@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VND2: (2017-11-13 )
MFQHIPPYAGDPILSLMEQFNADTRSEKVNLSIGLYYNEDSIVPQLETIIEAQKRIEPKNGKTKLYLPMEGFKPYREAIQALLFGANSPAVKAGRAVTIQTLGGSGALKVGADFLKTYFPNSDVWVSQPTWDNHVAIFNGAGIKTHFYPYFDAETRGVDFDGMLSTLKTLPEQSIVLLHPCCHNPTGADLNPAQWDQVIAVLKDRNLIPFLDIAYQGFGDGMEEDAYAIRALDQAGLNFIVSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDEVLNDAELNQQWQGEVKEMRERIIKMRSILKDELTKALPDRDFSYLVNQKGMFSYTGLTAEQVDILREEYAIYLVRSGRICVAGLNMNNVYTVAKAMAEVLAKSVEAA
Atome Classification :
(89 SA)
.........10........20........30.......-.-40.........50..-.-..-..-.---60........70........80.......--.90..--..---....100..--.......110.......120.-........130.......----140.......-150.......160.......-170........180.......190.......200.......210.......220..-.....230.......240.......250.......--260.--.--.--.----------...270.......280.......290.......300.......310.......320.......330.---..-.-----...340.......350.......360.......370.-......380.......390.......400..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFQHIPPYAG
D
P
I
L
S
L
M
E
Q
FNADTRS
E
K
V
N
L
S
I
G
L
Y
YN-E-D-S
I
V
P
Q
L
E
T
I
I
E
A
Q
-
K
-RI-EP-K---NG
K
T
K
L
Y
L
PMEG
F
K
P
Y
R
E
A
I
Q
A
L
L
FGANS--PAVKA--G
R
---
A
V
T
I
Q
--TL--GGSG
A
L
K
V
G
A
D
F
L
K
T
YFP--N-S
D
V
W
V
SQPTWDN
H
V
A
I
F
N----GAGIK
T
H
F
Y
P
-YFDAETRGV
D
F
D
G
M
L
S
T
L
K
T-L-PEQ
S
I
V
L
L
HPCCHNPTGADL
N
P
A
Q
W
D
Q
V
I
A
V
L
KDRNLI
P
F
L
D
I
A
Y
Q
GFGDGMEE-
D
A
Y
A
I
R
A
L
D
Q
AG
L
N
F
I
VS
N
S
F
S
K
I
F
S
L
Y
G
ERVG
G
L
--
T
F
V
C--D--D--A----------E
A
A
Q
C
T
F
G
Q
L
K
A
T
V
R
R
I
YSSPPTT
G
A
W
L
V
D
E
VL
N
D
A
E
L
N
Q
Q
W
Q
G
E
V
K
E
M
R
E
R
I
I
K
M
R
S
I
L
K
D
E
L
T
K
A---LP-D-----
R
D
F
S
Y
L
VNQKG
M
F
S
YTGL
T
A
E
Q
V
D
I
L
R
E
E
Y
A
I
Y
L
V
RS-G
R
I
C
V
A
GLNM
N
N
V
Y
T
V
A
K
A
M
A
E
V
L
A
K
S
VEAA
2
PsiBlast_PDB
98.43
65%
-129
- C1 -
-
3FSL
2
TYRB_ECOLI
A:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
30
PsiBlast_CBE
97.09
65%
-129
- C1 -
-
3FSL
2
TYRB_ECOLI
B:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
29
PsiBlast_CBE
96.85
65%
-132
- C1 -
-
3FSL
2
TYRB_ECOLI
C:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
26
PsiBlast_CBE
96.83
65%
-132
- C1 -
-
3FSL
2
TYRB_ECOLI
F:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
28
PsiBlast_CBE
96.68
65%
-131
- C1 -
-
3FSL
2
TYRB_ECOLI
D:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
27
PsiBlast_CBE
95.09
65%
-132
- C1 -
-
3FSL
2
TYRB_ECOLI
E:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
Q
A
G
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
K
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
5
PsiBlast_PDB
90.81
52%
-127
- C1 -
-
4WD2
4
?
A:
[9-404]
M
F
E
H
I
D
A
Y
P
G
D
P
I
L
T
L
N
E
N
F
Q
K
D
P
R
D
Q
K
V
N
L
S
I
G
I
Y
F
D
-
A
-
E
-
G
R
I
P
V
M
G
A
V
R
E
A
E
-
T
-
A
L
-
Q
R
-
D
---
S
G
P
-
K
P
Y
L
P
M
V
G
L
A
A
Y
R
D
A
V
Q
S
L
V
F
G
A
D
H
--
P
A
R
A
A
--
G
R
---
I
A
T
L
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
D
-
S
Q
V
W
L
S
D
P
S
W
E
N
H
R
F
I
F
E
----
R
A
G
F
T
V
N
T
Y
P
-
Y
Y
D
E
A
T
G
G
L
K
F
D
A
M
L
A
A
I
D
A
-
L
-
P
A
R
S
I
V
L
L
H
A
C
C
H
N
P
T
G
V
D
L
D
E
G
Q
W
E
K
L
I
D
V
I
E
A
R
E
L
L
P
F
V
D
M
A
Y
Q
G
F
G
A
G
L
D
A
-
D
A
F
A
V
R
E
L
A
R
R
G
V
P
T
L
V
A
N
S
F
S
K
N
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
V
C
--
E
--
D
--
A
----------
A
A
A
E
R
V
L
G
Q
L
A
G
A
V
R
S
N
Y
S
N
P
Q
T
Y
G
A
K
V
V
A
A
V
L
G
T
P
A
L
R
K
Q
W
E
E
E
L
S
A
M
C
R
R
I
A
R
M
R
Q
S
I
H
D
G
L
R
D
H
---
V
---------
A
L
T
R
Y
V
K
Q
R
G
M
F
T
Y
T
G
L
T
E
S
Q
V
D
A
L
R
E
V
H
G
V
Y
I
L
R
S
-
G
R
M
C
V
A
G
L
N
D
S
N
V
G
I
V
A
D
A
I
G
K
V
L
-------
22
PsiBlast_CBE
88.12
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
E:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
25
PsiBlast_CBE
87.47
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
B:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
1
PsiBlast_PDB
87.37
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
A:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
23
PsiBlast_CBE
87.21
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
D:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
24
PsiBlast_CBE
86.93
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
C:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
21
PsiBlast_CBE
86.87
65%
-121
- C1 -
-
3TAT
2
TYRB_ECOLI
F:
[1-397]
M
F
Q
K
V
D
A
Y
A
G
D
P
I
L
T
L
M
E
R
F
K
E
D
P
R
S
D
K
V
N
L
S
I
G
L
Y
Y
N
-
E
-
D
-
G
I
I
P
Q
L
Q
A
V
A
E
A
E
-
A
-
R
L
-
N
A
-
Q
---
P
H
G
A
S
L
Y
L
P
M
E
G
L
N
C
Y
R
H
A
I
A
P
L
L
F
G
A
D
H
--
P
V
L
K
Q
--
Q
R
---
V
A
T
I
Q
--
T
L
--
G
G
S
G
A
L
K
V
G
A
D
F
L
K
R
Y
F
P
--
E
-
S
G
V
W
V
S
D
P
T
W
E
N
H
V
A
I
F
A
----
G
A
G
F
E
V
S
T
Y
P
-
W
Y
D
E
A
T
N
G
V
R
F
N
D
L
L
A
T
L
K
T
-
L
-
P
A
R
S
I
V
L
L
H
P
C
C
H
N
P
T
G
A
D
L
T
N
D
Q
W
D
A
V
I
E
I
L
K
A
R
E
L
I
P
F
L
D
I
A
Y
Q
G
F
G
A
G
M
E
E
-
D
A
Y
A
I
R
A
I
A
S
A
G
L
P
A
L
V
S
N
S
F
S
K
I
F
S
L
Y
G
E
R
V
G
G
L
--
S
V
M
C
--
E
--
D
--
A
----------
E
A
A
G
R
V
L
G
Q
L
K
A
T
V
R
R
N
Y
S
S
P
P
N
F
G
A
Q
V
V
A
A
V
L
N
D
E
A
L
K
A
S
W
L
A
E
V
E
E
M
R
T
R
I
L
A
M
R
Q
E
L
V
K
V
L
S
T
E
---
M
P
-
E
-----
R
N
F
D
Y
L
L
N
Q
R
G
M
F
S
Y
T
G
L
S
A
A
Q
V
D
R
L
R
E
E
F
G
V
Y
L
I
A
S
-
G
R
M
C
V
A
G
L
N
T
A
N
V
Q
R
V
A
K
A
F
A
A
V
M
-------
13
PsiBlast_PDB
83.41
43%
-112
- C1 -
-
1TOE
-
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
-
E
-
T
-
G
K
I
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
D
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
45
PsiBlast_CBE
83.32
42%
-111
- C1 -
-
3QPG
5
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
59
PsiBlast_CBE
82.95
42%
-108
- C1 -
-
1ASN
2
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
16
PsiBlast_PDB
82.84
43%
-110
- C1 -
-
4F5L
6
AAT_ECOLI
A:
[12-406]
-
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
V
D
L
G
V
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
M
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
T
Y
L
G
L
D
G
L
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
T
W
P
N
H
K
A
I
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
A
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
I
D
I
A
Y
Q
G
F
G
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
C
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
I
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
39
PsiBlast_CBE
82.69
43%
-114
- C1 -
-
1AHY
4
AAT_ECOLI
B:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
-
E
-
T
-
G
K
I
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
9
PsiBlast_PDB
82.65
43%
-113
- C1 -
-
1AHX
4
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
-
E
-
T
-
G
K
I
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
18
PsiBlast_PDB
82.63
43%
-110
- C1 -
-
4F5I
-
AAT_ECOLI
A:
[12-406]
-
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
V
D
L
G
V
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
M
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
T
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
T
W
P
N
H
K
A
I
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
I
D
I
A
Y
Q
G
F
G
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
C
S
K
N
F
S
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
I
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
64
PsiBlast_CBE
82.62
42%
-116
- C1 -
-
1ASE
2
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
14
PsiBlast_PDB
82.58
43%
-116
- C1 -
-
1TOI
1
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
-
E
-
T
-
G
K
I
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
D
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
52
PsiBlast_CBE
82.30
42%
-110
- C1 -
-
1X28
2
AAT_ECOLI
B:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
73
PsiBlast_CBE
82.25
42%
-111
- C1 -
-
1AMQ
1
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
50
PsiBlast_CBE
82.21
42%
-109
- C1 -
-
1X29
2
AAT_ECOLI
B:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
65
PsiBlast_CBE
82.15
42%
-114
- C1 -
-
1ASD
2
AAT_ECOLI
A:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
V
Y
K
D
-
E
-
T
-
G
K
T
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
N
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
T
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
N
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------
40
PsiBlast_CBE
82.06
43%
-114
- C1 -
-
1AHX
4
AAT_ECOLI
B:
[1-396]
M
F
E
N
I
T
A
A
P
A
D
P
I
L
G
L
A
D
L
F
R
A
D
E
R
P
G
K
I
N
L
G
I
G
L
Y
Y
D
-
E
-
T
-
G
K
I
P
V
L
T
S
V
K
K
A
E
-
Q
-
Y
L
--
L
-
E
---
N
E
T
T
K
L
Y
L
G
I
D
G
I
P
E
F
G
R
C
T
Q
E
L
L
F
G
K
G
S
--
A
L
I
N
D
--
K
R
---
A
R
T
A
Q
--
T
P
--
G
G
S
G
A
L
R
V
A
A
D
F
L
A
K
N
T
S
--
V
-
K
R
V
W
V
S
N
P
S
W
P
N
H
K
S
V
F
N
----
S
A
G
L
E
V
R
E
Y
A
-
Y
Y
D
A
E
N
H
T
L
D
F
D
A
L
I
N
S
L
N
E
-
A
-
Q
A
G
D
V
V
L
F
H
G
C
C
H
N
P
T
G
I
D
P
T
L
E
Q
W
Q
T
L
A
Q
L
S
V
E
K
G
W
L
P
L
F
D
F
A
Y
Q
G
F
A
R
G
L
E
E
-
D
A
E
G
L
R
A
F
A
A
M
H
K
E
L
I
V
A
S
S
Y
S
K
N
F
G
L
Y
N
E
R
V
G
A
C
--
T
L
V
A
--
A
--
D
--
S
----------
E
T
V
D
R
A
F
S
Q
M
K
A
A
I
R
A
N
Y
S
S
P
P
A
H
G
A
S
V
V
A
T
I
L
S
N
D
A
L
R
A
I
W
E
Q
E
L
T
D
M
R
Q
R
I
Q
R
M
R
Q
L
F
V
N
T
L
Q
E
K
---
G
A
-
N
-----
R
D
F
S
F
I
I
K
Q
N
G
M
F
S
F
S
G
L
T
K
E
Q
V
L
R
L
R
E
E
F
G
V
Y
A
V
A
S
-
G
R
V
N
V
A
G
M
T
P
D
N
M
A
P
L
C
E
A
I
V
A
V
L
-------