@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNS6: (2017-11-17 )
MTARIQKGKLAIAKELYDFIENEALPGSGLDSETYWKNFEQVVVDLSPKNKALLAKRDELQAKIDEWHRNNKFELGAYKAFLTEIGYLLPEVEDFQITTENVDEEIALLAGPQLVVPVRNARYCLNAANARWGSLYDALYGFDVISEEGGAEKGKGYNPVRGAKVIEFAKNFLNEIFPLAQGSHADATKYAIEQNKIVVTLKDGTKTGLAHEAQFVGFNGEEANPSEVVLLSNGLHVIIEIDANSPIGQTDLAGVKDLTLEAAVTTIQDLEDSVAAVDAEEKVEGYRNWLGLMKGTLQESIEKNGKTIVRALNKDREIKNLIGGTTKLHGRSLMLLRNVGHLMTNPAILVDGEEIFEGIMDALVTPLLSIADIRSENENKNSRKGSMYIVKPKMHGPEEVAFAVELFERAEQALGLPAKSLKIGIMDEERRTSVNLKNCIAAAKDRTIFINTGFMDRTGDEIHTSMEAAPVVRKEAVKTQKWIAAYENRNVAIGLKCGLQGKAQIGKGMWPKPDSMKDMLATKAAHPNAGASCAWVPSPTGAVLHAMHYHQVNVKARQDQLKAEEMLSLDDLLTPPFATDTNWSAEEINNELENNCQGILGYVVRWVDLGVGCSKVPDINNVGLMEDRATLRISSQHVANWLRHGIVTREQVEEVLKRMAKIVDEQNANDPLYKPMAANFETNIAFQAASDLIFKGCEQPSGYTEPLLHAARLKLKGYTGD
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........---70...---.....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340........-350.......360.......370.......380-.........390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560-----.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTARIQKG
K
L
A
I
A
K
E
L
Y
D
F
I
ENEALPGSGLD
S
E
T
Y
W
K
N
F
E
Q
V
VVDLSPK
N
K
A
L
L
A
K
R
D
E
L
Q
A
K
I
D
E
W
HR---NNKFE---
L
G
A
Y
K
A
F
L
T
E
I
G
Y
LLPEVED
F
Q
I
TTENVD
E
E
I
A
LLAG
P
Q
L
V
V
P
VRNA
R
Y
C
L
NAANA
R
W
G
S
L
Y
D
A
L
Y
G
F
D
VISEEGGAEKGKGYNPVR
G
A
K
V
I
E
F
A
K
N
F
L
N
E
I
F
P
LAQGSHADA
T
K
Y
A
I
EQ
N
K
I
V
V
T
LKDGTKTGLAH
E
A
Q
F
V
GFNGEEANP
S
E
V
V
L
LSNG
L
H
V
I
I
E
IDANSPIGQTDLAGVK
D
L
T
L
E
A
A
V
T
T
I
Q
D
L
E
D
S
V
AAV
D
A
E
E
K
V
E
G
Y
R
N
W
L
G
L
M
K
G
T
L
Q
E
S
I
E
KN
G
K
T
I
V
R
A
LNK
D
R
E
I
K
N
L
IGGTTKLHG
R
S
L
M
L
L
R
N
V
G
-
H
L
MTN
P
A
I
L
-V
D
G
E
E
I
F
E
G
I
M
D
A
L
V
T
P
L
L
S
I
A
D
I
RSENENK---NSRKG
S
M
Y
I
V
KPKMH
G
P
E
E
V
A
F
A
V
E
L
F
E
R
A
E
Q
A
LGL
P
A
K
S
L
K
I
G
I
MD
E
E
RRTSV
N
L
K
N
C
I
AAAKD
R
T
I
F
I
NTGFMDRTG
D
E
I
HTSMEAAP
V
V
R
K
E
A
V
K
T
Q
K
W
I
A
A
YENR
N
V
A
I
G
L
KCGLQGKAQIGKGMWPK
P
D
S
M
K
D
M
L
A
T
KAAHPNAGAS
C
A
WVPSP
T
G
A
V
L
H
A
M
H
Y
H
Q
V
N
V
K
A
R
Q
D
Q
L
K
-----
A
E
E
M
L
S
L
D
D
LLTPPFATDTNW
S
A
E
E
I
N
N
E
L
E
N
N
C
Q
G
I
L
G
Y
V
V
R
W
V
DLGVGCSKVPDINNVGLMED
R
A
T
L
R
I
S
S
Q
H
V
A
N
W
L
R
HGIV
T
R
E
Q
V
E
E
V
L
K
R
M
A
K
I
VDEQNANDPLYKPMAANFET
N
I
A
F
Q
A
A
S
D
L
I
F
KGCEQPSG
Y
T
E
P
L
L
H
A
A
R
L
K
LKGYTGD
53
Fugue
87.97
60%
-35
- C4 -
-
1N8I
1
MASZ_MYCTO
A:
[2-727]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
---
D
---
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
-
K
S
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
----------
A
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
H
L
M
T
N
D
A
I
V
D
-
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
I
---
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
GKRRA-----
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
----
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
A
R
A
A
E
1
PsiBlast_PDB
83.51
64%
16
- C4 -
-
5VFB
1
MASZ_PSEAE
A:
[5-727]
-
T
E
R
V
Q
V
G
G
L
Q
V
A
K
V
L
F
D
F
V
N
N
E
A
I
P
G
T
G
V
S
A
D
T
F
W
T
G
A
E
A
V
I
N
D
L
A
P
K
N
K
A
L
L
A
K
R
D
E
L
Q
A
K
I
D
G
W
H
Q
A
R
A
G
Q
A
H
D
---
A
V
A
Y
K
A
F
L
E
E
I
G
Y
L
L
P
E
A
E
D
F
Q
A
G
T
Q
N
V
D
D
E
I
A
R
M
A
G
P
Q
L
V
V
P
V
M
N
A
R
F
A
L
N
A
S
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
S
E
E
G
G
A
E
K
G
K
G
Y
N
K
V
R
G
D
K
V
I
A
F
A
R
A
F
L
D
E
A
A
P
L
E
S
G
S
H
V
D
A
T
S
Y
S
V
K
N
G
A
L
V
V
A
L
K
N
G
S
E
T
G
L
K
N
A
G
Q
F
L
A
F
Q
G
D
A
A
K
P
Q
A
V
L
L
K
H
N
G
L
H
F
E
I
Q
I
D
P
S
S
P
V
G
Q
T
D
A
A
G
V
K
D
V
L
M
E
A
A
L
T
T
I
M
D
C
E
D
S
V
A
A
V
D
A
D
D
K
V
V
I
Y
R
N
W
L
G
L
M
K
G
D
L
A
E
E
V
S
K
G
G
S
T
F
T
R
T
M
N
P
D
R
V
Y
T
R
A
D
G
S
E
L
T
L
H
G
R
S
L
L
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
L
D
K
D
G
N
E
V
P
E
G
I
Q
D
G
L
F
T
S
L
I
A
I
H
D
L
N
G
N
T
S
R
K
---
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
E
E
A
A
F
T
N
E
L
F
G
R
V
E
D
V
L
G
L
P
R
N
T
L
K
V
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
K
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
A
V
V
R
K
G
A
M
K
S
E
K
W
I
G
A
Y
E
N
N
N
V
D
V
G
L
A
T
G
L
Q
G
K
A
Q
I
G
K
G
M
W
A
M
P
D
L
M
A
A
M
L
E
Q
K
I
G
H
P
L
A
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
K
V
D
V
F
A
R
Q
A
E
L
A
-----
K
R
T
P
A
S
V
D
D
I
L
T
I
P
L
A
P
N
T
N
W
T
A
E
E
I
K
N
E
V
D
N
N
A
Q
G
I
L
G
Y
V
V
R
W
I
D
Q
G
V
G
C
S
K
V
P
D
I
N
D
V
G
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
S
Q
E
Q
V
V
E
S
L
K
R
M
A
V
V
V
D
R
Q
N
A
S
D
P
S
Y
R
P
M
A
P
N
F
D
D
N
V
A
F
Q
A
A
L
E
L
V
V
E
G
T
R
Q
P
N
G
Y
T
E
P
V
L
H
R
R
R
R
E
F
K
A
K
N
G
-
21
PsiBlast_CBE
83.33
64%
15
- C4 -
-
5VFB
1
MASZ_PSEAE
B:
[5-727]
-
T
E
R
V
Q
V
G
G
L
Q
V
A
K
V
L
F
D
F
V
N
N
E
A
I
P
G
T
G
V
S
A
D
T
F
W
T
G
A
E
A
V
I
N
D
L
A
P
K
N
K
A
L
L
A
K
R
D
E
L
Q
A
K
I
D
G
W
H
Q
ARA
G
Q
A
H
D
---
A
V
A
Y
K
A
F
L
E
E
I
G
Y
L
L
P
E
A
E
D
F
Q
A
G
T
Q
N
V
D
D
E
I
A
R
M
A
G
P
Q
L
V
V
P
V
M
N
A
R
F
A
L
N
A
S
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
S
E
E
G
G
A
E
K
G
K
G
Y
N
K
V
R
G
D
K
V
I
A
F
A
R
A
F
L
D
E
A
A
P
L
E
S
G
S
H
V
D
A
T
S
Y
S
V
K
N
G
A
L
V
V
A
L
K
N
G
S
E
T
G
L
K
N
A
G
Q
F
L
A
F
Q
G
D
A
A
K
P
Q
A
V
L
L
K
H
N
G
L
H
F
E
I
Q
I
D
P
S
S
P
V
G
Q
T
D
A
A
G
V
K
D
V
L
M
E
A
A
L
T
T
I
M
D
C
E
D
S
V
A
A
V
D
A
D
D
K
V
V
I
Y
R
N
W
L
G
L
M
K
G
D
L
A
E
E
V
S
K
G
G
S
T
F
T
R
T
M
N
P
D
R
V
Y
T
R
A
D
G
S
E
L
T
L
H
G
R
S
L
L
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
L
D
K
D
G
N
E
V
P
E
G
I
Q
D
G
L
F
T
S
L
I
A
I
H
D
L
N
G
N
T
S
R
K
---
N
S
R
T
G
S
V
Y
I
V
K
P
K
M
H
G
P
E
E
A
A
F
T
N
E
L
F
G
R
V
E
D
V
L
G
L
P
R
N
T
L
K
V
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
K
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
A
V
V
R
K
G
A
M
K
S
E
K
W
I
G
A
Y
E
N
N
N
V
D
V
G
L
A
T
G
L
Q
G
K
A
Q
I
G
K
G
M
W
A
M
P
D
L
M
A
A
M
L
E
Q
K
I
G
H
P
L
A
G
A
N
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
K
V
D
V
F
A
R
Q
A
E
L
A
-----
K
R
T
P
A
S
V
D
D
I
L
T
I
P
L
A
P
N
T
N
W
T
A
E
E
I
K
N
E
V
D
N
N
A
Q
G
I
L
G
Y
V
V
R
W
I
D
Q
G
V
G
C
S
K
V
P
D
I
N
D
V
G
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
S
Q
E
Q
V
V
E
S
L
K
R
M
A
V
V
V
D
R
Q
N
A
S
D
P
S
Y
R
P
M
A
P
N
F
D
D
N
V
A
F
Q
A
A
L
E
L
V
V
E
G
T
R
Q
P
N
G
Y
T
E
P
V
L
H
R
R
R
R
E
F
K
A
K
N
G
-
17
PsiBlast_PDB
83.10
59%
-1
- C4 -
-
5CBJ
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---D--
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
7
PsiBlast_PDB
82.78
59%
1
- C4 -
-
3S9I
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
---------
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
-
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
3
PsiBlast_PDB
82.65
59%
1
- C4 -
-
1N8W
1
MASZ_MYCTO
A:
[5-722]
----
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
-----
A
F
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
23
PsiBlast_CBE
82.53
59%
4
- C4 -
-
5T8G
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
5
PsiBlast_PDB
82.52
59%
-0
- C4 -
-
5H8U
1
MASZ_MYCTU
A:
[3-722]
--
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
-----
A
F
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
18
PsiBlast_PDB
82.29
59%
-1
- C4 -
-
5CC5
2
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
--
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
22
PsiBlast_CBE
82.27
59%
1
- C4 -
-
1N8W
1
MASZ_MYCTO
B:
[3-722]
--
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
----
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
------
F
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
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D
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S
E
V
F
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G
I
M
D
A
L
F
T
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L
I
A
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H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
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G
P
A
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A
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V
E
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G
L
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Q
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E
R
R
T
T
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N
L
K
A
C
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K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
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M
V
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T
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I
A
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R
A
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A
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T
A
W
V
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A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
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D
E
I
R
E
E
V
D
N
N
C
Q
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I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
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D
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A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
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H
G
V
I
T
S
A
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A
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M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
8
PsiBlast_PDB
82.22
59%
-1
- C4 -
-
3SAZ
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
--------
F
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
---LI-
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
--
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
15
PsiBlast_PDB
82.21
59%
4
- C4 -
-
5CAK
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
---------
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
6
PsiBlast_PDB
82.19
59%
4
- C4 -
-
5DRC
2
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
--------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
20
PsiBlast_PDB
82.17
59%
2
- C4 -
-
5CEW
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
--
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
2
PsiBlast_PDB
82.14
59%
6
- C4 -
-
2GQ3
2
MASZ_MYCTU
A:
[4-724]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
D
K
D
G
T
A
F
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
---
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
C
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
12
PsiBlast_PDB
82.08
59%
3
- C4 -
-
5C9U
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
25
PsiBlast_CBE
81.89
59%
2
- C4 -
-
5E9X
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
--------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
16
PsiBlast_PDB
81.87
59%
6
- C4 -
-
5CBI
4
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
D
-------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
13
PsiBlast_PDB
81.86
59%
4
- C4 -
-
5C9X
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
11
PsiBlast_PDB
81.84
59%
3
- C4 -
-
5C7V
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
26
PsiBlast_CBE
81.80
59%
4
- C4 -
-
5DX7
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
10
PsiBlast_PDB
81.69
59%
3
- C4 -
-
5C9R
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
A
V
-------
L
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
--
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
19
PsiBlast_PDB
81.19
59%
5
- C4 -
-
5CCZ
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
24
PsiBlast_CBE
80.91
59%
2
- C4 -
-
5ECV
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
V
I
E
PID
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
V
N
G
PLI
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
---
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
9
PsiBlast_PDB
80.63
59%
11
- C4 -
-
3SB0
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---ID-
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
S
D
---LI-
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----
14
PsiBlast_PDB
79.88
59%
10
- C4 -
-
5CAH
1
MASZ_MYCTU
A:
[2-722]
-
T
D
R
V
S
V
G
N
L
R
I
A
R
V
L
Y
D
F
V
N
N
E
A
L
P
G
T
D
I
D
P
D
S
F
W
A
G
V
D
K
V
V
A
D
L
T
P
Q
N
Q
A
L
L
N
A
R
D
E
L
Q
A
Q
I
D
K
W
H
R
---
R
R
---ID-
M
D
A
Y
R
Q
F
L
T
E
I
G
Y
L
L
P
E
P
D
D
F
T
I
T
T
S
G
V
D
A
E
I
T
T
T
A
G
P
Q
L
V
V
P
V
L
N
A
R
F
A
L
N
A
A
N
A
R
W
G
S
L
Y
D
A
L
Y
G
T
D
V
I
P
E
T
D
G
A
E
K
G
P
T
Y
N
K
V
R
G
D
K
V
I
A
Y
A
R
K
F
L
D
D
S
V
P
L
S
S
G
S
F
G
D
A
T
G
F
T
V
Q
D
G
Q
L
V
V
A
L
P
D
K
S
-
T
G
L
A
N
P
G
Q
F
A
G
Y
T
G
A
A
E
S
P
T
S
V
L
L
I
N
H
G
L
H
I
E
I
L
I
D
P
E
S
Q
V
G
T
T
D
R
A
G
V
K
D
V
I
L
E
S
A
I
T
T
I
M
D
F
E
D
S
V
A
A
V
D
A
A
D
K
V
L
G
Y
R
N
W
L
G
L
N
K
G
D
L
A
A
----------
R
V
L
N
R
D
R
N
Y
T
A
P
G
G
G
Q
F
T
L
P
G
R
S
L
M
F
V
R
N
V
G
-
H
L
M
T
N
D
A
I
V
D
T
D
G
S
E
V
F
E
G
I
M
D
A
L
F
T
G
L
I
A
I
H
G
L
K
A
-----LI-
N
S
R
T
G
S
I
Y
I
V
K
P
K
M
H
G
P
A
E
V
A
F
T
C
E
L
F
S
R
V
E
D
V
L
G
L
P
Q
N
T
M
K
I
G
I
M
D
E
E
R
R
T
T
V
N
L
K
A
C
I
K
A
A
A
D
R
V
V
F
I
N
T
G
F
L
D
R
T
G
D
E
I
H
T
S
M
E
A
G
P
M
V
R
K
G
T
M
K
S
Q
P
W
I
L
A
Y
E
D
H
N
V
D
A
G
L
A
A
G
F
S
G
R
A
Q
V
G
K
G
M
W
T
M
T
E
L
M
A
D
M
V
E
T
K
I
A
Q
P
R
A
G
A
S
T
A
W
V
P
S
P
T
A
A
T
L
H
A
L
H
Y
H
Q
V
D
V
A
A
V
Q
Q
G
L
A
-----
G
K
R
R
A
T
I
E
Q
L
L
T
I
P
L
A
K
E
L
A
W
A
P
D
E
I
R
E
E
V
D
N
N
C
Q
S
I
L
G
Y
V
V
R
W
V
D
Q
G
V
G
A
S
K
V
P
D
I
H
D
V
A
L
M
E
D
R
A
T
L
R
I
S
S
Q
L
L
A
N
W
L
R
H
G
V
I
T
S
A
D
V
R
A
S
L
E
R
M
A
P
L
V
D
R
Q
N
A
G
D
V
A
Y
R
P
M
A
P
N
F
D
D
S
I
A
F
L
A
A
Q
E
L
I
L
S
G
A
Q
Q
P
N
G
Y
T
E
P
I
L
H
R
R
R
R
E
F
K
-----