@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNC7: (2017-11-13 )
MTKIQIKQRPLLTRPEQFQGVPPFIAEILARRGVQSEQELELKLKNLLAPELKGLDAAVALMDQAIDEQKKIVIVGDYDADGATSTALMMLVLRDMGAQVDYLVPDRFKYGYGLTPAIAELAHHTYQPDLLITVDNGISSHAGVDAAHALGMQVIITDHHLTTKETPLAEAVVNPNQLGCEFPSKALAGVGVAFYVLANLASLRNRQGKSTSKVTQYLDLVALGTYADVAVLDYNNRILVDAGVKRIQQHQCRVGILALLDIAGREATSIRAQDLGFVLGPRINAAGRMESMRIGIECLLADTMETAYPIAQQLNQLNIDRRQIEGEMKQQALSALDSLQLSQQDIPAALVLFEENWHQGVIGIVAGRLKEQFHRPTIVFAPDEDGIHIKGSARSIDGVHIRDTIEQVAEQHPELVSHFGGHAAAAGLTIRKENFEAFKTVFNDCVAAMDESIFQATLWTDGELPVSALQLDTLNWIEQLGPWGQKFPLPQFEGYFKVIDFRWLKETHLKLRLAIDQYSFDAIAFNAAGRFEFDPMRDHVHLVYEIDRNVFNGNVSLQLRIVHLNQ
Atome Classification :
(20 SA)
---.......----..10.-.--.--......20---........30........40........-50........60........70......--..80........90........100....--...110----.......120.......130.......-140.-......150.......160....--...170.......180-...-.-...190.......200.......210.......220.......230..----.....240..-----------.....250..----------------------...--------------------------..260.---......270--------------.........280.......290.......300.......310.......320.......330.......340.......350..--....---.360.......370---........380...-.....390.....-----..400.......410.......420.......430.......440.....-..450.......460.......470........480.......490...-....500..-..--...510..-.....520.......530.......540.......550.......560....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
T
K
I
Q
I
K----QRP-L-L--T--
R
P
E
QFQGV---
P
P
F
I
A
E
I
L
A
RRGVQ
S
E
Q
E
L
E
L
K
L
K
N
LL
A
-
P
E
LK
G
L
D
A
A
V
A
L
M
D
Q
A
IDEQK
K
I
V
I
V
GD--YDADG
A
T
S
T
A
L
M
M
L
V
L
R
D
MGAQVDYLVPD--RFKYGY----GL
T
P
A
I
A
E
L
A
H
HTYQP
D
L
L
I
T
VDNGIS-SHAG-
V
D
A
A
H
AL
G
M
Q
V
I
I
TDHHLTTKET--P
L
A
E
AVV
N
P
N
QLGCEF-
P
S
K
-
A
-
L
A
G
V
G
V
A
F
Y
V
L
A
N
L
A
S
L
R
NRQGK
S
T
S
K
V
T
Q
Y
L
D
L
VALGTY
A
D
V
A
V
L
DY----N
N
R
I
L
V
D
A
G
V
-----------
K
R
I
Q
Q
H
Q
C
R
V
----------------------
G
I
L
--------------------------
A
L
L
DIA---GREAT
S
I
----------------
R
A
Q
D
L
G
F
V
LGPRINAAGR
M
E
S
M
R
I
G
I
E
C
L
L
A
D
T
M
E
T
A
Y
P
I
A
Q
Q
L
N
QLNI
D
R
R
Q
I
E
G
E
M
K
Q
Q
A
L
S
A
L
D
S
L
QLSQQDI
P
A
A
L
V
L
F
E--ENWH---Q
G
V
I
G
I
V
A
G
R
L
K
E
----
Q
FHR
P
T
I
V
F
A-PDE-D
G
I
H
I
KGSARSID-----
G
V
H
I
R
D
T
I
E
Q
V
A
E
Q
H
P
E
L
V
S
H
FGGHAAAA
G
L
T
I
R
K
E
N
F
E
A
F
K
T
V
F
N
D
C
V
A
-
A
M
D
E
S
I
F
Q
ATLWTDGELPV
S
A
LQ-
L
D
T
L
N
W
I
E
QLGPWGQKFPLPQFEG
Y
-
F
K
V
I
D
F
R
W
L
-KE--T
H
L
K
L
R
L
A
-
I
DQYS
F
D
A
I
A
FNAAGRFEFDPMRD
H
V
H
L
V
Y
E
IDRNVFNGN
V
S
L
Q
L
R
I
V
H
LNQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.20
34%
-53
- C7 -
-
5F56
1
?
A:
[18-475]
------------------
L
-
L
--
A
--
T
M
R
E
W
Q
V
S
---
P
P
-
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
L
T
P
N
-
P
A
L
R
--
E
A
A
R
H
I
V
-
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
--
D
R
V
P
E
H
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
-
P
D
R
H
N
-
L
T
G
A
G
V
A
Y
H
L
---
L
W
A
V
Y
E
E
L
G
R
P
E
P
R
A
--
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
L
-
P
----------------------
G
L
R
--------------------------
A
L
M
N
-----
E
K
R
V
R
Q
P
----------------
T
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
------
L
Q
L
A
D
P
N
D
P
-
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
--------
Q
G
K
G
S
V
R
S
T
P
-----
G
I
---
S
A
V
Q
G
L
R
E
S
R
-
D
L
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
-
Q
F
P
T
P
V
P
A
V
R
L
--
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
-
G
P
L
T
D
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
84.85
33%
9
- C7 -
-
5F56
1
?
A:
[2-704]
-S
R
P
A
H
W
L
L
A
PPAS
R
D
A
-
L
-
L
--
A
--
T
M
R
E
W
Q
-
V
---
S
P
P
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
--
L
T
-
P
N
-
P
A
L
R
E
A
A
R
H
I
V
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
D
--
R
V
P
E
H
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
-
P
D
R
-
H
N
L
T
G
A
G
V
A
Y
H
L
L
W
A
V
Y
E
E
L
G
R
P
E
P
-----
R
A
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
-
L
P
----------------------
G
L
R
--------------------------
A
L
M
N
E
K
---
R
V
R
Q
P
T
------------------
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
L
Q
L
A
D
P
N
-------
D
P
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
-
Q
G
-------
K
G
S
V
R
S
T
P
-----
G
I
S
A
V
Q
G
L
R
E
S
R
D
L
----
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
-
Q
F
P
T
P
V
P
A
V
R
L
--
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
-
G
P
L
T
D
T
R
L
V
-
G
K
--
Q
G
D
V
L
Q
F
R
-
F
G
--
G
V
K
G
M
K
Y
S
-----
E
R
D
D
A
A
G
E
R
D
V
A
A
E
L
A
L
N
E
W
K
G
R
T
S
L
E
L
H
A
A
A
L
R
P
L
A
P
L
A
L
A
G
T
E
E
G
LPTLPRLNPREA
M
T
F
L
K
T
G
A
A
A
Y
A
E
Q
G
V
A
T
Y
L
R
D
N
V
PG
L
T
L
L
D
TNAPHPG
G
D
L
I
L
YGLPP
E
S
A
L
R
R
W
L
H
E
A
Q
E
Q
G
G
R
V
A
F
A
L
G
P
K
T
L
A
E
L
D
A
A
LT
L
A
K
L
L
PDSHT
E
A
A
Q
E
A
A
A
D
A
Y
R
S
W
Q
W
A
H
H
Y
R
VLN
D
A
G
W
S
A
S
V
Y
A
M
L
G
L
P
V
P
AAL
P
K
A
A
E
A
L
A
L
AA
2
PsiBlast_PDB
84.70
34%
-56
- C7 -
-
5F55
1
?
A:
[18-475]
------------------
L
-
L
--
A
--
T
M
R
E
W
Q
V
S
---
P
P
-
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
L
T
P
N
-
P
A
L
R
--
E
A
A
R
H
I
V
-
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
--
D
R
V
P
E
H
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
-
P
D
R
H
N
-
L
T
G
A
G
V
A
Y
H
L
---
L
W
A
V
Y
E
E
L
G
R
P
E
P
R
A
--
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
L
-
P
----------------------
G
L
R
--------------------------
A
L
M
N
-----
E
K
R
V
R
Q
P
----------------
T
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
------
L
Q
L
A
D
P
N
D
P
-
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
--------
Q
G
K
G
S
V
R
S
T
P
-----
G
I
---
S
A
V
Q
G
L
R
E
S
R
-
D
L
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
-
Q
F
P
T
P
V
P
A
V
R
L
--
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
-
G
P
L
T
D
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.61
34%
-58
- C7 -
-
5F54
1
?
A:
[18-483]
------------------
L
-
L
--
A
--
T
M
R
E
W
Q
V
S
---
P
P
-
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
L
T
P
N
-
P
A
L
R
--
E
A
A
R
H
I
V
-
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
--
D
R
V
P
E
H
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
-
P
D
R
H
N
-
L
T
G
A
G
V
A
Y
H
L
---
L
W
A
V
Y
E
E
L
G
R
P
E
P
R
A
--
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
L
-
P
----------------------
G
L
R
--------------------------
A
L
M
N
-----
E
K
R
V
R
Q
P
----------------
T
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
------
L
Q
L
A
D
P
N
D
P
-
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
--------
Q
G
K
G
S
V
R
S
T
P
-----
G
I
---
S
A
V
Q
G
L
R
E
S
R
-
D
L
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
-
Q
F
P
T
P
V
P
A
V
R
L
--
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
-
G
P
L
T
D
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.41
30%
-92
- C7 -
-
2ZXP
-
RECJ_THET8
A:
[73-529]
--------------------------------------------------------------------------------------
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
------------------
M
E
R
V
P
E
H
L
E
A
S
D
L
F
L
T
V
D
C
G
I
T
-
N
H
A
E
-
L
R
E
L
L
E
N
G
V
E
V
I
V
T
D
H
H
-
T
P
G
K
T
--
P
P
P
G
L
V
V
H
P
-
A
L
T
P
D
L
-
K
E
K
-
P
--
T
G
A
G
V
A
F
L
L
---
L
W
A
L
H
E
R
L
G
L
P
P
P
--
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
W
-
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
G
K
A
V
-------------------
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
P
E
A
-------
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
--------
Q
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
V
R
E
V
A
L
L
D
L
--
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
-
G
A
P
E
E
A
R
R
L
-
G
E
G-
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
-
Q
G
D
L
A
L
P
P
---
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.04
30%
-94
- C7 -
-
2ZXO
-
RECJ_THET8
A:
[73-529]
--------------------------------------------------------------------------------------
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
------------------
M
E
R
V
P
E
H
L
E
A
S
D
L
F
L
T
V
D
C
G
I
T
-
N
H
A
E
-
L
R
E
L
L
E
N
G
V
E
V
I
V
T
D
H
H
-
T
P
G
K
T
--
P
P
P
G
L
V
V
H
P
-
A
L
T
P
D
L
-
K
E
K
-
P
--
T
G
A
G
V
A
F
L
L
---
L
W
A
L
H
E
R
L
G
L
P
P
P
--
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
W
-
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
G
K
A
V
-------------------
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
P
E
A
-------
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
--------
Q
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
V
R
E
V
A
L
L
D
L
--
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
-
G
A
P
E
E
A
R
R
L
-
G
E
G-
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
-
Q
G
D
L
A
L
P
P
---
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
82.94
31%
-1
- C7 -
-
2ZXR
-
RECJ_THET8
A:
[1-658]
MRD
R
V
R
W
R
V
L
----
S
L
P
-
P
-
L
--
A
--
Q
W
R
E
V
M
A
A
L
EV
G
P
E
A
A
L
A
Y
W
H
R
G
F
R
R
K
E
D
L
D
P
P
L
A
L
L
P
----
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
S
--
D
--------------------------
L
F
L
T
V
D
C
G
V
----------------
E
V
I
V
T
D
H
H
-----------
T
L
V
V
H
P
A
L
T
P
--
D
-
L
K
E
-
K
-
P
T
G
A
G
V
A
F
L
L
L
W
A
L
H
E
R
L
G
L
P
-----
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
-
W
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
---
G
----------------
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
-------
D
P
E
A
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
-
Q
G
-------
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
D
L
----
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
--
V
R
E
V
A
L
L
D
L
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
-
G
A
P
E
E
A
R
R
L
G
E
G
--
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
Q
G
D
L
----
A
L
P
P
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
K
P
E
A
L
E
G
G
I
APF
A
Y
P
L
P
L
L
E
A
L
A
R
A
R
L
GEG
V
Y
V
P
EDN
P
E
G
L
D
Y
A
W
K
A
GFRLLPPEEAGLWLGLPP
R
P
V
L
GRR
V
E
V
A
L
G
REARARLSAPPVLHTPE
A
R
L
K
A
L
V
H
R
R
L
L
F
A
Y
E
R
RH
P
G
L
F
S
E
A
L
L
A
Y
W
E
V
N
R-------------------------------------------
17
HHSearch
81.71
32%
1
- C7 -
-
5F56
1
?
A:
[3-532]
---
R
P
A
H
W
L
L
----
A
P
P
A
S
R
D
A
L
L
--
A
T
M
R
E
W
Q
V
---
S
P
P
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
L
----
T
P
N
P
A
L
R
E
A
A
R
H
I
V
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
D
R
V
P
E
H
--
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
P
D
R
H
-
N
-
L
T
G
A
G
V
A
Y
H
L
L
W
A
V
Y
E
E
L
G
R
-----
P
E
P
R
A
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
-
L
P
----------------------
G
L
R
--------------------------
A
L
M
N
E
K
---
R
V
--
R
Q
P
----------------
T
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
L
Q
L
A
D
-----
P
--
N
D
P
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
-
Q
-------
G
K
G
S
V
R
S
T
P
-----
G
I
S
A
V
Q
G
L
R
E
S
R
----
D
L
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
Q
F
P
T
---
P
V
P
A
V
R
L
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
G
P
L
T
-
D
T
R
L
V
-
G
K
QG
D
V
L
Q
F
R
F
G
-----
G
V
K
G
M
K
Y
S
E
R
D
D
-----
A
A
G
E
R
D
V
A
A
E
L
A
L
N
E
W
K
G
R
T
S
L
E
L
H
A
A
A
L
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
81.24
32%
3
- C7 -
-
5F55
1
?
A:
[3-532]
---
R
P
A
H
W
L
L
----
A
P
P
A
S
R
D
A
L
L
--
A
T
M
R
E
W
Q
V
---
S
P
P
V
A
Q
V
L
C
G
R
D
L
R
T
E
L
-
L
A
L
P
L
E
L
----
T
P
N
P
A
L
R
E
A
A
R
H
I
V
A
A
V
R
E
G
K
R
I
R
I
H
G
D
--
Y
D
A
D
G
V
S
A
T
A
T
L
V
L
G
L
R
A
I
G
A
N
V
H
G
F
I
P
H
--
R
L
N
E
G
Y
----
G
I
H
P
D
R
V
P
E
H
--
A
A
A
A
D
L
V
V
T
V
D
C
G
V
S
-
N
L
D
E
-
V
K
S
L
L
A
T
G
T
E
V
V
V
T
D
H
H
A
P
G
E
N
F
--
P
E
C
-
L
V
V
H
P
H
L
T
P
D
Y
D
P
D
R
H
-
N
-
L
T
G
A
G
V
A
Y
H
L
L
W
A
V
Y
E
E
L
G
R
-----
P
E
P
R
A
L
L
P
L
A
T
L
G
T
V
A
D
V
A
P
L
L
G
----
E
N
R
A
L
V
R
A
G
L
-----------
A
E
M
A
R
T
E
-
L
P
----------------------
G
L
R
--------------------------
A
L
M
N
E
K
---
R
V
--
R
Q
P
----------------
T
A
R
D
V
A
F
I
L
A
P
R
I
N
A
A
G
R
M
G
E
A
D
R
A
L
E
L
L
T
T
P
S
D
H
E
A
K
S
L
A
A
Y
L
E
I
R
N
Q
E
R
R
K
I
Q
D
D
M
F
A
Q
A
L
Q
L
A
D
-----
P
--
N
D
P
A
L
V
L
T
H
--
D
D
W
H
---
A
G
V
M
G
I
V
A
S
K
L
V
E
----
T
F
N
R
P
V
Y
I
V
A
-
Q
-------
G
K
G
S
V
R
S
T
P
-----
G
I
S
A
V
Q
G
L
R
E
S
R
----
D
L
L
G
R
F
G
G
H
P
G
A
A
G
F
S
L
D
P
Q
N
F
G
A
L
R
E
R
I
H
G
Y
V
R
Q
F
P
T
---
P
V
P
A
V
R
L
D
A
P
L
P
V
A
A
L
T
-
P
E
L
L
S
E
L
S
I
L
E
P
F
G
E
G
N
P
R
P
L
W
H
L
R
G
P
L
T
-
D
T
R
L
V
-
G
K
QG
D
V
L
Q
F
R
F
G
-----
G
V
K
G
M
K
Y
S
E
R
D
D
-----
A
A
G
E
R
D
V
A
A
E
L
A
L
N
E
W
K
G
R
T
S
L
E
L
H
A
A
A
L
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
79.67
34%
-109
- C7 -
-
1IR6
-
RECJ_THET8
A:
[10-394]
---------------------------
P
L
A
L
-----------------------------------
L
P
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
H
--
R
L
E
E
G
Y
----
G
V
L
M
E
R
V
P
E
H
L
E
A
S
--
D
L
F
L
T
V
D
C
G
I
T
-
N
H
A
E
-
L
R
E
L
L
E
N
G
V
E
V
I
V
T
D
H
H
-
T
P
G
K
T
--
P
P
P
G
L
V
V
H
P
A
L
T
--
P
D
-
L
K
E
-
K
-
P
T
G
A
G
V
A
F
L
L
L
W
A
L
H
E
R
L
G
L
P
-----
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
-
W
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
G
K
A
-------------------
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
P
E
-------
A
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
-
Q
G
-------
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
D
L
----
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
V
R
E
V
A
L
L
D
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.47
30%
-97
- C7 -
-
2ZXR
-
RECJ_THET8
A:
[73-529]
--------------------------------------------------------------------------------------
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
----------------------------
S
D
L
F
L
T
V
D
C
----------------
G
V
E
V
I
V
T
D
H
H
-
T
----------
L
V
V
H
P
-
A
L
T
P
D
L
-
K
E
K
-
P
--
T
G
A
G
V
A
F
L
L
---
L
W
A
L
H
E
R
L
G
L
P
P
P
--
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
W
-
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
G
K
A
V
-------------------
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
P
E
A
-------
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
--------
Q
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
V
R
E
V
A
L
L
D
L
--
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
-
G
A
P
E
E
A
R
R
L
-
G
E
G-
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
-
Q
G
D
L
A
L
P
P
---
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
78.81
32%
8
- C7 -
-
2ZXO
-
RECJ_THET8
A:
[3-528]
---
D
R
V
R
W
R
V
----
L
S
L
P
P
L
A
--
Q
W
R
E
V
M
A
A
L
E
V
---
G
P
E
A
A
L
A
Y
W
H
R
G
F
R
R
K
E
D
L
D
P
P
----
L
A
L
L
P
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
----------------
M
E
R
V
P
E
H
L
--
E
A
S
D
L
F
L
T
V
D
C
G
I
T
-
N
H
A
E
-
L
R
E
L
L
E
N
G
V
E
V
I
V
T
D
H
H
T
P
G
K
T
P
--
P
P
G
-
L
V
V
H
P
A
L
T
P
D
---
L
K
E
-
K
-
P
T
G
A
G
V
A
F
L
L
L
W
A
L
H
E
R
L
G
L
-----
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
-
W
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
---
T
G
----------------
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
-----
P
--
E
A
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
-
Q
-------
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
--
V
R
E
V
A
L
L
D
L
-
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
-
E
A
R
R
L
-
G
E
G-
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
Q
G
D
L
A
----
L
P
P
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
77.56
32%
-5
- C7 -
-
2ZXR
-
RECJ_THET8
A:
[3-528]
---
D
R
V
R
W
R
V
----
L
S
L
P
P
L
A
--
Q
W
R
E
V
M
A
A
L
E
V
---
G
P
E
A
A
L
A
Y
W
H
R
G
F
R
R
K
E
D
L
D
P
P
----
L
A
L
L
P
L
K
G
L
R
E
A
A
A
L
L
E
E
A
L
R
Q
G
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
----------------------------
S
D
L
F
L
T
V
D
C
----------------
G
V
E
V
I
V
T
D
H
H
T
-----------
L
V
V
H
P
A
L
T
P
D
---
L
K
E
-
K
-
P
T
G
A
G
V
A
F
L
L
L
W
A
L
H
E
R
L
G
L
-----
P
P
P
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
-
W
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
---
T
G
----------------
K
A
V
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
-----
P
--
E
A
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
-
Q
-------
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
R
F
P
D
P
--
V
R
E
V
A
L
L
D
L
-
L
P
E
P
G
L
L
-
P
Q
V
F
R
E
L
A
L
L
E
P
Y
G
E
G
N
P
E
P
L
F
L
L
F
G
A
P
E
-
E
A
R
R
L
-
G
E
G-
R
H
L
A
F
R
L
K
-----
G
V
R
V
L
A
W
K
Q
G
D
L
A
----
L
P
P
E
V
E
V
A
G
L
L
S
E
N
A
W
N
G
H
L
A
Y
E
V
Q
A
V
D
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.92
32%
-106
- C7 -
-
1IR6
-
RECJ_THET8
A:
[34-394]
--------------------------------------------------------------------------------------
K
R
I
R
V
H
G
D
--
Y
D
A
D
G
L
T
G
T
A
I
L
V
R
G
L
A
A
L
G
A
D
V
H
P
F
I
P
H
--
R
L
E
E
G
Y
----
G
V
L
--
M
E
R
V
P
E
H
L
E
A
S
D
L
F
L
T
V
D
C
G
I
T
-
N
H
A
E
-
L
R
E
L
L
E
N
G
V
E
V
I
V
T
D
H
H
-
T
P
G
K
T
--
P
P
P
G
L
V
V
H
P
-
A
L
T
P
D
L
-
K
E
K
-
P
--
T
G
A
G
V
A
F
L
L
---
L
W
A
L
H
E
R
L
G
L
P
P
P
--
L
E
Y
A
D
L
A
A
V
G
T
I
A
D
V
A
P
L
W
G
----
W
N
R
A
L
V
K
E
G
L
-----------
A
R
I
P
A
S
S
W
-
V
----------------------
G
L
R
--------------------------
L
L
A
E
A
V
---
G
Y
T
G
K
A
V
-------------------
E
V
A
F
R
I
A
P
R
I
N
A
A
S
R
L
G
E
A
E
K
A
L
R
L
L
L
T
D
D
A
A
E
A
Q
A
L
V
G
E
L
H
R
L
N
A
R
R
Q
T
L
E
E
A
M
L
R
K
L
L
P
Q
A
D
P
E
A
-------
K
A
I
V
L
L
D
--
P
E
G
H
---
P
G
V
M
G
I
V
A
S
R
I
L
E
----
A
T
L
R
P
V
F
L
V
A
--------
Q
G
K
G
T
V
R
S
L
A
-----
P
I
S
A
V
E
A
L
R
S
A
E
----
D
L
L
L
R
Y
G
G
H
K
E
A
A
G
F
A
M
D
E
A
L
F
P
A
F
K
A
R
V
E
A
Y
A
A
-
R
F
P
D
P
V
R
E
V
A
L
L
D
--
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
65.83
23%
-32
- C7 -
-
5GHT
-
?
A:
[5-467]
------------------------------------------------------------------
A
F
L
E
R
V
R
E
G
A
E
L
I
K
M
H
I
E
L
G
H
T
I
R
L
I
S
H
--
R
D
A
D
G
I
T
A
G
A
I
L
A
K
A
V
A
R
E
G
G
T
F
Q
L
S
I
V
--------
K
----
Q
V
S
E
E
L
I
D
Q
L
A
-
R
E
K
R
E
I
Y
V
F
S
D
L
G
S
G
-
S
I
E
L
-
I
E
E
K
L
-
N
F
A
T
V
V
V
A
D
H
H
P
P
E
K
D
S
FS
T
D
S
H
V
L
V
N
P
V
P
F
G
A
-
N
-
S
V
R
-
D
-
L
S
G
S
G
V
A
Y
F
V
A
R
E
M
N
R
K
----------
N
R
D
M
A
Y
V
A
I
V
G
A
V
G
D
M
Q
E
I
D
G
TFHG
L
N
L
E
I
I
E
D
G
K
E
L
GI
L
E
V
R
KEL
R
L
F
G
R
E
S
-
R
P
L
Y
Q
M
L
A
Y
ATNPEIPEITGD
E
R
K
A
I
E
W
L
R
A
K
GFDPEMKYWQLR
E
E
E
K
R
K
L
H
E
A
L
L
V
H
M
I
K
H
G
A
P
K
E
A
I
D
R
L
I
G
D
V
V
I
S
PLYPEG
D
V
R
H
E
A
R
E
F
A
T
L
L
N
A
T
G
R
L
N
A
G
T
L
G
V
A
I
C
L
G
D
--
E
E
A
Y
K
V
A
R
K
M
L
D
D
Y
K
K
E
Q
I
E
A
R
K
F
I
I
Q
N
W
N
M
V
E
----
E
G
--
E
H
A
Y
V
F
Y
A
G
--
K
N
I
R
---
D
T
L
V
G
I
A
A
N
M
A
I
N
A
GLA
D
P
E
K
P
V
V
V
L
A
-
D
S
D
E
D
E
N
L
V
K
G
S
A
R
T
T
E
K
A
L
E
K
G
Y
H
L
G
E
A
L
K
E
V
A
E
---
K
L
G
G
E
G
G
G
H
A
I
A
A
G
I
R
F
P
K
N
R
I
D
E
F
I
K
L
F
N
E
A
L
G
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
57.71
23%
-56
* C7 *
-
5GHR
-
?
C:
[5-344]
------------------------------------------------------------------
A
F
L
E
R
V
R
E
G
A
E
L
I
K
M
H
I
E
L
G
H
T
I
R
L
I
S
H
--
R
D
A
D
G
I
T
A
G
A
I
L
A
K
A
V
A
R
E
G
G
T
F
Q
L
S
I
V
--------
K
----
Q
V
S
E
E
L
I
D
Q
L
A
-
R
E
K
R
E
I
Y
V
F
S
D
L
G
S
G
-
S
I
E
L
-
I
E
E
K
L
-
N
F
A
T
V
V
V
A
D
H
H
P
P
E
K
D
S
FS
T
D
S
H
V
L
V
N
P
V
P
F
G
A
-
N
-
S
V
R
-
D
-
L
S
G
S
G
V
A
Y
F
V
A
R
E
M
N
R
K
----------
N
R
D
M
A
Y
V
A
I
V
G
A
V
G
D
M
Q
E
I
D
G
TFHG
L
N
L
E
I
I
E
D
G
K
ELGILEVRKEL
R
L
F
G
R
E
S
-
R
P
LYQMLAYATNPEIPEITGDERK
A
I
E
WLRAKGFDPEMKYWQLREEEKRKLHE
A
L
L
V
H
M
IKH
G
A
P
K
E
A
I
DRLIGDVVISPLYPEG
D
V
R
H
E
A
R
E
F
A
T
L
L
N
A
T
G
R
L
N
A
G
T
L
G
V
A
I
C
L
G
D
--
E
E
A
Y
K
V
A
R
K
M
L
D
D
Y
K
K
E
Q
I
E
A
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
46.53
14%
-35
- C7 -
-
5CET
-
NRNA_MYCTU
A:
[10-331]
-----------------------------------------------------------------------
A
R
V
D
A
V
G
A
A
A
L
L
S
A
A
A
R
V
G
V
V
C
H
V
H
P
D
A
D
T
I
G
A
G
L
A
L
A
L
V
L
D
G
C
G
K
R
V
E
V
S
F
A
A
PA
T
L
P
E
S
L
RSLP
G
C
H
L
L
V
R
P
E
V
M
-
R
R
D
V
D
L
V
V
T
V
D
I
P
S
V
-
D
R
L
G
A
L
G
D
L
T
D
S
G
R
E
L
L
V
I
D
H
H
A
S
N
D
L
F
--
G
-
T
A
N
F
I
D
P
S
-----------
A
-
D
S
T
T
T
M
V
A
E
I
L
D
A
W
G
K
P
I
---------
D
P
R
V
A
H
C
I
Y
A
G
L
A
T
D
T
G
S
F
R
W
----
A
S
V
---
R
G
---------------------
Y
R
----------------------
L
A
A
--------------------------
R
L
V
E
-
I
---
G
V
-----------------------------------------
D
N
A
T
V
S
R
T
L
M
D
S
H
P
F
T
W
------
L
P
L
--------
L
S
R
V
L
G
S
A
Q
L
V
S
E
A
---
V
G
--
G
R
G
L
V
Y
V
V
V
D
N
R
E
W
V
A
A
R
S
E
E
V
E
S
I
V
D
I
V
R
T
----
T
Q
Q
A
E
V
A
A
V
F
-
K
E
V
-
E
P
H
R
W
S
V
S
M
R
A
K
------
T
V
N
L
A
A
V
A
S
G
---------
F
G
G
G
G
H
R
L
A
A
G
Y
T
T
T
G
-
S
I
D
D
A
V
A
S
L
R
A
A
L
G
L
T
R
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.25
26%
-48
- C7 -
-
5GHR
-
?
A:
[302-464]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
A
T
G
R
L
N
A
G
T
L
G
V
A
I
C
L
G
D
--
E
E
A
Y
K
V
A
R
K
M
L
D
---
D
Y
K
K
E
Q
I
E
A
R
K
F
I
I
Q
N
W
N
M
V
E
E
G
E
H
----
A
Y
V
F
Y
A
G-
K
N
I
R
---
D
T
L
V
G
I
A
A
N
M
A
I
N
----
A
---
P
V
V
V
L
A
D
S
D
E
-
D
E
N
L
V
K
G
S
A
R
T
T
E
K
A
L
E
K
G
Y
H
L
G
E
A
L
K
E
V
A
E
K
---
L
G
G
E
G
G
G
H
A
I
A
A
G
I
R
F
P
K
N
R
I
D
E
F
I
K
L
F
N
E
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.68
26%
-54
- C7 -
-
5GHS
-
?
A:
[302-464]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
A
T
G
R
L
N
A
G
T
L
G
V
A
I
C
L
G
D
--
E
E
A
Y
K
V
A
R
K
M
L
D
-
D
Y
K
K
E
Q
I
E
A
R
K
-----
F
I
I
Q
N
W
N
M
V
E
E
G
E
H
A
Y
V
F
Y
A
G
--
K
N
I
R
---
D
T
L
V
G
I
A
A
N
M
A
I
N
----
A
----
V
V
V
L
A
D
S
D
E
-
D
E
N
L
V
K
G
S
A
R
T
T
E
KALEK
G
Y
H
L
G
E
A
L
K
E
V
A
E
K
---
L
G
G
E
G
------
A
G
I
R
F
P
K
N
R
I
D
E
F
I
K
L
F
N
E
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
41.65
21%
12
- C6 -
-
4PG7
4
?
A:
[20-446]
--H
M
K
K
L
N
I
-------
A
-
L
-
L
--
G
--
L
G
T
V
G
S
G
V
---
V
K
I
I
E
E
--
N
R
Q
Q
I
Q
D
T
L
N
K
D
I
V
I
K
H
I
L
V
-
R
----------------
D
K
S
K
K
----------------------------------
R
P
L
--
N
I
S
Q
-
Y
----
H
L
T
E
D
V
N
E
I
L
N
D
D
-
S
L
D
I
I
V
E
V
M
G
G
I
E
P
T
V
D
W
-
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
L
L
A
V
H
L
--
K
L
L
E
D
L
A
E
E
N
G
V
A
L
K
F
-
E
A
S
-
V
-
A
G
G
------------------
P
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
E
Q
T
----
T
-------------------------------------------------------------------------------------------
F
E
E
A
L
D
----------------
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
-------
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
L
N
D
V
K
R
R
G
I
S
G
-
V
T
L
T
D
I
N
V
A
D
Q
L
-----
G
Y
K
I
K
L
I
G
K
G
--
I
Y
E
N
---
G
K
V
N
A
S
V
E
P
T
L
I
D
----
K
K
H
Q
L
A
A
V
-
E
-
D
E
Y
-
N
A
I
Y
V
I
G
D
A
V
G
----------------------
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
L
--------------
F
F
E
S
T
L
P
P
H
F
E
L
K
T
D
K
T
R
E
M
E
K
S
N
F
F
V
V
V
N
--
H
V
K
G
S
I
E
N
F
E
N
E
-
L
K
A
I
------
L
P
--
F
H
R
S
L
R
V
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
G
----
L
E
S
S
P
E
E
L
I
T
K
H
G
Y
E
V
D
K
V
Y
P
V
E
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------