@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNJ4: (2017-11-16 )
MPAVPHSSLNPVLIQLEQVSVHRDQRDILKKVDFALHENEIVTLIGPNGAGKSTLIKVLLGILKPSSGRVISNKKLKMAYVPQKFNPSHSLPLRVQDLLDLEKCSPALRQEIIQDTGIAKLQQSKVQQLSGGERQRVLLARALLRKPDILVLDEPMQGLDIQSEAELYEYVRSLPERYGCAILIVSHDLQWVMQGTQRVVCLNKHICCSGLPESIQQHPEYQAIFGTHRVFYQHHHDHCAHGDAAHPCPHNNRPHIHPEPEA
Atome Classification :
(25 SA)
.........10.-.......20....-----....30....-....40........50........60.......------.70--------.------------..-----------.---------------...----------..80...---..-----------...90.--------..--.....---100..-------.--------....110-----------.----.---....-----------.----.-----------.-----------120......-------..130.......140...------....150.......160.......170.......180.......-190.......200--.-.-.....-210.......220--.........230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPAVPHSSLN
P
V
-
L
I
Q
L
E
Q
V
SVH
R
D
Q
-----
R
D
I
L
K
K
V
D
F
A-LHEN
E
I
V
T
L
IGPNGA
G
K
S
T
L
I
K
V
L
L
G
I
LKPSS
G
------
R
V
---------I------------SN-----------K---------------
K
L
K
----------
M
A
YVPQK---FN-----------PSHSLP--------
L
R
--
V
Q
D
L
L
---
D
L
E
KC-------
S
--------
P
A
L
R
Q
-------------
E
----
I
---
I
Q
DT-----------G----
I
-----------
A
-----------
K
-
L
Q
Q
S
K
V
Q
-------
Q
LSGG
E
R
Q
R
V
L
L
A
R
A
L
LR------KP
D
I
L
V
LDEPMQGLDI
Q
S
E
A
E
L
Y
E
Y
V
R
S
L
P
E
RY
G
C
A
I
L
I
VSH
D
L
-
Q
W
V
M
QGT
Q
R
V
V
C
L--N-K-HICCS-G
L
P
E
S
I
Q
QHP
E
----
Y
Q
A
I
F
G
T
H
R
V
F
Y
QHHHDHCAHGDAAHPCPHNNRPHIHPEPEA
19
PsiBlast_PDB
70.89
29%
5
- C1 -
-
4G1U
-
HMUV_YERPE
C:
[5-253]
-------
A
V
T
P
V
A
L
L
E
A
S
H
L
H
Y
H
V
Q
Q
-----
Q
A
L
I
N
D
V
S
L
H
-
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
------
E
C
HLLGQNLNS
W
------------
Q
P
-----------
K
---------------
A
L
A
----------
R
T
R
A
V
M
R
---
Q
Y
-----------
S
E
L
A
F
P
--------
F
S
--
V
S
E
V
I
---
Q
M
G
R
A
PYGGSQD
R
--------
Q
A
L
-
Q
-------------
Q
----
V
---
M
A
Q
T
-----------
D
----
C
-----------
L
-----------
A
-
L
A
Q
R
D
Y
R
-------
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
-
N
L
A
A
L
Y
A
D
R
I
M
L
L
AQ
G
-
K
-
L
V
A
C
--
G
T
P
E
E
V
L
N
A
E
T
LTQW
Y
Q
A
D
L
G
V
S
R
---------------------------------
14
PsiBlast_PDB
69.71
28%
-24
- C1 -
-
4P32
1
LPTB_ECOLI
A:
[15-233]
-------------------------------
R
R
V
V
E
D
V
S
L
T
-
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
------
N
I
---------
I
I
DDDDISLLP
L
H
A
R
-----------
A
---------------
R
R
G
----------
I
G
Y
L
P
Q
E
---
A
S
-----------
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
--
I
R
D
D
L
---
S
A
E
Q
R
-------
E
--------
D
R
A
-
N
-------------
E
----
L
---
M
E
E
F
-----------
H
----
I
-----------
E
-----------
H
-
L
R
D
S
M
G
Q
-------
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
-
R
E
T
L
A
V
C
E
R
A
Y
I
V
--
S
-
Q
G
H
L
I
A
H
-
G
T
P
T
E
I
L
Q
D
E
H
----
V
K
R
V
Y
-------------------------------------
17
PsiBlast_PDB
67.76
28%
-20
- C1 -
-
4P31
1
LPTB_ECOLI
A:
[15-233]
-------------------------------
R
R
V
V
E
D
V
S
L
T
-
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
------
N
I
---------
I
I
DDDDISLLP
L
H
A
R
-----------
A
---------------
R
R
G
----------
I
G
Y
L
P
Q
E
---
A
S
-----------
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
--
I
R
D
D
L
---
S
A
E
Q
R
-------
E
--------
D
R
A
-
N
-------------
E
----
L
---
M
E
E
F
-----------
H
----
I
-----------
E
-----------
H
-
L
R
D
S
M
G
Q
-------
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
-
R
E
T
L
A
V
C
E
R
A
Y
I
V
--
S
-
Q
G
H
L
I
A
H
-
G
T
P
T
E
I
L
Q
D
E
H
----
V
K
R
V
Y
-------------------------------------
15
PsiBlast_PDB
66.88
28%
-15
- C1 -
-
4QC2
1
?
A:
[16-234]
-------------------------------
R
R
V
V
E
D
V
S
L
T
-
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
------
N
I
---------
I
I
DDDDISLLP
L
H
A
R
-----------
A
---------------
R
R
G
----------
I
G
Y
L
P
Q
E
---
A
S
-----------
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
--
I
R
D
D
L
---
S
A
E
Q
R
-------
E
--------
D
R
A
-
N
-------------
E
----
L
---
M
E
E
F
-----------
H
----
I
-----------
E
-----------
H
-
L
R
D
S
M
G
Q
-------
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
-
R
E
T
L
A
V
C
E
R
A
Y
I
V
--
S
-
Q
G
H
L
I
A
H
-
G
T
P
T
E
I
L
Q
D
E
H
----
V
K
R
V
Y
-------------------------------------
18
PsiBlast_PDB
64.23
27%
-19
- C1 -
-
4P33
6
LPTB_ECOLI
A:
[15-233]
-------------------------------
R
R
V
V
E
D
V
S
L
T
-
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
------
N
I
---------
I
I
DDDDISLLP
L
H
A
R
-----------
A
---------------
R
R
G
----------
I
G
Y
L
P
Q
E
---
A
S
-----------
I
F
R
R
L
S
V
Y
D
N
L
M
A
V
L
Q
--
I
R
D
D
L
---
S
A
E
Q
R
-------
E
--------
D
R
A
-
N
-------------
E
----
L
---
M
E
E
F
-----------
H
----
I
-----------
E
-----------
H
-
L
R
D
S
M
G
Q
-------
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
-
R
E
T
L
A
V
C
E
R
A
Y
I
V
--
S
-
Q
G
H
L
I
A
H
-
G
T
P
T
E
I
L
Q
D
E
H
----
V
K
R
V
Y
-------------------------------------
1
PsiBlast_PDB
63.96
29%
-28
- C1 -
-
2IT1
-
?
A:
[2-232]
-----------
V
-
E
I
K
L
E
N
I
V
K
K
F
G
N
-----
F
T
A
L
N
N
I
N
L
K
-
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
------
K
I
---------
Y
------------
F
D
-----------
E
---------------
K
D
V
----------
T
E
L
P
P
K
D
---
R
N
V
G
L
V
F
QNWALY
P
H
M
T
V
Y
--------
K
N
--
I
A
F
P
L
---
E
L
R
K
------------------
A
P
R
E
-------------
E
----
I
D
K
K
V
R
E
V
-----------
A
K
M
L
H
I
-----------
D
-----------
K
-
L
L
N
R
Y
P
W
-------
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
-
A
E
A
L
A
M
A
D
R
I
A
V
I
--
R
-
E
G
E
I
L
Q
V
-
G
T
P
D
E
V
Y
Y
K
P
K
----
Y
K
F
V
G
G
------------------------------------
40
HHSearch
63.20
27%
-47
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[3-223]
-------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
-----
V
V
V
S
K
D
I
N
L
D
-
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
------
D
L
---------
F
------------
I
G
EKRMNDTPP--
A
---------------
E
R
G
----------
V
G
M
V
F
Q
S
---
Y
A
-----------
L
Y
P
--
H
--------
L
S
--
V
A
E
N
M
---
S
F
G
L
K
-------
L
A
GAK
K
E
V
I
N
Q
R
V
N
-------------
Q
----
V
---
A
E
V
L
-----------
Q
----
L
-----------
A
-----------
H
-
L
L
D
R
K
P
K
-------
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
-
V
E
A
M
T
L
A
D
K
I
V
V
L
--
D
A
G
-
R
V
A
Q
V
-
G
K
P
L
E
L
Y
H
-------------------------------------------------
39
HHSearch
63.11
27%
-51
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-223]
-------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
-----
V
V
V
S
K
D
I
N
L
D
-
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
------
D
L
---------
F
------------
I
G
EKRMNDTPP--
A
---------------
E
R
G
----------
V
G
M
V
F
Q
S
---
Y
A
-----------
L
Y
P
--
H
--------
L
S
--
V
A
E
N
M
---
S
F
G
L
K
-------
L
A
GAK
K
E
V
I
N
Q
R
V
N
-------------
Q
----
V
---
A
E
V
L
-----------
Q
----
L
-----------
A
-----------
H
-
L
L
D
R
K
P
K
-------
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
-
V
E
A
M
T
L
A
D
K
I
V
V
L
--
D
A
G
-
R
V
A
Q
V
-
G
K
P
L
E
L
Y
H
-------------------------------------------------
42
HHSearch
62.69
27%
-42
* C1 *
-
4YER
2
?
A:
[3-254]
----------
E
D
-
I
I
V
V
E
N
L
V
K
K
F
G
D
-----
F
E
A
V
K
G
V
S
F
S
-
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
------
K
A
---------
W
------------
V
A
GHDVLKE
P
R
E
-
V
---------------
R
R
K
----------
I
G
I
V
F
Q
D
---
Q
S
-----------
L
D
R
--
E
--------
L
T
--
A
Y
E
N
M
---
Y
I
H
G
K
-------
I
Y
G
Y
G
G
E
K
L
K
K
R
I
L
-------------
E
----
L
---
L
E
F
V
-----------
E
----
L
-----------
L
-----------
E
-
F
K
D
K
P
V
K
-------
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
------
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
-
D
E
A
E
Q
L
A
D
R
V
A
I
I
--
D
H
G
-
K
I
I
A
L
-
G
T
P
T
E
L
K
R
-------------------------------------------------
51
HHSearch
62.66
28%
-41
- C1 -
-
2YYZ
1
?
A:
[2-223]
-----------
P
-
S
I
R
V
V
N
L
K
K
Y
F
G
K
-----
V
K
A
V
D
G
V
S
F
E
-
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
------
E
I
---------
Y
------------
F
D
-----------
D
VLVNDIPPK------
Y
R
E
----------
V
G
M
V
F
Q
N
---
Y
A
-----------
L
Y
P
--
H
--------
M
T
--
V
F
E
N
I
---
A
F
P
L
R
-------
A
RRISKD
E
V
E
K
R
V
V
-------------
E
----
I
---
A
R
K
L
-----------
L
----
I
-----------
D
-----------
N
-
L
L
D
R
K
P
T
-------
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
------
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
-
A
E
A
M
T
M
A
S
R
I
A
V
F
--
N
Q
G
-
K
L
V
Q
Y
-
G
T
P
D
E
V
Y
D
-------------------------------------------------
38
HHSearch
62.13
26%
-48
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-228]
-----------
A
-
A
L
H
I
G
H
L
S
K
S
F
Q
N
-----
T
P
V
L
N
D
I
S
L
S
-
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
------
E
I
---------
S
------------
L
S
-----------
G
KTIFSKNTNLPVR--
E
R
R
----------
L
G
Y
L
V
Q
E
---
G
V
-----------
L
F
P
--
H
--------
L
T
--
V
Y
R
N
I
---
A
Y
G
L
G
-------
N
GKGRTAQE
R
Q
R
I
E
-------------
A
----
M
---
L
E
L
T
-----------
G
----
I
-----------
S
-----------
E
-
L
A
G
R
Y
P
H
-------
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
-
E
E
A
L
Q
Y
A
D
R
I
A
V
M
--
K
Q
G
-
R
I
L
Q
T
-
A
S
P
H
E
L
Y
R
-------------------------------------------------
2
PsiBlast_PDB
58.25
29%
-23
- C1 -
-
1Z47
-
?
A:
[31-237]
----------------------------------
V
R
G
V
S
F
Q
-
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
------
D
V
---------
W
------------
I
G
-----------
G
---------------
K
R
V
----------
T
D
L
P
P
Q
K
---
R
N
V
G
L
V
F
------
Q
N
Y
A
L
-------------
F
Q
H
M
T
---
V
Y
D
N
V
-------
S
--------
F
G
L
R
E
K
RVP
K
D
E
M
D
A
R
V
R
E
----
L
---
L
R
F
M
-----------
R
----
L
-----------
E
-----------
S
-
Y
A
N
R
F
P
H
-------
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
-
E
E
A
L
E
V
A
D
R
V
L
V
L
--
H
-
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
E
K
P
-----------------------------------------------
56
HHSearch
57.82
26%
-52
- C1 -
-
3NHB
2
A:
[50-277]
---------
Q
K
G
-
R
I
E
F
E
N
V
H
F
S
Y
A
D
-----
R
E
T
L
Q
D
V
S
F
T
-
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
------
C
I
---------
R
------------
I
D
-----------
G
QDISQVT
Q
A
S
L
----
R
S
H
----------
I
G
V
V
P
Q
D
---
T
V
-----------
L
---
F
N
--------
D
T
--
I
A
D
N
I
---
R
Y
G
R
V
-------
T
AG------
N
D
E
V
E
-------------
A
----
A
---
A
Q
A
A
-----------
G
----
I
-----------
H
D
A
I
M
A
FPEGYR
T
-
Q
V
G
E
R
G
L
-------
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
------
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
N
R
T
T
I
V
V
A
H
R
L
-
S
T
V
V
-
N
A
D
Q
I
L
V
I
--
K
D
G
-
C
I
V
E
R
-
G
R
H
E
A
L
L
S
-------------------------------------------------
52
HHSearch
55.60
26%
-47
- C1 -
-
4TQU
-
?
T:
[3-224]
-----------
A
-
S
V
S
I
Q
N
V
V
K
R
Y
D
K
-----
T
T
V
V
H
G
V
S
L
D
-
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
------
T
I
---------
R
------------
I
D
-----------
G
RVINDLAPK------
D
R
D
----------
V
A
M
V
F
Q
N
---
Y
A
-----------
L
Y
P
--
H
--------
L
N
--
V
R
D
N
I
---
S
F
G
L
R
-------
L
KRTKKSVI
D
A
A
V
K
-------------
T
----
A
---
A
D
I
L
-----------
G
----
L
-----------
Q
-----------
P
-
L
L
E
R
K
P
S
-------
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
------
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
-
V
E
A
M
T
L
A
D
R
I
V
V
M
--
R
D
G
-
L
I
E
Q
I
-
G
K
P
M
D
L
F
L
-------------------------------------------------
49
HHSearch
54.73
28%
-
- C1 -
-
4HUQ
-
ECFA2_LACBA
A:
[2-235]
-------------
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
GTPMA
H
T
A
L
T
D
V
S
L
T
-
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
------
T
I
---------
K
------------
I
D
-----------
E
F
T
I
T
PETTNAAL
K
P
L
R
Q
H
----------
V
G
M
V
F
Q
F
---
P
E
-----------
N
Q
L
-
F
E
--------
E
T
--
V
R
Q
D
I
---
A
F
G
P
K
-------
N
F
GMA
D
A
D
A
L
A
L
A
D
-------------
E
----
M
---
L
T
T
V
-----------
G
----
L
-----------
D
-----------
Q
S
Y
A
E
R
S
P
F
-------
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
------
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
G
L
T
I
V
L
V
T
H
Q
M
-
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
--
H
E
G
-
R
L
M
K
F
-
G
T
P
A
D
V
F
S
-------------------------------------------------
50
HHSearch
54.58
28%
-
- C1 -
-
4HZU
-
ECFA2_LACBA
B:
[2-235]
-------------
A
I
A
F
E
H
V
T
Y
T
Y
Q
A
GTPMA
H
T
A
L
T
D
V
S
L
T
-
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
------
T
I
---------
K
------------
I
D
-----------
E
FTITPETTNAALKPL
R
Q
H
----------
V
G
M
V
F
Q
F
---
P
E
-----------
N
Q
L
-
F
E
--------
E
T
--
V
R
Q
D
I
---
A
F
G
P
K
-------
N
FGMADADA
L
A
L
A
D
-------------
E
----
M
---
L
T
T
V
-----------
G
----
L
-----------
D
-----------
Q
S
Y
A
E
R
S
P
F
-------
E
L
S
G
G
Q
M
R
R
V
A
I
A
G
V
L
A
M
------
Q
P
K
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
L
F
A
R
L
H
Q
E
Q
G
L
T
I
V
L
V
T
H
Q
M
-
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
--
H
E
G
-
R
L
M
K
F
-
G
T
P
A
D
V
F
S
-------------------------------------------------
41
HHSearch
54.05
28%
4
- C1 -
-
5U1D
-
TAP1_HUMAN
A:
[500-731]
----------
E
G
-
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
RPD--
V
L
V
L
Q
G
L
T
F
T
-
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
------
Q
L
---------
L
------------
L
D
GKPLPQYE
H
R
Y
L
---------------
H
R
Q
----------
V
A
A
V
G
Q
E
---
P
Q
-----------
V
---
F
G
--------
R
S
--
L
Q
E
N
I
---
A
Y
G
L
T
-------
Q
K
P
T
-----
M
E
E
I
T
-------------
A
----
A
---
A
V
K
S
GA
H
S
F
I
S
G
LPQ
G
----
Y
-----------
D
-----------
T
-
E
V
D
E
A
G
S
-------
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
L
L
Y
E
S
P
E
R
Y
S
R
S
V
L
L
I
T
Q
H
L
-
S
L
V
E
-
Q
A
D
H
I
L
F
L
--
E
G
G
-
A
I
R
E
G
-
G
T
H
Q
Q
L
M
E
-------------------------------------------------
20
PsiBlast_PDB
53.47
26%
-37
- C1 -
-
4TQU
-
?
S:
[5-226]
--------------
V
S
I
Q
N
V
V
K
R
Y
D
K
-----
T
T
V
V
H
G
V
S
L
D
-
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
TIRIDG
R
V
---------
I
------------
N
D
LAP--------
K
---------------
D
R
D
----------
V
A
M
V
F
Q
N
---
Y
A
-----------
L
Y
P
H
L
N
--------
V
R
DN
I
S
F
G
L
---
R
L
K
R
T
-------
K
--------
K
S
V
I
D
-------------
A
----
A
---
V
K
T
A
ADIL-------
G
----
L
-----------
Q
-----------
P
-
L
L
E
R
K
P
S
-------
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
------
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
-
V
E
A
M
T
L
A
D
R
I
V
V
M
--
R
-
D
-
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
-----------------------------------------------
12
PsiBlast_PDB
52.64
34%
-9
- C1 -
-
2ONK
-
WTPC_ARCFU
A:
[18-209]
-------------------------------------
V
D
F
E
-
M
G
R
D
Y
C
V
-
L
L
G
P
T
G
A
G
K
S
V
F
L
E
L
I
A
G
I
V
K
P
D
R
G
------
E
V
---------
R
------------
L
N
GADITPLPP--
E
---------------
R
R
G
----------
I
G
F
V
P
Q
D
---
Y
A
-----------
L
F
P
H
L
S
--------
V
Y
--
R
N
I
A
Y
---
G
L
R
N
V
-------
E
--------
R
V
E
R
D
-------------
R
R
V
R
E
M
---
A
E
K
L
-----------
G
----
I
-----------
A
-----------
H
-
L
L
D
R
K
P
A
-------
R
L
S
G
G
E
R
Q
R
V
A
L
A
R
A
L
V
I
------
Q
P
R
L
L
L
L
D
E
P
L
S
A
V
D
L
K
T
K
G
V
L
M
E
E
L
R
F
V
Q
R
E
F
D
V
P
I
L
H
V
T
H
D
L
I
E
A
A
M
L
A
D
E
V
A
V
M
L
--
N
-
G
-
R
I
V
E
K
-
G
--------------------------------------------------------
45
HHSearch
52.21
25%
-13
- C1 -
-
4AYX
1
ABCBA_HUMAN
A:
[339-570]
----------
Q
G
-
A
L
E
F
K
N
V
H
F
A
Y
P
A
RPE--
V
P
I
F
Q
D
F
S
L
S
-
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
------
T
I
---------
S
------------
L
D
GHDIRQLN
P
V
W
L
---------------
R
S
K
----------
I
G
T
V
S
Q
E
---
P
I
-----------
L
F
---
S
--------
C
S
--
I
A
E
N
I
---
A
Y
G
A
D
-------
D
PSSVT---
A
E
E
I
Q
-------------
R
----
V
---
A
E
V
A
-----------
N
----
A
V
A
F
I
R
N
FPQGF
N
-----------
T
-
V
V
G
E
K
G
V
-------
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
------
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
-
S
T
I
K
-
N
A
N
M
V
A
V
L
--
D
Q
G
-
K
I
T
E
Y
-
G
K
H
E
E
L
L
S
-------------------------------------------------
8
PsiBlast_PDB
51.08
33%
-35
- C1 -
-
3J15
1
?
B:
[365-531]
------------------------------------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
V
-----------------------
E
-----------
W
---------------
D
L
T
----------
V
A
Y
K
P
Q
Y
---
I
K
-----------
A
E
Y
E
G
T
------------
V
Y
E
L
L
S
K
I
D
S
S
K
L
N
------
S
--------
N
F
Y
K
T
-------------
E
----
L
---
L
K
P
L
-----------
G
----
I
-----------
I
-----------
D
-
L
Y
D
R
N
V
E
-------
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
-
L
M
I
D
Y
V
S
D
R
L
I
V
F
---------------------------------------------------------------------
11
PsiBlast_PDB
44.08
35%
-17
- C1 -
-
1YQT
1
?
A:
[309-462]
------------------------------------------
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
I
-----------------------
E
-----------
W
---------------
D
L
T
----------
V
A
Y
K
P
Q
Y
---
I
K
-----------
A
D
Y
E
G
T
------------
V
Y
E
L
L
S
K
I
D
A
S
K
L
N
------
S
--------
N
F
Y
K
T
-------------
E
----
L
---
L
K
P
L
-----------
G
----
I
-----------
I
-----------
D
-
L
Y
D
R
E
V
N
-------
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
-----------------------------------------------------------------------------------
27
PsiBlast_CBE
40.59
34%
13
- C1 -
-
5L22
2
?
A:
[348-529]
---------------------------------
V
L
R
N
I
N
M
R
-
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
------
T
V
E
--------
I
------------
D
G
-----------
A
---------------
D
L
K
QWD
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
IEL
F
E
-----------
G
T
V
A
E
N
--------
I
A
--
R
F
G
E
L
---
D
S
E
K
I
-------
I
--------
E
A
A
K
L
-------------
S
----
G
---
A
H
D
V
----------------
I
-----------
I
-----------
K
-
L
P
D
G
Y
D
T
Y
I
G
PGGI
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
------
N
P
R
I
V
I
L
D
E
P
D
S
N
L
D
E
Q
G
E
Q
A
L
Y
N
A
L
I
E
L
K
K
R
-
K
V
T
T
I
I
V
S
H
R
I
-
R
---------------------------------------------------------------------------------
24
PsiBlast_CBE
39.01
31%
-2
- C1 -
-
4CRM
1
RLI1_YEAST
P:
[358-541]
--------------------
S
L
K
K
T
Q
-----
G
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
------
Q
D
---------
I
------------
P
----------------------------
K
L
N
----------
V
S
M
K
P
Q
K
---
I
A
-----------
P
K
--
F
P
--------
G
T
--
V
R
Q
L
F
----
F
K
K
I
RGQFL--
N
--------
P
Q
F
Q
T
-------------
D
----
V
---
V
K
P
L
-----------
R
----
I
-----------
D
-----------
D
-
I
I
D
Q
E
V
Q
-------
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
------
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
-
I
M
A
T
Y
L
A
D
K
V
I
V
F
---------------------------------------------------------------------
26
PsiBlast_CBE
37.65
34%
16
- C1 -
-
5L22
2
?
B:
[348-529]
---------------------------------
V
L
R
N
I
N
M
R
-
I
L
P
G
E
F
V
A
I
I
G
P
S
G
S
G
K
S
S
L
V
R
T
I
L
G
I
W
L
P
V
H
G
------
T
V
E
--------
I
------------
D
G
-----------
A
---------------
D
L
K
QWD
R
D
Y
F
G
K
F
V
G
Y
L
P
Q
D
IEL
F
E
-----------
G
T
V
A
E
N
--------
I
A
--
R
F
G
E
L
---
D
S
E
K
I
-------
I
--------
E
A
A
K
L
-------------
S
----
G
---
A
H
D
V
----------------
I
-----------
I
-----------
K
-
L
P
D
G
Y
D
T
Y
I
G
PGGI
T
L
S
G
G
Q
R
Q
R
I
A
L
A
R
A
L
Y
G
------
N
P
R
I
V
I
L
D
E
P
D
S
N
L
D
E
Q
G
E
Q
A
L
Y
N
A
L
I
E
L
K
K
R
-
K
V
T
T
I
I
V
S
H
R
I
-
R
---------------------------------------------------------------------------------