@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMS0: (2017-11-10 )
MIKKAVLPVAGLGTRFLPASKSIPKEMVTVVDRPAIEYVVREAVEAGIEQIILVTHSSKASIENYFDRNLELETTLEQKKKFDLLAEITQIVPEHVSVVSVRQPQPLGLGHAVLCAKSVVGQDDFAVLLPDVLVKDSSGQNDLSRMISRYNSSQAAQIMVEAVPDHLVDQYGIVDVKHSPNEGESIAMQGIVEKPAVGSAPSNLSVVGRYVLPAKIMQLLENTPKGAGNEIQLTDAIAMLQDTDTVEAYRMQGQTFDCGSKIGYLKAVLHYGIEHPKLGNDFKKLIQELKL
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........-80........90........100.......110.......120-...--.....130....-.---..140.......150.......160.......170.......180........190.......200.......210.......220.......230.......240..-.....250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIKKAVLPVAGLGTRFLPASKSI
P
K
E
M
V
T
V
VD
R
P
A
I
E
Y
V
V
R
E
A
V
E
A
G
I
E
Q
I
I
L
V
THSSKA
S
I
E
N
Y
F
DRNLE
L
E
T
T
L
E
Q
K
-
K
K
F
D
L
L
A
E
I
T
Q
I
V
P
E
HV
S
V
V
SVRQPQPLGL
G
H
A
V
L
C
A
K
S
VVG--QD
D
--
F
A
V
L
L
P
D
V
LVKD-S---SG
Q
N
D
L
S
R
M
I
S
RYNS
S
Q
A
A
Q
I
M
V
E
AV
P
D
H
L
V
D
QY
G
I
V
DVKHSP-NEG
E
S
I
A
M
QGIVEKPAVGSAPS
N
L
S
V
V
GRYV
L
P
A
K
I
M
Q
L
L
ENTPKGAGN
E
I
Q
L
T
D
A
I
A
MLQDTD-
T
V
E
A
Y
RMQGQTFDCGSK
I
G
Y
L
K
A
V
L
H
YGIEHPKL
G
N
D
F
K
K
L
I
Q
E
LKL
2
PsiBlast_PDB
85.53
48%
-117
- C1 -
-
5I1F
1
?
A:
[12-292]
-
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
E
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
E
A
R
-
G
K
E
K
L
L
S
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
A
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
D
G
-
P
---
T
P
V
--
L
R
Q
M
I
D
V
F
D
H
Y
H
A
S
V
I
G
V
E
E
I
A
P
A
D
S
K
S
Y
G
V
I
D
G
K
R
W
---
E
D
D
L
F
K
L
S
G
I
V
E
K
P
E
P
A
Q
A
P
S
N
F
G
V
V
G
R
Y
V
L
K
P
K
I
F
K
H
L
R
G
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
L
T
D
E
-
Q
V
L
A
Y
R
Y
D
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
R
Y
L
-----
1
PsiBlast_PDB
85.13
47%
-116
* C1 *
-
5J49
1
?
A:
[12-293]
-
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
Q
A
R
-
G
K
D
K
L
L
E
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
Y
G
-
T
---
P
--
P
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
G
K
E
W
---
E
D
S
I
I
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
E
Y
L
R
----
4
PsiBlast_PDB
85.04
47%
-120
- C1 -
-
5VE7
1
?
A:
[12-293]
-
V
N
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
V
E
A
E
L
E
A
R
-
G
K
A
K
L
L
E
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
A
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
D
G
-
N
---
P
P
V
--
M
K
Q
M
V
D
V
F
D
H
Y
H
S
S
V
I
G
V
E
E
I
P
P
S
E
T
K
S
Y
G
I
V
D
G
K
E
W
---
E
E
S
I
V
K
M
S
A
I
V
E
K
P
A
P
E
V
A
P
S
N
L
G
V
V
G
R
Y
I
L
K
P
R
I
F
E
H
L
R
A
L
K
P
----
E
L
Q
L
T
D
A
I
Q
A
L
L
A
D
E
-
Q
V
L
A
Y
K
Y
Q
G
T
R
Y
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
G
T
E
F
D
A
Y
L
R
----
3
PsiBlast_PDB
83.81
47%
-123
- C1 -
-
5VCT
1
?
A:
[12-293]
-
V
N
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
V
V
D
K
P
L
I
Q
Y
A
V
E
E
A
I
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
V
E
A
E
L
E
A
R
-
G
K
A
K
L
L
E
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
A
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
D
G
-
N
---
P
P
V
--
M
K
Q
M
V
D
V
F
D
H
Y
H
S
S
V
I
G
V
E
E
I
P
P
S
E
T
K
S
Y
G
I
V
D
G
K
E
W
---
E
E
S
I
V
K
M
S
A
I
V
E
K
P
A
P
E
V
A
P
S
N
L
G
V
V
G
R
Y
I
L
K
P
R
I
F
E
H
L
R
A
L
K
P
----
E
L
Q
L
T
D
A
I
Q
A
L
L
A
D
E
-
Q
V
L
A
Y
K
Y
Q
G
T
R
Y
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
G
T
E
F
D
A
Y
L
R
----
21
PsiBlast_CBE
83.42
47%
-116
- C1 -
-
5J49
1
?
B:
[12-293]
-
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
Q
A
R
-
G
K
D
K
L
L
E
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
Y
G
-
T
---
P
--
P
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
G
K
E
W
---
E
D
S
I
I
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
A
A
D
F
E
E
Y
L
R
----
61
HHSearch
82.15
49%
-114
- C1 -
-
5J49
1
?
B:
[11-284]
K
V
T
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
S
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
A
A
G
I
T
E
M
I
F
V
T
G
R
S
K
R
A
I
E
D
H
F
D
K
S
Y
E
I
E
A
E
L
Q
A
R
-
G
K
D
K
L
L
E
L
V
R
S
I
K
P
S
H
V
D
C
F
Y
V
R
Q
P
E
A
L
G
L
G
H
A
V
L
C
A
E
K
L
V
G
--
D
N
P
--
F
A
V
I
L
A
D
D
L
L
Y
G
-
T
---
P
P
--
V
M
A
Q
M
I
E
V
F
D
H
Y
H
S
S
V
I
G
V
E
E
I
P
A
Q
E
T
K
S
Y
G
I
V
D
G
K
E
W
E
---
D
S
I
I
K
M
S
G
I
V
E
K
P
E
P
N
V
A
P
S
N
L
G
V
V
G
R
Y
V
L
K
P
R
I
F
E
H
L
R
A
L
K
P
G
A
G
G
E
L
Q
L
T
D
A
I
Q
S
L
L
A
D
E
-
Q
V
L
A
Y
K
Y
H
G
T
R
F
D
C
G
S
K
L
G
Y
L
K
A
T
V
E
F
A
L
R
H
P
E
V
-------------
5
PsiBlast_PDB
79.32
40%
-121
- C1 -
-
3JUJ
-
?
A:
[1-268]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
Q
G
T
-
N
K
E
N
A
L
K
S
I
R
N
I
I
-
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
-
H
---
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
-
L
E
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
--------------------
58
HHSearch
78.91
56%
-59
- C1 -
-
2E3D
-
GALU_ECOLI
B:
[7-296]
K
V
K
K
A
V
I
P
V
A
G
L
G
T
R
M
L
P
A
T
K
A
I
P
K
E
M
L
P
L
V
D
K
P
L
I
Q
Y
V
V
N
E
C
I
A
A
G
I
T
E
I
V
L
V
T
H
S
S
K
N
S
I
E
N
H
F
D
T
S
F
E
L
E
A
M
L
E
K
----
R
Q
L
L
D
E
V
Q
S
I
C
P
P
H
V
T
I
M
Q
V
R
Q
G
--
K
G
L
G
H
A
V
L
C
A
H
P
V
V
G
--
D
E
P
--
V
A
V
I
L
P
D
V
I
L
D
E
-
Y
ESD
L
S
Q
D
N
L
A
E
M
I
R
R
F
D
E
T
G
H
S
Q
I
M
V
E
--
P
V
A
D
V
T
A
Y
G
V
V
D
C
K
G
V
E
L
A
P
G
E
S
V
P
M
V
G
V
V
E
K
P
K
A
D
V
A
P
S
N
L
A
I
V
G
R
Y
V
L
S
A
D
I
W
P
L
L
A
K
T
--------
Q
L
T
D
A
I
D
M
L
I
E
K
E
-
T
V
E
A
Y
H
M
K
G
K
S
H
D
C
G
N
K
L
G
Y
M
Q
A
F
V
E
Y
G
I
R
H
N
T
L
G
T
E
F
K
A
W
L
E
E
---
6
PsiBlast_PDB
76.96
40%
-120
- C1 -
-
3JUK
1
?
A:
[1-268]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
-
N
K
E
N
A
L
K
S
I
R
N
I
I
-
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
-
H
---
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
-
L
E
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
--------------------
30
PsiBlast_CBE
76.33
40%
-121
- C1 -
-
3JUK
1
?
C:
[1-268]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
----------
N
K
E
N
A
L
K
S
I
R
N
I
I
-
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
-
H
---
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
-
L
E
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
--------------------
31
PsiBlast_CBE
76.31
40%
-117
- C1 -
-
3JUK
1
?
B:
[1-268]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
----------
N
K
E
N
A
L
K
S
I
R
N
I
I
-
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
-
H
---
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
-
L
E
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
--------------------
29
PsiBlast_CBE
75.74
40%
-118
- C1 -
-
3JUK
1
?
D:
[1-268]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
-
N
K
E
N
A
L
K
S
I
R
N
I
I
-
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
-
H
---
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
-
L
E
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
--------------------
27
PsiBlast_CBE
74.28
47%
-56
- C1 -
-
2UX8
1
?
C:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
25
PsiBlast_CBE
73.39
47%
-59
- C1 -
-
2UX8
1
?
E:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
--------
Q
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
24
PsiBlast_CBE
72.70
47%
-53
- C1 -
-
2UX8
1
?
F:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
------
Q
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
23
PsiBlast_CBE
72.65
47%
-50
- C1 -
-
2UX8
1
?
G:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
26
PsiBlast_CBE
72.35
47%
-59
- C1 -
-
2UX8
1
?
D:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
28
PsiBlast_CBE
71.88
47%
-60
- C1 -
-
2UX8
1
?
B:
[14-284]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
E
Q
M
I
F
V
T
G
R
G
K
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
-
D
G
T
R
L
K
P
G
N
I
A
Y
--
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
-
Q
---
P
G
C
--
L
K
Q
M
V
D
A
Y
N
K
V
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
-
Q
D
G
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
--------
L
T
D
A
M
Q
R
M
I
G
D
Q
-
P
F
H
G
V
T
F
Q
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
D
L
-------------
65
HHSearch
71.48
39%
-60
- C1 -
-
2PA4
1
?
B:
[11-299]
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
-
G
K
T
D
Q
V
E
I
I
R
R
A
-
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
--
V
A
V
M
L
P
D
D
L
V
L
P
T
G
---
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
L
-
67
HHSearch
71.35
39%
-72
- C1 -
-
3JUJ
-
?
A:
[1-271]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
Q
G
T
-
N
K
-
E
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
---
H
P
S
-
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
W
L
E
---
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
-----------------
68
HHSearch
71.18
39%
-70
- C1 -
-
3JUK
1
?
A:
[1-271]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
E
V
M
A
I
V
T
G
R
N
K
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
-
N
K
-
E
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
---
H
P
S
-
V
L
K
Q
M
T
S
L
Y
Q
K
Y
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
I
R
G
E
W
L
E
---
E
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
L
R
T
Q
A
K
R
K
-
R
I
I
A
Y
Q
F
K
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
-----------------
64
HHSearch
69.49
39%
-57
- C1 -
-
2PA4
1
?
D:
[11-299]
A
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
----
D
Q
V
E
I
I
R
R
A
-
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
--
V
A
V
M
L
P
D
D
L
V
L
P
T
G
---
V
----
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
L
-
7
PsiBlast_PDB
68.26
38%
-27
- C1 -
-
2PA4
1
?
A:
[12-298]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
-
G
K
T
D
Q
V
-
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
---
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
--
33
PsiBlast_CBE
68.19
38%
-28
- C1 -
-
2PA4
1
?
C:
[12-298]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
-
G
K
T
D
Q
V
-
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
---
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
--
34
PsiBlast_CBE
67.16
38%
-26
- C1 -
-
2PA4
1
?
B:
[12-298]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
-
G
K
T
D
Q
V
-
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
-
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
---
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
Q
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
V
Y
G
A
Q
L
K
D
A
I
K
Q
I
--
32
PsiBlast_CBE
66.52
38%
-29
- C1 -
-
2PA4
1
?
D:
[12-298]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
T
R
L
A
I
I
T
A
P
N
K
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
----
D
Q
V
-
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
DV
V
A
V
M
L
P
D
D
L
V
L
P
-
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
G
G
S
V
L
C
A
V
E
V
S
E
A
D
---
V
S
K
Y
G
I
F
E
I
E
A
D
T
-
K
D
S
D
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