@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMX5: (2017-11-11 )
MALISMRQLLDHAAEHNYGVPAFNVNNLEQMRAIMLAADATNSPVIVQASAGARKYAGAPFLRHLILAAIEEWPHIPVVMHQDHGTSPDVCQRSIQLGFSSVMMDGSLGADGKTPTTYDYNVDVTRQVVAMAHACGVSVEGEIGCLGSLETGMAGEEDGVGAEGVLDHSQLLTSAEEAKQFVADTNVDALAIAVGTSHGAYKFTRPPTGDILAIDRIKEIHVALPNTHLVMHGSSSVPQEWLKVINEFGGNIGDTYGVPVEQLVEAIKHGVRKINIDTDLRLASTGAIRRFMAENPAEFDPRKYFAKTVDSMKQICIDRYEAFGTAGNADKIRPISLEKMVDRYK
Atome Classification :
(24 SA)
--.........10........20........30........40........50......--..60........70--........80....-----------....90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.--......210........220......---.230.......240.......250.......260.......270.......280.......290.....-..300.......310.......320.......330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
A
L
I
S
M
R
Q
L
L
D
H
A
AEHNYGVPAFNVN
N
L
E
Q
M
R
A
I
M
L
AADATNS
P
V
I
V
Q
ASAGARKYA--
G
A
P
F
L
R
H
L
I
L
A
A
I
E
--EWPHI
P
V
V
M
HQDHG-----------T
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
VMMDGSLGADGKT
P
T
T
Y
D
YN
V
D
V
T
R
Q
V
V
A
M
A
H
ACGVSVEGEI
G
C
LGSLETGMAGEEDGVGAEGVL
D
H
S
Q
L
L
T
S
A
E
E
A
K
Q
F
V
ADTNV
D
A
L
A
I
A
V
GTSHGA
Y
K
F--TRPPTG
D
I
-
L
A
I
D
R
I
K
E
I
H
V
ALPN
T
H
---
L
V
MHGSSSV
P
Q
E
W
L
K
V
I
N
E
FGGNIGDTYGV
P
V
E
Q
L
V
E
A
I
K
H
G
V
R
K
INIDT
D
L
R
LA
S
T
G
A
I
R
R
F
M
AENPA-EF
D
P
R
K
Y
F
A
K
T
V
D
S
M
K
Q
I
C
I
D
R
Y
E
AFGTAGNADKIRPI
S
L
E
K
M
V
D
RYK
1
PsiBlast_PDB
97.38
99%
-98
- C5 -
-
5U7S
1
?
A:
[9-353]
--
M
A
L
I
S
M
R
Q
L
L
D
H
A
A
E
H
N
Y
G
V
P
A
F
N
V
N
N
L
E
Q
M
R
A
I
M
L
A
A
D
A
T
N
S
P
V
I
V
Q
A
S
A
G
--------
A
P
F
L
R
H
L
I
L
A
A
I
E
--
E
W
P
H
I
P
V
V
M
H
Q
D
H
G
-----------
T
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
V
M
M
D
G
S
L
G
A
D
G
K
T
P
T
T
Y
D
Y
N
V
D
V
T
R
Q
V
V
A
M
A
H
A
C
G
V
S
V
E
G
E
I
G
C
L
G
S
L
E
T
-------------
V
L
D
H
S
Q
L
L
T
S
V
E
E
A
K
Q
F
V
A
D
T
N
V
D
A
L
A
I
A
V
G
T
S
H
G
A
Y
K
F
--
T
R
P
P
T
G
D
I
-
L
A
I
D
R
I
K
E
I
H
A
A
L
P
N
T
H
---
L
V
M
H
G
S
S
S
V
P
Q
E
W
L
K
V
I
N
E
F
G
G
N
I
G
E
T
Y
G
V
P
V
E
Q
L
V
E
A
I
K
H
G
V
R
K
I
N
I
D
T
D
L
R
L
A
S
T
G
A
I
R
R
F
M
A
E
N
P
A
-
E
F
D
P
R
K
Y
F
A
K
T
V
D
S
M
K
Q
I
C
I
D
R
Y
E
A
F
G
T
A
G
N
A
D
K
I
R
P
I
S
L
E
K
M
V
D
R
Y
K
21
PsiBlast_CBE
96.43
99%
-93
- C5 -
-
5U7S
1
?
B:
[9-353]
--
M
A
L
I
S
M
R
Q
L
L
D
H
A
A
E
H
N
Y
G
V
P
A
F
N
V
N
N
L
E
Q
M
R
A
I
M
L
A
A
D
A
T
N
S
P
V
I
V
Q
A
S
A
G
A
R
K
Y
A
--
G
A
P
F
L
R
H
L
I
L
A
A
I
E
--
E
W
P
H
I
P
V
V
M
H
Q
D
H
G
-----------
T
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
V
M
M
D
G
S
L
G
A
D
G
K
T
P
T
T
Y
D
Y
N
V
D
V
T
R
Q
V
V
A
M
A
H
A
C
G
V
S
V
E
G
E
I
G
C
------------------------
Q
L
L
T
S
V
E
E
A
K
Q
F
V
A
D
T
N
V
D
A
L
A
I
A
V
G
T
S
H
G
A
Y
K
F
--
T
R
P
P
T
G
D
I
-
L
A
I
D
R
I
K
E
I
H
A
A
L
P
N
T
H
---
L
V
M
H
G
S
S
S
V
P
Q
E
W
L
K
V
I
N
E
F
G
G
N
I
G
E
T
Y
G
V
P
V
E
Q
L
V
E
A
I
K
H
G
V
R
K
I
N
I
D
T
D
L
R
L
A
S
T
G
A
I
R
R
F
M
A
E
N
P
A
-
E
F
D
P
R
K
Y
F
A
K
T
V
D
S
M
K
Q
I
C
I
D
R
Y
E
A
F
G
T
A
G
N
A
D
K
I
R
P
I
S
L
E
K
M
V
D
R
Y
K
40
HHSearch
95.06
81%
-81
- C5 -
-
5U4N
1
?
A:
[9-353]
--
M
A
L
V
S
M
R
Q
L
L
D
H
A
A
E
N
S
Y
G
L
P
A
F
N
V
N
N
L
E
Q
M
R
A
I
M
E
A
A
D
Q
V
N
A
P
V
I
V
Q
A
S
A
G
A
R
K
Y
A
--
G
A
P
F
L
R
H
L
I
L
A
A
V
E
--
E
F
P
H
I
P
V
V
M
H
Q
D
H
G
-----------
A
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
V
M
M
D
G
S
L
L
E
D
G
K
T
P
S
S
Y
E
Y
N
V
N
A
T
R
T
V
V
N
F
S
H
A
C
G
V
S
V
E
G
E
I
G
V
L
G
N
L
E
T
G
E
A
G
E
E
D
G
V
G
A
A
G
K
L
S
H
D
Q
M
L
T
S
V
E
D
A
V
R
F
V
K
D
T
G
V
D
A
L
A
I
A
V
G
T
S
H
G
A
Y
K
F
--
T
R
P
P
T
G
D
V
-
L
R
I
D
R
I
K
E
I
H
Q
A
L
P
N
T
H
---
I
V
M
H
G
S
S
S
V
P
Q
E
W
L
K
V
I
N
E
Y
G
G
N
I
G
E
T
Y
G
V
P
V
E
E
I
V
E
G
I
K
H
G
V
R
K
V
N
I
D
T
D
L
R
L
A
S
T
G
A
V
R
R
Y
L
A
E
N
P
S
-
D
F
D
P
R
K
Y
L
G
K
T
I
E
A
M
K
Q
I
C
L
D
R
Y
L
A
F
G
C
E
G
Q
A
G
K
I
K
P
V
S
L
E
K
M
A
S
R
Y
A
2
PsiBlast_PDB
94.83
80%
-82
- C5 -
-
5U4N
1
?
A:
[9-352]
--
M
A
L
V
S
M
R
Q
L
L
D
H
A
A
E
N
S
Y
G
L
P
A
F
N
V
N
N
L
E
Q
M
R
A
I
M
E
A
A
D
Q
V
N
A
P
V
I
V
Q
A
S
A
G
A
R
K
Y
A
--
G
A
P
F
L
R
H
L
I
L
A
A
V
E
--
E
F
P
H
I
P
V
V
M
H
Q
D
H
G
-----------
A
S
P
D
V
C
Q
R
S
I
Q
L
G
F
S
S
V
M
M
D
G
S
L
L
E
D
G
K
T
P
S
S
Y
E
Y
N
V
N
A
T
R
T
V
V
N
F
S
H
A
C
G
V
S
V
E
G
E
I
G
V
L
G
N
L
E
T
G
E
A
G
E
E
D
G
V
G
A
A
G
K
L
S
H
D
Q
M
L
T
S
V
E
D
A
V
R
F
V
K
D
T
G
V
D
A
L
A
I
A
V
G
T
S
H
G
A
Y
K
F
--
T
R
P
P
T
G
D
V
-
L
R
I
D
R
I
K
E
I
H
Q
A
L
P
N
T
H
---
I
V
M
H
G
S
S
S
V
P
Q
E
W
L
K
V
I
N
E
Y
G
G
N
I
G
E
T
Y
G
V
P
V
E
E
I
V
E
G
I
K
H
G
V
R
K
V
N
I
D
T
D
L
R
L
A
S
T
G
A
V
R
R
Y
L
A
E
N
P
S
-
D
F
D
P
R
K
Y
L
G
K
T
I
E
A
M
K
Q
I
C
L
D
R
Y
L
A
F
G
C
E
G
Q
A
G
K
I
K
P
V
S
L
E
K
M
A
S
R
Y
-
42
HHSearch
80.07
49%
-101
- C5 -
-
2ISW
1
?
A:
[2-322]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
-------
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
--
K
S
-----
R
-
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
---
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
-
5
PsiBlast_PDB
79.03
46%
-70
- C5 -
-
2ISW
1
?
A:
[2-322]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
-------
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-----------------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
--
K
S
------R
L
A
I
D
R
V
K
T
I
S
-
D
L
T
G
I
P
---
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
-
23
PsiBlast_CBE
78.76
46%
-70
- C5 -
-
2ISV
1
?
B:
[2-322]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
-------
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
----------------------
Q
N
T
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
---------
I
R
L
A
I
D
R
V
K
T
I
S
-
D
L
T
G
I
P
---
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
-
4
PsiBlast_PDB
77.10
46%
-72
- C5 -
-
2ISV
1
?
A:
[2-322]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
-------
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
---------------------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
-------------R
L
A
I
D
R
V
K
T
I
S
-
D
L
T
G
I
P
---
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
-
3
PsiBlast_PDB
76.86
47%
-108
- C5 -
-
3GAK
-
?
A:
[2-322]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
L
K
K
L
C
E
A
A
L
E
--
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
-------
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
G
V
S
V
E
A
E
L
G
----------------------------
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
V
D
A
L
A
V
A
I
--------------------
L
A
I
D
R
V
K
T
I
S
-
D
L
T
G
I
P
---
L
V
M
H
G
S
S
S
V
P
K
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
G
D
Y
K
V
V
S
L
E
E
A
K
A
W
Y
-
10
PsiBlast_PDB
76.16
37%
-88
- C5 -
-
3C56
2
ALF_HELPY
A:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
--------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
12
PsiBlast_PDB
76.10
37%
-87
- C5 -
-
3N9S
2
?
A:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
E
D
N
I
S
V
D
E
K
----------
D
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
45
HHSearch
75.83
43%
-94
- C5 -
-
1RVG
-
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
-
R
A
L
T
L
M
A
V
E
L
A
K
--
E
-
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
-------
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
-------
E
E
---------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
G
R
---
P
F
-
I
D
H
A
R
L
E
R
I
A
R
L
-
V
P
A
P
---
L
V
L
H
G
A
S
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
----------------
30
PsiBlast_CBE
75.82
37%
-90
- C5 -
-
3N9S
2
?
B:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
----------------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
9
PsiBlast_PDB
75.52
37%
-89
- C5 -
-
3C52
1
ALF_HELPY
A:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
---------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
8
PsiBlast_PDB
75.18
37%
-95
- C5 -
-
3C4U
-
ALF_HELPY
A:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
-------------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
13
PsiBlast_PDB
74.98
40%
-83
- C5 -
-
2FJK
1
ALF_THECA
A:
[2-305]
----
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
R
A
L
T
R
M
V
V
--
A
L
A
--
Q
E
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
-------
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
----------
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
G
R
P
F
I
D
H
-
P
R
L
A
R
I
A
K
L
-
V
P
A
P
------
L
V
L
H
G
A
S
A
V
P
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
E
A
S
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
----------------
36
PsiBlast_CBE
74.88
37%
-89
- C5 -
-
3C56
2
ALF_HELPY
B:
[2-304]
----
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
-------
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
-----------------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
G
E
P
K
L
D
----
F
E
R
L
Q
E
V
K
-
R
L
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
-------------------
43
HHSearch
74.36
39%
-46
- C5 -
-
3N9S
2
?
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
A
V
G
M
V
K
I
M
C
E
--
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
-------
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-------
E
D
N
I
S
V
---
D
E
K
D
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-----
K
-
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
---
L
V
L
H
G
A
S
A
I
P
D
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
----------------
46
HHSearch
74.35
42%
-88
- C5 -
-
2FJK
1
ALF_THECA
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
-
R
A
L
T
R
M
V
V
A
L
A
Q
--
E
-
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
-------
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
-------
E
E
H
V
A
V
---
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
G
R
---
P
F
-
I
D
H
P
R
L
A
R
I
A
K
L
-
V
P
A
P
---
L
V
L
H
G
A
S
A
V
P
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
E
A
S
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
----------------
7
PsiBlast_PDB
74.32
41%
1
- C5 -
-
1RVG
-
?
A:
[2-305]
----
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
----
R
A
L
T
L
M
A
V
E
L
A
K
E
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
-------
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
------
K
----------
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
G
R
P
F
I
D
H
-
A
R
L
E
R
I
A
R
L
-
V
P
A
P
------
L
V
L
H
G
A
S
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
----------------
39
PsiBlast_CBE
69.82
33%
-109
- C5 -
-
1GVF
10
KBAY_ECOLI
B:
[2-281]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
L
E
E
I
-
Y
A
L
C
S
A
Y
S
--
T
T
Y
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
-------
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
------------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
----
S
K
T
P
K
I
D
F
-
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
------
L
V
L
H
G
A
S
D
V
P
D
E
F
V
R
---------------------
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
-------------------
15
PsiBlast_PDB
69.82
33%
-115
- C5 -
-
1GVF
9
KBAY_ECOLI
A:
[2-281]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
L
E
E
I
-
Y
A
L
C
S
A
Y
S
--
T
T
Y
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
-------
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
---------------------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
----
S
K
T
P
K
I
D
F
-
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
------
L
V
L
H
G
A
S
D
V
P
D
E
F
V
R
---------------------
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
-------------------
47
HHSearch
68.87
37%
-107
- C5 -
-
1GVF
10
KBAY_ECOLI
B:
[2-284]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
L
E
E
I
Y
A
L
C
S
A
Y
S
T
--
T
-
Y
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
-------
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
-------
E
-----------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
-----
K
-
I
D
F
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
---
L
V
L
H
G
A
S
D
V
P
D
E
---------------------
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
----------------
64
Fugue
63.25
37%
26
* C5 *
-
1GVF
9
KBAY_ECOLI
A:
[2-285]
SI
I
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
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---------------------
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---------------------
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---------------