@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNF6: (2017-11-14 )
MPRPITAVIHRQALQNNLAVVRKAMPNSKVFAVVKANAYGHGIERVYEAFKAADGFALLDLEEAKRIRALGWTGPILLLEGVFSPQDLFDCVQYQLSFTIHSEAQIEWVEQHPYPAQFDVFLKMNSGMSRLGFKPQHYVQAWERLNNLANVAKITHMMHFSDADGDRFGQQGIDYQITAFEEIVKDLPGERSVSNSAAILRYQDQLKSDYVRSGIMLYGSSPDYPTHSIADWGLQPTMSLRSEIISVQHLEPNESVGYGSNFVAEQPMTIGIVACGYADGYQRISPTGTPVLVDSVRTRTVGRVSMDMLAVDLTGIESAKVGSEVVLWGQSSTGVVLPIDDVAVSSGTVGYELMCAVTARVQFINQV
Atome Classification :
(23 SA)
.........10........20.....-.-..30........40.-.......50.--.-.......60........70........80.---.......90........100.......110------.---.-...---..120.......130.-.----.-.-...140.......150-......-.160------...---.....170.......180......---.190.---......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPR
P
I
T
A
V
I
H
R
Q
A
L
Q
N
N
L
A
V
V
R
K
AMP-N-S
K
V
F
A
V
V
KANAYG
H
G
-
I
E
R
V
Y
E
A
F
-K--A-AD
G
F
A
L
L
D
L
E
E
A
K
R
I
RALGWT
G
P
I
L
L
L
EGV---F
S
P
Q
D
L
F
D
C
V
Q
Y
Q
L
S
F
T
IHSE
A
Q
I
E
W
VEQH------P---Y-PA
Q
---
F
D
V
F
L
K
MNS
G
M
S
RLGF-
K
----
P
-
Q
-
H
Y
V
Q
A
W
E
R
L
N
N
L
A
N
V
A
-
K
I
T
H
M
M
-HFS-------DAD---GDRFGQQGI
D
Y
Q
I
T
A
F
E
E
I
V
K
DLP---GERSV---SN
S
A
A
I
L
R
Y
Q
D
Q
L
K
S
D
Y
V
RS
G
I
M
L
YGSSPDYPTH
S
I
ADWGLQ
P
T
M
S
L
R
S
E
I
I
S
V
QHLEPNESVGYGSNFVAEQ
P
M
T
I
G
I
V
A
CGYADGYQRISPTGT
P
V
L
V
DSVRTRTVG
R
V
S
M
D
M
L
A
V
DLTGIESAKVG
S
E
V
V
L
W
GQSST
G
V
V
L
PID
D
V
AVSSGTV
G
Y
E
L
M
C
A
V
T
A
R
V
Q
F
INQV
59
HHSearch
97.98
40%
-70
- C3 -
-
4WR3
3
ALR1_ECOLI
A:
[1-357]
-
M
Q
A
A
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
Q
P
V
N
I
V
S
-
H
F
A
-------
R
A
D
---
E
P
K
--
C
G
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
Q
-
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
A
M
K
Y
--
25
PsiBlast_CBE
96.93
40%
-71
- C3 -
-
4WR3
2
ALR1_ECOLI
C:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
26
PsiBlast_CBE
96.44
40%
-69
- C3 -
-
4WR3
3
ALR1_ECOLI
B:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
2
PsiBlast_PDB
96.39
40%
-71
- C3 -
-
4WR3
3
ALR1_ECOLI
A:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
3
PsiBlast_PDB
95.62
40%
-71
- C3 -
-
4XBJ
2
ALR1_ECOLI
A:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
21
PsiBlast_CBE
95.43
40%
-73
- C3 -
-
4XBJ
1
ALR1_ECOLI
D:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
----
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
-----
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
-
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
--
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
22
PsiBlast_CBE
94.94
40%
-74
- C3 -
-
4XBJ
1
ALR1_ECOLI
C:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
----------
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
-
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
-
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
-
G
-----
L
P
V
E
R
I
--
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
24
PsiBlast_CBE
94.50
40%
-69
- C3 -
-
4WR3
2
ALR1_ECOLI
D:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
23
PsiBlast_CBE
94.49
40%
-68
- C3 -
-
4XBJ
2
ALR1_ECOLI
B:
[5-353]
-----
T
V
V
I
N
R
R
A
L
R
H
N
L
Q
R
L
R
E
L
A
P
-
A
-
S
K
M
V
A
V
V
K
A
N
A
Y
G
H
G
-
L
L
E
T
A
R
T
L
-
P
--
D
-
A
D
A
F
G
V
A
R
L
E
E
A
L
R
L
R
A
G
G
I
T
K
P
V
L
L
L
E
G
F
---
F
D
A
R
D
L
P
T
I
S
A
Q
H
F
H
T
A
V
H
N
E
E
Q
L
A
A
L
E
E
A
------
S
---
L
-
D
E
P
---
V
T
V
W
M
K
L
D
T
G
M
H
R
L
G
V
-
R
----
P
-
E
-
Q
A
E
A
F
Y
H
R
L
T
Q
C
K
N
V
R
-
Q
P
V
N
I
V
S
H
F
A
-------
R
A
D
---
E
P
K
C
G
--
A
T
E
K
Q
L
A
I
F
N
T
F
C
E
G
K
P
---
G
Q
R
S
I
---
A
A
S
G
G
I
L
L
W
P
-
Q
S
H
F
D
W
V
R
P
G
I
I
L
Y
G
V
S
P
L
E
D
R
S
T
G
A
D
F
G
C
Q
P
V
M
S
L
T
S
S
L
I
A
V
R
E
H
K
A
G
E
P
V
G
Y
G
G
T
W
V
S
E
R
D
T
R
L
G
V
V
A
M
G
F
G
D
G
Y
P
R
A
A
P
S
G
T
P
V
L
V
N
G
R
E
V
P
I
V
G
R
V
A
M
D
M
I
C
V
D
L
G
P
Q
A
Q
D
K
A
G
D
P
V
I
L
W
G
E
G
-----
L
P
V
E
R
I
A
E
M
T
K
V
S
A
Y
E
L
I
T
R
L
T
S
R
V
------
1
PsiBlast_PDB
90.23
40%
-46
- C3 -
-
4QHR
-
?
A:
[2-350]
--
R
Q
A
T
V
Y
I
D
R
Q
A
L
Q
Y
N
L
N
R
V
K
Q
L
A
A
-
N
-
S
K
I
V
S
M
V
K
A
N
A
Y
G
H
G
-
V
K
D
C
L
A
A
L
-
N
--
A
-
S
D
A
F
G
V
A
C
L
Q
E
G
L
E
I
R
E
L
G
F
E
Q
P
V
T
L
I
E
G
V
---
F
S
E
D
E
M
P
V
A
I
E
Q
K
F
E
C
V
I
H
H
Q
Q
Q
F
E
W
L
I
K
H
------
K
Q
A
-
Y
-
I
A
Q
G
--
L
K
V
W
V
K
L
N
S
G
M
N
R
L
G
F
-
K
----
D
-
P
-
E
I
I
E
V
I
K
T
L
K
S
E
G
F
T
C
-
V
L
A
--
M
-
H
F
A
-------
N
A
D
---
V
D
H
P
L
N
E
Q
Q
K
Q
Q
F
L
H
I
K
E
T
C
D
--
P
---
I
L
A
S
C
---
C
N
S
A
A
I
F
K
W
-
P
E
L
N
F
D
Y
V
R
P
G
I
M
L
Y
G
A
S
P
-
F
A
D
K
T
V
H
D
L
D
L
K
P
V
M
T
F
T
A
E
I
I
A
L
N
H
I
E
A
G
E
H
V
G
Y
G
S
T
F
C
A
Q
Q
A
M
D
I
A
I
V
S
I
G
Y
G
D
G
Y
P
R
A
Y
V
K
Q
N
F
V
A
I
D
G
K
L
C
P
V
V
G
R
V
S
M
D
M
I
A
I
D
V
T
N
T
Q
-
V
K
L
G
T
Q
V
E
L
W
G
N
H
R
L
-----
V
D
D
V
A
E
A
N
G
T
I
G
Y
E
L
L
C
R
L
S
S
R
-------
28
PsiBlast_CBE
75.07
33%
-36
- C3 -
-
1BD0
2
ALR_GEOSE
B:
[16-367]
------------
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
-
D
D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
--
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
-
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
---
D
W
L
E
E
A
SALYSG
P
---
F
-
P
I
H
---
F
H
--
L
K
M
D
T
G
M
G
R
L
G
V
-
K
DEEE
T
-
K
-
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
-
L
Y
T
H
F
A
-
T
A
D
-------
E
V
N
---
T
D
Y
F
S
-----
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
---
S
R
P
P
L
VHC
A
N
S
A
A
S
L
R
F
P
D
R
-
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
-
R
L
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
-
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
---
7
PsiBlast_PDB
75.07
33%
-14
- C3 -
-
3E6E
2
?
A:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
K
G
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
27
PsiBlast_CBE
74.95
33%
-34
- C3 -
-
1SFT
1
ALR_GEOSE
B:
[16-367]
------------
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
-
D
D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
--
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
-
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
---
D
W
L
E
E
A
SALYSG
P
---
F
-
P
I
H
---
F
H
--
L
K
M
D
T
G
M
G
R
L
G
V
-
K
DEEE
T
-
K
-
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
-
L
Y
T
H
F
A
-
T
A
D
-------
E
V
N
---
T
D
Y
F
S
-----
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
---
S
R
P
P
L
VHC
A
N
S
A
A
S
L
R
F
P
D
R
-
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
-
R
L
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
-
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
---
5
PsiBlast_PDB
74.78
33%
-36
- C3 -
-
1BD0
2
ALR_GEOSE
A:
[16-367]
------------
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
-
D
D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
--
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
-
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
---
D
W
L
E
E
A
S
A
L
Y
SG
P
---
F
-
P
I
H
---
F
H
--
L
K
M
D
T
G
M
G
R
L
G
V
-
K
D
E
E
E
T
-
K
-
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
-
L
Y
T
H
F
A
-
T
A
D
-------
E
V
N
---
T
D
Y
F
S
-----
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
---
S
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
-
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
-
R
L
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
-
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
---
46
PsiBlast_CBE
74.76
33%
-18
- C3 -
-
3E6E
1
?
B:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
KG
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
4
PsiBlast_PDB
74.71
33%
-34
- C3 -
-
1SFT
1
ALR_GEOSE
A:
[16-367]
------------
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
-
D
D
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
--
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
-
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
---
D
W
L
E
E
A
S
A
L
Y
SG
P
---
F
-
P
I
H
---
F
H
--
L
K
M
D
T
G
M
G
R
L
G
V
-
K
D
E
E
E
T
-
K
-
R
I
V
A
L
I
E
R
H
P
H
F
V
L
E
G
-
L
Y
T
H
F
A
-
T
A
D
-------
E
V
N
---
T
D
Y
F
S
-----
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
---
S
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
-
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
-
R
L
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
E
V
I
-
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
---
60
HHSearch
74.21
33%
-19
* C3 *
-
3E5P
6
?
C:
[6-369]
-
H
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
E
G
-
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
K
K
G-
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
-
S
V
---
V
D
L
A
Y
V
P
L
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
TPE
S
-
N
T
P
---
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
-
L
----
T
P
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
---
E
I
D
--
T
S
Y
F
E
K
Q
A
G
R
F
K
A
V
L
A
V
L
E
ELP
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
G
N
K
-
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
H
L
Q
G
F
-
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
E
--
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
-
E
E
N
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
P
R
E
---
48
PsiBlast_CBE
73.08
33%
-13
- C3 -
-
3E5P
2
?
B:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
K
G
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
45
PsiBlast_CBE
72.99
33%
-16
- C3 -
-
3E6E
2
?
C:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
KG
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
19
PsiBlast_PDB
72.88
29%
-38
- C3 -
-
3UW6
-
ALR_GEOSE
A:
[6-367]
--
R
D
T
W
A
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
-
D
D
T
H
I
M
A
S
V
C
G
N
A
Y
G
H
G
D
V
Q
V
A
R
T
A
L
-
E
--
A
G
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
-
T
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
---
D
W
L
E
E
A
S
A
L
YSG
P
---
F
-
P
I
H
---
F
H
L
Y
--
M
D
T
G
M
G
S
L
G
V
-
K
----
D
-
E
-
E
E
T
K
---
R
I
-----
V
A
-
L
I
E
R
H
P
-
H
F
V
LE
G
L
W
T
W
F
A
T
----------
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
---
S
R
P
P
L
V
H
C
A
N
S
A
A
S
L
R
F
P
D
R
-
T
F
N
M
V
Q
F
G
I
A
M
Y
G
L
A
P
S
P
G
-----
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
F
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
K
D
G
W
L
R
-
R
L
Q
H
F
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
L
G
D
M
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
K
V
I
-
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
---
6
PsiBlast_PDB
72.81
33%
-15
- C3 -
-
3E5P
5
?
A:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
K
G
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
47
PsiBlast_CBE
72.25
33%
-12
- C3 -
-
3E5P
6
?
C:
[7-366]
--
R
P
T
R
L
H
I
D
T
Q
A
I
T
E
N
V
Q
K
E
C
Q
R
L
P
-
E
G
T
A
L
F
A
V
V
K
A
N
G
Y
G
H
G
-
A
V
E
S
A
K
A
A
-
K
KG
G
-
A
T
G
F
C
V
A
L
L
D
E
A
I
E
L
R
E
A
G
V
Q
D
P
I
L
I
L
S
V
V
DLA
Y
V
P
L
----
L
I
Q
Y
D
L
S
V
T
V
A
T
Q
E
W
L
E
A
A
L
Q
Q
------
L
---
T
-
P
E
S
NTP
L
R
V
H
L
K
V
D
T
G
M
G
R
I
G
F
L
T
----
P
-
E
-
E
T
K
Q
A
V
R
F
V
Q
S
H
K
E
F
L
-
W
E
G
I
F
T
-
H
F
S
-------
T
A
D
EID
T
S
Y
F
E
K
Q
A
G
R
F
K
--
A
V
L
A
V
L
E
E
L
P
---
R
Y
V
H
V
---
S
N
S
A
T
A
L
W
H
P
D
-
V
P
G
N
M
I
R
Y
G
V
A
M
Y
G
L
N
P
S
-
G
N
K
L
A
P
S
Y
A
L
K
P
A
L
R
L
T
S
E
L
I
H
V
K
R
L
A
A
G
E
G
I
G
Y
G
E
T
Y
V
T
E
A
E
E
W
I
G
T
V
P
I
G
Y
A
D
G
W
L
R
-
H
L
Q
G
F
T
V
L
V
N
G
K
R
C
E
I
V
G
R
V
C
M
D
Q
C
M
I
R
L
A
--
E
E
V
P
V
G
P
V
V
T
L
V
G
K
D
G
N
E
E
N
-
T
L
Q
M
V
A
E
K
L
E
T
I
H
Y
E
V
A
C
T
F
S
Q
R
I
------
62
HHSearch
71.81
33%
-23
- C3 -
-
1BD0
2
ALR_GEOSE
B:
[5-368]
-
H
R
D
T
W
A
E
V
D
L
D
A
I
Y
D
N
V
E
N
L
R
R
L
L
P
D
D
-
T
H
I
M
A
V
V
K
A
N
A
Y
G
H
G
-
D
V
Q
V
A
R
T
A
L
E
A-
G
-
A
S
R
L
A
V
A
F
L
D
E
A
L
A
L
R
E
K
G
I
E
A
P
I
L
V
L
-
G
A
---
S
R
P
A
D
A
A
L
A
A
Q
Q
R
I
A
L
T
V
F
R
S
D
W
L
E
E
A
S
A
L
------
Y
---
S
G
P
F
P
---
I
H
F
H
L
K
M
D
T
G
M
G
R
L
G
V
-
K
----
D
-
E
E
E
T
K
R
I
V
A
L
I
E
R
H
P
H
F
V
-
L
E
G
L
Y
T
-
H
F
A
-------
T
A
D
---
E
V
N
--
T
D
Y
F
S
Y
Q
Y
T
R
F
L
H
M
L
E
W
L
P
SRP
P
L
V
H
C
---
A
N
S
A
A
S
L
R
F
P
D
-
R
T
F
N
M
V
R
F
G
I
A
M
Y
G
L
A
P
S
P
G
I
K
P
L
L
P
Y
P
L
K
E
A
F
S
L
H
S
R
L
V
H
V
K
K
L
Q
P
G
E
K
V
S
Y
G
A
T
Y
T
A
Q
T
E
E
W
I
G
T
I
P
I
G
Y
A
D
G
W
L
R
R
L
Q
H
F
-
H
V
L
V
D
G
Q
K
A
P
I
V
G
R
I
C
M
D
Q
C
M
I
R
L
P
G
--
P
L
P
V
G
T
K
V
T
L
I
G
R
Q
G
D
-
E
V
I
S
I
D
D
V
A
R
H
L
E
T
I
N
Y
E
V
P
C
T
I
S
Y
R
V
P
R
I
F
--