@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMU1: (2017-11-10 )
MSQNKIWVIDDDRAMRWVLEKTFKEEGFDVTNFEEAQTALERLHHDAPDVILTDIRMPGIDGLTFLSKVKNSHPDLPVIIMTAHSDLESAVSSYQTGAFEYLPKPFDIDEALALVNRAILHINKLQQQEATKTASPLQSTEIIGESPAMQEVFRAIGRLSQSHITVLINGESGTGKELVAHALHKHSPRRAKPFIALNMAAIPKDLIETELFGHEKGAFTGANTQHQGRFEQANGGTLFLDEIGDMPFETQTRLLRVLADGEFYRVGGHIPVKVDVRIVAATHQDLEKLVNEGRFREDLYHRLNVIRIHIPKLAHRSEDIPMLAQHFLARAGKELGVSPKILRTETTDYMQQLPWPGNVRQLENTCRWLTVMITGREVYPEDLPSELKQVPLQKSSETSQPAPSFERISLHHWDELLSQWAIQKLKNGEMKILDIATPMFERTLINAALQQTRGRKRHAAELLGWGRNTLTRKLKELGMDSADDDDEDEHKATLSEA
Atome Classification :
(34 SA)
.........10........20........30........40........50........--60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......---.330.......-340...-....350.......360.......370.......380.......390.......400.......410.......420.......430........440.......450.......460.......470.......480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSQN
K
I
W
V
IDD
D
R
A
M
R
W
V
L
E
K
T
F
K
EEGFDVT
N
F
E
E
A
Q
T
A
L
E
R
L
HHDAPD
V
I
L
TDIRMPG--I
D
G
L
T
F
L
S
K
V
KNSHPDL
P
V
I
I
M
TAH
S
D
L
E
S
A
V
S
S
YQT
G
A
F
EYLPKPF
D
I
D
E
A
L
A
L
V
N
R
A
I
L
H
I
N
K
L
Q
Q
Q
E
ATKTASPL
Q
S
T
EIIGES
P
A
M
Q
E
V
F
R
A
I
G
R
LSQS
H
I
T
V
L
I
NGESG
T
G
K
E
L
V
A
H
A
L
HKHSPRRAK
P
F
I
A
L
N
M
A
AI
P
K
D
L
I
E
T
E
LFGHEKGAFTGANTQHQGRFEQANG
G
T
L
F
L
D
EIGDMP
F
E
T
Q
T
R
L
L
R
V
LADG
E
F
Y
R
VGG
H
I
P
V
K
V
D
V
R
I
V
AA
T
H
Q
D
L
E
K
L
V
NEG
R
F
R
E
D
L
Y
H
R
L
N
V
I
R
I
HI
P
K
L
AHRSED
I
P
M
L
A
Q
H
F
L
---
A
RA
G
K
ELGVSP-
K
I
L
RTE-
T
T
D
Y
M
Q
QLPWPG
N
V
R
Q
L
E
N
TC
R
W
L
T
V
M
I
TGREVY
P
E
D
L
P
S
E
L
K
QVPLQKSSETSQPAPS
F
E
R
I
S
L
H
H
W
D
E
L
L
S
Q
W
A
I
Q
K
LKNG
E
M
K
-
I
L
DIA
T
P
M
F
E
R
T
L
I
N
A
A
L
Q
Q
TRGR
K
R
H
A
A
E
L
L
GW
G
R
N
T
L
T
R
K
L
K
E
LGMDSADDDD
E
D
E
H
K
ATLSEA
227
Fugue
89.03
40%
-124
- C5 -
-
1NY5
3
?
A:
[1-384]
---
M
N
V
L
V
I
E
D
D
K
V
F
R
G
L
L
E
E
Y
L
S
M
K
G
I
K
V
E
S
A
E
R
G
K
E
A
Y
K
L
L
S
E
K
H
F
N
V
V
L
L
D
L
L
L
P
D
--
V
N
G
L
E
I
L
K
W
I
K
E
R
S
P
E
T
E
V
I
V
I
T
G
H
G
T
I
K
T
A
V
E
A
M
K
M
G
A
Y
D
F
L
T
K
P
C
M
L
E
E
I
E
L
T
I
N
K
A
I
E
H
R
K
L
R
K
E
N
E
L
L
R
R
E
K
D
L
K
E
E
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
P
L
R
E
R
K
E
D
I
I
P
L
A
N
H
F
L
---
K
K
F
S
R
K
Y
A
K
E
V
-
E
G
F
T
K
S
-
A
Q
E
L
L
L
S
Y
P
W
Y
G
N
V
R
E
L
K
N
V
I
E
R
A
V
L
F
S
E
G
K
F
I
D
R
G
E
L
S
C
L
V
---------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.30
41%
-128
- C5 -
-
1NY5
3
?
B:
[3-373]
-----
V
L
V
I
E
D
D
K
V
F
R
G
L
L
E
E
Y
L
S
M
K
G
I
K
V
E
S
A
E
R
G
K
E
A
Y
K
L
L
S
E
K
H
F
N
V
V
L
L
D
L
L
L
P
D
--
V
N
G
L
E
I
L
K
W
I
K
E
R
S
P
E
T
E
V
I
V
I
T
G
H
G
T
I
K
T
A
V
E
A
M
K
M
G
A
Y
D
F
L
T
K
P
C
M
L
E
E
I
E
L
T
I
N
K
A
I
E
H
R
K
L
R
K
E
N
E
L
L
R
R
E
K
D
L
K
E
E
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
P
L
R
E
R
K
E
D
I
I
P
L
A
N
H
F
L
---
K
K
F
S
R
K
Y
A
K
E
V
-
E
G
F
T
K
S
-
A
Q
E
L
L
L
S
Y
P
W
Y
G
N
V
R
E
L
K
N
V
I
E
R
A
V
L
F
S
E
G
K
--------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.57
41%
-127
- C5 -
-
1NY5
3
?
A:
[3-373]
-----
V
L
V
I
E
D
D
K
V
F
R
G
L
L
E
E
Y
L
S
M
K
G
I
K
V
E
S
A
E
R
G
K
E
A
Y
K
L
L
S
E
K
H
F
N
V
V
L
L
D
L
L
L
P
D
--
V
N
G
L
E
I
L
K
W
I
K
E
R
S
P
E
T
E
V
I
V
I
T
G
H
G
T
I
K
T
A
V
E
A
M
K
M
G
A
Y
D
F
L
T
K
P
C
M
L
E
E
I
E
L
T
I
N
K
A
I
E
H
R
K
L
R
K
E
N
E
L
L
R
R
E
K
D
L
K
E
E
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
P
L
R
E
R
K
E
D
I
I
P
L
A
N
H
F
L
---
K
K
F
S
R
K
Y
A
K
E
V
-
E
G
F
T
K
S
-
A
Q
E
L
L
L
S
Y
P
W
Y
G
N
V
R
E
L
K
N
V
I
E
R
A
V
L
F
S
E
G
K
--------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.93
35%
-122
- C5 -
-
5M7P
1
?
B:
[6-454]
-----
I
L
V
V
D
D
E
V
D
I
R
D
L
V
A
G
I
L
S
D
E
G
H
E
T
R
T
A
F
D
A
D
S
A
L
A
A
I
N
D
R
A
P
R
L
V
F
L
D
I
W
L
-----
D
G
L
A
L
L
D
E
I
K
K
Q
H
P
E
L
P
V
V
M
I
S
G
H
G
N
I
E
T
A
V
S
A
I
R
R
G
A
Y
D
F
I
E
K
P
F
K
A
D
R
L
I
L
V
A
E
R
A
-
L
E
T
S
K
L
K
R
E
V
S
D
L
R
K
R
T
G
D
Q
L
E
L
V
G
T
S
L
A
M
N
Q
L
R
Q
T
I
E
R
V
A
P
T
N
S
R
I
M
I
T
G
P
S
G
A
G
K
E
L
V
A
R
A
I
H
A
Q
S
S
R
A
N
G
P
F
V
T
V
N
A
A
T
I
T
P
E
R
M
E
I
E
L
F
G
T
E
----
M
---
E
R
K
V
G
A
L
E
E
A
H
G
G
I
L
Y
L
D
E
V
A
D
M
P
R
E
T
Q
N
K
I
L
R
V
L
V
D
Q
Q
F
E
R
V
G
G
T
K
R
V
K
V
D
V
R
I
I
S
S
T
A
Q
N
L
E
G
M
I
A
E
G
T
F
R
E
D
L
F
H
R
L
S
V
V
P
V
Q
V
P
A
L
A
A
R
R
E
D
I
P
S
L
V
E
F
F
M
---
K
Q
I
A
E
Q
A
G
I
K
P
-
R
K
I
G
P
D
-
A
M
A
V
L
Q
A
H
S
W
P
G
N
L
R
Q
L
R
N
N
V
E
R
L
M
I
L
T
R
G
------
D
D
P
D
E
L
V
T
A
D
L
L
-
P
A
E
I
--------
T
E
S
D
Q
H
I
M
A
L
P
L
R
E
A
R
E
R
----------------
F
E
K
E
Y
L
I
A
Q
I
N
R
F
G
G
N
I
S
R
T
A
E
F
V
G
M
E
R
S
A
L
H
R
K
L
K
S
L
G
V
------------------
24
PsiBlast_CBE
86.65
35%
-124
- C5 -
-
5M7N
2
?
B:
[6-454]
-----
I
L
V
V
D
D
E
V
D
I
R
D
L
V
A
G
I
L
S
D
E
G
H
E
T
R
T
A
F
D
A
D
S
A
L
A
A
I
N
D
R
A
P
R
L
V
F
L
D
I
W
L
------
G
L
A
L
L
D
E
I
K
K
Q
H
P
E
L
P
V
V
M
I
S
G
H
G
N
I
E
T
A
V
S
A
I
R
R
G
A
Y
D
F
I
E
K
P
F
K
A
D
R
L
I
L
V
A
E
R
A
-
L
E
T
S
K
L
K
R
E
V
S
D
L
R
K
R
T
G
---
E
L
V
G
T
S
L
A
M
N
Q
L
R
Q
T
I
E
R
V
A
P
T
N
S
R
I
M
I
T
G
P
S
G
A
G
K
E
L
V
A
R
A
I
H
A
Q
S
S
R
A
N
G
P
F
V
T
V
N
A
A
T
I
T
P
E
R
M
E
I
E
L
F
G
T
E
----
M
---
E
R
K
V
G
A
L
E
E
A
H
G
G
I
L
Y
L
D
E
V
A
D
M
P
R
E
T
Q
N
K
I
L
R
V
L
V
D
Q
Q
F
E
R
V
G
G
T
K
R
V
K
V
D
V
R
I
I
S
S
T
A
Q
N
L
E
G
M
I
A
E
G
T
F
R
E
D
L
F
H
R
L
S
V
V
P
V
Q
V
P
A
L
A
A
R
R
E
D
I
P
S
L
V
E
F
F
M
---
K
Q
I
A
E
Q
A
G
I
K
P
-
R
K
I
G
P
D
-
A
M
A
V
L
Q
A
H
S
W
P
G
N
L
R
Q
L
R
N
N
V
E
R
L
M
I
L
T
R
G
------
D
D
P
D
E
L
V
T
A
D
L
L
-
P
A
E
I
-------------
H
I
M
A
L
P
L
R
E
A
R
E
R
----------------
F
E
K
E
Y
L
I
A
Q
I
N
R
F
G
G
N
I
S
R
T
A
E
F
V
G
M
E
R
S
A
L
H
R
K
L
K
S
L
G
V
------------------
2
PsiBlast_PDB
83.84
38%
-109
- C5 -
-
3DZD
1
?
A:
[1-368]
---
K
R
V
L
V
V
D
D
E
E
S
I
T
S
S
L
S
A
I
L
E
E
E
G
Y
H
P
D
T
A
K
T
L
R
E
A
E
K
K
I
K
E
L
F
F
P
V
I
V
L
D
V
W
M
P
D
--
G
D
G
V
N
F
I
D
F
I
K
E
N
S
P
D
S
V
V
I
V
I
T
G
H
G
S
V
D
T
A
V
K
A
I
K
K
G
A
Y
E
F
L
E
K
P
F
S
V
E
R
F
L
L
T
I
K
H
A
F
--------
E
E
Y
S
K
K
A
P
P
Q
E
E
I
E
F
V
G
E
H
P
K
I
L
E
I
K
R
L
I
P
K
I
A
K
S
K
A
P
V
L
I
T
G
E
S
G
T
G
K
E
I
V
A
R
L
I
H
R
Y
S
G
R
K
G
-
A
F
V
D
L
N
C
A
S
I
P
Q
E
L
A
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
L
T
R
K
K
G
K
L
E
L
A
D
Q
G
T
L
F
L
D
E
V
G
E
L
D
Q
R
V
Q
A
K
L
L
R
V
L
E
T
G
S
F
T
R
L
G
G
N
Q
K
I
E
V
D
I
R
V
I
S
A
T
N
K
N
L
E
E
E
I
K
K
G
N
F
R
E
D
L
Y
Y
R
L
S
V
F
Q
I
Y
L
P
P
L
R
E
R
G
K
D
V
I
L
L
A
E
Y
F
L
---
K
K
F
A
K
E
Y
K
K
N
C
-
F
E
L
S
E
E
-
T
K
E
Y
L
M
K
Q
E
W
K
G
N
V
R
E
L
K
N
L
I
E
R
A
V
I
L
C
E
G
E
V
I
K
P
----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.19
41%
-95
- C5 -
-
5EP0
2
?
A:
[4-385]
--
Q
R
Q
V
L
M
V
E
D
T
A
S
V
A
A
L
Y
K
S
Y
L
N
P
L
G
L
N
V
S
I
V
G
T
G
K
E
A
L
S
F
I
Q
D
I
I
P
D
L
I
L
L
D
L
R
L
P
D
--
M
T
G
M
E
V
L
E
R
V
R
K
E
H
G
N
V
P
V
V
I
M
T
A
H
G
S
I
D
I
A
V
E
A
I
R
Y
G
A
Q
D
F
L
I
K
P
C
E
A
D
R
L
R
I
T
V
N
K
A
L
K
A
E
S
---
T
S
T
Q
S
K
Q
S
D
G
A
Q
Y
Q
G
F
I
G
N
S
L
P
M
Q
A
V
Y
R
V
I
E
S
A
A
S
S
K
A
T
V
F
I
T
G
E
S
G
T
G
K
E
V
C
A
E
A
I
H
A
A
S
P
R
H
D
K
P
F
I
A
L
N
C
A
A
I
P
K
D
L
I
E
S
E
L
F
G
H
V
K
G
A
F
T
---
T
E
R
Q
G
A
V
E
M
A
H
N
G
T
L
M
L
D
E
L
C
E
M
D
L
D
L
Q
S
K
L
L
R
F
I
Q
T
G
T
Y
Q
K
V
G
S
S
K
M
S
S
V
D
V
R
F
V
C
A
T
N
R
N
P
W
E
E
V
Q
E
G
R
F
R
E
D
L
Y
Y
R
L
H
V
I
P
I
S
L
P
P
L
R
E
R
G
G
D
I
I
E
I
A
H
A
L
L
---
G
L
M
S
L
E
E
G
K
S
F
-
S
R
F
S
E
P
-
V
L
R
L
F
E
S
Y
S
W
P
G
N
V
R
E
L
Q
N
V
I
R
N
I
V
V
L
N
T
D
D
E
V
K
L
E
M
V
P
------------------------------------------------------------------------------------------------------------------
210
HHSearch
80.22
38%
-97
- C5 -
-
3DZD
1
?
B:
[2-364]
----
R
V
L
V
V
D
D
E
E
S
I
T
S
S
L
S
A
I
L
E
E
E
G
Y
H
P
D
T
A
K
T
L
R
E
A
E
K
K
I
K
E
L
F
F
P
V
I
V
L
D
V
W
M
P
D
--
G
D
G
V
N
F
I
D
F
I
K
E
N
S
P
D
S
V
V
I
V
I
T
G
H
G
S
V
D
T
A
V
K
A
I
K
K
G
A
Y
E
F
L
E
K
P
F
S
V
E
R
F
L
L
T
I
K
H
A
F
E
E
Y
S
K
K
A
--------
P
P
Q
E
E
I
E
F
V
G
E
H
P
K
I
L
E
I
K
R
L
I
P
K
I
A
K
S
K
A
P
V
L
I
T
G
E
S
G
T
G
K
E
I
V
A
R
L
I
H
R
Y
S
G
R
K
-
G
A
F
V
D
L
N
C
A
S
I
P
Q
E
L
A
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
L
T
R
K
K
G
K
L
E
L
A
D
Q
G
T
L
F
L
D
E
V
G
E
L
D
Q
R
V
Q
A
K
L
L
R
V
L
E
T
G
S
F
T
R
L
G
G
N
Q
K
I
E
V
D
I
R
V
I
S
A
T
N
K
N
L
E
E
E
I
K
K
G
N
F
R
E
D
L
Y
Y
R
L
S
V
-
F
Q
I
Y
L
P
P
L
R
--
E
R
G
K
D
V
I
L
L
A
E
YFL
K
K
F
A
K
E
Y
K
K
N
C
-
F
E
L
S
E
E
-
T
K
E
Y
L
M
K
Q
E
W
K
G
N
V
R
E
L
K
N
L
I
E
R
A
V
I
L
C
E
G
E
--------------------------------------------------------------------------------------------------------------------------
228
Fugue
73.67
47%
-101
- C5 -
-
1OJL
-
ZRAR_SALTY
A:
[3-304]
----------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
G
S
S
P
A
M
Q
H
L
L
N
E
I
A
M
V
A
P
S
D
A
T
V
L
I
H
G
D
S
G
T
G
K
E
L
V
A
R
A
L
H
A
C
S
A
R
S
D
R
P
L
V
T
L
N
C
A
A
L
N
E
S
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
K
R
R
---
E
G
R
F
V
E
A
D
G
G
T
L
F
L
D
E
I
G
D
I
S
P
L
M
Q
V
R
L
L
R
A
I
Q
E
R
E
V
Q
R
V
G
S
N
Q
T
I
S
V
D
V
R
L
I
A
A
T
H
R
D
L
A
E
E
V
S
A
G
R
F
R
Q
D
L
Y
Y
R
L
N
V
V
A
I
E
M
P
S
L
R
Q
R
R
E
D
I
P
L
L
A
D
H
F
L
---
R
R
F
A
E
R
N
R
K
V
V
-
K
G
F
T
P
Q
-
A
M
D
L
L
I
H
Y
D
W
P
G
N
I
R
E
L
E
N
A
I
E
R
A
V
V
L
L
T
G
E
Y
I
S
E
R
E
L
P
L
A
I
A
Y
S
G
E
I
Q
P
------------------------------------------
L
V
D
V
E
K
E
V
I
L
A
A
L
E
K
T
G
G
N
K
T
E
A
A
R
Q
L
G
I
T
R
K
T
L
L
A
K
L
S
R
---------------------
205
HHSearch
73.17
46%
-91
- C5 -
-
1OJL
-
ZRAR_SALTY
D:
[5-304]
------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
S
P
A
M
Q
H
L
L
N
E
I
A
M
V
A
P
S
D
A
T
V
L
I
H
G
D
S
G
T
G
K
E
L
V
A
R
A
L
H
A
C
S
A
R
S
D
R
P
L
V
T
L
N
C
A
A
L
N
E
S
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
D
K
R
R
E
G
R
F
V
E
A
D
G
G
T
L
F
L
D
E
I
G
D
I
S
P
L
M
Q
V
R
L
L
R
A
I
Q
E
R
E
V
Q
R
V
G
S
N
Q
T
I
S
V
D
V
R
L
I
A
A
T
H
R
D
L
A
E
E
V
S
A
G
R
F
R
Q
D
L
Y
Y
R
L
N
V
V
A
I
E
M
P
S
L
R
Q
R
R
E
D
I
P
L
L
A
D
H
F
L
---
R
R
F
A
E
R
N
R
K
V
V
-
K
G
F
T
P
Q
-
A
M
D
L
L
I
H
Y
D
W
P
G
N
I
R
E
L
E
N
A
I
E
R
A
V
V
L
L
T
G
E
Y
I
S
-----
E
R
E
L
P
L
A
I
A
A
T
P
I
-----------------------------
K
------
E
I
Q
P
L
V
D
V
E
K
E
V
I
L
A
A
L
E
K
T
G
G
N
K
T
E
A
A
R
Q
L
G
I
T
R
K
T
L
L
A
K
L
S
R
---------------------
3
PsiBlast_PDB
72.87
35%
21
* C6 *
-
5M7N
2
?
A:
[6-454]
-----
I
L
V
V
D
D
E
V
D
I
R
D
L
V
A
G
I
L
S
D
E
G
H
E
T
R
T
A
F
D
A
D
S
A
L
A
A
I
N
D
R
A
P
R
L
V
F
L
D
I
W
L
Q
G
SR
L
D
G
L
A
L
L
D
E
I
K
K
Q
H
P
E
L
P
V
V
M
I
S
G
H
G
N
I
E
T
A
V
S
A
I
R
R
G
A
Y
D
F
I
E
K
P
F
K
A
D
R
L
I
L
V
A
E
R
A
-
L
E
T
S
K
L
K
R
E
V
S
D
L
R
------
L
E
L
V
G
T
S
L
A
M
N
Q
L
R
Q
T
I
E
R
V
A
P
T
N
S
R
I
M
I
T
G
P
S
G
A
G
K
E
L
V
A
R
A
I
H
A
Q
S
S
R
A
N
G
P
F
V
T
V
N
A
A
T
I
T
P
E
R
M
E
I
E
L
F
G
T
E
----
M
-----
K
V
G
A
L
E
E
A
H
G
G
I
L
Y
L
D
E
V
A
D
M
P
R
E
T
Q
N
K
I
L
R
V
L
V
D
Q
Q
F
E
R
V
G
G
T
K
R
V
K
V
D
V
R
I
I
S
S
T
A
Q
N
L
E
G
M
I
A
E
G
T
F
R
E
D
L
F
H
R
L
S
V
V
P
V
Q
V
P
A
L
A
A
R
R
E
D
I
P
S
L
V
E
F
F
M
---
K
Q
I
A
E
Q
A
G
I
K
P
-
R
K
I
G
P
D
-
A
M
A
V
L
Q
A
H
S
W
P
G
N
L
R
Q
L
R
N
N
V
E
R
L
M
I
L
T
R
G
------
D
D
P
D
E
L
V
T
A
D
L
L
-
P
A
E
I
G
D
T
L
P
R
A
P
T
E
S
D
Q
H
I
M
A
L
P
L
R
E
A
R
E
R
----------------
F
E
K
E
Y
L
I
A
Q
I
N
R
F
G
G
N
I
S
R
T
A
E
F
V
G
M
E
R
S
A
L
H
R
K
L
K
S
L
G
V
------------------
5
PsiBlast_PDB
71.74
35%
26
- C6 -
-
5M7P
1
?
A:
[6-454]
-----
I
L
V
V
D
D
E
V
D
I
R
D
L
V
A
G
I
L
S
D
E
G
H
E
T
R
T
A
F
D
A
D
S
A
L
A
A
I
N
D
R
A
P
R
L
V
F
L
D
I
W
L
Q
G
SR
L
D
G
L
A
L
L
D
E
I
K
K
Q
H
P
E
L
P
V
V
M
I
S
G
H
G
N
I
E
T
A
V
S
A
I
R
R
G
A
Y
D
F
I
E
K
P
F
K
A
D
R
L
I
L
V
A
E
R
A
-
L
E
T
S
K
L
K
R
E
V
S
D
L
R
--------
L
V
G
T
S
L
A
M
N
Q
L
R
Q
T
I
E
R
V
A
P
T
N
S
R
I
M
I
T
G
P
S
G
A
G
K
E
L
V
A
R
A
I
H
A
Q
S
S
R
A
N
G
P
F
V
T
V
N
A
A
T
I
T
P
E
R
M
E
I
E
L
F
G
T
E
----
M
D
----
K
V
G
A
L
E
E
A
H
G
G
I
L
Y
L
D
E
V
A
D
M
P
R
E
T
Q
N
K
I
L
R
V
L
V
D
Q
Q
F
E
R
V
G
G
T
K
R
V
K
V
D
V
R
I
I
S
S
T
A
Q
N
L
E
G
M
I
A
E
G
T
F
R
E
D
L
F
H
R
L
S
V
V
P
V
Q
V
P
A
L
A
A
R
R
E
D
I
P
S
L
V
E
F
F
M
---
K
Q
I
A
E
Q
A
G
I
K
P
-
R
K
I
G
P
D
-
A
M
A
V
L
Q
A
H
S
W
P
G
N
L
R
Q
L
R
N
N
V
E
R
L
M
I
L
T
R
G
------
D
D
P
D
E
L
V
T
A
D
L
L
-
P
A
E
I
G
D
T
L
P
R
A
P
T
E
S
D
Q
H
I
M
A
L
P
L
R
E
A
R
E
R
----------------
F
E
K
E
Y
L
I
A
Q
I
N
R
F
G
G
N
I
S
R
T
A
E
F
V
G
M
E
R
S
A
L
H
R
K
L
K
S
L
G
V
------------------
4
PsiBlast_PDB
71.66
35%
22
- C5 -
-
5M7O
-
?
A:
[6-453]
-----
I
L
V
V
D
D
E
V
D
I
R
D
L
V
A
G
I
L
S
D
E
G
H
E
T
R
T
A
F
D
A
D
S
A
L
A
A
I
N
D
R
A
P
R
L
V
F
L
D
I
W
L
Q
G
SR
L
D
G
L
A
L
L
D
E
I
K
K
Q
H
P
E
L
P
V
V
M
I
S
G
H
G
N
I
E
T
A
V
S
A
I
R
R
G
A
Y
D
F
I
E
K
P
F
K
A
D
R
L
I
L
V
A
E
R
A
-
L
E
T
S
K
L
K
R
E
V
S
D
L
R
K
R
T
G
----
L
V
G
T
S
L
A
M
N
Q
L
R
Q
T
I
E
R
V
A
P
T
N
S
R
I
M
I
T
G
P
S
G
A
G
K
E
L
V
A
R
A
I
H
A
Q
S
S
R
A
N
G
P
F
V
T
V
N
A
A
T
I
T
P
E
R
M
E
I
E
L
F
G
T
E
----
M
D
G
G
E
R
K
V
G
A
L
E
E
A
H
G
G
I
L
Y
L
D
E
V
A
D
M
P
R
E
T
Q
N
K
I
L
R
V
L
V
D
Q
Q
F
E
R
V
G
G
T
K
R
V
K
V
D
V
R
I
I
S
S
T
A
Q
N
L
E
G
M
I
A
E
G
T
F
R
E
D
L
F
H
R
L
S
V
V
P
V
Q
V
P
A
L
A
A
R
R
E
D
I
P
S
L
V
E
F
F
M
---
K
Q
I
A
E
Q
A
G
I
K
P
-
R
K
I
G
P
D
-
A
M
A
V
L
Q
A
H
S
W
P
G
N
L
R
Q
L
R
N
N
V
E
R
L
M
I
L
T
R
G
------
D
D
P
D
E
L
V
T
A
D
L
L
-
P
A
E
I
G
D
T
L
P
R
A
P
T
E
S
D
Q
H
I
M
A
L
P
L
R
E
A
R
E
R
----------------
F
E
K
E
Y
L
I
A
Q
I
N
R
F
G
G
N
I
S
R
T
A
E
F
V
G
M
E
R
S
A
L
H
R
K
L
K
S
L
G
-------------------
16
PsiBlast_PDB
70.50
48%
-120
- C5 -
-
5EXP
4
?
A:
[12-259]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
S
R
A
I
Q
Q
V
R
Q
M
M
Q
Q
V
A
D
T
D
A
S
V
L
I
L
G
E
S
G
T
G
K
E
V
V
A
R
N
L
H
Y
H
S
K
R
R
E
G
P
F
V
P
V
N
C
G
A
I
P
A
E
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
I
T
S
R
A
G
R
F
E
L
A
N
G
G
T
L
F
L
D
E
I
G
D
M
P
L
P
M
Q
V
K
L
L
R
V
L
Q
E
R
T
F
E
R
V
G
S
N
K
T
Q
N
V
D
V
R
I
I
A
A
T
H
K
N
L
E
K
M
I
E
D
G
T
F
R
E
D
L
Y
Y
R
L
N
V
F
P
I
E
M
A
P
L
R
E
R
V
E
D
I
A
L
L
L
N
E
L
I
---
S
R
M
E
H
E
K
R
G
S
I
-
R
-
F
N
S
A
-
A
I
M
S
L
C
R
H
D
W
P
G
N
V
R
E
L
A
N
L
V
E
R
L
A
I
M
H
P
Y
G
V
I
G
V
G
E
L
P
K
K
F
R
H
V
------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.24
42%
-96
- C5 -
-
1OJL
-
ZRAR_SALTY
A:
[3-302]
----------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
G
S
S
P
A
M
Q
H
L
L
N
E
I
A
M
V
A
P
S
D
A
T
V
L
I
H
G
D
S
G
T
G
K
E
L
V
A
R
A
L
H
A
C
S
A
R
S
D
R
P
L
V
T
L
N
C
A
A
L
N
E
S
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
---
K
R
R
E
G
R
F
V
E
A
D
G
G
T
L
F
L
D
E
I
G
D
I
S
P
L
M
Q
V
R
L
L
R
A
I
Q
E
R
E
V
Q
R
V
G
S
N
Q
T
I
S
V
D
V
R
L
I
A
A
T
H
R
D
L
A
E
E
V
S
A
G
R
F
R
Q
D
L
Y
Y
R
L
N
V
V
A
I
E
M
P
S
L
R
Q
R
R
E
D
I
P
L
L
A
D
H
F
L
---
R
R
F
A
E
R
N
R
K
V
V
-
K
G
F
T
P
Q
-
A
M
D
L
L
I
H
Y
D
W
P
G
N
I
R
E
L
E
N
A
I
E
R
A
V
V
L
L
T
G
E
Y
I
S
E
R
E
L
P
L
A
I
A
-------
Y
------------------------------
S
G
E
I
Q
P
L
V
D
V
-----
E
K
E
V
I
L
A
A
L
E
K
T
G
G
N
K
T
E
A
A
R
Q
L
G
I
T
R
K
T
L
L
A
K
L
-----------------------
19
PsiBlast_PDB
69.96
49%
-115
- C5 -
-
5EP1
-
?
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
I
G
N
S
L
P
M
Q
A
V
Y
R
V
I
E
S
A
A
S
S
K
A
T
V
F
I
T
G
E
S
G
T
G
K
E
V
C
A
E
A
I
H
A
A
S
P
R
H
D
K
P
F
I
A
L
N
C
A
A
I
P
K
D
L
I
E
S
E
L
F
G
H
V
K
G
A
F
T
G
A
S
T
E
R
Q
G
A
V
E
M
A
H
N
G
T
L
M
L
D
E
L
C
E
M
D
L
D
L
Q
S
K
L
L
R
F
I
Q
T
G
T
Y
Q
K
V
G
S
S
K
M
S
S
V
D
V
R
F
V
C
A
T
N
R
N
P
W
E
E
V
Q
E
G
R
F
R
E
D
L
Y
Y
R
L
H
V
I
P
I
S
L
P
P
L
R
E
R
G
G
D
I
I
E
I
A
H
A
L
L
---
G
L
M
S
L
E
E
G
K
S
F
-
S
R
F
S
E
P
-
V
L
R
L
F
E
S
Y
S
W
P
G
N
V
R
E
L
Q
N
V
I
R
N
I
V
V
L
N
T
D
D
E
V
K
L
E
M
V
P
------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.94
49%
-113
- C5 -
-
5EP2
1
?
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
I
G
N
S
L
P
M
Q
A
V
Y
R
V
I
E
S
A
A
S
S
K
A
T
V
F
I
T
G
E
S
G
T
G
K
E
V
C
A
E
A
I
H
A
A
S
P
R
H
D
K
P
F
I
A
L
N
C
A
A
I
P
K
D
L
I
E
S
E
L
F
G
H
V
K
G
A
F
T
G
A
S
T
E
R
Q
G
A
V
E
M
A
H
N
G
T
L
M
L
D
E
L
C
E
M
D
L
D
L
Q
S
K
L
L
R
F
I
Q
T
G
T
Y
Q
K
V
G
S
S
K
M
S
S
V
D
V
R
F
V
C
A
T
N
R
N
P
W
E
E
V
Q
E
G
R
F
R
E
D
L
Y
Y
R
L
H
V
I
P
I
S
L
P
P
L
R
E
R
G
G
D
I
I
E
I
A
H
A
L
L
---
G
L
M
S
L
E
E
G
K
S
F
-
S
R
F
S
E
P
-
V
L
R
L
F
E
S
Y
S
W
P
G
N
V
R
E
L
Q
N
V
I
R
N
I
V
V
L
N
T
D
D
E
V
K
L
E
M
V
P
------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.81
49%
-116
- C5 -
-
5EP4
3
?
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
I
G
N
S
L
P
M
Q
A
V
Y
R
V
I
E
S
A
A
S
S
K
A
T
V
F
I
T
G
E
S
G
T
G
K
E
V
C
A
E
A
I
H
A
A
S
P
R
H
D
K
P
F
I
A
L
N
C
A
A
I
P
K
D
L
I
E
S
E
L
F
G
H
V
K
G
A
F
T
G
A
S
T
E
R
Q
G
A
V
E
M
A
H
N
G
T
L
M
L
D
E
L
C
E
M
D
L
D
L
Q
S
K
L
L
R
F
I
Q
T
G
T
Y
Q
K
V
G
S
S
K
M
S
S
V
D
V
R
F
V
C
A
T
N
R
N
P
W
E
E
V
Q
E
G
R
F
R
E
D
L
Y
Y
R
L
H
V
I
P
I
S
L
P
P
L
R
E
R
G
G
D
I
I
E
I
A
H
A
L
L
---
G
L
M
S
L
E
E
G
K
S
F
-
S
R
F
S
E
P
-
V
L
R
L
F
E
S
Y
S
W
P
G
N
V
R
E
L
Q
N
V
I
R
N
I
V
V
L
N
T
D
D
E
V
K
L
E
M
V
P
------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.39
49%
-114
- C5 -
-
5EP3
3
?
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
I
G
N
S
L
P
M
Q
A
V
Y
R
V
I
E
S
A
A
S
S
K
A
T
V
F
I
T
G
E
S
G
T
G
K
E
V
C
A
E
A
I
H
A
A
S
P
R
H
D
K
P
F
I
A
L
N
C
A
A
I
P
K
D
L
I
E
S
E
L
F
G
H
V
K
G
A
F
T
G
A
S
T
E
R
Q
G
A
V
E
M
A
H
N
G
T
L
M
L
D
E
L
C
E
M
D
L
D
L
Q
S
K
L
L
R
F
I
Q
T
G
T
Y
Q
K
V
G
S
S
K
M
S
S
V
D
V
R
F
V
C
A
T
N
R
N
P
W
E
E
V
Q
E
G
R
F
R
E
D
L
Y
Y
R
L
H
V
I
P
I
S
L
P
P
L
R
E
R
G
G
D
I
I
E
I
A
H
A
L
L
---
G
L
M
S
L
E
E
G
K
S
F
-
S
R
F
S
E
P
-
V
L
R
L
F
E
S
Y
S
W
P
G
N
V
R
E
L
Q
N
V
I
R
N
I
V
V
L
N
T
D
D
E
V
K
L
E
M
V
P
------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.34
48%
-117
- C5 -
-
5EXS
1
?
A:
[12-259]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
S
R
A
I
Q
Q
V
R
Q
M
M
Q
Q
V
A
D
T
D
A
S
V
L
I
L
G
E
S
G
T
G
K
E
V
V
A
R
N
L
H
Y
H
S
K
R
R
E
G
P
F
V
P
V
N
C
G
A
I
P
A
E
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
I
T
S
R
A
G
R
F
E
L
A
N
G
G
T
L
F
L
D
E
I
G
D
M
P
L
P
M
Q
V
K
L
L
R
V
L
Q
E
R
T
F
E
R
V
G
S
N
K
T
Q
N
V
D
V
R
I
I
A
A
T
H
K
N
L
E
K
M
I
E
D
G
T
F
R
E
D
L
Y
Y
R
L
N
V
F
P
I
E
M
A
P
L
R
E
R
V
E
D
I
A
L
L
L
N
E
L
I
---
S
R
M
E
H
E
K
R
G
S
I
-
R
-
F
N
S
A
-
A
I
M
S
L
C
R
H
D
W
P
G
N
V
R
E
L
A
N
L
V
E
R
L
A
I
M
H
P
Y
G
V
I
G
V
G
E
L
P
K
K
F
R
H
V
------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.32
48%
-116
- C5 -
-
5EXT
1
?
A:
[12-259]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
S
R
A
I
Q
Q
V
R
Q
M
M
Q
Q
V
A
D
T
D
A
S
V
L
I
L
G
E
S
G
T
G
K
E
V
V
A
R
N
L
H
Y
H
S
K
R
R
E
G
P
F
V
P
V
N
C
G
A
I
P
A
E
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
I
T
S
R
A
G
R
F
E
L
A
N
G
G
T
L
F
L
D
E
I
G
D
M
P
L
P
M
Q
V
K
L
L
R
V
L
Q
E
R
T
F
E
R
V
G
S
N
K
T
Q
N
V
D
V
R
I
I
A
A
T
H
K
N
L
E
K
M
I
E
D
G
T
F
R
E
D
L
Y
Y
R
L
N
V
F
P
I
E
M
A
P
L
R
E
R
V
E
D
I
A
L
L
L
N
E
L
I
---
S
R
M
E
H
E
K
R
G
S
I
-
R
-
F
N
S
A
-
A
I
M
S
L
C
R
H
D
W
P
G
N
V
R
E
L
A
N
L
V
E
R
L
A
I
M
H
P
Y
G
V
I
G
V
G
E
L
P
K
K
F
R
H
V
------------------------------------------------------------------------------------------------------------
212
HHSearch
68.73
49%
-120
- C5 -
-
5EXP
4
?
A:
[12-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
S
R
A
I
Q
Q
V
R
Q
M
M
Q
Q
V
A
D
T
D
A
S
V
L
I
L
G
E
S
G
T
G
K
E
V
V
A
R
N
L
H
Y
H
S
K
R
R
E
G
P
F
V
P
V
N
C
G
A
I
P
A
E
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
I
T
S
R
A
G
R
F
E
L
A
N
G
G
T
L
F
L
D
E
I
G
D
M
P
L
P
M
Q
V
K
L
L
R
V
L
Q
E
R
T
F
E
R
V
G
S
N
K
T
Q
N
V
D
V
R
I
I
A
A
T
H
K
N
L
E
K
M
I
E
D
G
T
F
R
E
D
L
Y
Y
R
L
N
V
F
P
I
E
M
A
P
L
R
E
R
V
E
D
I
A
L
L
L
N
E
L
I
---
S
R
M
E
H
E
K
-
R
G
S
-
I
R
F
N
S
A
-
A
I
M
S
L
C
R
H
D
W
P
G
N
V
R
E
L
A
N
L
V
E
R
L
A
I
M
H
P
Y
G
V
I
G
-----------------------------------------------------------------------------------------------------------------------
213
HHSearch
68.04
49%
-119
- C5 -
-
5EXS
1
?
A:
[12-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
V
G
T
S
R
A
I
Q
Q
V
R
Q
M
M
Q
Q
V
A
D
T
D
A
S
V
L
I
L
G
E
S
G
T
G
K
E
V
V
A
R
N
L
H
Y
H
S
K
R
R
E
G
P
F
V
P
V
N
C
G
A
I
P
A
E
L
L
E
S
E
L
F
G
H
E
K
G
A
F
T
G
A
I
T
S
R
A
G
R
F
E
L
A
N
G
G
T
L
F
L
D
E
I
G
D
M
P
L
P
M
Q
V
K
L
L
R
V
L
Q
E
R
T
F
E
R
V
G
S
N
K
T
Q
N
V
D
V
R
I
I
A
A
T
H
K
N
L
E
K
M
I
E
D
G
T
F
R
E
D
L
Y
Y
R
L
N
V
F
P
I
E
M
A
P
L
R
E
R
V
E
D
I
A
L
L
L
N
E
L
I
---
S
R
M
E
H
E
K
-
R
G
S
-
I
R
F
N
S
A
-
A
I
M
S
L
C
R
H
D
W
P
G
N
V
R
E
L
A
N
L
V
E
R
L
A
I
M
H
P
Y
G
V
I
G
-----------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
64.17
44%
-98
- C5 -
-
4QNR
4
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
--------
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
Q
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
63.18
44%
-95
- C5 -
-
2C9C
1
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
-------
K
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
A
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
62.56
44%
-93
- C5 -
-
2C99
1
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
-------
K
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
62.04
44%
-100
- C5 -
-
2C96
1
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
-------------
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.29
56%
-139
- C5 -
-
4BT1
1
?
B:
[2-172]
----------------------------------------------------------------------------------------------------------------------------------------------
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.29
56%
-139
- C5 -
-
4BS1
1
?
B:
[2-172]
----------------------------------------------------------------------------------------------------------------------------------------------
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
HHSearch
60.98
56%
-134
- C5 -
-
4BS1
1
?
B:
[5-173]
-------------------------------------------------------------------------------------------------------------------------------------------------
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.90
56%
-139
- C5 -
-
4BT0
1
?
B:
[2-172]
----------------------------------------------------------------------------------------------------------------------------------------------
E
Y
V
F
E
S
P
K
M
K
E
I
L
E
K
I
K
K
I
S
C
A
E
C
P
V
L
I
T
G
E
S
G
V
G
K
E
V
V
A
R
L
I
H
K
L
S
D
R
S
K
E
P
F
V
A
L
N
V
A
S
I
P
R
D
I
F
E
A
E
L
F
G
Y
E
K
G
A
F
T
G
A
V
S
S
K
E
G
F
F
E
L
A
D
G
G
T
L
F
L
D
E
I
G
E
L
S
L
E
A
Q
A
K
L
L
R
V
I
E
S
G
K
F
Y
R
L
G
G
R
K
E
I
E
V
N
V
R
I
L
A
A
T
N
R
N
I
K
E
L
V
K
E
G
K
F
R
E
D
L
Y
Y
R
L
G
V
I
E
I
E
I
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
PsiBlast_CBE
60.32
44%
-88
- C5 -
-
2C98
1
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
------
Q
K
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
60.21
44%
-90
- C5 -
-
2VII
1
PSPF_ECOLI
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
------
Q
K
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
-
F
P
G
F
T
E
R
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
-
S
V
Y
R
H
G
T
S
D
Y
P
L
D
--------------------------------------------------------------------------------------------------------------------
218
HHSearch
60.08
42%
-92
* C5 *
-
2VII
1
PSPF_ECOLI
A:
[8-246]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
E
A
N
S
F
L
E
V
L
E
Q
V
S
H
L
A
P
L
D
K
P
V
L
I
I
G
E
R
G
T
G
K
E
L
I
A
S
R
L
H
Y
L
S
S
R
W
Q
G
P
F
I
S
L
N
C
A
A
L
N
E
N
L
L
D
S
E
L
F
G
H
E
A
------
Q
K
R
H
P
G
R
F
E
R
A
D
G
G
T
L
F
L
D
E
L
A
T
A
P
M
M
V
Q
E
K
L
L
R
V
I
E
Y
G
E
L
E
R
V
G
G
S
Q
P
L
Q
V
N
V
R
L
V
C
A
T
N
A
D
L
P
A
M
V
N
E
G
T
F
R
A
D
L
L
D
R
L
A
F
D
V
V
Q
L
P
P
L
R
E
R
E
S
D
I
M
L
M
A
E
Y
F
A
---
I
Q
M
C
R
E
I
K
L
P
L
F
P
G
F
T
E
R
-
A
R
E
T
L
L
N
Y
R
W
P
G
N
I
R
E
L
K
N
V
V
E
R
S
V
Y
R
H
G
T
S
D
Y
P
-----------------------------------------------------------------------------------------------------------------------