@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMV2: (2017-11-10 )
MKVQQYRLDELAHLVKGELIGEGSLQFSNLASLENAEVNHLTFVNGEKHLDQAKVSRAGAYIVTAALKEHLPEKDNFIIVDNPYLAFAILTHVFDKKISSTGIESTARIHPSAVISETAYIGHYVVIGENCVVGDNTVIQSHTKLDDNVEVGKDCFIDSYVTITGSSKLRDRVRIHSSTVIGGEGFGFAPYQGKWHRIAQLGSVLIGNDVRIGSNCSIDRGALDNTILEDGVIIDNLVQIAHNVHIGSNTAIAAKCGIAGSTKIGKNCILAGACGVAGHLSIADNVTLTGMSMVTKNISEAGTYSSGTGLFENNHWKKTIVRLRQLADVPLTQITKRLDHIQAQIESLESTFNLRK
Atome Classification :
(21 SA)
.........10........20........30........40........50........60...-..-...70.-.....----..80.........90......-.-.100.........110.......120.......130.......140.......150.......160.......170....------------...180.......190.....-..200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300........-310.......320.......330.........340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
V
Q
Q
Y
R
L
D
E
L
A
H
L
V
K
G
ELIGEGS
L
Q
FSNLASLENAEV
N
H
L
T
FVNG
E
K
H
L
D
Q
A
K
V
SRA
G
A
Y
I
V
T
-
A
A
-
L
K
E
HLP-EKD
N
F
----
I
I
V-DN
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
-I-SS--TGIESTARIH
P
S
A
V
ISETAYI
G
H
Y
V
V
IGE
N
C
VVGDN
T
V
I
Q
SHTKLDDNVEVGKDCFI
D
S
Y
V
T
ITGS
S
K
L
R
D
R
V
R
IH------------S
S
T
V
IGGEGFGFAPYQ
G
K
W
H
R
-
I
A
Q
L
G
S
V
LIGNDVRIGSNCSIDRGALDNTILED
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
HIGSN
T
A
I
A
A
KCGIAGSTKIGKN
C
I
L
AGACGVAGH
L
S
IADN
V
T
L
T
G
M
S
M
V
T
K
N
I
SE-AGTYSSGTG-LFENN
H
W
K
K
T
I
V
R
L
R
Q
LADV
P
--
L
T
Q
I
T
K
R
L
D
H
I
Q
A
Q
I
E
S
L
E
S
TFNLRK
66
HHSearch
98.92
100%
-155
- C2 -
-
4E79
-
LPXD_ACIBS
B:
[6-355]
---
Q
Q
Y
R
L
D
E
L
A
H
L
V
K
G
E
L
I
G
E
G
S
L
Q
F
S
N
L
A
S
L
E
N
A
E
V
N
H
L
T
F
V
N
G
E
K
H
L
D
Q
A
K
V
S
R
A
G
A
Y
I
V
T
-
A
A
-
L
K
E
H
L
P
-
E
K
D
N
F
----
I
I
V
-
D
N
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
-
I
-
S
S
--
T
G
I
E
S
T
A
R
I
H
P
S
A
V
I
S
E
T
A
Y
I
G
H
Y
V
V
I
G
E
N
C
V
V
G
D
N
T
V
I
Q
S
H
T
K
L
D
D
N
V
E
V
G
K
D
C
F
I
D
S
Y
V
T
I
T
G
S
S
K
L
R
D
R
V
R
I
H
------------
S
S
T
V
I
G
G
E
G
F
G
F
A
P
Y
Q
G
K
W
H
R
-
I
A
Q
L
G
S
V
L
I
G
N
D
V
R
I
G
S
N
C
S
I
D
R
G
A
L
D
N
T
I
L
E
D
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
H
I
G
S
N
T
A
I
A
A
K
C
G
I
A
G
S
T
K
I
G
K
N
C
I
L
A
G
A
C
G
V
A
G
H
L
S
I
A
D
N
V
T
L
T
G
M
S
M
V
T
K
N
I
S
E
-
A
G
T
Y
S
S
G
T
G
-
L
F
E
N
N
H
W
K
K
T
I
V
R
L
R
Q
L
A
D
V
P
--
L
T
Q
I
T
K
R
L
D
H
I
Q
A
Q
I
E
S
L
E
S
T
F
N
---
2
PsiBlast_PDB
98.29
100%
-155
- C2 -
-
4E79
-
LPXD_ACIBS
A:
[5-350]
--
V
Q
Q
Y
R
L
D
E
L
A
H
L
V
K
G
E
L
I
G
E
G
S
L
Q
F
S
N
L
A
S
L
E
N
A
E
V
N
H
L
T
F
V
N
G
E
K
H
L
D
Q
A
K
V
S
R
A
G
A
Y
I
V
T
-
A
A
-
L
K
E
H
L
P
-
E
K
D
N
F
----
I
I
V
-
D
N
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
-
I
-
S
S
--
T
G
I
E
S
T
A
R
I
H
P
S
A
V
I
S
E
T
A
Y
I
G
H
Y
V
V
I
G
E
N
C
V
V
G
D
N
T
V
I
Q
S
H
T
K
L
D
D
N
V
E
V
G
K
D
C
F
I
D
S
Y
V
T
I
T
G
S
S
K
L
R
D
R
V
R
I
H
------------
S
S
T
V
I
G
G
E
G
F
G
F
A
P
Y
Q
G
K
W
H
R
-
I
A
Q
L
G
S
V
L
I
G
N
D
V
R
I
G
S
N
C
S
I
D
R
G
A
L
D
N
T
I
L
E
D
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
H
I
G
S
N
T
A
I
A
A
K
C
G
I
A
G
S
T
K
I
G
K
N
C
I
L
A
G
A
C
G
V
A
G
H
L
S
I
A
D
N
V
T
L
T
G
M
S
M
V
T
K
N
I
S
E
-
A
G
T
Y
S
S
G
T
G
-
L
F
E
N
N
H
W
K
K
T
I
V
R
L
R
Q
L
A
D
V
P
--
L
T
Q
I
T
K
R
L
D
H
I
Q
A
Q
I
E
S
L
--------
1
PsiBlast_PDB
97.56
100%
-157
- C2 -
-
4E75
-
LPXD_ACIBS
A:
[5-341]
--
V
Q
Q
Y
R
L
D
E
L
A
H
L
V
K
G
E
L
I
G
E
G
S
L
Q
F
S
N
L
A
S
L
E
N
A
E
V
N
H
L
T
F
V
N
G
E
K
H
L
D
Q
A
K
V
S
R
A
G
A
Y
I
V
T
-
A
A
-
L
K
E
H
L
P
-
E
K
D
N
F
----
I
I
V
-
D
N
P
Y
L
A
F
A
I
L
T
H
V
F
D
K
K
-
I
-
S
S
--
T
G
I
E
S
T
A
R
I
H
P
S
A
V
I
S
E
T
A
Y
I
G
H
Y
V
V
I
G
E
N
C
V
V
G
D
N
T
V
I
Q
S
H
T
K
L
D
D
N
V
E
V
G
K
D
C
F
I
D
S
Y
V
T
I
T
G
S
S
K
L
R
D
R
V
R
I
H
------------
S
S
T
V
I
G
G
E
G
F
G
F
A
P
Y
Q
G
K
W
H
R
-
I
A
Q
L
G
S
V
L
I
G
N
D
V
R
I
G
S
N
C
S
I
D
R
G
A
L
D
N
T
I
L
E
D
G
V
I
I
D
N
L
V
Q
I
A
H
N
V
H
I
G
S
N
T
A
I
A
A
K
C
G
I
A
G
S
T
K
I
G
K
N
C
I
L
A
G
A
C
G
V
A
G
H
L
S
I
A
D
N
V
T
L
T
G
M
S
M
V
T
K
N
I
S
E
-
A
G
T
Y
S
S
G
T
G
-
L
F
E
N
N
H
W
K
K
T
I
V
R
L
R
Q
L
A
D
V
P
--
L
T
Q
I
T
K
R
L
D
-----------------
32
PsiBlast_CBE
60.78
39%
-50
- C2 -
-
4IHF
3
LPXD_ECOLI
E:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
25
PsiBlast_CBE
60.41
39%
-49
- C2 -
-
4IHH
4
LPXD_ECOLI
B:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
35
PsiBlast_CBE
60.04
39%
-51
- C2 -
-
4IHF
3
LPXD_ECOLI
B:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
5
PsiBlast_PDB
59.66
39%
-48
- C2 -
-
4IHG
5
LPXD_ECOLI
A:
[12-341]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
--------------
34
PsiBlast_CBE
59.44
39%
-49
- C2 -
-
4IHF
3
LPXD_ECOLI
C:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
29
PsiBlast_CBE
59.33
39%
-44
- C2 -
-
4IHG
6
LPXD_ECOLI
C:
[12-341]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
--------------
23
PsiBlast_CBE
59.31
39%
-49
- C2 -
-
4IHH
4
LPXD_ECOLI
D:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
24
PsiBlast_CBE
59.23
39%
-50
- C2 -
-
4IHH
4
LPXD_ECOLI
C:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
33
PsiBlast_CBE
59.17
39%
-49
- C2 -
-
4IHF
3
LPXD_ECOLI
D:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
22
PsiBlast_CBE
59.15
39%
-48
- C2 -
-
4IHH
4
LPXD_ECOLI
E:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
31
PsiBlast_CBE
58.96
39%
-48
- C2 -
-
4IHF
3
LPXD_ECOLI
F:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
64
HHSearch
58.84
37%
-61
- C2 -
-
4IHF
3
LPXD_ECOLI
C:
[9-344]
---
A
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-
Q
D
D
L
---
P
F
-
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
-
P
A
--
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
------------
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
30
PsiBlast_CBE
58.71
39%
-47
- C2 -
-
4IHG
6
LPXD_ECOLI
B:
[12-341]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
--------------
7
PsiBlast_PDB
58.65
39%
-47
- C2 -
-
4IHF
3
LPXD_ECOLI
A:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
A
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
27
PsiBlast_CBE
58.58
39%
-50
- C2 -
-
4IHG
6
LPXD_ECOLI
E:
[12-344]
------
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-----
Q
D
D
L
P
F
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
---------
T
T
P
Q
P
A
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
------
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
HEIQIGQNCLIQ
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
-
P
G
V
Y
S
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
-----------
3
PsiBlast_PDB
58.44
42%
-49
- C2 -
-
3PMO
2
LPXD_PSEAE
A:
[21-359]
M
S
T
L
S
Y
T
L
G
Q
L
A
A
H
V
G
A
E
V
R
G
D
A
D
L
P
I
Q
G
L
A
T
L
Q
E
A
G
P
A
Q
L
S
F
L
A
N
P
Q
Y
R
K
Y
L
P
E
S
R
A
G
A
V
L
L
T
-
A
A
--------
D
A
D
G
F
AGTA
L
V
V
-
A
N
P
Y
L
A
Y
A
S
L
S
H
L
F
D
R
K
-
P
K
A
A
--
A
G
I
H
P
T
A
I
V
A
A
D
A
E
V
D
P
S
A
S
V
G
A
Y
A
V
I
E
S
G
A
R
I
G
A
G
V
S
I
G
A
H
C
V
I
G
A
R
S
V
I
G
E
G
G
W
L
A
P
R
V
T
L
Y
H
D
V
T
I
G
A
R
V
S
I
Q
------------
S
G
A
V
I
G
G
E
G
F
G
F
A
N
E
K
G
V
W
Q
K
-
I
A
Q
I
G
G
V
T
I
G
D
D
V
E
I
G
A
N
T
T
I
D
R
G
A
L
S
D
T
L
I
G
N
G
V
K
L
D
N
Q
I
M
I
A
H
N
V
Q
I
G
D
H
T
A
M
A
A
C
V
G
I
S
G
S
A
K
I
G
R
H
C
M
L
A
G
G
V
G
L
V
G
H
I
E
I
C
D
N
V
F
V
T
G
M
T
M
V
T
R
S
I
T
E
-
P
G
S
Y
S
S
G
T
A
-
M
Q
P
A
A
E
W
K
K
S
A
A
R
I
R
Q
L
D
D
M
A
R
R
L
Q
Q
L
E
K
R
L
------------------
65
HHSearch
58.40
37%
-62
- C2 -
-
3EH0
-
LPXD_ECOLI
B:
[1-340]
--
M
A
S
I
R
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
D
G
D
I
V
I
T
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
M
V
N
P
K
Y
R
E
H
L
G
L
C
Q
A
S
A
V
V
M
T
-
Q
D
D
L
---
P
F
-
A
K
S
A
A
----
L
V
V
-
K
N
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
-
P
A
--
Q
N
I
A
P
S
A
V
I
D
A
T
A
K
L
G
N
N
V
S
I
G
A
N
A
V
I
E
S
G
V
E
L
G
D
N
V
I
I
G
A
G
C
F
V
G
K
N
S
K
I
G
A
G
S
R
L
W
A
N
V
T
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
------------
S
G
T
V
V
G
A
D
G
F
G
Y
A
N
D
R
G
N
W
V
K
-
I
P
Q
I
G
R
V
I
I
G
D
R
V
E
I
G
A
C
T
T
I
D
R
G
A
L
D
D
T
I
I
G
N
G
V
I
I
D
N
Q
C
Q
I
A
H
N
V
V
I
G
D
N
T
A
V
A
G
G
V
I
M
A
G
S
L
K
I
G
R
Y
C
M
I
G
G
A
S
V
I
N
G
H
M
E
I
C
D
K
V
T
V
T
G
M
G
M
V
M
R
P
I
T
E
P
G
V
Y
S
-
S
G
I
P
-
L
Q
P
N
K
V
W
R
K
T
A
A
L
V
M
N
I
D
D
-------
M
S
K
R
L
K
S
L
E
R
K
V
N
Q
Q
--------
38
PsiBlast_CBE
54.40
34%
-43
- C2 -
-
2IU9
3
LPXD_CHLTR
C:
[23-368]
--
Q
S
T
Y
S
L
E
Q
L
A
D
F
L
K
V
E
F
Q
G
N
G
A
T
L
L
S
G
V
E
E
I
E
E
A
K
T
A
H
I
T
F
L
D
N
E
K
Y
A
K
H
L
K
S
S
E
A
G
A
I
I
I
S
R
T
Q
-
F
Q
K
Y
R
D
-
L
N
K
N
F
----
L
I
T
S
E
S
P
S
L
V
F
Q
K
C
L
E
L
F
I
T
P
-
V
-
D
S
GF
P
G
I
H
P
T
A
V
I
H
P
T
A
I
I
E
D
H
V
C
I
E
P
Y
A
V
V
C
Q
H
A
H
V
G
S
A
C
H
I
G
S
G
S
V
I
G
A
Y
S
T
V
G
E
H
S
Y
I
H
P
R
V
V
I
R
E
R
V
S
I
G
K
R
V
I
I
Q
------------
P
G
A
V
I
G
S
C
G
F
G
Y
V
T
S
A
F
G
Q
H
K
H
L
K
H
L
G
K
V
I
I
E
D
D
V
E
I
G
A
N
T
T
I
D
R
G
R
F
K
H
S
V
V
R
E
G
S
K
I
D
N
L
V
Q
I
A
H
Q
V
E
V
G
Q
H
S
M
I
V
A
Q
A
G
I
A
G
S
T
K
I
G
N
H
V
I
I
G
G
Q
A
G
I
T
G
H
I
C
I
A
D
H
V
I
M
M
A
Q
T
G
V
T
K
S
I
T
S
-
P
G
I
Y
G
G
A
P
A
R
P
Y
Q
E
I
H
--------
R
Q
V
A
K
V
R
N-
L
P
R
L
E
E
R
I
A
A
L
E
K
L
V
Q
K
L
E
-------