@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNG1: (2017-11-14 )
MNIAFIGLGNMGGRMAQNLLKAGLKVYGYDLSEVAIQHFAEAGGVVCDSPQDAAKQADVVITMLPAAKHVKEVYLGENGVLEVLKAGSLCIDSSTIDPQTIKDIAAVAHSKNIKICDAPVSGGTIGAQAGTLTFMVGADEQTFNEVKPVLSHMGKNIVHCGDVGAGQIAKICNNLILGISMAAVAEGMALGVKLGIDPQALAGVINTSSGRCWSSDVCNPWPHINENAPASRGYQDGFATQLMLKDLGLAVEAAGQVKQPVLLGGMVQQLYQQMCMRGNAHLDFSSIIQQYLPQEA
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...--....270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
I
A
F
I
GLGNM
G
G
R
M
A
Q
N
L
L
K
A
G
L
K
VYGY
D
L
S
E
V
A
I
Q
H
F
A
E
AGG
V
V
CDS
P
Q
D
A
AKQA
D
V
V
I
T
ML
P
A
A
K
H
V
K
E
V
YLGE
N
G
V
L
E
V
L
KAGS
L
C
IDSSTI
D
P
Q
T
I
K
D
I
A
A
V
AHSKN
I
K
I
CDAPVSGGTIGAQA
G
T
L
T
F
M
VGADE
Q
T
F
N
E
V
K
P
V
L
S
HMGKN
I
V
HCGD-V
G
A
G
Q
I
A
K
I
C
N
N
L
I
L
G
I
S
M
A
A
V
AEG
M
A
L
G
V
KLGI
D
P
Q
A
L
A
G
V
I
NTSSGRCWSSDVCNPWPHINENAPASRGYQD
G
F
A
T
Q
L
M
L
K
D
L
G
L
A
V
EAAGQVKQ
P
V
L
L
G
G
--
M
V
Q
Q
L
Y
Q
Q
M
CMRGNAHL
D
F
S
S
I
I
Q
Q
YLPQEA
1
PsiBlast_PDB
85.46
49%
-119
- C1 -
-
2I9P
1
3HIDH_HUMAN
A:
[23-315]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
-
Q
F
L
R
E
--
21
PsiBlast_CBE
85.43
49%
-119
- C1 -
-
2I9P
1
3HIDH_HUMAN
D:
[23-315]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
-
Q
F
L
R
E
--
65
HHSearch
83.89
49%
-118
- C1 -
-
2GF2
-
3HIDH_HUMAN
B:
[40-332]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
---
23
PsiBlast_CBE
83.29
49%
-120
- C1 -
-
2I9P
1
3HIDH_HUMAN
B:
[23-316]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
-
Q
F
L
R
E
E
-
22
PsiBlast_CBE
83.27
49%
-117
- C1 -
-
2I9P
1
3HIDH_HUMAN
C:
[23-315]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
-
Q
F
L
R
E
--
68
HHSearch
83.10
46%
-129
- C1 -
-
3OBB
2
SERDH_PSEAE
A:
[4-298]
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
V
Y
N
P
W
P
G
V
M
E
N
A
P
A
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
--
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
T
Q
-
2
PsiBlast_PDB
82.56
49%
-115
- C- -
-
2GF2
-
3HIDH_HUMAN
A:
[40-333]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
-
Q
F
L
R
E
E
-
66
HHSearch
82.00
49%
-114
- C- -
-
2GF2
-
3HIDH_HUMAN
A:
[40-334]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
-
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
S
G
R
C
W
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
--
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
E
E
-
4
PsiBlast_PDB
81.20
44%
-132
- C1 -
-
3OBB
2
SERDH_PSEAE
A:
[6-298]
--
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
V
Y
N
P
W
P
G
V
M
E
N
A
P
A
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
--
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
T
Q
-
5
PsiBlast_PDB
80.41
44%
-128
- C1 -
-
3Q3C
1
SERDH_PSEAE
A:
[5-297]
--
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
D
-
G
L
L
A
H
I
A
P
G
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
I
F
H
A
G
P
-
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
M
R
R
S
S
G
G
N
W
A
L
E
V
Y
N
P
W
P
G
V
M
E
N
A
P
A
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
--
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
T
Q
-
3
PsiBlast_PDB
73.23
42%
-128
- C- -
-
3CKY
-
HMGD_EUBBA
A:
[5-289]
I
K
I
G
F
I
G
L
G
A
M
G
K
P
M
A
I
N
L
L
K
E
G
V
T
V
Y
A
F
D
L
M
E
A
N
V
A
A
V
V
A
Q
G
A
Q
A
C
E
N
N
Q
K
V
A
A
A
S
D
I
I
F
T
S
L
P
N
A
G
I
V
E
T
V
M
N
G
P
G
G
V
L
S
A
C
K
A
G
T
V
I
V
D
M
S
S
V
S
P
S
S
T
L
K
M
A
K
V
A
A
E
K
G
I
D
Y
V
D
A
P
V
S
G
G
T
K
G
A
E
A
G
T
L
T
I
M
V
G
A
S
E
A
V
F
E
K
I
Q
P
V
L
S
V
I
G
K
D
I
Y
H
V
G
D
-
T
G
A
G
D
A
V
K
I
V
N
N
L
L
L
G
C
N
M
A
S
L
A
E
A
L
V
L
G
V
K
C
G
L
K
P
E
T
M
Q
E
I
I
G
K
S
S
G
R
S
Y
A
M
E
A
K
------
M
E
K
F
I
M
S
G
D
F
A
G
G
F
A
M
D
L
Q
H
K
D
L
G
L
A
L
E
A
G
K
E
G
N
V
P
L
P
M
T
A
--
M
A
T
Q
I
F
E
G
G
R
A
M
G
L
G
R
E
D
M
S
A
V
I
K
V
W
-----
83
HHSearch
72.84
35%
-116
- C1 -
-
1VPD
1
?
A:
[6-293]
M
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
H
T
G
D
-
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
R
G
G
L
A
G
S
T
V
L
D
A
K
A
P
-------
M
V
M
D
R
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
--
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
L
A
-
79
HHSearch
72.40
42%
-125
- C- -
-
3CKY
-
HMGD_EUBBA
A:
[5-293]
I
K
I
G
F
I
G
L
G
A
M
G
K
P
M
A
I
N
L
L
K
E
G
V
T
V
Y
A
F
D
L
M
E
A
N
V
A
A
V
V
A
Q
G
A
Q
A
C
E
N
N
Q
K
V
A
A
A
S
D
I
I
F
T
S
L
P
N
A
G
I
V
E
T
V
M
N
G
P
G
G
V
L
S
A
C
K
A
G
T
V
I
V
D
M
S
S
V
S
P
S
S
T
L
K
M
A
K
V
A
A
E
K
G
I
D
Y
V
D
A
P
V
S
G
G
T
K
G
A
E
A
G
T
L
T
I
M
V
G
A
S
E
A
V
F
E
K
I
Q
P
V
L
S
V
I
G
K
D
I
Y
H
V
G
D
-
T
G
A
G
D
A
V
K
I
V
N
N
L
L
L
G
C
N
M
A
S
L
A
E
A
L
V
L
G
V
K
C
G
L
K
P
E
T
M
Q
E
I
I
G
K
S
S
G
R
S
Y
A
M
E
A
K
M
E
K
F
------
I
M
S
G
D
F
A
G
G
F
A
M
D
L
Q
H
K
D
L
G
L
A
L
E
A
G
K
E
G
N
V
P
L
P
M
T
A
--
M
A
T
Q
I
F
E
G
G
R
A
M
G
L
G
R
E
D
M
S
A
V
I
K
V
W
E
Q
M
T
-
78
HHSearch
72.33
42%
-124
- C- -
-
3CKY
-
HMGD_EUBBA
B:
[5-293]
I
K
I
G
F
I
G
L
G
A
M
G
K
P
M
A
I
N
L
L
K
E
G
V
T
V
Y
A
F
D
L
M
E
A
N
V
A
A
V
V
A
Q
G
A
Q
A
C
E
N
N
Q
K
V
A
A
A
S
D
I
I
F
T
S
L
P
N
A
G
I
V
E
T
V
M
N
G
P
G
G
V
L
S
A
C
K
A
G
T
V
I
V
D
M
S
S
V
S
P
S
S
T
L
K
M
A
K
V
A
A
E
K
G
I
D
Y
V
D
A
P
V
S
G
G
T
K
G
A
E
A
G
T
L
T
I
M
V
G
A
S
E
A
V
F
E
K
I
Q
P
V
L
S
V
I
G
K
D
I
Y
H
V
G
D
-
T
G
A
G
D
A
V
K
I
V
N
N
L
L
L
G
C
N
M
A
S
L
A
E
A
L
V
L
G
V
K
C
G
L
K
P
E
T
M
Q
E
I
I
G
K
S
S
G
R
S
Y
A
M
E
A
K
M
E
K
F
------
I
M
S
G
D
F
A
G
G
F
A
M
D
L
Q
H
K
D
L
G
L
A
L
E
A
G
K
E
G
N
V
P
L
P
M
T
A
--
M
A
T
Q
I
F
E
G
G
R
A
M
G
L
G
R
E
D
M
S
A
V
I
K
V
W
E
Q
M
T
-
67
HHSearch
71.30
28%
-108
- C1 -
-
3DOJ
-
GLYR1_ARATH
A:
[22-309]
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
-
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
L
G
A
M
T
N
P
M
F
K
G
K
G
P
S
-------
M
N
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
--
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
64
HHSearch
71.01
33%
-112
- C1 -
-
3PEF
2
?
C:
[2-286]
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
M
A
N
P
M
F
A
L
K
G
G
L
-------
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
--
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
----
8
PsiBlast_PDB
70.70
35%
-136
- C1 -
-
3W6Z
1
?
A:
[21-300]
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
-
V
G
Y
G
Q
A
M
M
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
R
G
A
A
R
S
G
A
I
E
L
Y
L
P
K
L
L
K
G
D
L
S
P
-------
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
--
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
---------
7
PsiBlast_PDB
70.03
36%
-134
- C1 -
-
3WS7
2
?
A:
[21-300]
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
-
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
---
A
R
S
G
A
I
E
L
Y
L
P
K
L
L
K
G
D
L
S
P
-------
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
--
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
---------
9
PsiBlast_PDB
69.99
33%
-119
- C1 -
-
1VPD
1
?
A:
[8-289]
--
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
V
V
H
T
G
D
-
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
I
R
--
G
G
L
A
G
S
T
V
L
D
A
K
A
P
M
V
M
D
-----
R
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
--
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
-----
10
PsiBlast_PDB
69.91
33%
-115
- C1 -
-
3PEF
6
?
A:
[3-285]
-
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
-
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
A
G
A
-------
M
A
N
P
M
F
A
L
K
G
G
L
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
--
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
-----
26
PsiBlast_CBE
67.58
33%
-81
- C1 -
-
5JE8
5
?
B:
[10-296]
--
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
A
E
A
S
F
E
K
E
G
G
I
I
G
L
S
I
S
K
L
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
Y
F
G
A
E
G
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
L
N
V
S
Y
G
Q
------
S
R
I
Y
E
R
N
Y
K
S
F
I
A
P
E
N
Y
E
P
G
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
--
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
K
V
S
E
Q
--
6
PsiBlast_PDB
66.82
33%
-79
- C1 -
-
5JE8
2
?
A:
[10-296]
--
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
A
E
A
S
F
E
K
E
G
G
I
I
G
L
S
I
S
K
L
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
Y
F
G
A
E
G
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
L
N
V
S
Y
G
Q
------
S
R
I
Y
E
R
N
Y
K
S
F
I
A
P
E
N
Y
E
P
G
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
--
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
K
V
S
E
Q
--
24
PsiBlast_CBE
66.71
33%
-80
- C1 -
-
5JE8
4
?
D:
[10-296]
--
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
A
E
A
S
F
E
K
E
G
G
I
I
G
L
S
I
S
K
L
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
Y
F
G
A
E
G
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
L
N
V
S
Y
G
Q
------
S
R
I
Y
E
R
N
Y
K
S
F
I
A
P
E
N
Y
E
P
G
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
--
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
K
V
S
E
Q
--
25
PsiBlast_CBE
64.97
33%
-79
- C1 -
-
5JE8
1
?
C:
[10-296]
--
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
A
E
A
S
F
E
K
E
G
G
I
I
G
L
S
I
S
K
L
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
Y
F
G
A
E
G
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
L
N
V
S
Y
G
Q
------
S
R
I
Y
E
R
N
Y
K
S
F
I
A
P
E
N
Y
E
P
G
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
--
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
K
V
S
E
Q
--