@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNL8: (2017-11-17 )
MALLPILSFPDPRLRTIAKPVEEVTDEIRQLAADMFETMYAAPGIGLAASQVDRHIQLIVMDLSESKDEPMVFINPKVTPLTEETQPYEEGCLSVPQIYDKVDRPSRVKIEAINLEGQAFEIEADGLLAVCIQHEMDHLNGKLFVDYLSPLKRQRVREKVEKIVRQREREKVAVKR
Atome Classification :
(84 SA)
.........10........20..---......30........40........50........60..-----.--...-----..---70-.-------........80........90........100.......110.......120.......130.......140.......150--.......160.......170....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MALLPILSFP
D
P
R
L
R
T
I
A
K
P
V
E
E
---
V
T
D
E
I
R
Q
L
A
A
D
M
F
E
T
M
YAAPGIG
L
A
A
S
Q
V
DR
H
I
Q
L
I
V
M
DL-----S--ESK-----DE---
P
--
M
-------
V
F
INPKVTPLTEETQ
P
Y
E
E
GC
L
S
V
P
Q
I
Y
D
KVDRP
S
R
V
K
I
E
A
I
NLEG
Q
A
F
E
I
EAD
G
L
L
A
V
C
I
Q
H
E
M
D
HLN
G
K
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
V
R
E
K
V
E
K
I
V
R
Q
R
E
R
E
K
VAVKR
22
PsiBlast_CBE
94.57
68%
-101
- C4 -
-
1N5N
1
DEF_PSEAE
B:
[14-177]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
-----------
134
HHSearch
93.16
68%
-96
- C4 -
-
1IX1
3
DEF_PSEAE
B:
[2-167]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---------
135
HHSearch
93.13
69%
-100
- C4 -
-
1N5N
2
DEF_PSEAE
A:
[13-178]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
----------
2
PsiBlast_PDB
92.96
68%
-99
- C4 -
-
1S17
2
DEF_PSEAE
A:
[14-179]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---------
21
PsiBlast_CBE
92.90
68%
-105
- C4 -
-
1S17
1
DEF_PSEAE
B:
[14-177]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
-----------
23
PsiBlast_CBE
92.80
67%
-96
- C4 -
-
1IX1
3
DEF_PSEAE
B:
[2-167]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---------
1
PsiBlast_PDB
92.64
68%
-100
- C4 -
-
1N5N
2
DEF_PSEAE
A:
[13-179]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---------
3
PsiBlast_PDB
92.17
67%
-97
- C4 -
-
1IX1
3
DEF_PSEAE
A:
[2-167]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---------
4
PsiBlast_PDB
91.21
67%
-105
- C4 -
-
1LRY
1
DEF_PSEAE
A:
[1-165]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
-----
S
--
E
D
K
-----
S
E
---
P
--
R
-------
V
F
I
N
P
E
F
E
P
L
T
E
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
----------
25
PsiBlast_CBE
90.59
59%
-114
- C4 -
-
3K6L
1
DEF_ECOLI
B:
[2-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
28
PsiBlast_CBE
90.50
58%
-111
- C4 -
-
2AI8
1
DEF_ECOLI
C:
[1-166]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--------
42
PsiBlast_CBE
90.36
58%
-115
- C4 -
-
1G27
1
DEF_ECOLI
B:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
137
HHSearch
90.15
60%
-111
- C4 -
-
1XEO
1
DEF_ECOLI
A:
[1-163]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
-----------
36
PsiBlast_CBE
90.15
58%
-112
- C4 -
-
1LRU
1
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
32
PsiBlast_CBE
90.08
58%
-111
- C4 -
-
1XEN
6
DEF_ECOLI
A:
[1-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---------
29
PsiBlast_CBE
90.02
58%
-111
- C4 -
-
2AI8
1
DEF_ECOLI
B:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
30
PsiBlast_CBE
89.89
58%
-108
- C4 -
-
2AI8
1
DEF_ECOLI
A:
[1-166]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--------
6
PsiBlast_PDB
89.81
59%
-116
- C4 -
-
3K6L
1
DEF_ECOLI
A:
[2-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
10
PsiBlast_PDB
89.79
58%
-112
- C4 -
-
1ICJ
1
DEF_ECOLI
A:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
127
Fugue
89.67
59%
-115
- C4 -
-
1G2A
1
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
16
PsiBlast_PDB
89.67
58%
-111
- C4 -
-
1BSZ
1
DEF_ECOLI
A:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
19
PsiBlast_PDB
89.64
58%
-114
- C4 -
-
1G27
1
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
18
PsiBlast_PDB
89.48
58%
-116
- C4 -
-
1BSK
1
DEF_ECOLI
A:
[1-166]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--------
38
PsiBlast_CBE
89.41
58%
-115
- C4 -
-
1ICJ
1
DEF_ECOLI
B:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
33
PsiBlast_CBE
89.41
58%
-108
- C4 -
-
1XEM
10
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
41
PsiBlast_CBE
89.31
58%
-112
- C4 -
-
1G27
1
DEF_ECOLI
C:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
20
PsiBlast_PDB
89.31
58%
-115
- C4 -
-
1G2A
1
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
9
PsiBlast_PDB
89.31
58%
-113
- C4 -
-
2W3U
1
DEF_ECOLI
A:
[1-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---------
31
PsiBlast_CBE
89.23
58%
-111
- C4 -
-
1XEO
1
DEF_ECOLI
A:
[1-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---------
39
PsiBlast_CBE
89.10
58%
-111
- C4 -
-
1G2A
1
DEF_ECOLI
C:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
54
PsiBlast_CBE
88.94
58%
-116
- C4 -
-
1BS4
1
DEF_ECOLI
B:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
17
PsiBlast_PDB
88.94
58%
-112
- C4 -
-
1BSJ
1
DEF_ECOLI
A:
[1-166]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--------
26
PsiBlast_CBE
88.86
57%
-128
- C4 -
-
4AL2
1
DEF_ECOLI
C:
[1-162]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
------------
40
PsiBlast_CBE
88.81
58%
-110
- C4 -
-
1G2A
1
DEF_ECOLI
B:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
44
PsiBlast_CBE
88.77
58%
-115
- C4 -
-
1BSZ
1
DEF_ECOLI
B:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
53
PsiBlast_CBE
88.76
58%
-114
- C4 -
-
1BS4
1
DEF_ECOLI
C:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
43
PsiBlast_CBE
88.65
58%
-114
- C4 -
-
1BSZ
1
DEF_ECOLI
C:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
57
PsiBlast_CBE
88.58
56%
-121
- C4 -
-
4AL3
1
DEF_ECOLI
A:
[1-162]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
------------
7
PsiBlast_PDB
88.58
57%
-120
- C4 -
-
4AL2
1
DEF_ECOLI
A:
[1-162]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
------------
145
HHSearch
88.56
59%
-111
- C4 -
-
2W3T
1
DEF_ECOLI
A:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
34
PsiBlast_CBE
88.49
58%
-123
- C4 -
-
1LRU
1
DEF_ECOLI
C:
[1-161]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
-------------
37
PsiBlast_CBE
88.39
58%
-113
- C4 -
-
1ICJ
1
DEF_ECOLI
C:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
8
PsiBlast_PDB
88.20
58%
-111
- C4 -
-
2W3T
1
DEF_ECOLI
A:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
35
PsiBlast_CBE
88.16
58%
-110
- C4 -
-
1LRU
1
DEF_ECOLI
B:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
27
PsiBlast_CBE
87.93
57%
-117
- C4 -
-
4AL2
1
DEF_ECOLI
B:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
56
PsiBlast_CBE
87.91
56%
-113
- C4 -
-
4AZ4
1
DEF_ECOLI
A:
[1-163]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
-----------
61
PsiBlast_CBE
87.87
50%
-127
- C4 -
-
4WXL
1
DEF_HAEI8
D:
[3-165]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
11
PsiBlast_PDB
87.00
58%
-110
- C4 -
-
1BS4
1
DEF_ECOLI
A:
[1-167]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-------
125
Fugue
86.97
58%
-110
- C4 -
-
1BS4
1
DEF_ECOLI
A:
[1-168]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
G
-
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
A
------
68
PsiBlast_CBE
85.98
50%
-125
- C4 -
-
4WXK
1
DEF_HAEI8
A:
[3-165]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
62
PsiBlast_CBE
85.68
50%
-126
- C4 -
-
4WXL
2
DEF_HAEI8
C:
[2-165]
-
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
65
PsiBlast_CBE
84.94
50%
-127
- C4 -
-
4WXK
2
DEF_HAEI8
D:
[2-165]
-
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
64
PsiBlast_CBE
84.75
50%
-126
- C4 -
-
4WXL
2
DEF_HAEI8
A:
[3-165]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
66
PsiBlast_CBE
84.39
50%
-125
- C4 -
-
4WXK
1
DEF_HAEI8
C:
[1-165]
M
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
63
PsiBlast_CBE
83.87
50%
-124
- C4 -
-
4WXL
1
DEF_HAEI8
B:
[5-165]
----
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
136
HHSearch
83.85
51%
-126
- C4 -
-
4WXK
1
DEF_HAEI8
C:
[1-162]
M
T
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
-------------
67
PsiBlast_CBE
83.78
50%
-125
- C4 -
-
4WXK
1
DEF_HAEI8
B:
[3-165]
--
A
L
N
V
L
I
Y
P
D
D
H
L
K
V
V
C
E
P
V
T
E
---
V
N
D
A
I
R
K
I
V
D
D
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
-----
E
--
G
D
K
-----
Q
N
---
Q
--
F
-------
V
L
I
N
P
E
I
L
A
S
E
G
E
T
-
G
I
E
E
G
C
L
S
I
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
--
R
Q
R
I
K
E
K
L
I
K
Y
K
K
Q
----------
126
Fugue
79.88
56%
-47
- C4 -
-
1G2A
1
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
EN
R
D
-------
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
-
G
E
T
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
--
P
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----------
141
HHSearch
74.46
59%
-119
- C4 -
-
2KMN
1
DEF_ECOLI
A:
[1-147]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
-----------------------------
59
PsiBlast_CBE
74.14
58%
-119
- C4 -
-
2KMN
1
DEF_ECOLI
A:
[1-147]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
-----
S
--
E
N
R
-----
D
E
---
R
--
L
-------
V
L
I
N
P
E
L
L
E
K
S
G
E
T
-
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
D
Y
L
S
-----------------------------
77
PsiBlast_CBE
71.81
43%
-31
- C4 -
-
2EW6
1
?
A:
[1-166]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
P
Q
EDG
V
--
Q
H
K
-----
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
-
T
G
G
S
M
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
K
E
L
-------------
143
HHSearch
70.92
44%
-37
- C4 -
-
2EW5
1
?
A:
[1-166]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
-----
P
--
Q
E
D
GVQHK
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
T
G
G
S
M
-
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
K
E
L
-------------
142
HHSearch
70.77
44%
-46
- C4 -
-
4E9A
4
?
A:
[1-163]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
-----
P
--
Q
E
D
GVQHK
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
T
G
G
S
M
-
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
----------------
74
PsiBlast_CBE
70.63
43%
-45
- C4 -
-
4E9B
4
?
A:
[1-163]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
P
Q
EDG
V
--
Q
H
K
-----
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
-
T
G
G
S
M
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
----------------
78
PsiBlast_CBE
70.03
43%
-35
- C4 -
-
2EW5
1
?
A:
[1-166]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
P
Q
EDG
V
--
Q
H
K
-----
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
-
T
G
G
S
M
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
K
E
L
-------------
75
PsiBlast_CBE
69.70
43%
-42
- C4 -
-
4E9A
4
?
A:
[1-163]
-
A
L
L
E
I
I
H
Y
P
S
K
I
L
R
T
I
S
K
E
V
V
S
---
F
D
A
K
L
H
Q
Q
L
D
D
M
Y
E
T
M
I
A
S
E
G
I
G
L
A
A
I
Q
V
G
L
P
L
R
M
L
I
I
N
L
P
Q
EDG
V
--
Q
H
K
-----
E
D
---
C
--
L
-------
E
I
I
N
P
K
F
I
E
-
T
G
G
S
M
M
Y
K
E
G
C
L
S
V
P
G
F
Y
E
E
V
E
R
F
E
K
V
K
I
E
Y
Q
N
R
F
A
E
V
K
V
L
E
A
S
E
L
L
A
V
A
I
Q
H
E
I
D
H
L
N
G
V
L
F
V
D
K
L
S
I
L
K
--
R
K
K
F
E
K
E
L
----------------
140
HHSearch
68.29
34%
-116
- C4 -
-
1RL4
2
?
B:
[10-172]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
-------------------------
R
-------
I
F
I
N
P
S
I
V
E
Q
S
L
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
------------
92
PsiBlast_CBE
61.41
37%
-19
- C4 -
-
3O3J
1
DEF1B_ARATH
A:
[1-167]
---
M
E
I
V
E
Y
P
D
P
I
L
R
A
K
N
K
R
I
D
I
---
F
D
E
N
L
K
N
L
V
D
A
M
F
D
V
M
Y
K
T
D
G
I
G
L
S
A
P
Q
V
G
L
N
V
Q
L
M
V
F
N
P
-----
A
--
G
E
P
-----
G
E
---
G
K
E
I
-------
V
L
V
N
P
K
I
K
K
Y
S
D
K
L
V
P
F
D
E
G
C
L
S
F
P
G
I
Y
A
E
V
V
R
P
Q
S
V
K
I
D
A
R
D
I
T
G
E
R
F
S
I
S
L
S
R
L
P
A
R
I
F
Q
H
E
Y
D
H
L
E
G
V
L
F
F
D
R
M
T
D
Q
V
--
L
D
S
I
R
E
E
L
E
A
L
E
K
K
Y
E
--------
123
PsiBlast_CBE
60.84
35%
-29
- C4 -
-
1RL4
2
?
B:
[10-173]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
--------------------------R------
I
F
I
N
P
S
I
V
E
Q
S
L
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
R
-----------
124
PsiBlast_CBE
60.67
35%
-30
- C4 -
-
1RL4
2
?
A:
[10-173]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
--------------------------R------
I
F
I
N
P
S
I
V
E
Q
S
L
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
R
-----------
79
PsiBlast_CBE
60.15
51%
-21
- C4 -
-
4DR9
1
?
D:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
QAP
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
81
PsiBlast_CBE
59.93
51%
-21
- C4 -
-
4DR9
2
?
B:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
Q
A
P
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
83
PsiBlast_CBE
59.60
51%
-26
- C4 -
-
4DR8
1
?
D:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
QAP
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
85
PsiBlast_CBE
59.47
51%
-18
- C4 -
-
4DR8
2
?
B:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
Q
A
P
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
82
PsiBlast_CBE
59.42
51%
-51
- C4 -
-
4DR9
1
?
A:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
--------P--
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
80
PsiBlast_CBE
59.26
51%
-24
- C4 -
-
4DR9
1
?
C:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
QA
P
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
84
PsiBlast_CBE
58.94
51%
-23
- C4 -
-
4DR8
1
?
C:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
Q
A
P
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
86
PsiBlast_CBE
58.53
51%
-19
- C4 -
-
4DR8
2
?
A:
[29-163]
-------------
L
R
Q
P
A
K
R
V
S
R
---
I
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
--------
E
L
E
-----
D
E
Q
A
P
P
--
L
-------
V
L
I
N
P
K
I
E
R
T
A
G
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
--------------------------------
100
PsiBlast_CBE
57.05
39%
24
- C4 -
-
1VEZ
8
DEF_LEPIN
A:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
TPDV
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------
97
PsiBlast_CBE
56.18
39%
24
- C4 -
-
1Y6H
5
DEF_LEPIN
B:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
DEI
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
TPDVPER
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------
103
PsiBlast_CBE
55.89
39%
30
- C4 -
-
1VEV
2
DEF_LEPIN
B:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
DEI
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
TPDVPER
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------
99
PsiBlast_CBE
55.87
39%
20
- C4 -
-
1VEZ
7
DEF_LEPIN
B:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
DEI
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
TPDVPER
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------
98
PsiBlast_CBE
55.86
39%
28
- C4 -
-
1Y6H
4
DEF_LEPIN
A:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
DEI
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
T
P
D
V
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------
104
PsiBlast_CBE
55.05
39%
24
- C4 -
-
1VEV
3
DEF_LEPIN
A:
[5-161]
-----
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
D
E
I
Q
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
-----
E
--
D
N
E
-----
R
Y
---
P
--
G
TPDV
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
--------------------------