@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VND0: (2017-11-13 )
MIISSGNDYRAAAQRRLPPFLFHYIDGGAYAEYTLKRNVQDLSEIALRQRVLNDMSALSLETKLFNETLSMPVALAPVGLTGMYARRGEVQAAMAADKKGIPFTLSTVSVCPIEEVAPAINRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPVPGARYRDAHSGMSGPNAAMRRYMQSVFHPHWSWNVGLMGRPHDLGNISKYLGKPTGLEDYIGWLGSNFDPSISWKDLEWIREFWDGPMVIKGILDPEDAKDAVRFGADGIVVSNHGGRQLDGVMSSARALPAIADAVKGDLAILADSGIRNGLDVVRMLALGADTVLLGRAFVYALAAAGGQGVSNLLDLIDKEMRVAMTLTGAKSISDINTDCLVQAIKQGL
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80......-..90........--100.......110.......120-.-...-.....130.......140.......150.......160.......170.-......180--....--...190.......200.......210........220.......230.......240.......250.......260.......270.......280.......290......-----.300.......310.......320.......330.......340.......350.......360.......370.......380.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
ISSGN
D
Y
R
A
A
A
Q
RRLPP
F
L
F
H
YIDGG
A
Y
A
E
Y
T
L
KR
N
V
Q
D
L
S
E
I
A
L
R
Q
R
V
L
N
D
M
S
A
L
S
L
E
T
K
L
F
N
E
TLSM
P
V
A
LAPVGL
T
G
MYARR-G
E
V
Q
A
A
MAADKK--GI
P
F
T
L
S
T
V
SVC
P
I
E
E
V
A
P
A
I---N-R
P
M
-
W
F
Q
L
Y
V
L
RDR
G
F
M
R
N
A
L
E
R
A
K
AAGC
S
T
L
V
F
T
VDMPVPGARY
R
D
AHSGMS-G
P
N
A
A
M
R
R
Y
--
M
Q
S
V--FHPHWSWNVGLMGRPHD
L
G
N
I
S
K
Y
L-GKPT
G
L
E
D
Y
I
G
W
LGSNFDPSISW
K
D
L
E
W
I
R
E
FWDG
P
M
V
I
K
GIL
D
P
E
D
A
K
D
A
V
RFGA
D
G
I
V
V
SNHGG
R
Q
L
D
G
V
M
S
S
A
RA
L
P
A
I
A
D
A
VK-----G
D
L
A
I
L
ADSGIR
N
G
L
D
V
V
R
M
L
ALGA
D
T
V
L
L
G
R
A
F
V
Y
A
L
AAAGGQ
G
V
S
N
L
L
D
L
I
D
K
E
M
R
V
A
M
T
LTGAKSISDI
N
T
D
C
L
V
Q
A
I
KQGL
132
HHSearch
90.71
35%
-113
- C2 -
-
3GIY
2
MDLB_PSEPU
A:
[4-356]
-
N
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
--
D
L
G
K
M
D
------------------
K
-
A
N
L
E
M
Q
---
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-------
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
E
-----
4
PsiBlast_PDB
89.73
35%
-110
- C2 -
-
2A7N
2
GOX_SPIOL
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
133
HHSearch
89.67
35%
-111
- C2 -
-
1P4C
2
GOX_SPIOL
A:
[4-356]
-
N
L
F
N
V
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
--
D
L
-
G
K
M
--------
D
---------
K
-
A
N
L
E
M
Q
---
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
Q
S
V
A
K
T
-------
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
Q
N
E
-----
7
PsiBlast_PDB
89.40
35%
-109
- C2 -
-
3GIY
2
MDLB_PSEPU
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
6
PsiBlast_PDB
88.68
35%
-111
- C2 -
-
2A85
3
GOX_SPIOL
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
3
PsiBlast_PDB
88.67
35%
-108
- C2 -
-
1P5B
2
GOX_SPIOL (first)
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
2
PsiBlast_PDB
88.36
35%
-108
- C2 -
-
1P4C
2
GOX_SPIOL
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
5
PsiBlast_PDB
88.22
35%
-113
- C2 -
-
2A7P
3
GOX_SPIOL (first)
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
A
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
K
------
A
N
L
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
1
PsiBlast_PDB
87.77
35%
-110
- C2 -
-
1HUV
2
GOX_SPIOL (first)
A:
[9-353]
------
E
D
Y
R
K
L
A
Q
K
R
L
P
K
M
V
Y
D
Y
L
E
G
G
A
E
D
E
Y
G
V
K
H
N
R
D
V
F
Q
Q
W
R
F
K
P
K
R
L
V
D
V
S
R
R
S
L
Q
A
E
V
L
G
K
R
Q
S
M
P
L
L
I
G
P
T
G
L
N
G
A
L
W
P
K
-
G
D
L
A
L
A
R
A
A
T
K
A
--
G
I
P
F
V
L
S
T
A
S
N
M
S
I
E
D
L
A
R
Q
C
---
D
-
G
D
L
-
W
F
Q
L
Y
V
I
H
-
R
E
I
A
Q
G
M
V
L
K
A
L
H
T
G
Y
T
T
L
V
L
T
T
D
V
A
V
N
G
Y
R
E
R
D
L
H
N
R
F
K
-
I
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
K
M
D
----------
E
M
Q
A
A
L
M
S
R
Q
M
D
A
S
F
N
W
E
A
L
R
W
L
R
D
L
W
P
H
K
L
L
V
K
G
L
L
S
A
E
D
A
D
R
C
I
A
E
G
A
D
G
V
I
L
S
N
H
G
G
R
Q
L
D
C
A
I
S
P
M
E
V
L
A
--
Q
S
V
A
K
-----
T
G
K
P
V
L
I
D
S
G
F
R
R
G
S
D
I
V
K
A
L
A
L
G
A
E
A
V
L
L
G
R
A
T
L
Y
G
L
A
A
R
G
E
T
G
V
D
E
V
L
T
L
L
K
A
D
I
D
R
T
L
A
Q
I
G
C
P
D
I
T
S
L
S
P
D
Y
L
--------
134
HHSearch
87.44
34%
-119
- C2 -
-
1GOX
2
GOX_SPIOL
A:
[2-357]
-
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
E
-
G
E
Y
A
T
A
R
A
A
S
A
A
--
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
-
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
-
L
P
P
F
L
T
L
K
N
--
F
E
G
I
--
D
L
---
G
-------------------------
L
---
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
A
A
D
-----
130
HHSearch
86.30
34%
-117
- C2 -
-
1AL7
2
GOX_SPIOL
A:
[2-356]
-
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
E
-
G
E
Y
A
T
A
R
A
A
S
A
A
--
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
-
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
-
L
P
P
F
L
T
L
K
N
--
F
E
G
I
--
D
L
---
G
-------------------------
L
---
S
S
Y
V
A
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
R
S
H
I
A
A
------
12
PsiBlast_PDB
86.09
34%
-118
- C2 -
-
1GOX
2
GOX_SPIOL
A:
[1-350]
M
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
E
-
G
E
Y
A
T
A
R
A
A
S
A
A
--
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
-
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
-
L
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
------------
L
S
S
Y
V
A
---
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
------------
13
PsiBlast_PDB
85.00
34%
-114
- C2 -
-
1AL7
2
GOX_SPIOL
A:
[1-350]
M
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
E
-
G
E
Y
A
T
A
R
A
A
S
A
A
--
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
-
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
G
R
R
E
A
D
I
K
N
R
F
V
-
L
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
------------
L
S
S
Y
V
A
---
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
------------
14
PsiBlast_PDB
83.79
34%
-120
- C2 -
-
1AL8
2
GOX_SPIOL
A:
[1-350]
M
E
I
T
N
V
N
E
Y
E
A
I
A
K
Q
K
L
P
K
M
V
Y
D
Y
Y
A
S
G
A
E
D
Q
W
T
L
A
E
N
R
N
A
F
S
R
I
L
F
R
P
R
I
L
I
D
V
T
N
I
D
M
T
T
T
I
L
G
F
K
I
S
M
P
I
M
I
A
P
T
A
M
Q
K
M
A
H
P
E
-
G
E
Y
A
T
A
R
A
A
S
A
A
--
G
T
I
M
T
L
S
S
W
A
T
S
S
V
E
E
V
A
S
T
G
---
P
-
G
I
R
-
F
F
Q
L
Y
V
Y
K
D
R
N
V
V
A
Q
L
V
R
R
A
E
R
A
G
F
K
A
I
A
L
T
V
D
T
P
R
L
------
I
K
N
R
F
V
-
L
P
P
F
L
T
L
K
N
--
F
E
G
I
------------------
D
L
G
------------
L
S
S
Y
V
A
---
G
Q
I
D
R
S
L
S
W
K
D
V
A
W
L
Q
T
I
T
S
L
P
I
L
V
K
G
V
I
T
A
E
D
A
R
L
A
V
Q
H
G
A
A
G
I
I
V
S
N
H
G
A
R
Q
L
D
Y
V
P
A
T
I
M
A
L
E
E
V
V
K
A
A
Q
-----
G
R
I
P
V
F
L
D
G
G
V
R
R
G
T
D
V
F
K
A
L
A
L
G
A
A
G
V
F
I
G
R
P
V
V
F
S
L
A
A
E
G
E
A
G
V
K
K
V
L
Q
M
M
R
D
E
F
E
L
T
M
A
L
S
G
C
R
S
L
K
E
I
S
------------
127
HHSearch
83.18
34%
-46
- C2 -
-
2RDU
2
HAOX1_HUMAN
A:
[21-379]
-
R
L
I
C
I
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
P--
E
-
A
L
R
-
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
-
L
P
P
Q
L
R
M
K
N
--
F
E
T
S
--
T
L
S
F
S
---------
P
E
E
------
N
F
-
G
D
D
S
G
L
---
A
A
Y
V
A
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
K
T
L
V
R
K
------
8
PsiBlast_PDB
80.44
34%
-51
- C2 -
-
2RDT
2
HAOX1_HUMAN
A:
[26-373]
------
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
---
P
-
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
--------------------------------------------------
L
A
A
Y
V
A
---
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------
9
PsiBlast_PDB
79.89
34%
-35
- C2 -
-
2RDU
2
HAOX1_HUMAN
A:
[26-373]
------
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
---
P
-
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
P
Q
L
R
M
K
N
F
--
E
T
S
T
LS
F
S
P
E
------------------
E
N
F
-
G
D
D
S
G
L
A
A
Y
V
A
---
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------
10
PsiBlast_PDB
79.65
34%
-37
- C2 -
-
2RDW
1
HAOX1_HUMAN
A:
[26-373]
------
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
---
P
-
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
K
L
P
P
Q
L
R
M
K
N
F
--
E
T
S
T
LS
F
S
P
E
------------------
E
N
F
-
G
D
D
S
G
L
A
A
Y
V
A
---
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------
131
HHSearch
79.12
32%
-49
- C2 -
-
2DU2
1
?
C:
[18-367]
-
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N--
G
-
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
V
K
N
K
F
V
-
Y
P
F
G
M
P
I
V
Q
RY
L
R
G
T
----------------------------
A
E
G
M
S
L
---
N
-
N
I
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
D
------
22
PsiBlast_CBE
78.76
34%
-47
- C2 -
-
2W0U
2
HAOX1_HUMAN
C:
[9-356]
------
N
D
Y
E
Q
H
A
K
S
V
L
P
K
S
I
Y
D
Y
Y
R
S
G
A
N
D
E
E
T
L
A
D
N
I
A
A
F
S
R
W
K
L
Y
P
R
M
L
R
N
V
A
E
T
D
L
S
T
S
V
L
G
Q
R
V
S
M
P
I
C
V
G
A
T
A
M
Q
R
M
A
H
V
D
-
G
E
L
A
T
V
R
A
C
Q
S
L
--
G
T
G
M
M
L
S
S
W
A
T
S
S
I
E
E
V
A
E
A
G
---
P
-
E
A
L
R
W
L
Q
L
Y
I
Y
K
D
R
E
V
T
K
K
L
V
R
Q
A
E
K
M
G
Y
K
A
I
F
V
T
V
D
T
P
Y
L
G
N
R
L
D
D
V
R
N
R
F
-------------------------------------------------
G
L
A
A
Y
V
A
---
K
A
I
D
P
S
I
S
W
E
D
I
K
W
L
R
R
L
T
S
L
P
I
V
A
K
G
I
L
R
G
D
D
A
R
E
A
V
K
H
G
L
N
G
I
L
V
S
N
H
G
A
R
Q
L
D
G
V
P
A
T
I
D
V
L
P
E
I
V
E
A
V
E
-----
G
K
V
E
V
F
L
D
G
G
V
R
K
G
T
D
V
L
K
A
L
A
L
G
A
K
A
V
F
V
G
R
P
I
V
W
G
L
A
F
Q
G
E
K
G
V
Q
D
V
L
E
I
L
K
E
E
F
R
L
A
M
A
L
S
G
C
Q
N
V
K
V
I
D
------------
137
HHSearch
76.41
32%
-44
- C2 -
-
2NLI
3
?
A:
[11-360]
I
D
V
V
N
T
Y
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
N
--
G
-
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
---------
Y
P
F
G
M
P
I
V
Q
R
Y
L
R
G
---------------------------
T
-
A
E
G
M
---------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
G
L
D
L
F
-------
50
PsiBlast_CBE
73.60
31%
-47
- C2 -
-
2ZFA
2
?
B:
[24-360]
-------
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
---
N
G
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
------------------------------------------------------------------------
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
-------------
60
PsiBlast_CBE
72.41
31%
-44
- C2 -
-
2NLI
3
?
B:
[18-355]
-------
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
---
N
G
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
---------------------------------------------------------------------------
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
------------
51
PsiBlast_CBE
71.71
31%
-20
- C2 -
-
2ZFA
2
?
A:
[24-360]
-------
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
---
N
G
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
V
S
G
N
R
D
R
D
-----------------------------------
F
G
M
P
----
I
V
Q
R
Y
L
R
G
T
A
E
---------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
-------------
61
PsiBlast_CBE
71.34
31%
-20
- C2 -
-
2NLI
3
?
A:
[18-355]
-------
D
L
E
E
E
A
S
K
V
V
P
H
G
G
F
N
Y
I
A
G
A
S
G
D
E
W
T
K
R
A
N
D
R
A
W
K
H
K
L
L
Y
P
R
L
A
Q
D
V
E
A
P
D
T
S
T
E
I
L
G
H
K
I
K
A
P
F
I
M
A
P
I
A
A
H
G
L
A
H
T
T
-
K
E
A
G
T
A
R
A
V
S
E
F
--
G
T
I
M
S
I
S
A
Y
S
G
A
T
F
E
E
I
S
E
G
L
---
N
G
G
P
R
-
W
F
Q
I
Y
M
A
K
D
D
Q
Q
N
R
D
I
L
D
E
A
K
S
D
G
A
T
A
I
I
L
T
A
D
S
T
---
N
R
D
---------
Y
P
--------------------------
F
G
M
P
----
I
V
Q
R
Y
L
R
G
T
A
E
G
M
-------
Y
G
A
S
K
Q
K
I
S
P
R
D
I
E
E
I
A
G
H
S
G
L
P
V
F
V
K
G
I
Q
H
P
E
D
A
D
M
A
I
K
R
G
A
S
G
I
W
V
S
N
H
G
A
R
Q
L
Y
E
A
P
G
S
F
D
T
L
P
A
I
A
E
R
V
N
-----
K
R
V
P
I
V
F
D
S
G
V
R
R
G
E
H
V
A
K
A
L
A
S
G
A
D
V
V
A
L
G
R
P
V
L
F
G
L
A
L
G
G
W
Q
G
A
Y
S
V
L
D
Y
F
Q
K
D
L
T
R
V
M
Q
L
T
G
S
Q
N
V
E
D
L
K
------------
135
HHSearch
70.51
30%
-14
- C2 -
-
1KBI
3
CYB2_YEAST
B:
[122-481]
--
I
I
N
L
Y
D
F
E
Y
L
A
S
Q
T
L
T
K
Q
A
W
A
Y
Y
S
S
G
A
N
D
E
V
T
H
R
E
N
H
N
A
Y
H
R
I
F
F
K
P
K
I
L
V
D
V
R
K
V
D
I
S
T
D
M
L
G
S
H
V
D
V
P
F
Y
V
S
A
T
A
L
C
K
L
G
N
P
L
E
G
E
K
D
V
A
R
G
C
G
Q
G
V
T
K
V
P
Q
M
I
S
T
L
A
S
C
S
P
E
E
I
I
E
A
A
PSD
K
-
Q
I
Q
-
W
Y
Q
L
Y
V
N
S
D
R
K
I
T
D
D
L
V
K
N
V
E
K
L
G
V
K
A
L
F
V
T
V
D
A
P
S
L
G
Q
R
E
K
D
M
K
L
K
F
S
-
N
T
-----------
K
-----
T
N
V
---------------------
E
E
S
Q
G
A
---
S
R
A
L
S
K
F
I
D
P
S
L
T
W
K
D
I
E
E
L
K
K
K
T
K
L
P
I
V
I
K
G
V
Q
R
T
E
D
V
I
K
A
A
E
I
G
V
S
G
V
V
L
S
N
H
G
G
R
Q
L
D
F
S
R
A
P
I
E
V
L
A
E
T
M
P
I
L
E
Q
R
NLK
D
K
L
E
V
F
V
D
G
G
V
R
R
G
T
D
V
L
K
A
L
C
L
G
A
K
G
V
G
L
G
R
P
F
L
Y
A
N
S
C
Y
G
R
N
G
V
E
K
A
I
E
I
L
R
D
E
I
E
M
S
M
R
L
L
G
V
T
S
I
A
E
L
K
P
D
L
L
D
L
S
-----