@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VND6: (2017-11-13 )
MNTKYRKPLAGTQLEYYDVRQAVEDIQPGAYEKLPYTSKVLAEQLVRRADAENLTAYLTQLIERRQDLDFPWYPARVVCHDILGQTALVDLAGLRDAIAEKGGDPSKVNPVVPTQLIVDHSLAVEYGGADPDAFAKNRAVEDRRNEDRFHFIEWTKTAFKNVDVIPAGNGIMHQINLEKMSPVIQARDGVAFPDTCVGTDSHTPHTDALGVISVGVGGLEAENVMLGRASWMRLPDIIGVELVGQRQAGITATDIVLALTEFLRKERVVGAYLEFFGEGADSMSVGDRATISNMTPEYGATAAMFYIDQNTIDYLRLTGREDAQVALVEQYAKEIGLWASEMTKAEYPRVLRFDLSTVTRNIAGPSNPHARVSTSDLKEKGIAGVVENRSDGLMPDGAIIIAAITSCTNTSNPRNTVAAGLLARKANGLGLVRKPWVKSSFAPGSKAAALYLEEAGVLKDLEKLGFGIVAYACTTCNGMSGALNPVIQQEIIDRDLYATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGTIRFDIEKDALGYDKEGNPIYLKDIWPSDAEIDALVKQAVKPEQFRKVYIPMFDLGEVEQAKSPLYDWRPQSTYIRRPPYWEGALAAPRTLANMRPLAILGDNITTDHLSPSNAILMDSAAGEYLHKMGVPEEDFNSYATHRGDHLTAQRATFANPKLYNEMVRRSDGTIKQGSKARVEPEGEVMRMWEAIETYMNRKQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNLVGMGVLPLEFKPGVNRKTLKLDGTELYSVIGNIAPRSTLTLVIERATADGKEEIVEVPVTCRLDTEEEVSVYEAGGVLQRFAQDFLEGQVA
Atome Classification :
(20 SA)
.........--10........20........30........40........50-------.-----........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190....-...200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....---..340--.......---.350.......360......---.370......---------.------------380..-------------...----------------------..390----------.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.....-..520.......530.......540.......550.......560.......570.......580.......590---....----....600.......610.-..--....---.620-.........630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.....-..790.......800.....--.-.-810.......820.......830.......840.......850.......860......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNTKYRKPL--AGTQL
E
Y
Y
D
V
R
Q
A
V
E
DIQPGAYEKLP
Y
T
S
K
V
L
A
E
Q
L
V
R
RA
D
--------
A
-----
E
N
L
T
A
Y
L
T
Q
L
I
E
R
R
QDLDFPWY
P
A
R
V
V
C
H
D
I
LG
Q
T
A
L
V
D
L
A
G
L
R
D
A
I
A
EKGGDPSKVNPVVP
T
Q
L
I
VD
H
S
L
A
V
E
YGGA
D
P
D
A
F
AKNRAVEDRRNED
R
F
H
F
I
E
W
T
K
T
A
FKN
V
D
V
I
PAGNG
I
M
H
Q
I
N
L
E
KM
S
P
V
I
QARDGVAFPDTC-VGTDSHTPHTDA
L
G
V
I
S
VGVGGLEAE
N
V
M
LG
R
A
S
WMRLP
D
I
I
G
V
E
L
V
GQRQAG
I
T
A
T
D
I
V
L
A
L
T
E
F
L
R
K
E
R
V
V
G
A
Y
L
E
F
FGEGADSMSVGDRATISNMTPEYGA
T
A
A
M
F
Y
IDQNT
I
D
Y
L
R
LTGRE
D
A
Q
V
A
L
V
E
Q
Y
A
K
E
IG
L
---
W
A
S
E
---MTKAEY
P
---
R
V
L
R
F
D
L
S
T
V
T
R
NIAGPSNP---HARV
S
T
S
D
L
K
---------E------------KGI
A
G
-------------
V
VE----------------------NRSDG----------LMPDG
A
I
I
I
A
A
I
T
SCTNTSNP
R
N
T
V
A
A
G
L
L
A
RKANGLGLVRKPWVKSSFAPGS
K
A
A
A
L
Y
L
E
E
A
G
V
L
K
D
L
E
K
LG
F
G
I
V
A
Y
A
C
TTCNGMSG
A
L
N
P
V
I
Q
Q
E
I
ID
R
D
L
Y
A
T
A
V
LSGNRNFDGRIH
P
Y
A
K
-
Q
AFLASP
P
L
V
V
A
Y
A
I
A
G
T
I
R
F
D
IEKDALGYDKEG
N
P
I
Y
L
KDIWPS
D
A
E
I
D
A
L
V
K
QAV
K
P
E
Q
F
R
K
V
Y
I
PMFDLG
E
----
V
E
Q
A----KSPLYDWRPQS
T
Y
IR-RP-PY--WEGA---LA---A
P
R
T
LANMR
P
L
A
I
LGDNITTDHLSPSN
A
I
L
MDS
A
A
G
E
Y
L
H
KMGV
P
E
E
D
F
N
S
Y
ATHRGDHLTAQRATFAN
P
K
L
Y
N
E
M
V
R
RSDGTIKQGSKARVEP
E
G
E
V
M
R
M
W
E
A
I
E
T
Y
MNRKQ
P
L
I
I
I
A
GADYGQGSSR
D
W
A
AKGV
R
L
A
G
V
E
A
I
V
A
E
G
F
E
R
I
H
RTNLVG
M
G
V
L
P
L
EF-KPGV
N
R
K
T
L
K
LD
G
T
E
L
Y
S
V
I
--G-N-IAPR
S
T
L
T
L
V
I
E
RATADGKE
E
I
V
EV
P
V
T
C
RLD
T
E
E
E
V
S
V
Y
EA
G
G
V
L
Q
R
F
A
Q
D
F
LEGQVA
26
HHSearch
84.45
42%
5
- C5 -
-
2B3Y
2
ACOC_HUMAN
B:
[8-887]
-----
A
E
P
L
DP
V
Q
P
G
K
K
F
F
N
L
N
K
L
-
E
---
D
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
EFLVKKQD
I
-----
E
N
I
L
H
W
N
V
T
Q
---
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
-
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
---
F
R
D
F
NDP
S
Q
D
P
D
F
T
---
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
---------
K
------------
D
F
E
S
C
-------------
L
G
A
KQGFKGFQVAPEHHNDHKTFIY
D
N
T
E
F
----------
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
SWNA
L
A
T
P
----
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
---
T
L
DLQ
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
-----
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
--
I
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
-
D
T
-------
G
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
-----
27
HHSearch
83.38
42%
4
- C5 -
-
2B3X
2
ACOC_HUMAN
A:
[8-887]
-----
A
E
P
L
DP
V
Q
P
G
K
K
F
F
N
L
N
K
L
-
E
---
D
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
EFLVK
K
Q
D
I
-----
E
N
I
L
H
W
N
V
T
Q
---
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
-
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
---
F
R
D
F
NDP
S
Q
D
P
D
F
T
---
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
---------
K
------------
D
F
E
S
C
-------------
L
G
A
KQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
D
N
T
E
F
----------
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
----
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
---
T
L
DLQ
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
-----
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
--
I
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
-
D
T
-------
G
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
-----
2
PsiBlast_PDB
81.84
41%
8
- C5 -
-
2B3Y
3
ACOC_HUMAN
A:
[31-880]
--------------------------------
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
EFLVK---
K
-----
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
-
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
---
F
R
D
F
---
N
D
P
S
Q
D
P
DFT
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
---------
K
D
F
E
S
C
L
G
AKQGF
K
G
F
Q
V
-------------
A
P
E
----------------------
H
H
N
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
----
S
W
N
A
L
A
T
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
TL
D
L
Q
---
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
------
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
-
N
-
L
K
P
Q
M
K
V
Q
V
K
L
D
T
G
K
T
--------
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
------------
21
PsiBlast_CBE
81.71
41%
6
- C5 -
-
2B3Y
2
ACOC_HUMAN
B:
[31-880]
--------------------------------
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
EFLVK---
K
-----
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
-
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
---
F
R
D
F
---
N
D
P
S
Q
D
P
DFT
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
---------
K
DFESCLGAKQGF
K
G
F
Q
V
-------------
A
P
E
----------------------
H
H
N
D
H
KTFIYDNTEF
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
----
S
W
N
A
LATP
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
TLD
L
Q
---
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
------
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
IP
E
-
N
-
L
K
P
Q
M
K
V
Q
V
K
L
D
T
G
K
T
--------
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
------------
1
PsiBlast_PDB
80.71
41%
9
- C5 -
-
2B3X
2
ACOC_HUMAN
A:
[31-880]
--------------------------------
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
EFLVK---
K
-----
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
-
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
---
F
R
D
F
---
N
D
P
S
Q
D
P
DFT
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
---------
K
D
F
E
S
C
L
G
AKQGF
K
G
F
Q
V
-------------
A
P
E
----------------------
H
H
N
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
----
S
W
N
A
L
A
T
P
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
TLD
L
Q
---
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
------
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
-
N
-
L
K
P
Q
M
K
V
Q
V
K
L
D
T
G
K
T
--------
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
------------
3
PsiBlast_PDB
75.97
41%
14
- C5 -
-
3SNP
-
ACOC_RABIT
A:
[32-881]
--------------------------------
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
--------
K
FLVK
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
-------------------
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
FRD
Y
S
D
P
---
S
Q
D
P
D
F
T
---
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
------------
Q
G
F
K
G
FQVAPDHHN
D
H
K
T
F
I
Y
----------------------
N
D
S
E
F
----------
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
----
S
W
--------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
TLD
L
Q
---
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
------
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
I
P
E
-
N
-
L
T
P
R
--
M
H
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
I
------
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
------------
4
PsiBlast_PDB
75.05
41%
12
- C5 -
-
3SN2
-
ACOC_RABIT
A:
[32-881]
--------------------------------
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
--------
K
FLVK
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
----------------------
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
FRD
Y
S
D
P
---
S
Q
D
P
D
F
T
---
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
---
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
------------
Q
G
F
K
G
FQVAPDHHN
D
H
K
T
F
I
Y
----------------------
N
D
S
E
F
----------
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
P
N
T
R
-
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
----
S
-------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
-
S
P
-
P
F
--
F
E
N
L
TL
D
L
Q
---
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
------
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
-
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
I
P
E
-
N
-
L
T
P
R
--
M
H
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
I
------
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
------------
14
PsiBlast_PDB
61.64
27%
13
- C5 -
-
7ACN
2
ACON_PIG
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
17
PsiBlast_PDB
61.44
27%
14
- C5 -
-
1B0J
2
ACON_PIG
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
D
K
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
15
PsiBlast_PDB
61.44
27%
12
- C5 -
-
1C97
3
ACON_BOVIN
A:
[65-749]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
19
PsiBlast_PDB
60.90
27%
13
- C5 -
-
1B0M
1
ACON_PIG
A:
[65-749]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
D
K
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
Q
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
16
PsiBlast_PDB
60.63
27%
12
- C5 -
-
1B0K
2
ACON_PIG
A:
[65-749]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
D
K
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
11
PsiBlast_PDB
60.39
27%
14
- C5 -
-
1NIT
1
ACON_BOVIN
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
S
G
C
H
Y
D
---
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
13
PsiBlast_PDB
60.26
27%
12
- C5 -
-
6ACN
2
ACON_PIG
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
12
PsiBlast_PDB
60.25
27%
11
- C5 -
-
5ACN
2
ACON_PIG
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
6
PsiBlast_PDB
60.13
27%
13
- C5 -
-
1FGH
1
ACON_BOVIN
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
S
G
C
H
Y
D
---
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
7
PsiBlast_PDB
60.03
27%
14
- C5 -
-
8ACN
2
ACON_BOVIN
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
S
G
C
H
Y
D
---
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
10
PsiBlast_PDB
59.99
27%
13
- C5 -
-
1NIS
2
ACON_BOVIN
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
S
G
C
H
Y
D
---
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
9
PsiBlast_PDB
59.49
27%
13
- C5 -
-
1AMJ
1
ACON_BOVIN
A:
[66-750]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
S
G
C
H
Y
D
---
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
---------------
R
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
-
P
F
DK
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
S
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
T
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------
18
PsiBlast_PDB
59.48
27%
16
- C5 -
-
1C96
2
ACON_BOVIN
A:
[65-749]
----------------------------------------------------------------------------------------
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
--------
S
S
G
L
P
-
K
V
--
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
L
R
R
A
K
D
I
------
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
----------
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-----
I
A
N
L
A
D
E
F
K
D
---
H
L
V
P
---
D
P
G
C
H
Y
D
---
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
DLA
H
P
V
A
E
V
G
S
V
A
---------
E
------------
K
---------------------------------------------
E
G
----------
W
P
L
D
--
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
-------
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
F
K
L
E
-----
A
P
D
A
D
E
L
P
R
A
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
-----
R
V
A
----
V
S
P
T
----
S
Q
R
L
Q
L
L
-
E
P
F
D
K
--
W
D
G
-----------
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
---------
S
A
A
G
P
W
L
--------
K
F
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
---------
R
K
A
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
------
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
-
L
--
K
-
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
--
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
---
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
--------