@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNX0: (2017-11-18 )
MNLQNPKKFKMMIDQAHDVAINVLRPISRKYDKAEHAYPKELDMLASLIDGMNEGGEGINAGAAGAGKRGESDNEGVRNGTNMSTALGIIEMCYGDTGLLLSMPRQGLGNSAIAAVANDEQLERFKGTWAAMAITEPGCGSDSAAIRTTATKDGNDYILNGEKIFVTSGERADSVVVWATLDRKLGRAAIKSFVVPKGTPGMKVERLEHKLGIKASDTAVISFTDCRVPAENLLGNPEIDVAKGFAGVMETFDNTRPLVAAMAIGCAKASLERIKEIFKDQLDSNYSTPYLQTSNLAAQIYRMEAEWEAARLLMLKATWMADNKKPNSKEASIAKAKAGRVGNEITLKCVELAASVGYKEDELLEKWARDSKILDIFEGTQQIQQLIIARRELGKSSSELK
Atome Classification :
(23 SA)
-.........10........20........30.-.......----40------........-.50...----.....60......----..70---.....-....80........90....--.--...100.-...-...110.......120...------.-----...---------130----.------........140.......150.......160.......170.......180---...---....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..-...-..330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MNLQ
N
P
K
K
F
K
M
M
I
DQA
H
D
V
A
I
N
V
L
R
P
I
S
R
K
YD-KAEHAY
P
----
K
-------
E
L
D
M
L
A
S
L
-
I
D
G
MNE----GGEGINAGAAGAG----KRG----ESDNE-GVRNGT
N
M
S
T
A
L
G
I
I
E
M
C
YG--D--TG
L
L
L
SM-PRQ-GLGN
S
A
I
A
AVA
N
D
E
Q
L
E
R
F
------K-----G
T
W
---------
A
------
A
------
M
A
ITEPGCGSDS
A
A
I
R
T
T
ATKDGN
D
Y
I
LNG
E
K
I
F
V
TSGERA
D
S
V
V
V
W
A
T
L
D
---
R
K
L
---
G
R
A
A
I
K
S
FVVPKGTPG
M
K
V
E
R
L
E
H
K
LGIKAS
D
T
A
V
I
S
F
TDCRV
P
A
E
NLLGNPE
I
D
V
A
K
G
F
A
G
V
M
E
T
FDNT
R
P
L
V
A
A
M
A
I
G
C
A
K
A
S
L
E
R
I
K
E
I
F
K
D
Q
LDSNYST
P
Y
L
QTS
N
L
A
A
Q
I
Y
R
MEA
E
W
E
A
A
R
L
L
M
L
K
A
T
W
MADNK-KPN-SKE
A
S
I
A
K
A
KAGRVGN
E
I
T
L
K
C
V
E
L
A
A
SVGY
K
E
D
E
L
L
E
K
W
ARDS
K
I
L
D
I
F
E
G
T
Q
Q
I
Q
Q
L
I
I
A
R
R
E
LGKSSSELK
96
Fugue
91.76
32%
27
- C2 -
-
3MDD
2
ACADM_PIG
A:
[1-385]
G
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
R
T
G
E
-
Y
P
-------------
V
P
L
L
K
R
A
-
W
E
L
--------------
G
L
M
N
T
H
----
I
P
E
----
S
F
G
G
L
-
G
---
L
G
I
I
D
S
C
L
I
T
E
E
L
A
Y
G
--
C
--
T
G
V
Q
T
A
I
-
E
A
N
T
-
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
------
L
-----
G
R
M
---------
T
E
EP
L
M
C
A
------
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
PDP
K
A
P
---
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
----
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
--
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
-
R
R
N
-
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
----
94
HHSearch
91.17
32%
32
- C2 -
-
4P13
3
ACADM_HUMAN
D:
[3-386]
-
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
-
E
Y
P
----
V
-------
P
--
L
I
R
R
A
-
W
E
L
G
L
M
-------
N
-------
T
-------
H
----
I
P
E
N
C
-
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
--
C
--
T
G
V
Q
T
A
I
-
E
G
N
-
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
LGRMTE
E
-----
P
L
M
---------
C
------
A
------
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
P
KAP
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
----
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
--
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
V
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
-
R
R
N
-
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
----
89
HHSearch
87.33
29%
-11
- C2 -
-
4N5F
2
?
A:
[9-385]
-
M
D
E
L
Y
T
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
-
H
D
A
-
H
L
P
----
D
-------
A
--
I
V
A
Q
L
-
G
E
L
G
L
L
-------
G
-------
M
-------
I
----
V
P
Q
E
L
-
G
G
S
Y
T
D
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
--
D
--
A
A
C
A
T
M
M
S
V
H
N
-
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
-----
R
V
I
---------
G
------
A
------
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
D
G
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
---
P
E
A
---
G
K
R
G
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
----
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
--
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
-
L
P
C
-
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------
90
HHSearch
87.22
32%
5
- C2 -
-
4L1F
5
?
A:
[1-380]
-
M
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
H
-
I
W
D
----
R
-------
K
--
L
I
D
K
M
-
G
E
A
G
F
C
-------
G
-------
I
-------
C
----
F
P
E
E
Y
-
G
G
M
G
L
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
--
D
--
D
G
T
G
I
T
L
S
A
N
V
-
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
-----
T
H
V
---------
G
------
A
------
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---
K
S
Q
---
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
--
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
-
K
P
Y
-
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
------
77
HHSearch
86.74
29%
11
- C2 -
-
2JIF
10
ACDSB_HUMAN
D:
[25-403]
-
P
L
Q
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
-
E
N
S
-
K
M
E
----
K
-------
S
--
V
I
Q
G
L
-
F
Q
Q
G
L
M
-------
G
-------
I
-------
E
----
V
D
P
E
Y
-
G
G
T
G
A
S
F
L
S
T
V
L
V
I
E
E
L
A
K
V
--
D
--
A
S
V
A
V
F
C
E
I
Q
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
LPQLT-
T
-----
E
K
V
---------
G
------
S
------
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
---
P
T
I
---
G
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
----
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
--
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
-
K
P
F
-
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
E
------
6
PsiBlast_PDB
86.32
34%
11
- C2 -
-
4L1F
5
?
A:
[10-375]
----------
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
-
H
I
W
D
----
R
-------
K
L
-------
I
D
K
M
G
E
----------
A
G
F
C
G
I
C
----
F
P
E
----
E
Y
G
G
M
-
G
L
---
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
--
D
D
G
T
G
I
T
L
S
--
A
N
V
-
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
-
E
-----
G
T
H
---------
V
G
-----
A
------
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---
K
S
Q
---
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
--
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
-
K
P
Y
-
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
-----------
34
PsiBlast_CBE
86.13
34%
9
- C2 -
-
4L1F
4
?
B:
[10-375]
----------
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
-
K
A
-
H
I
W
D
----
R
-------
K
L
-------
I
D
K
M
G
E
----------
A
G
F
C
G
I
C
----
F
P
E
----
E
Y
G
G
M
-
G
L
---
D
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
--
D
DG
T
G
I
T
L
S
--
A
N
V
-
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
LAPIA-
E
-----
G
T
H
---------
V
G-----
A
------
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---
K
S
Q
---
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
--
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
-
K
P
Y
-
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
-----------
19
PsiBlast_PDB
85.20
30%
23
- C2 -
-
2DVL
2
?
A:
[8-368]
----------
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
A
E
Y
P
W
P
------------
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
PEEW
G
G
V
G
L
D
S
----------------------------
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
--
S
--
V
A
V
I
V
S
V
-
T
-
S
-
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
-
R
-----
G
E
W
I
--------
G
------
A
------
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
V
K
G
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
---
K
--------
G
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
----
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
--
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
-
E
R
F
-
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
-----------
11
PsiBlast_PDB
84.97
31%
11
- C2 -
-
4U83
1
?
A:
[19-380]
--------------
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
-
R
-
E
H
A
F
P
----
R
A
------
E
L
T
E
M
G
A
L
-----------
G
F
L
G
M
L
A
----
P
E
----
E
W
G
----
G
S
D
L
D
-
M
V
------
A
Y
A
L
A
L
E
E
I
A
A
G
--
D
G
A
C
S
T
I
V
S
V
--
H
S
-
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
------
L
P
K
M
A
C
G
E
W
I
--------
G
------
G
------
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
---
P
A
A
---
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
----
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
--
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
-
K
P
C
-
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----------
8
PsiBlast_PDB
84.56
30%
11
- C2 -
-
2VIG
5
ACADS_HUMAN
A:
[6-375]
-----
L
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
-
K
-
E
H
L
F
P
A
A
Q
V
K
-------
K
M
G
G
L
G
L
L
-
A
M
D
V
P
E
EL--
G
G
A
G
L
D
------------------------------
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
--
T
G
V
I
M
S
V
--
N
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
K
E
Q
K
Q
A
W
------
V
-----
T
P
F
---------
T
------
S
GD
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
A
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
A
W
E
A
S
A
A
V
V
F
A
S
T
D
---
R
A
L
---
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
D
S
I
L
G
E
P
G
M
----
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
--
A
F
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
-
K
P
F
-
I
K
E
A
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------
44
PsiBlast_CBE
83.42
31%
11
- C2 -
-
4U83
5
?
B:
[19-380]
--------------
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
-
R
-
E
H
A
F
P
----
R
A
------
E
L
T
E
M
G
A
L
-----------
G
F
L
G
M
L
A
----
P
E
----
E
W
G
----
G
S
D
L
D
-
M
V
------
A
Y
A
L
A
L
E
E
I
A
A
G
--
D
G
A
C
S
T
I
V
S
V
--
H
S
-
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
------
L
P
K
M
A
C
G
E
W
I
--------
G
------
G
------
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
---
P
A
A
---
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
----
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
--
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
-
K
P
C
-
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----------
43
PsiBlast_CBE
83.17
31%
10
- C2 -
-
4U83
1
?
C:
[19-380]
--------------
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
-
R
-
E
H
A
F
P
----
R
A
------
E
L
T
E
M
G
A
L
-----------
G
F
L
G
M
L
A
----
P
E
----
E
W
G
----
G
S
D
L
D
-
M
V
------
A
Y
A
L
A
L
E
E
I
A
A
G
--
D
G
A
C
S
T
I
V
S
V
--
H
S
-
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
------
L
P
K
M
A
C
G
E
W
I
--------
G
------
G
------
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
---
P
A
A
---
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
----
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
--
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
-
K
P
C
-
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----------
83
HHSearch
83.10
26%
4
- C2 -
-
1RX0
9
ACAD8_HUMAN
C:
[16-392]
--
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
-
Q
K
E
-
L
F
P
----
V
-------
D
--
V
M
R
K
A
-
A
Q
L
G
F
G
-------
G
-------
V
-------
Y
----
I
Q
T
D
V
-
G
G
S
G
L
S
R
L
D
T
S
V
I
F
E
A
L
A
T
G
--
C
--
T
S
T
T
A
Y
I
-
S
I
H
-
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
CPPLCT
M
-----
E
K
F
---------
A
------
S
------
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
---
G
P
----
G
P
K
G
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
----
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
--
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
D
A
-
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-------
92
HHSearch
83.00
29%
18
- C2 -
-
3PFD
-
?
C:
[23-393]
---------
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
-
E
K
A
-
R
F
P
----
E
-------
E
--
A
L
A
A
L
-
N
S
S
G
F
S
-------
A
-------
I
-------
H
----
V
P
E
E
Y
-
G
G
Q
G
A
D
S
V
A
T
C
I
V
I
E
E
V
A
R
V
--
D
--
C
S
A
S
L
I
P
-
A
V
N
-
K
L
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
LPAVAS
G
-----
E
A
M
---------
A
------
S
------
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
D
G
D
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
---
P
D
K
---
G
A
N
G
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
----
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
--
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
--
D
L
-
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------
21
PsiBlast_CBE
82.79
33%
38
- C2 -
-
1JQI
4
ACADS_RAT
B:
[7-379]
--
S
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
-
E
H
L
F
P
----
T
SQVKKMG
E
L
G
L
L
A
---
M
D
V
P
E
E
L---
S
G
A
G
L
D
Y
L
A
Y
S
I
A
LEEI
S
R
G
----
C
A
S
T
--
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
-
L
K
F
G
--
S
-------
S
Q
-
Q
K
Q
-----
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
---------------------------------------
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---
R
S
R
---
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
----
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
--
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
-
K
P
F
-
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------
82
HHSearch
82.47
26%
5
- C2 -
-
1RX0
8
ACAD8_HUMAN
A:
[16-392]
--
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
-
Q
K
E
-
L
F
P
----
V
-------
D
--
V
M
R
K
A
-
A
Q
L
G
F
G
-------
G
-------
V
-------
Y
----
I
Q
T
D
V
-
G
G
S
G
L
S
R
L
D
T
S
V
I
F
E
A
L
A
T
G
--
C
--
T
S
T
T
A
Y
I
-
S
I
H
-
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
-----
E
K
F
---------
A
------
S
------
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
---
G
P
----
G
P
K
G
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
----
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
--
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
D
A
-
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-------
85
HHSearch
81.25
22%
-10
- C2 -
-
2IX5
5
ACOX4_ARATH
A:
[51-427]
-
F
N
D
L
L
T
P
E
E
Q
A
I
R
K
K
V
R
E
C
M
E
K
E
V
A
P
I
M
T
E
Y
W
-
E
K
A
-
E
F
P
----
F
-------
H
--
I
T
P
K
L
-
G
A
M
G
V
A
-------
G
-------
G
-------
S
----
I
-
K
G
Y
-
G
C
P
G
L
S
I
T
A
N
A
I
A
T
A
E
I
A
R
V
--
D
--
A
S
C
S
T
F
I
L
V
H
S
-
S
L
G
M
L
T
I
A
L
C
G
S
E
A
Q
K
E
K
Y
L
P
S
L
A
Q
L
-----
N
T
V
---------
A
------
C
------
W
A
L
T
E
P
D
N
G
S
D
A
S
G
L
G
T
T
A
T
K
V
E
G
G
W
K
I
N
G
Q
K
R
W
I
G
N
S
T
F
A
D
L
L
I
I
F
A
R
N
T
---
T
T
------
N
Q
I
N
G
F
I
V
K
K
D
A
P
G
L
K
A
T
K
I
P
N
K
I
G
L
R
M
V
Q
N
G
D
I
L
L
Q
N
V
F
V
P
D
E
D
R
L
P
G
V
----
N
-
S
F
Q
D
T
S
K
V
L
A
V
S
R
V
M
V
A
W
Q
P
I
G
I
S
M
G
I
Y
D
M
C
H
R
Y
L
K
E
--
R
K
Q
F
G
A
P
L
A
A
F
Q
L
N
Q
Q
K
L
V
Q
M
L
G
N
V
Q
A
M
F
L
M
G
W
R
L
C
K
L
Y
E
T
G
-
Q
M
T
-
P
G
Q
A
S
L
G
K
A
W
I
S
S
K
A
R
E
T
A
S
L
G
R
E
L
L
G
G
N
G
I
L
A
D
F
L
V
A
K
A
F
C
D
L
E
P
I
Y
T
Y
E
G
T
Y
D
I
N
T
L
V
T
G
R
E
V
T
G
I
A
S
----
1
PsiBlast_PDB
81.23
33%
39
- C2 -
-
1JQI
4
ACADS_RAT
A:
[7-379]
--
S
V
E
L
P
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
-
K
-
E
H
L
F
P
----
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
---
M
D
V
P
E
E
L---
S
G
A
G
L
D
Y
L
A
Y
S
I
A
L
E
E
I
S
R
G
----
C
A
S
T
--
G
V
I
M
S
V
N
N
S
L
Y
L
G
P
I
-
L
K
F
G
--
S
-------
S
Q
-
Q
K
Q
-----
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
---------------------------------------
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---
R
S
R
---
Q
N
K
G
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
----
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
--
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
-
K
P
F
-
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
------------
16
PsiBlast_PDB
81.13
30%
16
- C2 -
-
2JIF
6
ACDSB_HUMAN
A:
[46-399]
-------------------------------------------------------
E
Q
I
A
P
L
-
V
S
T
M
D
E
----
N
S
K
M
E
K
S
V
I
Q
G
L
F
----
Q
Q
G
LMGI
E
V
D
P
E
Y
G
G
T
G
A
S
F
L
S
T
V
L
V
I
E
E
L
A
K
V
--
D
--
A
S
V
A
V
F
C
-
E
I
Q
----
N
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
------
K
-----
A
T
Y
L
P
Q
L
T
T
E
K
V
G
------
S
------
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
D
K
E
G
D
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
---
P
T
I
---
G
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
----
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
--
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
-
K
P
F
-
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
----------
42
PsiBlast_CBE
80.71
31%
12
- C2 -
-
4U83
2
?
D:
[19-380]
--------------
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
-
R
-
E
H
A
F
P
----
R
A------
E
L
T
E
M
G
A
L
-----------
G
F
L
G
M
L
A
----
P
E
----
E
W
G
----
G
S
D
L
D
-
M
V
------
A
Y
A
L
A
L
E
E
I
A
A
G
--
D
GA
C
S
T
I
V
S
V
--
H
S
-
S
V
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
------
L
PKMAC
G
E
W
I--------
G
------
G
------
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
D
---
P
A
A
---
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
A
E
----
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
--
T
F
------
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
-
K
P
C
-
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
-----------
65
PsiBlast_CBE
71.68
33%
-66
- C2 -
-
3P4T
3
?
B:
[144-390]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
---
G
P
----
G
A
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
----
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
--
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
-
E
T
N
L
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
------------------
66
PsiBlast_CBE
71.66
33%
-64
- C2 -
-
3P4T
3
?
A:
[144-390]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
---
G
P
----
G
A
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
----
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
--
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
-
E
T
N
L
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
------------------
68
PsiBlast_CBE
70.88
33%
-61
- C2 -
-
3OIB
2
?
A:
[144-390]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------
L
A
I
T
E
P
G
G
G
S
D
V
G
H
L
R
T
R
A
D
L
D
G
D
H
Y
V
I
N
G
A
K
T
Y
I
T
S
G
V
R
A
D
Y
V
V
T
A
A
R
T
G
---
G
P
----
G
A
G
G
V
S
L
I
V
V
D
K
G
T
P
G
F
E
V
T
R
K
L
D
K
M
G
W
R
S
S
D
T
A
E
L
S
Y
T
D
V
R
V
P
V
A
N
L
V
G
S
E
N
----
T
G
F
A
Q
I
A
A
A
F
V
A
E
R
V
G
L
A
T
Q
A
Y
A
G
A
Q
R
C
L
D
L
T
V
E
W
C
R
N
R
--
D
T
F
G
R
P
L
I
S
R
Q
A
V
Q
N
T
L
A
G
M
A
R
R
I
D
V
A
R
V
Y
T
R
H
V
V
E
R
Q
L
A
G
-
E
T
N
L
I
A
E
V
C
F
A
K
N
T
A
V
E
A
G
E
W
V
A
N
Q
A
V
Q
L
F
G
G
M
G
Y
M
A
E
S
E
V
E
R
Q
Y
R
D
M
R
I
L
G
I
G
G
G
T
T
E
I
------------------