@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNI1: (2017-11-16 )
MTTNTQITEDRILILDFGSQYSQLIARRVREAGVYSEMYAFDMSEEDIRAFKPNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGLQTMSEQLGGKVELGTVHEFGYAEVDIVKRDQLIGNLQDRENQLHVWMSHGDKVSQIPEGFTITASTPSCPVAAVSDETRRFYGVQFHPEVTHTAKGEELLSNFVHKICGCGGLWTPEHIIDLRVEQLREQIGNEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFAENMGIRVIRADAEARFLNALAGVTDPEAKRKIIGREFIEVFAEEARKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGTTLGLPHSMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRDSGWYGKTAQAFAVFQPVKSVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPATIEWE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70...----.....80---.........90........100.......110.......---------------------------120...-----..-..130---.....------------------------....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......-250.......260.......270......-.280.........290.....----------..300.......310.......320----..---.-....330.......340...-....350.......360...--....370.......380.......390.......400.......410---------------------------------------------------------------------------------------------------------------------------------.......420.......430.......440.......450.-......460.......470.......480.----......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTTNTQITE
D
R
I
L
I
L
DF
G
S
Q
Y
S
Q
L
I
A
R
R
V
R
EAGV
Y
S
E
M
Y
AFDMSE
E
D
I
R
AFKPN
G
I
I
LSGGP
E
S
V
HEEGSPRA
P
----
Q
V
V
F
E
L----GV
P
V
L
G
I
C
Y
G
L
Q
T
M
S
E
QLGG
K
V
E
L
G
T
V
HEFGYA
E
V
D
I
V
K
---------------------------
R
D
Q
L
I
G
-----
N
L
-
Q
DR-----EN
Q
L
H
------------------------
V
W
MSHG
D
K
V
S
QIPE
G
F
T
I
TASTPSC
P
V
AAVSDET
R
R
F
Y
G
V
Q
FHPEVTHTAK
G
E
E
L
L
S
N
F
V
H
K
ICGCGGLW
T
P
E
H
I
I
D
L
R
V
E
Q
L
R
E
Q
IGN
E
K
V
L
L
G
LSGGV
D
S
S
V
V
A
A
L
L
H
K
AIG-D
Q
L
T
C
V
F
VDN
G
L
L
RLNE
G
D
Q
V
M
Q
M
F
A
ENM-
G
I
--
R
V
I
RADA
E
A
R
F
L
N
A
LAG----------VT
D
P
E
A
K
R
K
I
I
G
R
E
F
I
E
V
F
A
E
E
A
R
K----LD---G-
V
K
F
L
AQGTI
Y
P
D
V
I
E
S
A
A
SK-QG
K
A
H
V
I
KSHHNVGGL
P
D
D
L
--
A
F
E
L
V
E
P
L
R
D
L
F
K
D
E
V
R
K
L
G
T
TLGL
P
H
S
M
I
YRHPFPGP
G
L
G
V
R
I
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
A
D
I
L
R
L
A
D
D
I
F
M
Q
E
L
R
DSGWYGKT
A
Q
A
F
A
V
F
Q
P
V
K
S
-VGVVGDG
R
R
Y
A
W
V
I
A
L
R
A
V
E
T
V
D
F
M
T
A
R
F
A----HL
P
Y
E
L
V
D
K
I
S
T
R
I
M
N
E
I
K
D
V
S
R
V
V
Y
DVSSKPPA
T
I
EWE
23
PsiBlast_CBE
82.23
65%
-26
- C1 -
-
1GPM
3
GUAA_ECOLI
B:
[3-525]
--
E
N
--
I
H
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
---------------------------
D
S
A
L
V
R
-----
G
I
-
E
D
A
LTADG
K
P
L
L
D
------------------------
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
-------------------------
M
--
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
-
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
40
HHSearch
82.18
66%
-26
- C1 -
-
1GPM
3
GUAA_ECOLI
A:
[3-525]
----
E
N
I
H
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
---------------------------
D
S
A
L
V
R
-----
G
I
-
E
D
A
LTADG
K
P
L
L
D
------------------------
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A
-------------------------
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
-
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
1
PsiBlast_PDB
81.51
65%
-26
- C1 -
-
1GPM
3
GUAA_ECOLI
A:
[3-525]
--
E
N
--
I
H
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
---------------------------
D
S
A
L
V
R
-----
G
I
-
E
D
A
LTADG
K
P
L
L
D
------------------------
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A
-------------------------
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
-
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
21
PsiBlast_CBE
81.45
65%
-30
- C1 -
-
1GPM
3
GUAA_ECOLI
D:
[3-525]
--
E
N
--
I
H
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
---------------------------
D
S
A
L
V
R
-----
G
I
-
E
D
A
LTADG
K
P
L
L
D
------------------------
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
-------------------------
M
--
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
-
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
22
PsiBlast_CBE
80.82
65%
-24
- C1 -
-
1GPM
3
GUAA_ECOLI
C:
[3-525]
--
E
N
--
I
H
K
H
R
I
L
I
L
D
F
G
S
Q
Y
T
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
V
T
E
A
Q
I
R
D
F
N
P
S
G
I
I
L
S
G
G
P
E
S
T
T
E
E
N
S
P
R
A
P
----
Q
Y
V
F
E
A
----
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
E
F
G
Y
A
Q
V
E
V
V
N
---------------------------
D
S
A
L
V
R
-----
G
I
-
E
D
A
LTADG
K
P
L
L
D
------------------------
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
T
V
A
S
T
E
S
C
P
F
A
I
M
A
N
E
E
K
R
F
Y
G
V
Q
F
H
P
E
V
T
H
T
R
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
A
L
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
A
A
-------------------------
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
G
P
G
L
G
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
K
K
E
Y
C
D
L
L
R
R
A
D
A
I
F
I
E
E
L
R
K
A
D
L
Y
D
K
V
S
Q
A
F
T
V
F
L
P
V
R
S
-
V
G
V
M
G
D
G
R
K
Y
D
W
V
V
S
L
R
A
V
E
T
I
D
F
M
T
A
H
W
A
----
H
L
P
Y
D
F
L
G
R
V
S
N
R
I
I
N
E
V
N
G
I
S
R
V
V
Y
D
I
S
G
K
P
P
A
T
I
E
W
E
38
HHSearch
79.87
53%
-81
- C1 -
-
2YWC
1
GUAA_THET8
A:
[1-503]
----------
M
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
G
R
A
E
Y
G
K
A
L
L
T
R
H
----------------------------
E
G
P
L
F
R
-----
G
L
---------
E
G
E
V
Q
------------------------
V
W
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
L
-
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
-
G
-
V
D
H
L
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
-
R
A
L
-
G
V
--
N
L
L
V
V
D
A
K
E
R
F
L
K
A
L
K
G
----------
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
V
A
R
E
----
R
----
G
P
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
-------------------
G
G
L
P
E
D
L
--
E
F
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
R
L
E
I
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
E
K
V
A
Q
A
L
A
V
L
T
P
V
-------------
G
Y
V
L
A
L
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
39
HHSearch
79.85
53%
-86
- C1 -
-
2YWB
-
GUAA_THET8
C:
[1-503]
----------
M
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
----
Y
G
K
A
L
L
T
R
H
----------------------------
E
G
P
L
F
R
-----
G
L
---------
E
G
E
V
Q
------------------------
V
W
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
L
-
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
-
G
-
V
D
H
L
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
-
R
A
L
-
G
V
--
N
L
L
V
V
D
A
K
E
R
F
L
K
A
L
K
G
----------
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
V
A
R
E
----
R
----
G
P
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
S
A
--------------------------
E
F
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
R
L
E
I
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
E
K
V
A
Q
A
L
A
V
L
T
P
V
-------------
G
Y
V
L
A
L
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
4
PsiBlast_PDB
75.44
52%
-38
- C1 -
-
2YWC
1
GUAA_THET8
A:
[2-503]
-----------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
G
R
A
E
Y
G
K
A
---
L
L
T
---------------------------
R
H
E
--
G
-----
P
L
F
R
G
L
-----
E
G
E
V
Q
------------------------
V
W
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
L
-
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
G
V
-
D
H
L
-
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
-
R
A
L
-
G
V
--
N
L
L
V
V
D
A
K
E
R
F
L
K
A
L
K
G
----------
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
V
A
R
E
----
R
G
---
P
-
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
-------------------
G
G
L
P
E
D
L
--
E
F
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
R
L
E
I
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
E
K
V
A
Q
A
L
A
V
L
T
P
V
-------------
G
Y
V
L
A
L
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
3
PsiBlast_PDB
75.20
52%
-37
- C1 -
-
2YWB
-
GUAA_THET8
A:
[2-503]
-----------
V
L
V
L
D
F
G
S
Q
Y
T
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
A
P
L
E
E
V
L
K
H
R
P
Q
A
L
I
L
S
G
G
P
R
S
V
F
D
P
D
A
P
R
P
D
----
P
R
L
F
S
S
----
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
---
E
Y
G
K
A
---
L
L
T
---------------------------
R
H
E
--
G
-----
P
L
F
R
G
L
-----
E
G
E
V
Q
------------------------
V
W
M
S
H
Q
D
A
V
T
A
P
P
P
G
W
R
V
V
A
E
T
E
E
N
P
V
A
A
I
A
S
P
D
G
R
A
Y
G
V
Q
F
H
P
E
V
A
H
T
P
K
G
M
Q
I
L
E
N
F
L
-
E
L
A
G
V
K
R
D
W
T
P
E
H
V
L
E
E
L
L
R
E
V
R
E
R
A
G
K
D
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
A
K
A
G
V
-
D
H
L
-
A
V
F
V
D
H
G
L
L
R
L
G
E
R
E
E
V
E
G
A
L
-
R
A
L
-
G
V
--
N
L
L
V
V
D
A
K
E
R
F
L
K
A
L
K
G
----------
V
E
D
P
E
E
K
R
K
I
I
G
R
E
F
V
A
A
F
S
Q
V
A
R
E
----
R
G
---
P
-
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
E
--------------------
G
L
P
E
D
L
--
E
F
E
L
L
E
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
P
F
P
G
P
G
L
A
V
R
V
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
R
L
E
I
L
R
R
A
D
D
I
F
T
S
L
L
R
E
W
G
L
Y
E
K
V
A
Q
A
L
A
V
L
T
P
V
-------------
G
Y
V
L
A
L
R
A
V
T
T
E
D
F
M
T
A
D
W
A
----
R
L
P
L
E
F
L
D
E
A
A
R
R
I
T
R
R
V
P
E
I
G
R
V
V
Y
D
L
T
S
K
P
P
A
T
I
E
W
E
44
HHSearch
74.49
61%
-
- C1 -
-
3TQI
-
GUAA_COXBU
C:
[5-523]
------
I
H
Q
H
R
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
C
D
I
D
E
E
T
I
R
D
F
N
P
H
G
I
I
L
S
G
G
P
E
---------
A
P
----
A
F
I
F
E
I
----
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
-----
E
F
G
H
A
Q
L
R
V
L
N
---------------------------
P
A
F
L
F
D
-----
G
I
-
E
D
Q
VSPQG
E
P
L
L
D
------------------------
V
W
M
S
H
G
D
I
V
S
E
L
P
P
G
F
E
A
T
A
C
T
D
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
T
P
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
E
D
S
I
R
D
I
Q
E
K
V
G
K
E
Q
V
I
V
G
L
S
G
G
V
D
S
A
V
T
A
T
L
V
H
K
A
I
G
-
D
Q
L
V
C
V
L
V
D
T
G
L
L
R
L
N
E
V
D
E
V
L
N
V
F
Q
K
H
L
-
G
A
--
K
V
I
C
V
D
A
K
D
R
F
M
K
A
L
K
G
----------
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
Q
A
K
K
----
L
----
N
-
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
S
-----------------------------
K
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
S
A
E
Y
I
N
I
L
K
Q
A
D
A
I
F
I
E
E
L
K
K
S
D
Y
Y
H
Q
V
S
Q
A
F
A
V
F
M
P
L
K
S
-
V
--------
Y
G
Y
I
I
A
L
R
A
V
K
-------
Q
W
A
----
D
L
P
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
2
PsiBlast_PDB
73.70
60%
-
- C1 -
-
3TQI
-
GUAA_COXBU
A:
[5-523]
------
I
H
Q
H
R
I
L
I
L
D
F
G
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
C
D
I
D
E
E
T
I
R
D
F
N
P
H
G
I
I
L
S
G
G
P
E
---------
A
P
----
A
F
I
F
E
I
----
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
-----
E
F
G
H
A
Q
L
R
V
L
N
---------------------------
P
A
F
L
F
D
-----
G
I
-
E
D
Q
VSPQG
E
P
L
L
D
------------------------
V
W
M
S
H
G
D
I
V
S
E
L
P
P
G
F
E
A
T
A
C
T
D
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
T
P
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
P
N
W
T
T
K
H
I
I
E
D
S
I
R
D
I
Q
E
K
V
G
K
E
Q
V
I
V
G
L
S
G
G
V
D
S
A
V
T
A
T
L
V
H
K
A
I
G
-
D
Q
L
V
C
V
L
V
D
T
G
L
L
R
L
N
E
V
D
E
V
L
N
V
F
Q
K
H
L
-
G
A
--
K
V
I
C
V
D
A
K
D
R
F
M
K
A
L
K
G
----------
I
S
D
P
E
E
K
R
K
I
A
G
E
Q
F
I
R
V
F
E
E
Q
A
K
K
----
L
N
-----
V
K
W
L
G
Q
G
T
I
Y
P
D
V
I
E
S
-----------------------------
K
L
I
E
P
L
R
E
L
F
K
D
E
V
R
K
L
G
L
E
L
G
L
P
A
D
L
I
Y
R
H
P
F
P
G
P
G
L
A
I
R
I
L
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
S
A
E
Y
I
N
I
L
K
Q
A
D
A
I
F
I
E
E
L
K
K
S
D
Y
Y
H
Q
V
S
Q
A
F
A
V
F
M
P
L
K
S
-
V
--------
Y
G
Y
I
I
A
L
R
A
V
K
-------
Q
W
A
----
D
L
P
H
E
F
L
S
K
V
S
H
R
I
V
N
E
I
K
E
V
S
R
V
V
Y
D
M
T
N
K
P
P
A
T
I
E
W
-
41
HHSearch
69.92
40%
-56
- C1 -
-
2VXO
2
GUAA_HUMAN
B:
[27-697]
------
H
Y
E
G
A
V
V
I
L
D
A
G
A
Q
Y
G
K
V
I
D
R
R
V
R
E
L
F
V
Q
S
E
I
F
P
L
E
T
P
A
F
A
I
K
E
Q
G
F
R
A
I
I
I
S
G
G
P
N
S
V
Y
A
E
D
A
P
W
F
D
----
P
A
I
F
T
I
----
G
K
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
K
S
---
D
G
V
F
N
I
S
V
D
N
---------------------------
T
C
S
L
F
R
-----
G
L
---------
Q
K
E
E
V
------------------------
V
L
L
T
H
G
D
S
V
D
K
V
A
D
G
F
K
V
V
A
R
S
G
N
I
-
V
A
G
I
A
N
E
S
K
K
L
Y
G
A
Q
F
H
P
E
V
G
L
T
E
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
G
T
F
T
V
Q
N
R
E
L
E
C
I
R
E
I
K
E
R
V
G
T
S
K
V
L
V
L
L
S
G
G
V
D
S
T
V
C
T
A
L
L
N
R
A
L
N
Q
E
Q
V
I
A
V
H
I
D
N
G
F
M
R
K
R
E
S
Q
S
V
E
E
A
L
-
K
K
L
-
G
I
--
Q
V
K
V
I
N
A
A
H
S
F
Y
N
G
T
T
T
L
PRISKTLNM
T
T
S
P
E
E
K
R
K
I
I
G
D
T
F
V
K
I
A
N
E
V
I
G
E
----
M
N
LKP
E
-
E
V
F
L
A
Q
G
T
L
R
P
D
L
I
E
S
A
S
L
V
A
S
G
K
A
E
L
I
K
T
H
H
N
D
T
E
L
I
R
K
L
R
E
E
G
K
V
I
E
P
L
K
D
F
H
K
D
E
V
R
I
L
G
R
E
L
G
L
P
E
E
L
V
S
R
H
P
F
P
G
P
G
L
A
I
R
V
I
C
A
EEPYICKD
F
P
E
T
N
N
I
L
K
I
V
A
D
F
S
A
S
V
K
K
PH
T
L
L
Q
R
V
K
A
C
TT
E
E
D
Q
E
K
L
M
Q
I
T
S
L
H
S
L
N
A
F
L
L
P
I
K
T
V
G
V
Q
GD
C
R
S
Y
S
Y
V
C
G
I
S
S
KDEPD
W
E
S
L
I
F
L
A
R
L
I
P
R
M
C
HNVN
R
V
V
Y
I
F
G
PPVKEPPTDVTPTF
L
T
T
G
V
L
S
T
L
R
Q
A
D
F
E
A
H
N
I
L
R
E
S
G
Y
A
G
K
I
S
Q
M
P
V
I
L
T
P
L
H
F
D
R
D
P
L
Q
K
Q
P
S
C
Q
R
S
V
V
I
R
T
F
I
T
S
D
F
M
T
G
I
P
A
TPGN
E
I
P
V
E
V
V
L
K
M
V
T
E
I
-
K
K
I
P
G
I
S
R
I
M
Y
D
L
T
S
K
P
P
G
T
T
E
W
E
45
HHSearch
69.35
44%
-14
* C1 *
-
3UOW
1
?
A:
[7-556]
--------
Y
D
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
P
H
L
K
K
E
V
F
E
Y
F
L
E
K
----
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
NDNINNITYCRNFSS
A
M
D
L
Y
S
N
Y
K
L
M
N-
C
C
L
F
E
-----
N
I
-
K
-------
S
D
I
T
T
------------------------
V
W
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
T
F
L
-
K
S
T
-
F
P
D
M
N
I
T
K
I
D
A
S
E
N
F
L
S
N
L
Q
G
----------
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
A
V
N
N
I
DID
I
----
N
-
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
C
S
---------------------
L
--
K
F
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
I
N
K
H
K
L
N
I
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
N
Q
I
S
Q
A
F
A
V
L
L
S
S
K
S
-
V
--------
Y
D
Y
V
C
V
L
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
6
PsiBlast_PDB
65.14
41%
7
- C1 -
-
3UOW
1
?
A:
[8-556]
---------
D
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
P
H
L
K
----
K
E
V
F
E
Y
F
L
E
K
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
---------------------------
N
D
N
I
N
N
ITYCR
N
F
---------
S
S
A
M
D
L
Y
S
N
Y
K
L
M
NCCLFENIKSD
I
T
T
--
V
W
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
-
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
T
F
L
K
S
T
F
P
D
M
--
N
I
T
K
I
D
A
S
E
N
F
L
S
N
L
Q
G
----------
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
A
V
N
N
----
I
D
IDI
N
-
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
C
S
---------------------
L
--
K
F
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
I
N
K
H
K
L
N
I
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
N
Q
I
S
Q
A
F
A
V
L
L
S
S
K
S
-
V
--------
Y
D
Y
V
C
V
L
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
7
PsiBlast_PDB
63.11
41%
1
- C1 -
-
4WIO
1
?
A:
[19-567]
---------
D
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
Y
S
V
T
E
A
G
S
P
H
L
K
----
K
E
V
F
E
Y
F
L
E
K
K
I
P
I
F
G
I
A
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
---------------------------
N
D
N
I
N
N
ITYCR
N
F
---------
S
S
A
M
D
LYSN
Y
K
L
M
NECLFENIKSD
I
T
T
--
V
W
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
Q
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
T
F
L
K
S
T
F
P
D
M
--
N
I
T
K
I
D
A
S
E
N
F
L
S
N
L
Q
G
----------
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
A
V
N
N
----
I
D
IDI
N
-
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
C
S
K
--
N
L
S
D
T
I
K
T
H
H
-------
N
L
--
K
F
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
I
N
K
H
K
L
N
I
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
N
Q
I
S
Q
A
F
A
V
L
L
S
-------------
Y
D
Y
V
C
V
L
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
46
HHSearch
62.68
53%
-142
- C1 -
-
2DPL
-
GUAAB_PYRHO
A:
[4-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
-
G
M
--
N
L
H
Y
V
D
A
Q
D
R
F
F
S
A
L
K
G
----------
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
V
A
K
K
----
I
----
G
-
A
E
Y
L
I
Q
G
T
I
A
P
-----------------------------
L
--
N
L
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
P
E
K
I
R
I
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
--
R
P
W
Q
A
F
A
V
L
L
G
V
K
T
-
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
8
PsiBlast_PDB
62.63
52%
-142
- C1 -
-
2DPL
-
GUAAB_PYRHO
A:
[5-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
-
G
M
--
N
L
H
Y
V
D
A
Q
D
R
F
F
S
A
L
K
G
----------
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
V
A
K
K
----
I
----
G
-
A
E
Y
L
I
Q
G
T
I
A
P
-----------------------------
L
--
N
L
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
P
E
K
I
R
I
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
--
R
P
W
Q
A
F
A
V
L
L
G
V
K
T
-
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
9
PsiBlast_PDB
62.53
52%
-139
- C1 -
-
3A4I
-
GUAAB_PYRHO
A:
[5-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
V
E
E
K
V
R
E
I
R
E
T
V
G
D
S
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
H
K
A
I
G
-
D
R
L
H
A
V
F
V
N
T
G
F
L
R
K
G
E
P
E
F
V
V
K
T
F
R
D
E
F
-
G
M
--
N
L
H
Y
V
D
A
Q
D
R
F
F
S
A
L
K
G
----------
V
T
D
P
E
E
K
R
K
I
I
G
R
V
F
I
E
V
F
E
E
V
A
K
K
----
I
----
G
-
A
E
Y
L
I
Q
G
T
I
A
P
--------------------------------
N
L
K
L
I
E
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
P
F
P
G
P
G
L
A
V
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
V
T
P
E
K
I
R
I
V
R
E
A
N
A
I
V
E
E
E
V
E
R
A
G
L
--
R
P
W
Q
A
F
A
V
L
L
G
V
K
T
-
V
G
V
Q
G
D
I
R
A
Y
K
E
T
I
A
V
R
I
V
E
S
I
D
G
M
T
A
N
A
M
----
N
V
P
W
E
V
L
Q
R
I
A
F
R
I
T
S
E
I
P
E
V
G
R
V
L
Y
D
I
T
N
K
P
P
A
T
I
E
F
E
5
PsiBlast_PDB
60.63
41%
4
- C1 -
-
4WIM
-
?
A:
[7-555]
---------
D
K
I
L
V
L
N
F
G
S
Q
Y
F
H
L
I
V
K
R
L
N
N
I
K
I
F
S
E
T
K
D
Y
G
V
E
L
K
D
I
K
D
M
N
I
K
G
V
I
L
S
G
G
P
-
S
V
T
E
A
G
S
P
H
L
K
----
K
E
V
F
E
Y
F
L
EK
K
I
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
E
Y
G
C
T
D
V
N
I
L
R
---------------------------
N
D
N
I
N
N
ITYCR
N
F
-
G
D
S
-----
S
S
A
M
D
L
Y
S
N
Y
KLMNETCCLFENIKSD
I
T
T
V
W
M
N
H
N
D
E
V
T
K
I
P
E
N
F
Y
L
V
S
S
S
E
N
C
L
I
C
S
I
Y
N
K
E
Y
N
I
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
K
Q
F
D
P
I
R
Y
H
E
L
E
L
K
N
I
E
K
Y
K
H
D
H
Y
V
I
A
A
M
S
G
G
I
D
S
T
V
A
A
A
Y
T
H
K
I
F
K
-
E
R
F
F
G
I
F
I
D
N
G
L
L
R
K
N
E
A
E
N
V
Y
T
F
L
K
S
T
F
P
D
M
--
N
I
T
K
I
D
A
S
E
N
F
L
S
N
L
Q
G
----------
V
T
D
P
E
Q
K
R
K
I
I
G
K
L
F
I
E
E
F
E
K
A
V
N
N
----
I
D
IDI
N
-
K
T
F
L
L
Q
G
T
L
Y
P
D
I
I
E
S
K
C
S
---------------------
L
--
K
F
K
L
F
E
P
F
K
Y
L
F
K
D
D
V
K
T
L
S
R
E
L
N
L
P
E
E
I
T
N
R
H
P
F
P
G
P
G
L
A
I
R
V
I
G
E
---------------------------------------------------------------------------------------------------------------------------------
I
N
K
H
K
L
N
I
L
R
E
V
D
D
I
F
I
N
D
L
K
Q
Y
G
L
Y
N
Q
I
S
Q
A
F
A
V
L
L
S
S
K
------------
D
Y
V
C
V
L
R
A
V
K
T
S
S
F
M
T
A
N
W
Y
----
Q
I
P
Y
D
I
L
D
K
I
T
T
R
I
L
S
E
V
K
G
V
N
R
I
L
Y
D
V
S
S
K
P
P
A
T
I
E
F
E
62
Fugue
57.90
68%
-159
- C1 -
-
1GPM
2
GUAA_ECOLI
A:
[208-404]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
P
A
K
I
I
D
D
A
V
A
R
I
R
E
Q
V
G
D
D
K
V
I
L
G
L
S
G
G
V
D
S
S
V
T
A
M
L
L
H
R
A
I
G
-
K
N
L
T
C
V
F
V
D
N
G
L
L
R
L
N
E
A
E
Q
V
L
D
M
F
G
D
H
F
-
G
L
--
N
I
V
H
V
P
A
E
D
R
F
L
S
A
L
A
G
----------
E
N
D
P
E
A
K
R
K
I
I
G
R
V
F
V
E
V
F
D
E
E
A
L
K
----
L
E
---
D
-
V
K
W
L
A
Q
G
T
I
Y
P
D
V
I
E
S
-----------------------
A
A
--
K
M
G
L
V
E
P
L
K
E
L
F
K
D
E
V
R
K
I
G
L
E
L
G
L
P
Y
D
M
L
Y
R
H
P
F
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------