
N
L
S
S
P
---
S
K
Q
V
L
V
K
K
D
C
K
K
S
-----
N
A
I
T
E
D
Q
L
A
S
A
Y
A
M
Y
S
L
E
T
T
N
E
Q
E
F
V
C
P
F
K
T
T
V
T
S
D
G
V
D
F
G
NFK
T
F
A
F
S
T
ID
E
N
N
R
K
L
-
E
T
V
I
N
E
C
I
E
---
N
E
L
T
K
K
G
L
T
V
D
IAK
P
-----
D
L
L
I
Q
T
F
Y
F
F
D
K
N
P
-
N
----
Y
L
G
A
N
E
K
E
P
T
Y
---
R
Y
N
FSHS
K
M
E
K
F
-
P
F
L
N
Y
A
A
A
E
--
A
E
A
E
Y
L
L
Q
-
F
--
G
I
R
----------------
I
I
D
Q
K
D
I
P
G
-
R
V
L-------------------------------------------
W
E
--
C
E
A
N
E
L
L
E
-
D
S
Y
R
L
D
E
Y
A
R
V
H
--
V
P
---------
L
M
C
M
Q
Y
--
P
Y
T
K
----
Y
G
R
N
V
P
F
K
-
V
S
K
K
T
Y
N
Y
T
----
G
I
S
Y
---
D
I
D
K
L
D
Q
V
V
D
V
D
R
----
N
S
P
A
Y
A
A
G
I
--------
R
P
R
---------
D
---
I
---
I
---
E
K
------
I
G
R
H
K
M
D
H
S
A
E
E
F
S
S
A
Y
K
R
F
I
T
N
T
M
QYR
D
-----
P
K
T
M
F
T
D
A
N
G
FK
Y
C
M
F
W
D
V
------
F
K
Y
P
Q
I
A
D
--------
A
S
Q
SSD
Y
L
--
P
A
F
S
Y
L
Y
YFAPYINPSGNN
A
C
T
F
N
I
K
R
G
K
T
K
L
E
V
I
I
R
P
T
I
R
S
E
V
T
V
E
IK
26
Fugue
49.07
19%
26
- C2 -
-
5HTX
1
?
A:
[14-437]
-----
E
K
L
Y
L
G
M
D
F
G
T
-
S
G
G
----------
R
F
T
V
I
D
EQGEIK
A
-
Q
G
K
R
E
Y
PPFM
K
E
E
S
M
G
-
W
A
S
S
W
K
A
T
L
F
S
L
L
E
D
I
P
V
T
V
R
S
L
V
S
S
----
I
S
L
D
G
T
S
A
T
T
L
I
L
N
S
E
S
G
E
V
L
C
Q
-
P
YLY
N
Q
S
C
P
D
A
L
P
E
V
K
S
I
A
P
A
N
H
T
V
C
S
G
T
S
T
L
C
K
L
-
V
S
W
W
N
T
E
V
P
N
R
--
E
S
A
V
L
L
H
Q
A
D
W
L
L
W
-----------
L
L
H
G
R
L
G
V
S
D
Y
N
N
A
L
K
VGY
D
-------------
P
-----
E
S
E
S
Y
P
S
W
L
L
G
Q
P
Y
-
S
----
Q
L
L
P
K
V
Q
A
P
G
T
---
S
I
-------
G
N
L
-
K
E
S
F
T
R
Q
F
G
--
F
-
P
D
D
C
I
V
C
T
--
G
T
T
----------------
D
S
I
A
A
F
L
A
A
-
R
A
--------------------------------------------
T
E
--
P
G
K
A
V
T
S
L
-
G
S
T
L
A
I
K
L
L
S
T
K
R
V
D
D
---------
A
-
R
--
Y
G
V
Y
S
H
R
----
L
D
D
K
W
L
V
G
G
A
S
--
N
T
G
G
A
I
L
R
Q
L
F
S
D
---
E
-
Q
L
E
R
L
S
Q
E
I
N
P
M
V
G
S
P
L
D
Y
Y
P
L
Q
S
S
G
E
RFPIA
D
P
N
L
A
P
R
LLPRP
E
---
S
---
D
---
V
E
------
F
L
H
G
I
-
L
E
S
I
A
R
I
E
G
K
G
Y
K
L
L
K
E
-----
L
GATEA
E
E
V
-
L
T
A
G
G
G
--------
A
KN----
D
K
W
I
K
I
R
Q
--------
R
-----
V
L
G
L
P
V
K
K
A
V
H
----------------
T
E
A
S
Y
G
A
S
L
L
A
L
K
G
A
K
Q
N
S-------
28
Fugue
48.18
18%
0
- C- -
-
4TNW
-
?
A:
[1-342]
S
D
S
K
I
L
A
H
L
F
T
S
G
Y
D
F
-
R
V
R
----------
P
P
T
D
--------
N
-
G
G
P
V
V
V
----
S
V
N
M
L
L
-
R
T
I
S
K
----
I
D
V
V
N
-
M
E
Y
S
A
Q
L
T
L
R
E
----
S
W
I
D
K
R
L
S
Y
G
V
K
G
D
G
Q
P
D
F
V
I
L
T
-
V
---
G
H
----
Q
I
W
M
P
D
T
F
F
P
--------
N
E
K
Q
A
Y
K
-
H
T
I
D
K
P
N
-------
V
L
I
R
I
H
N
D
G
T
V
L
Y
-----------
S
V
R
I
S
L
-
V
L
S
C
P
M
Y
L
Q
YY-
P
-------------
M
-----
D
V
Q
Q
C
S
I
D
L
A
S
Y
A
Y
-
T
---------
T
K
D
I
E
Y
---
L
W
-------
K
E
H
S
P
L
Q
L
K
V
G
L
S
SS
L
-
P
S
F
Q
L
T
-
N
--
T
S
T
----------------
T
Y
C
T
S
V
T
N
T
-
G
I
--------------------------------------------
Y
S
C
L
R
T
T
I
Q
L
K
R
E
F
S
F
Y
L
L
Q
L
Y
I
P
S
--
C
M
---------
L
-
V
--
I
--
V
S
W
V
S
F
W
F
D
R
T
A
I
P
A
R
V
T
L
G
V
T
T
L
L
T
M
T
A
Q
S
A
G
I
---
N
-
S
Q
L
-----------------------------------------
P
---
P
---
V
---
S
Y
------
I
K
A
I
D
-
V
W
I
G
A
C
M
T
F
I
F
C
A
L
L
E
F
-----
A
-----
L
V
N
-
H
I
A
N
A
G
--------
T
------
T
E
W
N
D
I
S
K
--------
R
-----
V
D
--
L
I
S
R
A
L
F
----------------
P
V
L
F
F
V
F
N
I
L
Y
W
S
R
F
GHHH-------
25
Fugue
45.14
17%
-8
- C2 -
-
4MSX
-
SAD1_YEAST
A:
[63-482]
--
Y
A
Y
L
E
T
V
V
R
E
K
L
D
F
D
S
E
K
----------
I
C
C
I
--------
T
L
S
P
L
N
V
Y
----
C
C
L
V
C
G
H
Y
Y
Q
G
R
H
E
K
S
P
A
F
I
H
-
S
I
D
E
N
H
H
V
F
L
N
----
L
T
---
S
L
K
F
Y
M
L
P
Q
N
V
Q
I
L
H
D
G
E
-
V
---
Q
L
L
N
S
I
K
F
A
A
Y
P
T
Y
C
P
K
D
L
E
D
F
P
R
Q
C
F
D
L
S
N
--
R
T
Y
L
N
G
F
I
G
F
--
T
N
A
A
T
Y
D
Y
A
H
S
V
L
L
-----------
L
I
S
H
-
M
-
V
P
V
R
D
H
F
L
L
---
N
-------------
H
FDNQG
E
F
I
K
R
L
S
I
C
V
K
K
I
W
-
S
---------
P
K
L
F
K
H
---
H
L
-------
S
V
D
-
D
F
V
S
Y
L
K
V
R
--
E
-
G
L
N
L
N
P
-
I
--
D
P
R
----------------
L
F
L
L
W
L
F
N
K
-
I
C
--------------------------------------------
S
S
--
S
N
D
L
K
S
I
L
-
N
H
S
C
K
G
K
V
K
I
A
K
--
S
E
SVT
G
K
V
I
V
K
P
-
F
--
W
--
V
L
T
L
----
D
L
P
E
F
S
P
F
E
D
G
N
S
V
D
D
L
P
Q
I
N
I
T
K
L
L
---
T
-
K
F
T
K
T
V
F
E
L
T
R
L
P
----
Q
F
L
I
F
H
F
--------
N
R
F
---------
D
---
R
---
N
---
S
D
HPVKNR
N
Q
T
L
V
-
E
F
S
S
E
L
E
I
L
H
V
K
Y
R
L
K
A
-----
N
-----
V
V
H
-
V
V
I
G
D
E
--------
K
------
S
H
W
I
T
Q
L
Y
D
NKSE
K
W
I
E
-----
I
D
--
G
I
N
T
T
E
R
----------------
E
A
E
L
L
F
L
KETF
I
Q
V
W
E
K
Q
E-------
33
HHSearch
42.40
13%
-78
- C4 -
-
3P42
-
?
A:
[126-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
V
T
I
-
T
----
L
L
G
A
V
S
G
A
G
Q
L
---
P
W
-------
L
-
A
-
G
R
S
V
T
D
Y
L
Q
--
D
-
H
P
R
L
-
A
-
G
--
A
D
K
----------------
N
N
V
M
V
I
T
P
E
G
E
T
--------------------------------------------
V
V
--
A
P
V
A
L
-
W
-----
N
K
R
H
V
E
P
P
P
--
G
S
---------
Q
-
L
--
W
--
L
G
F
S
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
41.52
13%
-79
- C4 -
-
3P42
-
?
D:
[126-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
V
T
I
-
T
----
L
L
G
A
V
S
G
A
G
Q
L
---
P
W
-------
L
-
A
-
G
R
S
V
T
D
Y
L
Q
--
D
-
H
P
R
L
-
A
-
G
--
A
D
K
----------------
N
N
V
M
V
I
T
P
E
G
E
T
--------------------------------------------
V
V
--
A
P
V
A
L
-
W
-----
N
K
R
H
V
E
P
P
P
--
G
S
---------
Q
-
L
--
W
--
L
G
F
S
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
39.37
9%
-0
- C4 -
-
3P42
-
?
A:
[4-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
V
T
I
Y
L
P
G
E
Q
Q
T
L
S
V
-------
G
-
P
-
V
E
N
V
A
Q
L
V
T
--
Q
-
P
Q
-
L
R
D
-
R
--
L
W
W
----------------
P
G
A
L
L
T
D
S
A
-
A
K
A
K
A
L
K
D
Y
Q
H
V
M
A
Q
L
A
S
W
E
A
E
AD
D
D
V
A
A
T
I
K
S
V
R
Q
Q
L
LNLNITGR
L
P
--
V
K
L
D
P
D
F
V
-
R
V
D
E
N
S
N
P
P
L
V
G
--
D
Y
---------
T
-
L
--
Y
--
T
V
Q
R
----
P
-
V
T
I
T
L
L
G
A
V
S
G
A
G
Q
L
P
W
L
A
G
-
R
S
V
---
T
-
D
Y
L
Q
D
H
P
R
L
-
A
-
G
A
D
K
N
N
V
M
V
I
T
P
--------
E
G
------------------
E
---
T
V
------
V
A
P
V
A
-
L
W
------
N
K
R
H
V
E
P
P
P
-----
G
-----
S
Q
L
-
W
L
G
F
S
A
--------
H
VLPEKY
A
D
L
N
D
Q
I
V
--------
S
-----
V
L
--
T
Q
R
V
P
E
-------------------------------------------
30
HHSearch
38.47
9%
1
- C4 -
-
3P42
-
?
D:
[4-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
V
T
I
Y
L
P
G
E
Q
QTL
S
V
-------
G
-
P
-
V
E
N
V
A
Q
L
V
T
--
Q
-
P
Q
-
L
R
D
-
R
--
L
W
W
----------------
P
G
A
L
L
T
D
S
A
-
A
K
AKALKDYQHVMAQLASWEAEADDDVAATIKSVRQQLLNLNITGR
L
P
--
V
K
L
D
P
D
F
V
-
R
V
D
E
N
S
N
P
P
L
V
G
--
D
Y
---------
T
-
L
--
Y
--
T
V
Q
R
----
P
-
V
T
I
T
L
L
G
A
V
S
G
A
G
Q
L
P
W
L
A
G
-
R
S
V
---
T
-
D
Y
L
Q
D
H
P
R
L
-
A
-
G
A
D
K
N
N
V
M
V
I
T
P
--------
E
G
------------------
E
---
T
V
------
V
A
P
V
A
-
L
W
------
N
K
R
H
V
E
P
P
P
-----
G
-----
S
Q
L
-
W
L
G
F
S
A
--------
H
VLPEKY
A
D
L
N
D
Q
I
V
--------
S
-----
V
L
--
T
Q
R
V
P
E
-------------------------------------------
11
PsiBlast_PDB
37.85
37%
-32
- C3 -
-
4OZX
-
ALYA_KLEPN
A:
[236-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
-
T
--
G
N
K
----------------
L
T
V
T
L
M
R
E
G
-
R
P
--------------------------------------------
D
V
--
V
K
T
V
D
M
S
K
-
S
G
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.16
25%
4
- C5 -
-
2R5E
1
?
A:
[82-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
-----------
Q
A
L
S
K
L
-
Y
S
Q
L
V
D
R
T
I
---
N
-------------
P
MT---
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
-
T
----
I
Q
G
H
V
D
E
G
D
E
V
---
I
I
-------
I
E
P
-
F
F
D
C
Y
E
P
M
V
--
K
-
A
A
G
-------
G
I
P
----------------
R
F
I
P
L
K
P
N
K
-
T
G
--------------------------------------------
G
T
--
I
S
S
A
D
W
V
L
-
D
N
N
E
L
E
A
L
F
N
E
K
--
T
K
---------
M
-
I
--
I
--
I
N
T
P
----
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.44
25%
4
* C5 *
-
1YIZ
-
?
A:
[82-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
-----------
Q
A
L
S
K
L
-
Y
S
Q
L
V
D
R
T
I
---
N
-------------
P
MT---
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
-
T
----
I
Q
G
H
V
D
E
G
D
E
V
---
I
I
-------
I
E
P
-
F
F
D
C
Y
E
P
M
V
--
K
-
A
A
G
-------
G
I
P
----------------
R
F
I
P
L
K
P
N
K
-
T
G
--------------------------------------------
G
T
--
I
S
S
A
D
W
V
L
-
D
N
N
E
L
E
A
L
F
N
E
K
--
T
K
---------
M
-
I
--
I
--
I
N
T
P
----
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
36.28
25%
-1
- C5 -
-
2R5C
-
?
A:
[82-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
-----------
Q
A
L
S
K
L
-
Y
S
Q
L
V
D
R
T
I
---
N
-------------
P
MT---
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
-
T
----
I
Q
G
H
V
D
E
G
D
E
V
---
I
I
-------
I
E
P
-
F
F
D
C
Y
E
P
M
V
--
K
-
A
A
G
-------
G
I
P
----------------
R
F
I
P
L
K
P
N
K
-
T
G
--------------------------------------------
G
T
--
I
S
S
A
D
W
V
L
-
D
N
N
E
L
E
A
L
F
N
E
K
--
T
K
---------
M
-
I
--
I
--
I
N
T
P
----
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
36.18
25%
4
- C5 -
-
1YIY
1
?
A:
[82-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
-----------
Q
A
L
S
K
L
-
Y
S
Q
L
V
D
R
T
I
---
N
-------------
P
MT---
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
-
T
----
I
Q
G
H
V
D
E
G
D
E
V
---
I
I
-------
I
E
P
-
F
F
D
C
Y
E
P
M
V
--
K
-
A
A
G
-------
G
I
P
----------------
R
F
I
P
L
K
P
N
K
-
T
G
--------------------------------------------
G
T
--
I
S
S
A
D
W
V
L
-
D
N
N
E
L
E
A
L
F
N
E
K
--
T
K
---------
M
-
I
--
I
--
I
N
T
P
----
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
34.63
26%
9
- C6 -
-
5K69
-
LDT2_MYCTU
A:
[58-162]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L
V
P
K
L
T
A
S
V
T
D
G
A
V
G
---
V
T
-------
V
D
A
-
P
V
S
V
T
A
A
D
G
--
V
-
L
A
A
V
T
M
-
V
--
N
D
N
G
R
P
V
A
G
R
L
S
PDGL
R
W
S
T
T
E
Q
L
G
Y
N
--
R
R
--------------------------------------------
Y
T
--
L
N
A
T
A
L
G
L
-
G
G
A
A
T
R
Q
L
T
F
Q
T
--
S
S
---------
P
-
A
--
H
--
L
T
M
P
---------
Y
V
M
P
G
D
G
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------