@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMY7: (2017-11-11 )
MKHIVIPARFSSSRLPGKPLLLIHDRPMILRVVDQAKKVEGFDDLCVATDDERIAEICRAEGVDVVLTSADHPSGTDRLSEVARIKGWDADDIIVNVQGDEPLLPAQLVQQVAKLLVDKPNCSMSTLCEPIHALDEFQRDSIVKVVMSKQNEALYFSRATIPYDRDSAKQAEPTLHSQAFRHLGLYAYRVSLLQEYVTWEMGKLEKLESLEQLRVLENGHRIAIAVAEANLPPGVDTQADLDRLNNMPVESFE
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70.....-...80........90-........100.......110.......120..-......130.......140.......150.......160-.....-...170..----.....180.......190....-...200.......210.......220....-.-.-.230.......240---........250.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
H
I
V
I
PARFSSSRLPGK
P
L
L
L
IHDR
P
M
I
L
R
V
V
D
Q
A
K
KVEGFD
D
L
C
VAT
D
D
E
R
I
A
E
I
C
R
AEG
V
D
V
V
L
TSADHPS
G
T
-
D
R
L
S
E
V
A
R
IKGWDA
D
-
D
I
I
V
NVQGDEPL
L
P
A
Q
L
V
Q
Q
V
A
K
L
LVDKPN-C
S
-
M
S
T
L
C
E
P
I
H
A
L
D
E
F
Q
R
D
S
I
V
K
V
V
M
SKQN
E
A
L
Y
F
S
RATI--PYDRD-SAKQAEP
T
----
L
H
S
Q
A
F
R
H
L
G
L
Y
A
Y
R
V
S
L
L
Q
E
Y
-
V
T
W
E
MG
K
L
E
K
L
E
S
L
E
Q
L
R
V
L
ENG
H
R
I
A
I
A
V
-A-E-ANLPPGVD
T
Q
A
D
L
----
D
R
LNNMPVESFE
2
PsiBlast_PDB
80.00
98%
-
- C- -
-
3POL
-
KDSB_ACIBT
A:
[1-253]
M
K
H
I
V
I
P
A
R
F
S
S
S
R
L
P
G
K
P
L
L
L
I
H
D
R
P
M
I
L
R
V
V
D
Q
A
K
K
V
E
G
F
D
D
L
C
V
A
T
D
D
E
R
I
A
E
I
C
R
A
E
G
V
D
V
V
L
T
S
A
D
H
P
S
G
T
-
D
R
L
S
E
V
A
R
I
K
G
W
D
A
D
-
D
I
I
V
N
V
Q
G
D
E
P
L
L
P
A
Q
L
V
Q
Q
V
A
K
L
L
V
D
K
P
N
-
C
S
-
M
S
T
L
C
E
P
I
H
A
L
D
E
F
Q
R
D
S
I
V
K
V
V
M
S
K
Q
N
E
A
L
Y
F
S
R
A
T
I
--
P
Y
D
R
D
-
G
A
K
R
D
E
P
T
----
L
H
T
Q
A
F
R
H
L
G
L
Y
A
Y
R
V
S
L
L
Q
E
Y
-
V
T
W
E
M
G
K
L
E
K
L
E
S
L
E
Q
L
R
V
L
E
N
G
H
R
I
A
I
A
V
-
A
-
E
-
A
N
L
P
P
G
V
D
T
Q
A
D
L
----
D
R
L
N
N
M
P
V
E
S
F
E
1
PsiBlast_PDB
80.00
98%
-
- C- -
-
4FCU
-
KDSB_ACIBT
A:
[1-253]
M
K
H
I
V
I
P
A
R
F
S
S
S
R
L
P
G
K
P
L
L
L
I
H
D
R
P
M
I
L
R
V
V
D
Q
A
K
K
V
E
G
F
D
D
L
C
V
A
T
D
D
E
R
I
A
E
I
C
R
A
E
G
V
D
V
V
L
T
S
A
D
H
P
S
G
T
-
D
R
L
S
E
V
A
R
I
K
G
W
D
A
D
-
D
I
I
V
N
V
Q
G
D
E
P
L
L
P
A
Q
L
V
Q
Q
V
A
K
L
L
V
D
K
P
N
-
C
S
-
M
S
T
L
C
E
P
I
H
A
L
D
E
F
Q
R
D
S
I
V
K
V
V
M
S
K
Q
N
E
A
L
Y
F
S
R
A
T
I
--
P
Y
D
R
D
-
G
A
K
R
D
E
P
T
----
L
H
T
Q
A
F
R
H
L
G
L
Y
A
Y
R
V
S
L
L
Q
E
Y
-
V
T
W
E
M
G
K
L
E
K
L
E
S
L
E
Q
L
R
V
L
E
N
G
H
R
I
A
I
A
V
-
A
-
E
-
A
N
L
P
P
G
V
D
T
Q
A
D
L
----
D
R
L
N
N
M
P
V
E
S
F
E
12
PsiBlast_PDB
79.43
46%
-132
- C1 -
-
3JTJ
2
KDSB_YERPE
A:
[9-249]
----
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
A
D
I
A
G
K
P
M
V
V
H
V
M
E
R
A
L
-
A
S
G
A
D
R
V
I
V
A
T
D
H
P
D
V
V
K
A
V
E
A
A
G
G
E
V
C
L
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
I
E
H
Y
G
F
A
D
D
-
D
I
I
V
N
V
Q
G
D
E
P
L
V
P
P
V
I
I
R
Q
V
A
D
N
L
A
-
A
C
S
-
A
G
-
M
A
T
L
A
V
P
I
A
S
S
E
E
A
F
N
P
N
A
V
K
V
V
M
D
A
Q
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
E
R
E
-
R
F
A
Q
S
K
E
T
----
I
G
D
C
F
L
R
H
I
G
I
Y
A
Y
R
A
G
F
I
R
R
Y
-
V
N
W
A
P
S
Q
L
E
Q
I
E
L
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
K
-
A
V
P
A
V
G
V
D
T
Q
S
D
L
----
D
R
V
R
A
I
------
34
HHSearch
78.13
97%
-
- C- -
-
4FCU
-
KDSB_ACIBT
A:
[2-253]
-
K
H
I
V
I
P
A
R
F
S
S
S
R
L
P
G
K
P
L
L
L
I
H
D
R
P
M
I
L
R
V
V
D
Q
A
K
K
V
E
G
F
D
D
L
C
V
A
T
D
D
E
R
I
A
E
I
C
R
A
E
G
V
D
V
V
L
T
S
A
D
H
P
S
G
T
-
D
R
L
S
E
V
A
R
I
K
G
W
D
A
D
-
D
I
I
V
N
V
Q
G
D
E
P
L
L
P
A
Q
L
V
Q
Q
V
A
K
L
L
V
D
-
K
P
N
C
S
-
M
S
T
L
C
E
P
I
H
A
L
D
E
F
Q
R
D
S
I
V
K
V
V
M
S
K
Q
N
E
A
L
Y
F
S
R
A
T
I
--
P
Y
D
R
D
-
G
A
K
R
D
E
P
T
----
L
H
T
Q
A
F
R
H
L
G
L
Y
A
Y
R
V
S
L
L
Q
E
Y
-
V
T
W
E
M
G
K
L
E
K
L
E
S
L
E
Q
L
R
V
L
E
N
G
H
R
I
A
I
A
V
-
A
E
A
-
N
-
L
P
P
G
V
D
T
Q
A
D
L
----
D
R
L
N
N
M
P
V
E
S
F
E
4
PsiBlast_PDB
76.29
46%
-129
- C1 -
-
3K8E
-
KDSB_ECOLI
C:
[5-243]
---
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
21
PsiBlast_CBE
75.37
46%
-111
- C1 -
-
3K8D
3
KDSB_ECOLI
D:
[21-259]
---
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
7
PsiBlast_PDB
75.20
45%
-128
- C1 -
-
1VH1
-
KDSB_ECOLI
A:
[5-243]
---
V
I
I
P
A
R
Y
A
S
T
--
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
-----
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
16
PsiBlast_PDB
75.19
43%
-108
- C1 -
-
1H7G
-
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
22
PsiBlast_CBE
75.13
46%
-113
- C1 -
-
3K8D
3
KDSB_ECOLI
C:
[21-259]
---
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
23
PsiBlast_CBE
74.92
46%
-111
- C1 -
-
3K8D
3
KDSB_ECOLI
B:
[21-259]
---
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
14
PsiBlast_PDB
74.75
43%
-106
- C1 -
-
1H7E
-
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
3
PsiBlast_PDB
74.26
46%
-112
- C1 -
-
3K8D
3
KDSB_ECOLI
A:
[21-259]
---
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
-
S
G
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
R
-
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
--
P
W
D
R
D
-
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
-
Q
-
E
V
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
---------
17
PsiBlast_PDB
73.86
43%
-104
- C1 -
-
1H7H
1
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
28
PsiBlast_CBE
73.81
43%
-104
- C1 -
-
1H7F
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
44
HHSearch
73.75
44%
-93
- C1 -
-
3TQD
-
KDSB_COXBU
A:
[9-256]
E
F
R
V
I
I
P
A
R
F
D
---
L
P
G
K
A
L
V
D
I
A
G
K
P
M
I
Q
H
V
Y
E
S
A
I
K
S
G
-
A
E
E
V
V
I
A
T
D
D
K
R
I
R
Q
V
A
E
D
F
G
A
V
V
C
M
T
S
S
D
H
Q
S
G
T
-
E
R
I
A
E
A
A
V
A
L
G
F
E
D
D
-
E
I
I
V
C
L
Q
G
D
E
P
L
I
P
P
D
A
I
R
K
L
A
E
D
L
D
E
-
H
D
---K
V
A
S
L
C
T
P
I
T
E
V
D
E
L
F
N
P
H
S
T
K
V
V
L
N
R
R
N
Y
A
L
Y
F
S
H
A
P
I
--
P
W
G
R
D
-
T
F
S
D
K
E
N
L
Q
---
L
N
G
S
H
Y
R
H
V
G
I
Y
A
Y
R
V
G
F
L
E
E
Y
-
L
S
W
D
A
C
P
A
E
K
M
E
A
L
E
Q
L
R
I
L
W
H
G
G
R
I
H
M
V
V
A
K
-
S
-
K
-
C
P
P
G
V
D
T
E
E
D
L
----
E
R
V
R
A
Y
F
-----
26
PsiBlast_CBE
73.51
43%
-106
- C1 -
-
1H7H
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
15
PsiBlast_PDB
73.39
43%
-104
- C1 -
-
1H7F
-
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
29
PsiBlast_CBE
73.34
43%
-98
- C1 -
-
1GQC
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
18
PsiBlast_PDB
73.25
43%
-103
- C1 -
-
1H7T
-
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
27
PsiBlast_CBE
72.87
43%
-104
- C1 -
-
1H7G
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
37
HHSearch
72.33
44%
-75
- C1 -
-
3K8D
3
KDSB_ECOLI
A:
[18-263]
S
F
V
V
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
V
D
I
N
G
K
P
M
I
V
H
V
L
E
R
A
R
E
S
G
-
A
E
R
I
I
V
A
T
D
H
E
D
V
A
R
A
V
E
A
A
G
G
E
V
C
M
T
R
A
D
H
Q
S
G
T
-
E
R
L
A
E
V
V
E
K
C
A
F
S
D
D
-
T
V
I
V
N
V
Q
G
D
E
P
M
I
P
A
T
I
I
R
Q
V
A
D
N
L
A
Q
-
R
Q
-
V
G
-
M
A
T
L
A
V
P
I
H
N
A
E
E
A
F
N
P
N
A
V
K
V
V
L
D
A
E
G
Y
A
L
Y
F
S
R
A
T
I
P-
W
D
R
D
--
R
F
A
E
G
L
E
T
----
V
G
D
N
F
L
R
H
L
G
I
Y
G
Y
R
A
G
F
I
R
R
Y
-
V
N
W
Q
P
S
P
L
E
H
I
E
M
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
-
A
Q
E
-
V
-
P
G
T
G
V
D
T
P
E
D
L
----
E
R
V
R
A
E
M
-----
30
PsiBlast_CBE
71.95
43%
-100
- C1 -
-
1GQ9
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
25
PsiBlast_CBE
71.62
43%
-100
- C1 -
-
1H7T
1
KPSU5_ECOLX
B:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
20
PsiBlast_PDB
71.57
43%
-98
- C1 -
-
1GQC
1
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
19
PsiBlast_PDB
70.25
43%
-98
- C1 -
-
1GQ9
1
KPSU5_ECOLX
A:
[5-236]
---
I
V
I
P
A
R
Y
G
S
S
R
L
P
G
K
P
L
L
D
I
V
G
K
P
M
I
Q
H
V
Y
E
R
A
L
Q
V
A
G
V
A
E
V
W
V
A
T
D
D
P
R
V
E
Q
A
V
Q
A
F
G
G
K
A
I
M
T
R
N
D
H
E
S
G
T
-
D
R
L
V
E
V
--
M
H
K
V
E
A
--
D
I
Y
I
N
L
Q
G
D
E
P
M
I
R
P
R
D
V
E
T
L
L
Q
G
M
R
D
D
P
A
-
L
P
-
V
A
T
L
C
H
A
I
S
A
A
-
E
A
A
E
P
S
T
V
K
V
V
V
N
T
R
Q
D
A
L
Y
F
S
R
S
P
I
--
P
Y
P
R
N
-
A
E
K
-----------
A
R
Y
L
K
H
V
G
I
Y
A
Y
R
R
D
V
L
Q
N
Y
-
S
Q
L
P
E
S
M
P
E
Q
A
E
S
L
E
Q
L
R
L
M
N
A
G
--
I
N
I
R
T
-
F
-
E
V
A
A
T
G
P
G
V
D
T
P
A
C
L
----
E
K
V
R
A
L
------
36
HHSearch
65.88
42%
-73
- C1 -
-
3JTJ
2
KDSB_YERPE
A:
[5-253]
S
F
I
A
I
I
P
A
R
Y
A
S
T
R
L
P
G
K
P
L
A
D
I
A
G
K
P
M
V
V
H
V
M
E
R
A
L
A
S
G
-
A
D
R
V
I
V
A
T
D
H
P
D
V
V
K
A
V
E
A
A
G
G
E
V
C
L
T
R
A
D
H
Q
S
G
T
E
R
L
A
E
V
I
E
H
Y
G
F
-
A
D
D
-
D
I
I
V
N
V
Q
G
D
E
P
L
V
P
P
V
I
I
R
Q
V
A
D
N
L
A
A
-
C
S
-
A
G
-
M
A
T
L
A
V
P
I
A
S
S
E
E
A
F
N
P
N
A
V
K
V
V
M
D
A
Q
G
Y
A
L
Y
F
S
R
A
T
I
PW
E
R
E
R
F
A
Q
S
K
E
--
T
I
-----
G
D
C
F
L
R
H
I
G
I
Y
A
Y
R
A
G
F
I
R
R
Y
V
N
W
A
P
S
Q
L
E
Q
I
-
E
L
L
E
Q
L
R
V
L
W
Y
G
E
K
I
H
V
A
V
A
K
-
A
-
V
-
P
A
V
G
V
D
T
Q
S
D
L
----
D
R
V
R
A
I
M
L
N
Q
--
11
PsiBlast_PDB
64.90
43%
-85
- C1 -
-
3DUV
2
KDSB_HAEIN
A:
[5-247]
---
V
I
I
P
A
R
----------------
K
P
M
I
Q
H
V
F
E
K
A
L
Q
-
S
G
A
S
R
V
I
I
A
T
D
N
E
N
V
A
D
V
A
K
S
F
G
A
E
V
C
M
T
S
V
N
H
N
S
G
T
-
E
R
L
A
E
V
V
E
K
L
A
I
P
D
N
-
E
I
I
V
N
I
Q
G
D
E
P
L
I
P
P
V
I
V
R
Q
V
A
D
N
L
A
-
K
F
N
-
V
N
-
M
A
S
L
A
V
K
I
H
D
A
E
E
L
F
N
P
N
A
V
K
V
L
T
D
K
D
G
Y
V
L
Y
F
S
R
S
V
I
--
P
Y
D
R
D
-
Q
F
M
N
L
Q
D
V
QKVQ
L
S
D
A
Y
L
R
H
I
G
I
Y
A
Y
R
A
G
F
I
K
Q
Y
-
V
Q
W
A
P
T
Q
L
E
N
L
E
K
L
E
Q
L
R
V
L
Y
N
G
E
R
I
H
V
E
L
-
A
-
K
-
E
V
P
A
V
G
V
D
T
A
E
D
L
----
E
K
V
---------
10
PsiBlast_PDB
64.35
43%
-104
- C1 -
-
1VH3
1
KDSB_HAEIN
A:
[5-229]
---
V
I
I
P
A
R
-----------------
P
M
I
Q
H
V
F
E
K
A
L
Q
-
S
G
A
S
R
V
I
I
A
T
D
N
E
N
V
A
D
V
A
K
S
F
G
A
E
V
C
M
T
S
V
N
H
N
S
G
T
-
E
R
L
A
E
V
V
E
K
L
A
I
P
D
N
-
E
I
I
V
N
I
Q
G
D
E
P
L
I
P
P
V
I
V
R
Q
V
A
D
N
L
A
-
K
F
N
-
V
N
-
M
A
S
L
A
V
K
I
H
D
A
E
E
L
F
N
P
N
A
V
K
V
L
T
D
K
D
G
Y
V
L
Y
F
S
R
S
V
I
--
P
Y
D
R
D
-
Q
F
M
N
L
Q
D
V
QKVQ
L
S
D
A
Y
L
R
H
I
G
I
Y
A
Y
R
A
G
F
I
K
Q
Y
-
V
Q
W
A
P
T
Q
L
E
N
L
E
K
L
E
Q
L
R
V
L
Y
N
G
E
R
I
H
V
E
L
----------------------------------
31
PsiBlast_CBE
57.65
36%
-59
- C1 -
-
2Y6P
2
KDSB_AQUAE
C:
[3-231]
-
R
A
V
I
I
P
A
R
L
G
S
T
R
L
K
E
K
P
L
K
N
L
L
G
K
P
L
I
R
W
V
V
E
G
L
--
V
K
T
G
E
R
V
I
L
A
T
D
S
E
R
V
K
E
V
V
-
E
D
L
C
E
V
F
L
T
P
S
D
L
P
S
G
S
-
D
R
V
L
Y
V
V
R
----
D
L
D
V
D
L
I
I
N
Y
Q
G
D
E
P
F
V
Y
E
E
D
I
K
L
I
F
R
E
L
--
E
K
G
-
E
R
-
V
V
T
L
A
R
--
K
D
K
E
A
Y
E
R
P
E
D
V
K
V
V
L
D
R
E
G
Y
A
L
Y
F
S
R
S
P
I
--
P
Y
F
R
K
-
N
D
-----
T
----
F
Y
--
P
L
K
H
V
G
I
Y
G
F
R
K
E
T
L
M
E
F
-
G
A
M
P
P
S
K
L
E
Q
I
E
G
L
E
Q
L
R
L
L
E
N
G
I
K
I
K
V
L
I
-
T
-
E
--
N
Y
Y
H
G
V
D
T
E
E
D
L
KIVE
E
K
L
---------
32
PsiBlast_CBE
56.59
36%
-55
- C1 -
-
2Y6P
1
KDSB_AQUAE
B:
[3-234]
-
R
A
V
I
I
P
A
R
L
G
S
T
R
L
K
E
K
P
L
K
N
L
L
G
K
P
L
I
R
W
V
V
E
G
L
--
V
K
T
G
E
R
V
I
L
A
T
D
S
E
R
V
K
E
V
V
-
E
D
L
C
E
V
F
L
T
P
S
D
L
P
S
G
S
-
D
R
V
L
Y
V
V
R
----
D
L
D
V
D
L
I
I
N
Y
Q
G
D
E
P
F
V
Y
E
E
D
I
K
L
I
F
R
E
L
--
E
K
G
-
E
R
-
V
V
T
L
A
R
--
K
D
K
E
A
Y
E
R
P
E
D
V
K
V
V
L
D
R
E
G
Y
A
L
Y
F
S
R
S
P
I
--
P
Y
F
R
K
-
N
D
-----
T
----
F
Y
--
P
L
K
H
V
G
I
Y
G
F
R
K
E
T
L
M
E
F
-
G
A
M
P
P
S
K
L
E
Q
I
E
G
L
E
Q
L
R
L
L
E
N
G
I
K
I
K
V
L
I
-
T
-
E
--
N
Y
Y
H
G
V
D
T
E
E
D
L
KIVE
E
K
L
K
N
L
------
33
PsiBlast_CBE
56.30
36%
-53
- C1 -
-
2Y6P
3
KDSB_AQUAE
A:
[3-232]
-
R
A
V
I
I
P
A
R
L
G
S
T
R
L
K
E
K
P
L
K
N
L
L
G
K
P
L
I
R
W
V
V
E
G
L
--
V
K
T
G
E
R
V
I
L
A
T
D
S
E
R
V
K
E
V
V
-
E
D
L
C
E
V
F
L
T
P
S
D
L
P
S
G
S
-
D
R
V
L
Y
V
V
R
----
D
L
D
V
D
L
I
I
N
Y
Q
G
D
E
P
F
V
Y
E
E
D
I
K
L
I
F
R
E
L
--
E
K
G
-
E
R
-
V
V
T
L
A
R
--
K
D
K
E
A
Y
E
R
P
E
D
V
K
V
V
L
D
R
E
G
Y
A
L
Y
F
S
R
S
P
I
--
P
Y
F
R
K
-
N
D
-----
T
----
F
Y
--
P
L
K
H
V
G
I
Y
G
F
R
K
E
T
L
M
E
F
-
G
A
M
P
P
S
K
L
E
Q
I
E
G
L
E
Q
L
R
L
L
E
N
G
I
K
I
K
V
L
I
-
T
-
E
--
N
Y
Y
H
G
V
D
T
E
E
D
L
K
I
V
E
E
K
L
K
--------