@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMU8: (2017-11-10 )
MTQSVCILGVTGSIGQSTLKILGQHPDKYSVFAVSAHSRISELVEICKQFRPKVVVVPEQKIAELKTLFAQQNISAIDVLAGQEGLVDIASHTDVDIVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGEIMMQAARDHQALLLPVDSEHNAIFQSLPHNYLQADRTGQPQLGVSKILLTASGGPFLNHSLEQLVHVTPQKACKHPNWSMGQKISVDSATLMNKGLELIEACHLFSISEHFVTVVVHPQSIIHSMVQYVDGSTLAQMGNPDMCTPIAHALAWPERLQTNVPALDLFEYSQLNFQAPDTQKFPALNLARQAMRAGGLAPTILNAANEIAVEAFLMERIGFTSIPQVVEHTLEKLENTAAESIECILDKDKVARSVAQQYIKYWRLK
Atome Classification :
(91 SA)
.........10........20....---....30.....---.-..40........50........-60.-.-......70........80........90........100.......110.......120.......130.......140-..-.....150.......160----.----.....--.-170..--....----.-..180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370-------...-----------.-.....380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQ
S
V
C
I
L
GVTGSI
G
Q
S
T
L
K
I
L
GQH---PDK
Y
S
V
F
A
V
S
A
---
H
-
S
R
I
S
E
L
V
E
I
C
K
QFRP
K
V
V
V
V
P
E
-
Q
K
I
-
A
-
E
L
K
T
L
F
A
QQNI
S
A
I
D
V
LAGQEGL
V
D
IASHT
D
V
D
I
V
M
A
A
I
VGAA
G
L
L
P
T
L
A
A
V
KAG
K
R
V
L
L
ANK
E
A
L
V
MS
G
E
I
M
M
Q
AARD-H
Q
-
A
L
L
L
P
VDSE
H
N
A
I
F
Q
SL
P
----
H
----
N
Y
L
QA--D-R--TG--QPQL----G-
V
S
K
I
L
L
TASGGP
F
L
N
H
S
L
E
Q
L
V
HV
T
P
Q
K
ACKHPNWSMG
Q
K
ISV
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
IS
E
H
F
V
T
V
V
VH
P
Q
S
I
I
H
S
M
V
Q
YVDG
S
T
L
AQMGNP
D
M
C
T
P
I
A
H
A
LA
W
P
E
R
LQTNVP
A
L
D
L
F
E
YSQLNFQAPDTQKF
P
A
L
N
L
A
R
Q
A
M
R
AGGL
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
RIGFTS
I
P
Q
V
V
E
H
T
L
E
K
L
E
N
T
---------
A
A
E
-----------
S
-
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
K
Y
WRLK
1
PsiBlast_PDB
99.39
98%
-144
- C5 -
-
4ZN6
2
DXR_ACIB3
A:
[10-401]
-
T
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
---
H
-
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
-
Q
K
I
-
A
-
E
L
K
T
L
F
A
Q
Q
N
I
S
D
I
D
V
L
A
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
M
Q
A
A
R
D
-
H
Q
-
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
----
H
----
N
Y
L
Q
A
--
D
-
R
--
T
G
--
Q
P
Q
L
----
G
-
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
C
K
-----
M
G
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
Q
Y
V
D
G
S
T
L
A
Q
M
G
N
P
D
M
C
T
P
I
A
H
A
L
A
W
P
E
R
L
Q
T
N
V
P
A
L
D
L
F
E
Y
S
Q
L
N
F
Q
A
P
D
T
Q
K
F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
E
K
L
E
N
A
---------
A
A
E
-----------
S
-
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
------
21
PsiBlast_CBE
97.58
98%
-143
- C5 -
-
4ZN6
1
DXR_ACIB3
B:
[10-401]
-
T
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
---
H
-
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
-
Q
K
I
-
A
-
E
L
K
T
L
F
A
Q
Q
N
I
S
D
I
D
V
L
A
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
M
Q
A
A
R
D
-
H
Q
-
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
----
H
----
N
Y
L
Q
A
--
D
-
R
--
T
G
--
Q
P
Q
L
----
G
-
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
---------
Q
K
I
S
V
D
S
A
T
L
M
N
K
G
L
E
L
I
E
A
C
H
L
F
S
I
S
E
H
F
V
T
V
V
V
H
P
Q
S
I
I
H
S
M
V
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Y
V
D
G
S
T
L
A
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N
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D
M
C
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A
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A
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A
W
P
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L
Q
T
N
V
P
A
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F
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Y
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N
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A
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N
L
A
R
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A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
E
K
L
E
N
A
---------
A
A
E
-----------
S
-
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
------
122
HHSearch
91.43
98%
-83
- C5 -
-
4ZN6
2
DXR_ACIB3
A:
[10-404]
-
T
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
---
H
-
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
-
Q
K
I
-
A
-
E
L
K
T
L
F
A
Q
Q
N
I
S
D
I
D
V
L
A
G
Q
E
G
L
V
D
I
A
S
H
T
D
V
D
I
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
V
K
A
G
K
R
V
L
L
A
N
K
E
A
L
V
M
S
G
E
I
M
M
Q
A
A
R
D
-
H
Q
-
A
L
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
----
H
----
N
Y
L
Q
A
--
D
-
R
--
T
G
--
Q
P
-
Q
----
L
G
V
S
K
I
L
L
T
A
S
G
G
P
F
L
N
H
S
L
E
Q
L
V
H
V
T
P
Q
Q
A
C
K
-----
M
G
Q
K
I
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V
D
S
A
T
L
M
N
K
G
L
E
L
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A
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F
S
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T
V
V
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P
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S
M
V
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Y
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L
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G
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P
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C
T
P
I
A
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A
L
A
W
P
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R
L
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T
N
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P
A
L
D
L
F
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Y
S
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L
N
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P
D
T
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F
P
A
L
N
L
A
R
Q
A
M
R
A
G
G
L
A
P
T
I
L
N
A
A
N
E
I
A
V
E
A
F
L
M
E
R
I
G
F
T
S
I
P
Q
V
V
E
H
T
L
E
K
L
E
N
A
---------
A
A
E
-----------
S
-
I
E
C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
---
123
HHSearch
90.38
98%
-84
- C5 -
-
4ZN6
1
DXR_ACIB3
B:
[10-404]
-
T
Q
S
V
C
I
L
G
V
T
G
S
I
G
R
S
T
L
K
I
L
G
Q
H
---
P
D
K
Y
S
V
F
A
V
S
A
---
H
-
S
R
I
S
E
L
V
E
I
C
K
Q
F
R
P
K
V
V
V
V
P
E
-
Q
K
I
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A
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L
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T
L
F
A
Q
Q
N
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S
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I
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A
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G
L
V
D
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A
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H
T
D
V
D
I
V
M
A
A
I
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G
A
A
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L
L
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A
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A
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V
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L
A
N
K
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A
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G
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M
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A
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D
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H
Q
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A
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L
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N
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L
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----
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----
N
Y
L
Q
A
--
D
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R
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T
G
--
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P
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Q
----
L
G
V
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K
I
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L
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H
V
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Q
A
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Q
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L
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K
L
E
N
A
---------
A
A
E
-----------
S
-
I
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C
I
L
D
K
D
K
V
A
R
S
V
A
Q
Q
Y
I
S
S
I
---
130
HHSearch
75.94
50%
-88
- C5 -
-
4ZQE
3
?
B:
[22-427]
T
L
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
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R
Q
H
---
P
N
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Y
R
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A
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G
---
F
-
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L
L
A
L
A
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A
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----
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--
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T
--
A
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--
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H
T
S
----
Y
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L
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A
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K
E
A
V
--------
Q
K
I
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A
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D
YSQDFGD
E
V
L
-----------
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
24
PsiBlast_CBE
75.88
50%
-76
- C5 -
-
4ZQF
1
?
B:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
------
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
DYSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
4
PsiBlast_PDB
75.66
50%
-77
- C5 -
-
4ZQF
1
?
A:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
------
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
D
YSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
25
PsiBlast_CBE
75.45
50%
-73
- C5 -
-
4ZQE
3
?
B:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
--------
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
D
YSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
2
PsiBlast_PDB
75.16
50%
-68
- C5 -
-
4ZQG
4
?
A:
[7-410]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
H
P
N
W
S
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
D
YSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
128
HHSearch
74.90
50%
-79
- C5 -
-
4ZQG
4
?
A:
[6-410]
-
L
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
-
A
G
L
D
T
I
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
----
A
----
A
I
Q
A
D
--
N
-
T
--
A
I
--
H
H
T
S
----
Y
G
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
H
P
N
W
S
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
D
K
T
I
A
Q
D
YSQDFGD
E
V
L
-----------
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
22
PsiBlast_CBE
74.76
50%
-68
- C5 -
-
4ZQG
4
?
B:
[7-410]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
H
P
N
W
S
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
DYSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
5
PsiBlast_PDB
74.73
50%
-68
- C5 -
-
4ZQH
6
?
A:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
H
P
N
W
S
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
D
YSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
23
PsiBlast_CBE
74.45
50%
-67
- C5 -
-
4ZQH
7
?
B:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
H
P
N
W
S
M
G
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
DYSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
3
PsiBlast_PDB
74.22
50%
-72
- C5 -
-
4ZQE
2
?
A:
[24-427]
--
Q
S
L
A
I
L
G
A
T
G
S
I
G
D
S
T
L
A
I
I
R
Q
H
---
P
N
R
Y
R
I
H
A
L
T
G
---
F
-
S
R
V
D
K
L
L
A
L
A
M
E
F
H
P
V
K
I
C
T
S
P
-
D
N
Y
-
A
-
Q
L
S
Q
K
V
T
D
A
G
L
D
T
I
-
I
L
S
G
D
E
G
L
I
E
I
A
S
D
E
A
V
D
T
V
V
A
A
I
V
G
A
A
G
L
S
S
T
L
A
A
A
G
A
G
K
R
I
L
L
A
N
K
E
S
L
V
M
A
G
D
L
V
I
K
T
A
K
K
-
H
G
-
A
T
I
L
P
I
D
S
E
H
N
A
I
Y
Q
C
L
P
---------
A
A
I
Q
A
--
D
-
N
--
T
A
IH
H
T
S
Y
----
G
-
I
K
K
L
W
L
T
A
S
G
G
S
F
L
D
K
S
I
K
Q
M
Q
N
A
S
V
K
E
A
V
N
-------
Q
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
C
H
L
F
D
L
K
E
H
Q
I
Q
V
V
I
H
P
N
S
V
V
H
S
L
V
E
Y
V
D
G
S
F
L
A
Q
L
G
T
P
D
M
K
T
P
I
A
H
A
L
A
Y
P
E
R
I
K
S
G
V
M
P
L
D
L
Y
Q
L
G
S
L
K
F
L
A
P
D
L
D
K
F
A
C
L
K
L
A
R
Y
A
A
R
L
G
T
G
A
C
I
A
L
N
T
A
N
E
I
A
V
E
A
F
L
A
E
K
I
C
L
T
D
I
A
V
I
V
K
A
C
L
D
--
D
K
T
---------
I
A
Q
D
YSQDFGDEVL
G
-
L
E
R
I
L
T
M
D
K
K
V
R
K
I
A
T
A
K
I
K
L
L
K
--
127
HHSearch
72.32
51%
-46
- C5 -
-
5KRY
2
?
B:
[3-403]
G
M
Q
K
L
T
I
L
G
A
T
G
S
I
G
A
S
T
L
K
V
I
E
Q
N
---
P
D
K
F
S
V
V
A
L
A
A
---
D
-
S
N
V
E
K
M
Q
Q
L
C
Q
R
W
Q
P
E
Y
A
V
M
A
N
K
E
A
A
-
L
-
R
L
K
M
A
L
A
V
-
L
A
P
N
T
Q
V
L
G
G
Q
E
A
L
C
Y
V
A
T
L
E
Q
V
D
S
V
M
A
A
I
V
G
A
A
G
L
V
P
T
M
A
A
V
K
A
G
K
R
I
L
L
A
N
K
E
A
L
V
M
S
G
Q
L
F
I
D
E
V
E
K
-
S
G
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
L
P
----
Q
----
T
V
Q
G
N
LG
R
-
C
--
D
L
--
A
--
S
----
Q
G
V
S
H
I
L
L
T
G
S
G
G
P
F
R
Y
T
D
V
A
E
L
E
A
V
T
P
E
Q
A
I
A
H
P
N
W
S
M
G
P
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
K
W
L
F
N
A
S
R
D
Q
L
K
V
I
I
H
P
Q
S
V
I
H
S
M
V
Q
Y
L
D
G
S
V
L
A
Q
M
G
E
P
D
M
A
T
P
I
A
L
T
L
S
Y
P
E
R
V
K
A
G
V
K
P
L
D
F
T
Q
V
G
E
L
T
F
L
Q
P
D
F
E
R
Y
P
C
L
A
L
A
I
E
A
C
Y
L
G
Q
H
A
T
T
T
L
N
A
A
N
E
V
A
V
A
A
F
L
A
R
Q
I
K
F
T
D
I
A
R
V
N
D
S
V
L
N
Q
V
C
K
Q
S---------
L
D
-----------
S
-
L
E
S
L
L
E
L
D
R
M
A
R
T
L
A
D
E
V
V
R
E
R
---
32
PsiBlast_CBE
71.73
51%
-57
- C5 -
-
1T1R
1
DXR_ECOLI
B:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
18
PsiBlast_PDB
71.69
51%
-62
- C5 -
-
3R0I
1
DXR_ECOLI
A:
[14-405]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
13
PsiBlast_PDB
71.43
51%
-58
- C5 -
-
1T1S
1
DXR_ECOLI
A:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
126
HHSearch
71.29
51%
-50
- C5 -
-
5KRY
2
?
A:
[3-403]
G
M
Q
K
L
T
I
L
G
A
T
G
S
I
G
A
S
T
L
K
V
I
E
Q
N
---
P
D
K
F
S
V
V
A
L
A
A
---
D
-
S
N
V
E
K
M
Q
Q
L
C
Q
R
W
Q
P
E
Y
A
V
M
A
N
K
E
A
A
-
L
-
R
L
K
M
A
L
A
V
-
L
A
P
N
T
Q
V
L
G
G
Q
E
A
L
C
Y
V
A
T
L
E
Q
V
D
S
V
M
A
A
I
V
G
A
A
G
L
V
P
T
M
A
A
V
K
A
G
K
R
I
L
L
A
N
K
E
A
L
V
M
S
G
Q
L
F
I
D
E
V
E
K
-
S
G
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
L
P
----
Q
----
T
V
Q
G
N
LG
R
-
C
--
D
L
--
A
--
S
----
Q
G
V
S
H
I
L
L
T
G
S
G
G
P
F
R
Y
T
D
V
A
E
L
E
A
V
T
P
E
Q
A
I
A
-------
P
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
K
W
L
F
N
A
S
R
D
Q
L
K
V
I
I
H
P
Q
S
V
I
H
S
M
V
Q
Y
L
D
G
S
V
L
A
Q
M
G
E
P
D
M
A
T
P
I
A
L
T
L
S
Y
P
E
R
V
K
A
G
V
K
P
L
D
F
T
Q
V
G
E
L
T
F
L
Q
P
D
F
E
R
Y
P
C
L
A
L
A
I
E
A
C
Y
L
G
Q
H
A
T
T
T
L
N
A
A
N
E
V
A
V
A
A
F
L
A
R
Q
I
K
F
T
D
I
A
R
V
N
D
S
V
L
N
Q
V
C
K
Q
----------
L
D
-----------
S
-
L
E
S
L
L
E
L
D
R
M
A
R
T
L
A
D
E
V
V
R
E
R
---
12
PsiBlast_PDB
71.10
51%
-56
- C5 -
-
1T1R
1
DXR_ECOLI
A:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
8
PsiBlast_PDB
70.96
51%
-55
- C5 -
-
3ANM
2
DXR_ECOLI
A:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
35
PsiBlast_CBE
70.75
51%
-59
- C5 -
-
3R0I
1
DXR_ECOLI
B:
[14-405]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
7
PsiBlast_PDB
70.69
51%
-56
- C5 -
-
3ANL
2
DXR_ECOLI
A:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
30
PsiBlast_CBE
70.55
51%
-57
- C5 -
-
1Q0Q
2
DXR_ECOLI
B:
[10-401]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
31
PsiBlast_CBE
70.39
51%
-56
- C5 -
-
1T1S
1
DXR_ECOLI
B:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
26
PsiBlast_CBE
69.99
51%
-55
- C5 -
-
2EGH
2
DXR_ECOLI
B:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
11
PsiBlast_PDB
69.93
51%
-56
- C5 -
-
1Q0Q
2
DXR_ECOLI
A:
[10-401]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
129
HHSearch
69.57
50%
-42
- C5 -
-
1JVS
1
DXR_ECOLI
A:
[1-397]
-
G
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
-
K
-
L
L
K
T
M
L
Q
-
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
----
Q
----
P
I
Q
H
N
--
L
-
G
--
Y
A
--
D
L
E
Q
----
N
G
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
--
6
PsiBlast_PDB
69.57
51%
-53
- C5 -
-
2EGH
2
DXR_ECOLI
A:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
9
PsiBlast_PDB
69.52
51%
-57
- C5 -
-
3ANN
2
DXR_ECOLI
A:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
28
PsiBlast_CBE
69.36
51%
-57
- C5 -
-
3ANM
2
DXR_ECOLI
B:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
10
PsiBlast_PDB
69.15
51%
-56
- C5 -
-
1Q0L
2
DXR_ECOLI
A:
[10-401]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
29
PsiBlast_CBE
69.05
51%
-56
- C5 -
-
3ANL
2
DXR_ECOLI
B:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
27
PsiBlast_CBE
68.95
51%
-57
- C5 -
-
3ANN
2
DXR_ECOLI
B:
[12-403]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
125
HHSearch
68.92
50%
-45
- C5 -
-
1Q0Q
2
DXR_ECOLI
A:
[9-404]
-
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
-
K
-
L
L
K
T
M
L
Q
Q
Q
-
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
----
Q
----
P
I
Q
H
N
--
L
-
G
--
Y
A
--
D
L
E
Q
----
N
G
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
---
49
PsiBlast_CBE
68.60
53%
-54
- C5 -
-
5KRY
2
?
B:
[5-374]
--
Q
K
L
T
I
L
G
A
T
G
S
I
G
A
S
T
L
K
V
I
E
Q
N
---
P
D
K
F
S
V
V
A
L
A
A
---
D
-
S
N
V
E
K
M
Q
Q
L
C
Q
R
W
Q
P
E
Y
A
V
M
A
N
-
K
E
A
-
A
L
R
L
K
M
A
L
A
V
L
A
P
N
T
-
Q
V
L
G
G
Q
E
A
L
C
Y
V
A
T
L
E
Q
V
D
S
V
M
A
A
I
V
G
A
A
G
L
V
P
T
M
A
A
V
K
A
G
K
R
I
L
L
A
N
K
E
A
L
V
M
S
G
Q
L
F
I
D
E
V
E
K
-
S
G
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
L
P
----
Q
T
V
Q
G
N
L
G
R
C
--
D
-
L
--
A
S
--
Q
-------
G
-
V
S
H
I
L
L
T
G
S
G
G
P
F
R
Y
T
D
V
A
E
L
E
A
V
T
P
E
Q
A
I
A
H
P
N
W
S
M
G
P
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
K
W
L
F
N
A
S
R
D
Q
L
K
V
I
I
H
P
Q
S
V
I
H
S
M
V
Q
Y
L
D
G
S
V
L
A
Q
M
G
E
P
D
M
A
T
P
I
A
L
T
L
S
Y
P
E
R
V
K
A
G
V
K
P
L
D
F
T
Q
V
G
E
L
T
F
L
Q
P
D
F
E
R
Y
P
C
L
A
L
A
I
E
A
C
Y
L
G
Q
H
A
T
T
T
L
N
A
A
N
E
V
A
V
A
A
F
L
A
R
Q
I
K
F
T
D
I
A
R
V
N
D
S
V
L
N
Q
V
-----------------------------------------------------
17
PsiBlast_PDB
68.45
51%
-52
- C5 -
-
1ONP
1
DXR_ECOLI
A:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
33
PsiBlast_CBE
67.81
51%
-53
- C5 -
-
1ONP
1
DXR_ECOLI
B:
[2-393]
--
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
---
P
E
H
F
R
V
V
A
L
V
A
---
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
-
E
A
S
-
A
-
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
V
L
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
Q
-
S
K
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
QPIQ
H
----
N
L
G
Y
A
--
D
-
L
--
E
-----
Q
N
----
G
-
V
V
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
---------
E
P
Q
-----------
C
-
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
------
51
PsiBlast_CBE
67.79
53%
-54
- C5 -
-
5KRV
7
?
B:
[27-396]
--
Q
K
L
T
I
L
G
A
T
G
S
I
G
A
S
T
L
K
V
I
E
Q
N
---
P
D
K
F
S
V
V
A
L
A
A
---
D
-
S
N
V
E
K
M
Q
Q
L
C
Q
R
W
Q
P
E
Y
A
V
M
A
N
-
K
E
A
-
A
L
R
L
K
M
A
L
A
V
L
A
P
N
T
-
Q
V
L
G
G
Q
E
A
L
C
Y
V
A
T
L
E
Q
V
D
S
V
M
A
A
I
V
G
A
A
G
L
V
P
T
M
A
A
V
K
A
G
K
R
I
L
L
A
N
K
E
A
L
V
M
S
G
Q
L
F
I
D
E
V
E
K
-
S
G
-
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
L
P
----
Q
T
V
Q
G
N
L
G
R
C
--
D
-
L
--
A
S
--
Q
-------
G
-
V
S
H
I
L
L
T
G
S
G
G
P
F
R
Y
T
D
V
A
E
L
E
A
V
T
P
E
Q
A
I
A
-----
M
G
P
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
K
W
L
F
N
A
S
R
D
Q
L
K
V
I
I
H
P
Q
S
V
I
H
S
M
V
Q
Y
L
D
G
S
V
L
A
Q
M
G
E
P
D
M
A
T
P
I
A
L
T
L
S
Y
P
E
R
V
K
A
G
V
K
P
L
D
F
T
Q
V
G
E
L
T
F
L
Q
P
D
F
E
R
Y
P
C
L
A
L
A
I
E
A
C
Y
L
G
Q
H
A
T
T
T
L
N
A
A
N
E
V
A
V
A
A
F
L
A
R
Q
I
K
F
T
D
I
A
R
V
N
D
S
V
L
N
Q
V
-----------------------------------------------------
106
PsiBlast_CBE
64.87
42%
-49
- C5 -
-
3RAS
3
DXR_MYCTU
A:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
104
PsiBlast_CBE
64.13
42%
-48
- C5 -
-
4A03
3
DXR_MYCTU
A:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
93
PsiBlast_CBE
64.11
42%
-58
- C5 -
-
4RCV
2
DXR_MYCTU
A:
[30-402]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
103
PsiBlast_CBE
64.10
42%
-48
- C5 -
-
4A03
2
DXR_MYCTU
B:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
102
PsiBlast_CBE
64.07
42%
-51
- C5 -
-
4AIC
2
DXR_MYCTU
A:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
110
PsiBlast_CBE
64.00
42%
-55
- C5 -
-
2Y1F
2
DXR_MYCTU
A:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
108
PsiBlast_CBE
63.67
42%
-51
- C5 -
-
2Y1G
1
DXR_MYCTU
A:
[24-396]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
98
PsiBlast_CBE
63.53
42%
-54
- C5 -
-
3ZHY
2
DXR_MYCTU
A:
[23-395]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
121
HHSearch
63.35
37%
-25
- C5 -
-
5JAZ
7
DXR_PLAF7
B:
[11-420]
-
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
NKI
E
N
V
F
N
V
K
A
L
Y
V
---
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
-
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
-
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
CL
Q
D
N-
F
S
K
I
----
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
KVSE-----
N
S
E
-----------
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
N
--
95
PsiBlast_CBE
63.16
42%
-63
- C5 -
-
3ZI0
1
DXR_MYCTU
A:
[23-395]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
----------------------
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
100
PsiBlast_CBE
62.64
42%
-50
- C5 -
-
3ZHX
1
DXR_MYCTU
A:
[23-395]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
133
HHSearch
62.57
42%
-36
- C5 -
-
4A03
3
DXR_MYCTU
A:
[20-397]
G
R
L
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
G
----------
D
I
P
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
---
P
-
G
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
R
----
G
----
G
T
-----------------
P
----
D
E
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
AV-------
E
P
A
-----------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
----
97
PsiBlast_CBE
62.55
42%
-54
- C5 -
-
3ZHY
2
DXR_MYCTU
B:
[23-395]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
H
----------
A
A
Q
R
V
G
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
96
PsiBlast_CBE
62.55
42%
-53
- C5 -
-
3ZHZ
1
DXR_MYCTU
A:
[23-395]
----
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
N
---
P
D
R
F
E
V
V
G
L
A
A
---
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
-
E
-----------------
D
I
P
-
Y
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
P
-
G
Q
---
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
-------------------
R
--
G
G
--
T
P
D
E
------
V
A
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
G
A
A
A
A
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
A
G
V
A
G
G
C
M
T
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
---------
A
V
E
PA---------
T
-
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-----
124
HHSearch
60.33
37%
-23
- C5 -
-
4GAE
3
DXR_PLAFX
A:
[14-424]
K
P
I
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
---
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
-
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
-
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
I
K
--
T
K
C
LQ
D
N
--
F
S
K
I
----
N
N
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
KVSE-----
N
S
E
-----------
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
Y
N
K
H
N
--
136
HHSearch
60.29
34%
-51
- C5 -
-
3A14
2
DXR_THEMA
B:
[3-372]
-
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
V
----
K
G
I
R
L
I
G
I
S
F
---
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
-
E
-----------
D
S
S
I
N
V
W
K
G
S
H
S
I
E
E
M
L
E
A
L
K
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
E
-
K
G
-
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
E
----
P
-----
E
------------------------
V
E
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
-----
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
V
A
L
--
E
P
-
F
F
L
R
T
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
I
K
D
S
-
Y
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P--------
Q
P
R
-----------
T
-
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
S
--
67
PsiBlast_CBE
59.47
39%
-22
- C5 -
-
5JNL
6
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
76
PsiBlast_CBE
59.40
39%
-25
- C5 -
-
5JAZ
7
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
65
PsiBlast_CBE
59.29
39%
-24
- C5 -
-
5JO0
8
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
78
PsiBlast_CBE
59.17
39%
-22
- C5 -
-
4Y6S
1
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
64
PsiBlast_CBE
59.11
39%
-25
- C5 -
-
5JO0
7
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
72
PsiBlast_CBE
59.04
39%
-24
- C5 -
-
5JC1
13
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
56
PsiBlast_CBE
59.00
39%
-25
- C5 -
-
3WQR
2
DXR_PLAFX
A:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
77
PsiBlast_CBE
58.85
39%
-21
- C5 -
-
5JAZ
4
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
79
PsiBlast_CBE
58.77
39%
-19
- C5 -
-
4Y6S
1
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
69
PsiBlast_CBE
58.62
39%
-21
- C5 -
-
5JMW
6
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
58
PsiBlast_CBE
58.60
39%
-24
- C5 -
-
3WQQ
2
DXR_PLAFX
A:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
135
HHSearch
58.54
34%
-48
- C5 -
-
3A06
2
DXR_THEMA
B:
[2-372]
E
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
V
----
K
G
I
R
L
I
G
I
S
F
---
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
-
E
-----------
D
S
S
I
N
V
W
K
G
S
H
S
I
E
E
M
L
E
A
L
K
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
E
-
K
G
-
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
E
----
P
-----
E
------------------------
V
E
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
V
A
L
--
E
P
-
F
F
L
R
T
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
I
K
D
S
-
Y
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P--------
Q
P
R
-----------
T
-
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
S
--
80
PsiBlast_CBE
58.53
39%
-19
- C5 -
-
4Y6R
1
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
81
PsiBlast_CBE
58.52
39%
-17
- C5 -
-
4Y6R
1
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
60
PsiBlast_CBE
58.44
39%
-24
- C5 -
-
3AUA
2
DXR_PLAFX
A:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
66
PsiBlast_CBE
58.39
39%
-22
- C5 -
-
5JNL
11
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
85
PsiBlast_CBE
58.25
39%
-21
- C5 -
-
4Y67
1
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
73
PsiBlast_CBE
58.25
39%
-22
- C5 -
-
5JC1
10
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
71
PsiBlast_CBE
58.25
39%
-22
- C5 -
-
5JMP
9
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
88
PsiBlast_CBE
58.24
39%
-24
- C5 -
-
4GAE
4
DXR_PLAFX
B:
[17-389]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
I
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
87
PsiBlast_CBE
58.21
39%
-22
- C5 -
-
4KP7
2
DXR_PLAFX
A:
[18-390]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
75
PsiBlast_CBE
58.18
39%
-21
- C5 -
-
5JBI
9
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
84
PsiBlast_CBE
58.09
39%
-21
- C5 -
-
4Y67
1
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
70
PsiBlast_CBE
58.07
39%
-22
- C5 -
-
5JMP
12
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
82
PsiBlast_CBE
58.05
39%
-24
- C5 -
-
4Y6P
1
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
54
PsiBlast_CBE
58.04
39%
-23
- C5 -
-
3WQS
2
DXR_PLAFX
B:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
74
PsiBlast_CBE
58.00
39%
-23
- C5 -
-
5JBI
9
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
62
PsiBlast_CBE
57.98
39%
-20
- C5 -
-
3AU9
2
DXR_PLAFX
A:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
89
PsiBlast_CBE
57.92
39%
-24
- C5 -
-
4GAE
3
DXR_PLAFX
A:
[17-389]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
I
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
83
PsiBlast_CBE
57.86
39%
-22
- C5 -
-
4Y6P
1
DXR_PLAF7
A:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
55
PsiBlast_CBE
57.76
39%
-22
- C5 -
-
3WQR
2
DXR_PLAFX
B:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
57
PsiBlast_CBE
57.74
39%
-21
- C5 -
-
3WQQ
2
DXR_PLAFX
B:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
59
PsiBlast_CBE
57.53
39%
-21
- C5 -
-
3AUA
2
DXR_PLAFX
B:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
68
PsiBlast_CBE
57.45
39%
-22
- C5 -
-
5JMW
6
DXR_PLAF7
B:
[13-385]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------
61
PsiBlast_CBE
57.30
39%
-22
- C5 -
-
3AU9
2
DXR_PLAFX
B:
[79-452]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
LYV
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
SKIN
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
----------------------------------------------------
86
PsiBlast_CBE
56.52
39%
-23
- C5 -
-
4KP7
1
DXR_PLAFX
B:
[18-390]
---
N
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
---
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
-
K
S
V
Y
E
-
E
L
K
E
L
V
K
N
I
K
D
Y
K
P
I
I
L
C
G
D
E
G
M
K
E
I
C
S
S
N
S
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
-
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
D
----
N
----
N
K
V
L
K
--
T
-
K
--
C
L
--
Q
D
N
F
S
K
I
N
N
-
I
N
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
------
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
-----------------------------------------------------