@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNV8: (2017-11-18 )
MPLLQIAEPGQSSAPHQHRIAIGIDLGTTHSLAATVLSGKPKVLNDVQNRRLLPSIVHYGDNTTHYGEEAKPFIIADPKNTIVSVKRFMGRSKADIKFQHPYELVGSEKNEMPAFETRAGRKTPVEISAEILKQLKDRAEDSLQNPVNGAVITVPAYFDEAQRQATRYAAQLAGLNILRLLNEPTAAAVAYGLDQESNLATDRNYVIYDLGGGTFDVSILRFSQGVFEVLATGGHTALGGDDLDRLIVKWAKKQLNIDVLSDEDYAVFIVAARQAKEQLSTQDSVELKLLEATLTLDRPTFESIIQVALDKTISVCKRVLRDAKLELTDIQNVVLVGGSTRSYAVQKAVREVFAQEPLCTINPDEVVAIGASITANQLIGNSQDGSLLLDVTPLSLGLETMGGLVERLISRNTAIPVARRQEFTTYQDGQTAMLIHVVQGERDLVEHCRSLGRFVLHGIPPMTAGQARIEVTFQVDADGLLTVSAREATSGVQAHIDIKPSYGLSEADTERLLIEGFQHAEEDKNLRHLKETKVEAERELEALEQALKVDADLLDEKQLEALNSAKESLKAQLEGSDIQAIEQAVQQLKVHSDAFAALRMNRHIDHALKGTKLDDWSKSN
Atome Classification :
(94 SA)
.........10........20........30........40........50........60...-......70........80........90.------...--.--.--.-----.100---.....--.---------...110..--.--.--.--.---...-120-..---.----......130.......140.......150.......160.......170.......180.......190.......200.......210.......220----..----.....230.......240..----...----..250--.----....---....-----260.-....--..-270-........--280.--......-..------290--------...--------.----.--------....300.......310.......320.......330.......340.......350.-.-.-...-.-360.......370.......380--...---...--.-..390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500..-......510.......520.......530.......540.......---550.......560.......570....-.--..580.....----..590.......600.......610.......620
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPLLQIAEPGQSSAPH
Q
H
R
I
A
I
G
I
DLGT
T
H
S
L
A
A
T
V
LSGK
P
K
V
L
N
D
V
QNRRL
L
P
S
I
V
HYG-DNT-THYGEEAK
P
F
I
I
ADPK
N
T
I
V
S
V
K
R
F
MGRS------KA
D
--
I
--
K
--
F
-----QH-----
P
Y
E
L
V--G---------SEKN--EM--P--A--F--E---TRA-G---RK---T----
P
V
E
I
S
A
E
I
L
K
Q
L
K
D
R
A
E
D
S
LQNPVN
G
A
V
I
T
VP
A
Y
F
D
E
A
Q
R
Q
A
T
R
Y
A
A
Q
L
A
G
L
N
I
L
R
L
LNEP
T
A
A
A
V
A
YGLDQESNLATDR
N
Y
V
I
Y
DLGG
G
T
F
D
V
S
I
L
R
F----S
Q
----
G
V
F
E
V
L
ATGGHTAL
G
G
D
D
L
D
----
R
L
I
----
V
K
W
----
A
----
K
K
QL---
N
I
D
V
-----LSDE-D
Y
A
V
--
F
I
-
V
A
--
A
R
Q
A
K
E
QL--S--T--QDS
V
E
L
-
K
L
------
L
----------
E
A
T
--------
L
----T--------LDRP
T
F
E
S
I
I
Q
V
A
L
D
K
T
I
S
V
C
K
R
V
L
R
DAK
L
E
L
T
DI
Q
N
V
V
L
VGGS
T
R
S
Y
A
V
Q
K
A
V
R
E
V
F
-A-Q-EP
L
-
C
-TINPD
E
V
V
A
IGA
S
I
T
A
N
Q
LIG----NSQ---D
G
S
--
L
-
L
L
D
V
T
P
L
S
L
G
L
E
T
M
G
G
L
V
E
R
L
I
SRNTAIPVARRQEFTTYQDG
Q
T
A
M
L
I
H
V
VQG
E
R
D
L
V
E
H
C
R
S
L
G
R
F
V
L
HGIPPMTAG
Q
A
R
I
E
V
T
F
Q
VDAD
G
L
L
T
V
SAREATSG
V
Q
A
H
I
D
I
KPS-YG-LS
E
A
D
T
E
R
L
L
I
E
G
F
Q
H
A
E
E
D
K
N
L
R
H
L
K
E
T
K
V
E
A
E
R
E
L
E
A
L
E
Q
A
L
K
V
---
D
A
D
L
L
D
E
K
Q
L
E
A
L
N
S
A
K
E
S
L
K
A
QLEGS-
D
--
I
Q
A
I
E
Q
A
V
Q
Q
----
L
KVH
S
D
A
F
A
A
L
R
M
N
R
H
I
D
H
A
LKGTKLDDWSKSN
125
HHSearch
79.12
46%
-26
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[2-504]
------------------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
-
N
G
E
-
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
------
Y
K
-------------------------------------------------------
V
--
E
---
I
E
G
-
K
---
Q
Y
---
T
----
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
----
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
----
Q
V
I
----
I
D
Y
----
L
----
V
N
Q
F
---
K
Q
E
H
GIDLS
K
D
K
M
-
A
L
Q
R
--
L
K
-
D
A
--
A
E
K
A
K
K
E
L
--
S
--
G
--
V
T
Q
T
Q
I
-
S
L
------
P
FISANEN
G
P
L
H
L
E
--------
M
----
T
--------
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
-
E
P
H
-
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
----
E
V
----
K
D
V
--
V
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.24
45%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[5-509]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
-
N
G
E
-
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
---------
T
D
--
Y
--
K
--
V
------------------------------------------------
E
---
I
E
G
-
K
---
Q
Y
---
T
----
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
E
----
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
----
Q
V
I
----
I
D
Y
----
L
V
N
Q
F
K
Q
E
H
---
G
I
D
------
L
S
K
D
-
K
M
A
L
Q
R
L
K
-
D
A
--
A
E
K
A
K
K
E
L
--
S
G
V
T
--
Q
T
Q
I
S
L
-
P
F
------
I
----------
S
A
N
EN
G
P
L
H
L
E
M
----
T
--------
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
-
E
P
H
-
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
----
E
V
K
---
D
-
V
--
V
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
---------------------------------------------------------------------------------------------
126
HHSearch
77.59
46%
-
- C2 -
-
4ANI
-
DNAK_GEOKA
C:
[2-509]
------------------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
-
N
G
E
-
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
------
Y
K
-------------------------------------------------------
V
--
E
---
I
E
G
-
K
---
Q
Y
---
T
----
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
----
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
----
Q
V
I
----
I
D
Y
----
L
----
V
N
Q
F
---
K
Q
E
H
GIDLS
K
D
K
M
-
A
L
Q
R
--
L
K
-
D
A
--
A
E
K
A
K
K
E
L
--
S
--
G
--
V
T
Q
T
Q
I
-
S
L
------
P
FISANEN
G
P
L
H
L
E
--------
M
----
T
--------
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
-
E
P
H
-
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
----
E
V
----
K
D
V
--
V
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
---------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.14
45%
-9
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[5-504]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
-
N
G
E
-
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
---------
T
D
--
Y
--
K
--
V
------------------------------------------------
E
---
I
E
G
-
K
---
Q
Y
---
T
----
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
E
----
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
----
Q
V
I
----
I
D
Y
----
L
V
N
Q
F
K
Q
E
H
---
G
I
D
------
L
S
K
D
-
K
M
A
L
Q
R
L
K
-
D
A
--
A
E
K
A
K
K
E
L
--
S
G
V
T
--
Q
T
Q
I
S
L
-
P
F
------
I
----------
S
A
N
EN
G
P
L
H
L
E
M
----
T
--------
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
-
E
P
H
-
K
-
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
----
E
V
K
---
D
-
V
--
V
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
-
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------
117
HHSearch
73.03
40%
41
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[2-600]
------------------
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
-
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
E
V
Q
--
R
D
V
S
--
I
M
-----
P
F
K
I
I
--
A
---------
A
D
-
N
--
G
D
--
A
--
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
---
G
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
S
R
L
----
I
N
Y
----
L
----
V
E
E
F
---
K
K
D
Q
GIDLR
N
D
P
L
-
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
--
A
Q
Q
T
D
V
-
N
L
------
P
YITADAT
G
P
K
H
M
N
--------
I
----
K
--------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
----
K
D
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-------------------
116
HHSearch
72.68
41%
44
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[2-602]
------------------
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
-
Q
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
E
V
Q
--
R
D
V
S
--
I
M
-----
P
F
K
I
I
--
A
---------
A
D
-
N
--
G
D
--
A
--
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
---
G
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
----
D
E
V
DG
E
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
S
R
L
----
I
N
Y
----
L
----
V
E
E
F
---
K
K
D
Q
GIDLR
N
D
P
L
-
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
--
A
Q
Q
T
D
V
-
N
L
------
P
YITADAT
G
P
K
H
M
N
--------
I
----
K
--------
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
----
K
D
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
A
Q
V
S
Q
K
L
M
E
I
A
---------------------
118
HHSearch
72.67
37%
22
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[11-619]
---------------
E
V
Y
D
G
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
-
E
N
C
-
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
------
F
D
D
--
P
T
V
K
--
K
D
M
E
--
S
W
-----
P
F
K
V
V
--
D
---------
D
N
G
N
--
P
K
--
V
--
E
--
V
QY
L
---
G
Q
T
-
H
---
T
F
---
S
----
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
-
S
D
K
E
R
N
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
----
T
N
L
----
L
E
Y
----
C
----
K
K
E
F
---
T
R
K
T
KKDLS
G
D
A
R
-
A
L
R
R
--
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
--
S
--
G
A
Q
T
T
I
-
E
I
------
D
SLFDG
E
----
D
F
N
--------
I
----
Q
--------
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
F
F
-
D
-
G
K
K
L
E
-
K
-
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
----
K
A
T
SAD-
D
L
--
L
-
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
G
K
-
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
S
D
------------
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
L
E
I
E
-
D
ST
A
D
E
L
K
K
K
E
L
A
----
L
K
R
L
V
T
K
A
M
A
-----------------------
21
PsiBlast_CBE
71.28
41%
41
- C2 -
-
4JNE
4
DNAK_ECOLI
B:
[5-587]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
DVSIM
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S---
R
L
I
NYL-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
GPKHMNIK
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
22
PsiBlast_CBE
70.78
41%
43
- C2 -
-
4JN4
4
DNAK_ECOLI
B:
[5-587]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
DVSIM
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S---
R
L
I
NYL-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
GPKHMNIK
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
8
PsiBlast_PDB
70.52
41%
24
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[6-550]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
-
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
FDD
A
V
V
Q
S
D
--
M
--
K
--------
H
W
-----
P
F
M
V
V
--
N
---------
D
A
G
R
--
P
K
--
V
--
Q
--
V
--
E
---
Y
K
G
-
E
---
T
K
---
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
--
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
----
N
R
M
----
V
N
H
----
F
I
A
E
F
K
R
K
H
---
K
K
D
I
------
S
E
N
-
K
R
A
V
R
R
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
S
S
T
--
Q
A
S
I
E
I
-
D
S
------
L
----------
Y
E
G
--------
I
D
F
Y
T
S
--------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
E
L
-
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D------------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
-
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
----
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
----------------------------------------------------------------------------------
6
PsiBlast_PDB
70.47
41%
43
- C2 -
-
4JNE
4
DNAK_ECOLI
A:
[5-587]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
D
V
S
I
M
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
---
R
L
I
N
Y
L
-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
124
HHSearch
70.21
40%
19
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[4-553]
------------------
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
-
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
------
F
D
D
--
A
--
V
--
V
Q
S
D
M
K
H
W
-----
P
F
M
V
V
--
N
---------
D
A
G
R
--
P
K
--
V
Q
V
E
--
Y
--
K
---
G
E
T
-
K
---
S
F
---
Y
----
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
V
--
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
----
N
R
M
----
V
N
H
----
F
----
I
A
E
F
---
K
R
K
H
KKDIS
E
N
K
R
-
A
V
R
R
--
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
--
S
--
S
T
Q
A
S
I
-
E
I
------
D
SLYEG
I
----
D
F
Y
--------
T
----
S
--------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
-
E
L
N
-
K
-
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
----
D
--------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
-
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
70.21
41%
46
- C2 -
-
4B9Q
1
DNAK_ECOLI
A:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
C
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
D
V
S
I
M
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
---
R
L
I
N
Y
L
-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
120
HHSearch
70.08
36%
39
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[3-606]
----------------
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
-
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
------
W
N
D
--
P
SV
Q
--
Q
DIK--
F
L
-----
P
F
K
V
V
--
E
---------
K
K
T
K
--
P
Y
--
I
--
Q
--
V
--
D
IGG
G
Q
T
-
K
---
T
F
---
A
----
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
E
---
G
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
Q
R
V
----
M
E
H
----
F
----
I
K
L
Y
---
K
K
K
T
GKDVR
K
D
N
R
-
A
V
Q
K
--
L
R
-
R
E
--
V
E
K
A
K
R
A
L
--
S
--
S
--
Q
H
Q
A
R
I
-
E
I
------
E
SFYEGE----
D
F
S
--------
E
----
T
--------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
-
N
G
K
-
E
P
S
-
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----
D
Q
D
T--
G
D
L
--
V
-
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
----
G
G
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
-
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
KEK
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
AD
I
E
D
F
K
A
K
K
K
E
----
L
E
E
I
V
Q
P
I
I
S
K
----------------------
5
PsiBlast_PDB
69.95
41%
46
- C2 -
-
4JN4
4
DNAK_ECOLI
A:
[5-587]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
D
V
S
I
M
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
---
R
L
I
N
Y
L
-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
11
PsiBlast_PDB
69.50
38%
40
- C2 -
-
5E84
1
GRP78_HUMAN
A:
[8-584]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
-
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
WND
P
S
V
Q
Q
D
--
I
--
K
--
F
------
L
-----
P
F
K
V
V
-------------
E
K
K
--
T
K
--
P
--
Y
--
I
--
Q
---
V
D
I
-
G
GG
Q
T
K
---
T
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
E
G
---
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
Q
R
V
M
E
H
F
I
K
L
----
Y
----
K
K
K
T
---
G
K
D
V
-----
R
K
D
--
N
R
A
V
Q
K
L
R
-
R
E
--
V
E
K
A
K
R
A
L
--
S
--
S
--
Q
H
Q
A
R
I
-
E
I
E
SFYEG
E
----------
D
F
S
--------
E
----
T
--------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
-
E
P
S
-
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----
D
Q
D
---
T
G
D
--
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
---
G
G
T
-
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
-
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
----
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
-----------
N
Q
I
----
G
D
K
E
K
L
G
G
K
L
S
S
E
-
D
--
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
A
--------------------------
27
PsiBlast_CBE
69.18
38%
42
- C2 -
-
5E84
1
GRP78_HUMAN
C:
[8-584]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
-
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
WNDPSV
Q
Q
D
--
I
--
K
--
F
------
L
-----
P
F
K
V
V
-------------
E
K
K
--
T
K
--
P
--
Y
--
I
--
Q
---
V
D
I
-
G
GGQ
T
K
---
T
FA--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
E
G
---
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
Q
R
V
MEHF
I
K
L
----
Y
----
K
K
K
T
---
G
K
D
V
-----
R
K
D
--
N
R
A
V
QK
L
R
-
R
E
--
V
E
K
A
K
R
A
L
--
S
--
S
--
Q
H
Q
A
R
I
-
E
I
ESFYEG
E
----------
D
F
S
--------
E
----
T
--------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
-
E
P
S
-
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----
D
Q
D
---
T
G
D
--
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
---
G
G
T
-
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
-
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
----
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
-----------
N
Q
I
----
G
D
K
E
K
L
G
G
K
L
S
S
E
-
D
--
K
E
T
M
E
K
A
V
E
E
KIEW
L
E
S
H
Q
D
A
--------------------------
1
PsiBlast_PDB
69.18
42%
51
- C2 -
-
2KHO
-
DNAK_ECOLI
A:
[5-591]
---------------------
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
-
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
------
F
Q
D
--
E
--
E
--
V
-----
Q
R
D
V
S
IM
P
F
K
I
I
--
A
---------
A
D
N
G
--
D
A
-----
W
--
V
--
E
---
V
K
G
-
Q
---
K
M
---
A
----
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
T
G
---
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
----
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
---
R
L
I
N
Y
L
-
V
E
E
----
F
----
K
K
D
Q
---
G
I
D
L
-----
R
N
D
P
L
A
M
Q
R
--
L
K
-
E
A
--
A
E
K
A
K
I
E
L
--
S
--
S
AQ
Q
T
D
V
N
L
-
P
Y
------
I
----------
T
A
D
--------
A
----
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
-
E
P
R
-
K
-
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
----
D
V
K
---
D
-
V
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
-
D
--
K
A
A
I
E
A
K
M
Q
E
----
L
--------------------------------
28
PsiBlast_CBE
68.93
38%
40
- C2 -
-
5E84
1
GRP78_HUMAN
B:
[8-584]
---------------------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
-
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
WNDPSV
Q
Q
D
--
I
--
K
--
F
------
L
-----
P
F
K
V
V
-------------
E
K
K
--
T
K
--
P
--
Y
--
I
--
Q
---
V
D
I
-
G
GGQ
T
K
---
T
FA--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
E
G
---
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
----
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
----
Q
R
V
MEHF
I
K
L
----
Y
----
K
K
K
T
---
G
K
D
V
-----
R
K
D
--
N
R
A
V
QK
L
R
-
R
E
--
V
E
K
A
K
R
A
L
--
S
--
S
--
Q
H
Q
A
R
I
-
E
I
ESFYEG
E
----------
D
F
S
--------
E
----
T
--------
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
-
E
P
S
-
R
-
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
----
D
Q
D
---
T
G
D
--
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
---
G
G
T
-
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
-
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
----
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
-----------
N
Q
I
----
G
D
K
E
K
L
G
G
K
L
S
S
E
-
D
--
K
E
T
M
E
K
A
V
E
E
KIEW
L
E
S
H
Q
D
A
--------------------------
7
PsiBlast_PDB
68.79
41%
25
- C2 -
-
1YUW
-
HSP7C_BOVIN
A:
[6-550]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
-
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
FDD
A
V
V
Q
S
D
--
M
--
K
--------
H
W
-----
P
F
M
V
V
--
N
---------
D
A
G
R
--
P
K
--
V
--
Q
--
V
--
E
---
Y
K
G
-
E
---
T
K
---
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
--
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
----
N
R
M
----
V
N
H
----
F
I
A
E
F
K
R
K
H
---
K
K
D
I
------
S
E
N
-
K
R
A
V
R
R
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
S
S
T
--
Q
A
S
I
E
I
-
D
S
------
L
----------
Y
E
G
--------
I
D
F
Y
T
S
--------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
E
L
-
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
DKSE
N
V
Q
---
D
-
L
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
-
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
----
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
----------------------------------------------------------------------------------
29
PsiBlast_CBE
67.24
40%
31
- C2 -
-
5TKY
2
SSB1_CHATD
B:
[16-566]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
-
E
N
C
-
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
FDD
P
T
V
K
K
D
--
M
--
E
--------
S
W
-----
P
F
K
V
V
-------------
D
D
N
--
G
N
--
P
--
K
--
V
--
E
---
V
Q
Y
-
L
---
G
Q
---
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
S
-
D
K
E
R
N
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
----
T
N
L
----
L
E
Y
----
C
----
K
K
E
F
---
T
R
K
T
KKD--
L
S
G
D
-
A
R
A
L
R
R
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
--
S
GA
Q
T
T
I
E
I
-
D
S
------
L
FDG
E
------
D
F
N
--------
I
----
Q
--------
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
F
F
-
D
-
G
-
K
K
L
E
K
-
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
K---------
D
T
S
D
L
L
-
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
----
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
-
V
G
K
L
S
T
D
E
I
E
K
M
I
----
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
----------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.21
41%
26
- C2 -
-
3C7N
2
HSP7C_BOVIN
B:
[6-547]
--------------------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
T
E
-
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
FDD
A
V
V
Q
S
D
--
M
--
K
--------
H
W
-----
P
F
M
V
V
--
N
---------
D
A
G
R
--
P
K
--
V
--
Q
--
V
--
E
---
Y
K
G
-
E
---
T
K
---
S
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
--
V
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
----
N
R
M
----
V
N
H
----
F
I
A
E
F
K
R
K
H
---
K
K
D
I
------
S
E
N
-
K
R
A
V
R
R
L
R
-
T
A
--
C
E
R
A
K
R
T
L
--
S
S
S
T
--
Q
A
S
I
E
I
-
D
S
------
L
----------
Y
E
G
--------
I
D
F
Y
T
S
--------
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
-
G
-
K
E
L
-
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
DK--------
D
-
L
--
L
-
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
-
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
----
K
V
S
S
K
N
S
L
E
S
Y
A
F
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.05
40%
38
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[16-567]
--------------------
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
-
E
N
C
-
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
FDD
P
T
V
K
K
D
--
M
--
E
--------
S
W
-----
P
F
K
V
V
-------------
D
D
N
--
G
N
--
P
--
K
--
V
--
E
---
V
Q
Y
-
L
---
G
Q
---
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
S
-
D
K
E
R
N
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
----
Q
G
----
G
V
F
T
V
K
A
T
A
G