@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VN85: (2017-11-12 )
MRCFMSQSHIRIRGARTHNLKNVSLDIPRDKFVVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSQMEKPEVDSIEGLSPAIAIEQKSTSHNPRSTVGTITEIYDYLRLLYARVGTPYCPEHDLPMVAQTVSEMVDAVKNLEEGTALMLLASVVRERKGEYSNLFEQLQGQGFVRARVDGEIIDIDTPPELDKKKKHTIEVVVDRFKVRDDLGNRIAESFETALRLGGDIAVLSWMNGEHPDRVFSAKHSCPECDRAVAELEPRLFSFNNPFGACPVCDGLGTRSHFSPEKLIPNPELAISEGAIRGWDRQRPYYYSMLQKVADHFGFQLDTPWNQLDKDTQKKFLQGTGKEKIDLSYIDERGRKHTRVQPFEGILPHLERRYRETESNYVRDDLAQYLSNAACDACGGSRLNEISRHVRVKDKTIADITRMSIGDAESYYQGINLEGAKGEIADKIFKEIRERLHFLVSVGLNYLSLARSAETLSGGEAQRIRLASQIGAGLMGVMYVLDEPSIGLHQRDNDRLLQTLIRLRDLGNTVLVVEHDEDAIRAADHIIDIGPGAGVHGGVVIAEGTYDELAKHADSLTGQYLSGKLKIEVPKQRTQPPKPEEKIKLSGAAGHNLKNVDLTIPLGIMTCVTGVSGSGKSTLINRTLLPLAATQLNGATTLTAEKFDSIDGLQHLDKVVDIDQSPIGRTPRSNPATYTGLFTPIRELFAQTPEAKARGYSAGRFSFNVKGGRCEACEGDGMIKVAMHFLPDMYVPCDACHGKRYNRETLEVGYKGKNISDVLEMTIEDAAEFFSAIPVIHRRLETLTQVGLGYIRLGQAATTLSGGEAQRVKLARELAKRDTGKTLYILDEPTTGLHFHDIAKLLDILHELRNKGNTIVVIEHNLDVIKTADWVVDLGPEGGSGGGMIIAEGTPEQVAEVEISHTGRFLKPMLKQ
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230..-.....240.......250.......260.-......270.......280.......290.......300.......310.......320...-......330.......340.......350.-------------------......360......-.370----.........380...----....390.......400.......410.......420.......430------.........---440.......450.....---------..-----------460........470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610......---.620.......630.......640.......650.......660.......670..-----------.....680.------...----..---.690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810-------------........820.......830.......840.......850......---.860.......870.......880.......890.......-.900-.-......910.......920.......930.......940......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
C
F
MSQS
H
I
R
I
RGARTHNL
K
N
V
S
LDIPRD
K
F
V
V
I
TGLSGSGKS
S
L
A
F
D
T
L
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
S
Q
MEKPEVDSIEGLS
P
A
I
A
I
E
QKSTSHNPRSTVG
T
I
T
E
I
Y
D
Y
L
R
L
L
Y
A
RVGTPYCPEHD
L
P
M
V
A
Q
T
V
S
E
M
V
D
A
V
K
N
LEEG
T
A
L
M
L
L
A
S
V
V
R
ERKG
E
Y
S
N
L
F
E
Q
L
QGQ
G
F
V
R
A
RVDG
E
I
I
DIDTPPELDKKKK
H
T
I
E
V
V
V
D
R
F
K
V
R
D
D
L
G
N
R
I
A
E
S
F
E
T
A
L
RLG-G
D
I
A
V
L
S
WMNGEHP
D
R
V
F
SAKHSC
P
E
C
D
R
-
A
V
A
E
LEP
R
L
FSFNNPFGACPVCDGLGTRSHF
S
P
E
KLIPNPELAISEGAIRGWDRQR
P
--
Y
Y
Y
-
S
M
L
Q
K
V
A
D
HF
G
F
QLDT
P
W
N
QL
D
K
D
T
Q
K
K
F
L
-------------------QGTGK
E
K
I
D
L
S
Y
I
D
E
-RG------RKHTRVQ
P
F
E
G
I
L
P
H
----
L
E
R
R
Y
R
ETESN
Y
V
R
D
D
L
A
Q
Y
L
S
NAACDACGG
S
R
L
N
E
I
S
R
H
VRVKD--------
K
T
I
A
D
I
T
RM---SIG
D
A
E
S
Y
YQGINLEGAK---------
G
E
-----------
I
A
-
D
K
I
F
K
E
I
R
E
R
L
H
F
L
V
S
V
G
L
N
Y
L
S
L
A
RSAETLSGG
E
A
Q
R
I
R
L
A
S
Q
I
G
A
G
L
M
G
V
M
Y
V
LDEPSIGLHQRD
N
D
R
L
L
Q
T
L
I
R
L
R
DLG
N
T
V
L
V
V
EHD
E
D
A
I
R
AAD
H
I
I
DIGPGAGVHG
G
V
V
I
AEG
T
Y
D
E
L
A
K
H
A
D
S
L
T
G
Q
YLS
G
K
L
K
I
EVPKQRTQPPK
P
E
E
K
---
I
K
LSGAAGHN
L
K
N
V
D
L
T
I
P
L
G
I
M
T
C
VTGVSGSGK
S
T
L
I
NRTLL
P
L
A
ATQLNG
A
T
T
L
-----------
T
A
E
KFDS
I
D
------
G
L
Q
----
H
L
---
D
K
V
VDIDQSPIGRTPRSNPATYT
G
L
F
T
P
I
R
E
L
F
AQTP
E
A
KARGYSA
G
R
F
S
F
NVKG
G
R
CEACEGDG
M
I
K
V
A
M
H
FLPDMYVPCDACHGKRYNRE
T
L
E
VGYKGK
N
I
S
D
V
L
E
M
T
I
E
D
A
A
E
F
F
S
A
I
P
V
--------------
I
H
R
R
L
E
T
L
T
Q
VGL
G
Y
I
R
LG
Q
A
ATTLSGG
E
A
Q
R
V
K
L
A
R
E
L
A
KRDTG
K
T
---
L
Y
I
L
DEPTTGL
H
F
H
D
I
A
K
L
L
D
I
L
H
E
L
R
NKG
N
T
I
-
V
V
I
EHNL-
D
V
I
K
-T-A
D
W
V
V
D
LGPEGGSGG
G
M
I
I
AEGTPE
Q
V
A
E
V
E
ISHT
G
R
F
L
K
P
M
LKQ
1
PsiBlast_PDB
77.55
59%
12
- C2 -
-
3UWX
-
?
A:
[24-958]
---------
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
---
L
L
F
S
E
K
H
A
C
P
Y
C
G
F
-
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
-------------------
Y
G
S
G
G
E
P
I
Y
F
R
Y
T
N
D
-
F
G
------
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
P
N
----
V
E
R
R
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
---
S
V
T
E
A
L
A
F
F
D
G
L
E
L
T
E
K
E
---------
A
Q
-----------
I
A
-
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
R
R
P
D
G
--
R
W
---
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
K
-----------
P
G
E
H
R
D
-
I
R
------
G
L
E
----
H
L
---
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
K
--------------
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
---
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
-
L
V
I
E
H
N
L
-
D
V
I
K
-
T
-
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
3
PsiBlast_PDB
77.53
56%
-8
- C2 -
-
3ZQJ
-
UVRA_MYCTU
A:
[28-970]
-----------
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
-
D
G
I
V
V
L
E
F
V
D
----
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
-
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
-------------------
E
G
-
A
D
E
Q
V
H
V
R
Y
R
N
R
-
Y
G
------
R
T
R
S
Y
Y
A
D
F
E
G
V
L
A
F
----
L
Q
R
K
M
S
Q
T
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
---
S
I
A
D
C
A
D
F
L
N
A
L
T
L
G
P
R
E
---------
Q
A
-----------
I
A
-
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
S
I
E
I
P
A
I
R
-
R
S
V
D
P
R
R
Q
---
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
A
R
Q
V
-----------
P
G
-
R
H
T
R
V
T
------
G
L
D
----
Y
L
---
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
M
N
F
L
P
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
G
--------------
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
---
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
K
G
N
T
V
-
I
V
I
E
H
N
L
-
D
V
I
K
-
T
-
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
------
2
PsiBlast_PDB
73.82
58%
17
- C2 -
-
2R6F
2
?
A:
[24-958]
---------
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
E
---
L
L
F
S
E
K
H
A
C
P
Y
C
G
F
-
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
-------------------
Y
G
S
G
G
E
P
I
Y
F
R
Y
T
N
D
-
F
G
------
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
P
N
----
V
E
R
R
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
---
S
V
T
E
A
L
A
F
F
D
G
L
E
L
T
E
K
E
---------
A
Q
-----------
I
A
-
R
L
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
R
R
P
D
G
--
R
W
---
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
K
A
K
-----------
P
G
E
H
R
D
-
I
R
------
G
L
E
----
H
L
---
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
H
F
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
K
--------------
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
---
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
-
L
V
I
E
H
N
L
-
D
V
I
K
-
T
-
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
24
PsiBlast_CBE
54.28
40%
6
- C2 -
-
2VF8
2
?
B:
[142-842]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
----
W
G
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
FTDEQPV
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
-----------------
F
S
S
A
R
R
H
----
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
---------
G
H
A
E
R
V
K
NR
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-------
R
H
T
E
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
P
V
N
P
DP
E
D
D
E
DPADH
T
A
G
S
A
R
L
G
G
------
D
L
A
----
Q
I
---
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-
4
PsiBlast_PDB
52.83
40%
21
- C2 -
-
2VF7
2
?
A:
[142-842]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
----
W
G
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
-----------------
F
S
S
A
R
R
H
----
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
---------
G
H
AERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-------
R
H
T
E
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
S
A
R
L
G
G
------
D
L
A
----
Q
I
---
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-
26
PsiBlast_CBE
52.22
40%
21
- C2 -
-
2VF7
2
?
B:
[142-842]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
----
W
G
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
-----------------
F
S
S
A
R
R
H
----
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
---------
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-------
R
H
T
E
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
S
A
R
L
G
G
------
D
L
A
----
Q
I
---
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-
137
HHSearch
52.09
43%
24
- C2 -
-
2VF8
2
?
B:
[141-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
W
G
----
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
-------------------
F
T
D
E
Q
P
V
V
P
--
V
Y
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
E
R
V
K
NR
P
E
Q
A
I
-----------
A
L
-
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
----
E
P
H
T
P
R
E
P
A
G
W
---
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
-
G
Q
P
V
------------
N
P
D
P
E
D
D
E
D
PADHTA
G
S
A
R
L
G
G
D
L
AQI
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
--
136
HHSearch
52.07
43%
13
- C2 -
-
2VF7
2
?
C:
[141-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
W
G
----
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
-------------------
F
T
D
E
Q
P
V
V
P
--
V
Y
P
G
L
T
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
G
H
A
E
R
V
K
N
R
PEQ
A
I
-----------
A
L
-
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
----
E
P
H
T
P
R
E
P
A
G
W
---
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
-
G
-------------------------------
S
A
R
L
G
G
D
L
AQI
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
---
G
R
GG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
--
5
PsiBlast_PDB
50.94
40%
21
- C2 -
-
2VF8
2
?
A:
[142-842]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
----
W
G
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
YPGLT
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
-----------------
F
S
S
A
R
R
H
----
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
---------
G
H
AERVKNRP
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
----------
E
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
-----------------
G
S
A
R
L
G
G
------
D
L
A
----
Q
I
---
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-----
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-
25
PsiBlast_CBE
50.21
40%
27
- C2 -
-
2VF7
2
?
C:
[142-842]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
A
----
W
G
G
-
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
-----------------
F
S
S
A
R
R
H
----
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
---
P
L
A
R
V
S
E
L
L
R
P
Y
A
E
E
R
E
P
---------
G
H
A
E
R
V
K
N
R
PEQ
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
-------
R
H
T
E
P
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
-------------------
S
A
R
L
G
G
------
D
L
A
----
Q
I
---
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
L
L
F
L
P
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
A
--------------
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
---
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
G
N
T
V
-
I
A
V
E
H
K
M
-
Q
V
V
A
-
A
-
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
R
-
72
PsiBlast_CBE
41.20
34%
-107
- C2 -
-
5X40
2
CBIO_RHOCB
B:
[153-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
---
P
E
---
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
A
G
M
T
L
-
V
F
S
T
H
D
V
-
E
L
A
A
-
A
L
A
D
R
V
A
L
F
R
T
------
G
R
V
L
A
E
G
A
A
E
A
V
------------------
73
PsiBlast_CBE
40.30
34%
-93
- C2 -
-
5X40
2
CBIO_RHOCB
A:
[153-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
---
P
E
---
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
A
G
M
T
L
-
V
F
S
T
H
D
V
-
E
L
A
A
-
A
L
A
D
R
V
A
L
F
R
T
------
G
R
V
L
A
E
G
A
A
E
A
V
------------------
122
PsiBlast_CBE
40.19
55%
-144
* C4 *
-
4S0F
1
?
B:
[499-532]
-------------
G
L
R
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
39.97
31%
-107
- C2 -
-
3B60
2
MSBA_SALTY
C:
[450-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
A
A
R
M
A
Y
A
M
D
F
--------------
I
N
K
M
D
N
G
L
D
T
I
------
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
-
R
D
S
--
P
---
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
-
L
V
I
A
H
R
L
-
S
T
I
E
-
Q
-
A
D
E
I
V
V
V
E
D
------
G
I
I
V
E
R
G
T
H
S
E
L
------------------
83
PsiBlast_CBE
39.42
31%
-107
- C2 -
-
3B60
2
MSBA_SALTY
A:
[450-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
A
A
R
M
A
Y
A
M
D
F
--------------
I
N
K
M
D
N
G
L
D
T
I
------
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
-
R
D
S
--
P
---
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
-
L
V
I
A
H
R
L
-
S
T
I
E
-
Q
-
A
D
E
I
V
V
V
E
D
------
G
I
I
V
E
R
G
T
H
S
E
L
------------------
33
PsiBlast_CBE
39.36
33%
-78
- C2 -
-
3C41
1
?
K:
[118-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
---
P
K
---
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
-
V
V
V
T
H
E
M
-
G
F
A
R
E
V
-
G
D
R
V
L
F
M
------
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
------------------
32
PsiBlast_CBE
39.35
33%
-77
- C2 -
-
3C4J
2
?
B:
[139-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
---
P
K
---
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
-
V
V
V
T
H
E
M
-
G
F
A
R
E
V
-
G
D
R
V
L
F
M
------
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
------------------
62
PsiBlast_CBE
39.28
31%
-105
- C2 -
-
4MKI
2
ECFA2_CALS4
B:
[123-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
------
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
-
I
-
A
D
K
I
I
V
M
------
N
R
G
K
I
E
L
I
G
T
P
R
E
V
------------------
80
PsiBlast_CBE
39.09
31%
-107
- C2 -
-
3B60
2
MSBA_SALTY
D:
[450-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
A
A
R
M
A
Y
A
M
D
F
--------------
I
N
K
M
D
N
G
L
D
T
I
------
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
-
R
D
S
--
P
---
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
-
L
V
I
A
H
R
L
-
S
T
I
E
-
Q
-
A
D
E
I
V
V
V
E
D
------
G
I
I
V
E
R
G
T
H
S
E
L
------------------
82
PsiBlast_CBE
39.08
31%
-107
- C2 -
-
3B60
2
MSBA_SALTY
B:
[450-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
A
A
R
M
A
Y
A
M
D
F
--------------
I
N
K
M
D
N
G
L
D
T
I
------
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
-
R
D
S
--
P
---
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
N
R
T
S
-
L
V
I
A
H
R
L
-
S
T
I
E
-
Q
-
A
D
E
I
V
V
V
E
D
------
G
I
I
V
E
R
G
T
H
S
E
L
------------------
148
HHSearch
33.00
43%
-5
- C2 -
-
3PIH
2
UVRA_THEMA
A:
[383-561]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
S
V
C
G
G
R
R
L
N
R
E
A
L
S
V
K
I
N
G
L
N
I
H
E
F
T
E
L
S
I
S
E
E
L
E
F
L
K
N
L
N
L
T
E
R
E
R
E
I
V
G
E
L
L
K
E
I
E
K
R
L
E
F
L
V
D
V
G
L
E
Y
L
T
L
S
R
S
A
T
T
L
S
G
G
E
S
Q
R
I
R
L
A
T
Q
I
G
S
G
L
-
T
G
V
---
I
Y
V
L
D
E
P
T
I
G
L
H
P
R
D
T
E
R
L
I
K
T
L
K
K
L
R
D
L
G
N
T
V
-
I
V
V
E
H
D
E
-
E
V
I
R
-
N
-
A
D
H
I
I
D
I
G
P
G
G
G
T
N
G
G
R
V
V
F
Q
G
T
V
D
E
L
L
K
N
---------------