@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNG3: (2017-11-14 )
MQFTEEQLLIRDMAKSFAQEQIKPNASDWDRDGTFPKETLTQMGQLGFMGMLVSEEWGGSDTGNLAYVLALEEVAAADGATSTIMSVHNSVGCVPILKFGTDEQKERFLKPLAQGEMIGAFALTEPHTGSDAAAIKTRAVKDGDDYILNGAKQFITSGNNAGVIIVFAVTDPSAGKKGISAFLVPRETPGYEVIRVEEKLGLHASDTCQIALTDVRIHKSLMLGKEGEGLKIALANLEGGRIGIAAQAVGLARAALEEATRYAKERITFGKPIFEHQTIAFRLASMATEIEAARQLVHYAARFKEVGQPCLNEASMAKLFASEMTERVCSSALQVFGGYGYLRDFPIERIYRDARICQIYEGTSDIQRLVIARSL
Atome Classification :
(30 SA)
--.........10........20........30........40........50........60.---..---.....70........80........90........100.......110.......120.......130.......-140...-.....150.......160.......170.----.-.----....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370...--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MQF
T
E
E
Q
L
L
I
R
D
M
A
K
S
F
A
Q
E
QIKPNASDWDRDGTF
P
K
E
T
L
T
QMGQLGF
M
G
M
L
V
SEEWGGSDT---G
N
---
L
A
Y
V
L
A
L
E
E
V
AAADGA
T
S
T
I
M
S
V
HNSVG
C
V
P
I
LKFGT
D
E
Q
K
E
R
F
L
K
P
L
AQG
E
M
I
G
A
F
A
LTEPHTGSDA
A
A
I
K
T
R
A-VK-DGD-
D
Y
I
L
N
G
A
K
Q
F
I
TSGNN
A
G
V
I
I
V
F
A
VTDPS----A-G----KKG
I
S
A
F
L
V
PRETPG
Y
E
V
I
R
V
E
E
K
LGLHASD
T
C
Q
I
A
L
T
D
V
R
I
H
K
S
LMLGKEGE
G
L
K
I
A
L
A
NLEGG
R
I
G
I
A
A
Q
A
V
G
L
A
R
A
A
L
E
E
A
T
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Y
A
K
E
RITFGKPIFEH
Q
T
I
A
F
R
L
A
S
M
A
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A
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R
Q
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V
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Y
A
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K
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CL
N
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A
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L
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M
T
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V
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S
A
L
Q
V
FGGY
G
Y
L
R
DF
P
I
E
R
I
Y
R
D
A
R
I
C
QIYE
G
T
S
D
I
Q
R
L
V
IARSL--
112
HHSearch
94.02
61%
-91
- C2 -
-
4N5F
2
?
A:
[13-385]
----
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
Y
---
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
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M
A
A
G
R
V
I
G
A
F
C
L
T
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P
H
A
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S
E
A
N
N
L
R
T
R
A
-
E
L
-
R
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
----
A
-
G
----
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
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D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
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G
G
R
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A
A
Q
A
L
G
I
A
R
A
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F
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K
A
R
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Y
A
G
E
R
V
Q
F
G
K
P
I
A
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H
Q
A
I
Q
Q
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L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
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M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
113
HHSearch
93.73
67%
-97
- C2 -
-
4U83
1
?
A:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
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A
A
R
D
Y
A
R
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R
I
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F
G
K
P
I
I
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H
Q
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V
A
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R
L
A
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M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
1
PsiBlast_PDB
93.73
67%
-97
- C2 -
-
4U83
1
?
A:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
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G
E
G
Y
K
I
A
L
A
N
L
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G
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A
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A
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A
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A
A
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A
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D
Y
A
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P
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A
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M
A
T
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I
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T
A
R
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V
L
H
A
A
A
L
R
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A
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K
P
C
L
T
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A
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M
A
K
L
V
A
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M
A
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Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
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R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
23
PsiBlast_CBE
93.41
67%
-95
- C2 -
-
4U83
5
?
B:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
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R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
22
PsiBlast_CBE
91.59
67%
-91
- C2 -
-
4U83
1
?
C:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
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G
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G
Y
K
I
A
L
A
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L
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G
G
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I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
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A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
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K
P
C
L
T
E
A
S
M
A
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L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
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G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
114
HHSearch
90.70
67%
-93
- C2 -
-
4U83
2
?
D:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
------
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
21
PsiBlast_CBE
90.70
67%
-93
- C2 -
-
4U83
2
?
D:
[8-382]
--
M
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
---
D
M
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
S
T
I
V
S
V
H
S
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
-
R
L
-
D
G
D
-
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
P
A
----
A
-
G
----
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
------
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
--
2
PsiBlast_PDB
87.12
61%
-43
- C2 -
-
4N5F
2
?
A:
[13-385]
----
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
Y
---
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
-
D
G
--
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
----
A
-
G
----
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
116
HHSearch
86.88
60%
-90
- C2 -
-
4M9A
1
?
A:
[14-385]
-----
T
E
D
Q
R
M
I
L
D
A
A
R
A
F
C
A
E
V
L
A
P
N
A
A
Q
W
D
R
E
S
H
L
P
D
E
V
V
A
Q
M
G
E
L
G
F
L
G
M
I
V
P
A
D
W
G
G
S
Y
T
---
D
Y
---
V
A
Y
A
L
A
L
E
E
I
A
A
G
C
A
S
C
A
T
L
V
S
V
H
N
S
V
G
C
G
P
V
L
N
Y
G
T
T
E
Q
K
E
R
W
L
R
D
L
A
S
G
K
T
V
G
A
F
S
L
T
E
P
H
-----
H
N
L
R
T
R
A
-
E
L
-
R
D
G
-
K
W
I
L
N
G
S
K
Q
F
V
T
N
G
A
R
A
G
L
A
I
V
F
A
M
T
D
P
D
----
E
-
G
----
K
R
G
L
S
A
F
V
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
L
E
N
C
A
I
P
Q
E
N
L
L
G
K
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
T
G
I
A
R
A
A
F
D
R
A
R
R
Y
A
R
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
A
E
K
L
A
N
M
A
T
Q
I
N
A
A
R
L
L
T
H
H
A
A
R
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
A
V
C
S
D
A
I
Q
I
H
G
G
Y
G
F
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
--
39
PsiBlast_CBE
85.38
43%
-86
- C2 -
-
2JIF
6
ACDSB_HUMAN
C:
[29-400]
----
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
-
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
-
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
-
G
----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
--
104
HHSearch
85.11
43%
-87
- C2 -
-
2JIF
10
ACDSB_HUMAN
D:
[28-400]
---
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
-
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
-
G
----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
--
40
PsiBlast_CBE
85.05
43%
-86
- C2 -
-
2JIF
7
ACDSB_HUMAN
B:
[29-400]
----
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
-
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
-
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
-
G
----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
--
38
PsiBlast_CBE
85.05
43%
-86
- C2 -
-
2JIF
10
ACDSB_HUMAN
D:
[29-400]
----
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
-
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
-
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
-
G
----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
--
32
PsiBlast_CBE
84.81
45%
-87
- C2 -
-
2VIG
5
ACADS_HUMAN
E:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
-
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
----
L
-
Q
----
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
121
HHSearch
84.68
46%
-88
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
K
K
M
G
G
L
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
---
D
Y
---
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
A
-
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
R
A
----
L
-
Q
----
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
--
41
PsiBlast_CBE
84.68
49%
-93
- C2 -
-
2DVL
2
?
B:
[3-370]
----
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
R
-
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
--------------
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
--
9
PsiBlast_PDB
84.56
43%
-87
- C2 -
-
2JIF
6
ACDSB_HUMAN
A:
[29-400]
----
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
-
P
Q
L
T
T
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
K
-
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
-
G
----
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
--
124
HHSearch
84.47
49%
-91
- C2 -
-
2DVL
2
?
A:
[3-370]
----
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
R
-
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
K
--------------
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
--
10
PsiBlast_PDB
84.40
49%
-91
- C2 -
-
2DVL
2
?
A:
[3-370]
----
L
T
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
V
A
V
I
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
R
-
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
--------------
K
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
--
6
PsiBlast_PDB
84.31
45%
-88
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[6-378]
----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
F
P
A
A
Q
V
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--