@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNX2: (2017-11-18 )
MSNQNDKLKSLKTSSMDRRLSIAKASLLAGTRWATASASSLFSSEEEKEKKRKKAMSEQANYLVSEIGKLKGSIVKIGQMMALYGEHFLPEEITQALNTLNNQTVALNWPAIKPHLQEQLGSKLNDLTIDHEPIGTASLAQVHCATRKSDGLELVLKIQYPGVANAIDSDMSLFKNMLKLTRMVPQTREFDQWFDEVREMMHREVNYHVEAATTRRFAERLKDDERYIVPTIVDEYCTDQVLCMTFERGVPINSPVMLSLPQERRNQLGEASLEIAVREIFEWGEMQTDPNFGNYLVRLGNGQDIQDKIVLLDFGAIRQFDEHLLSVARNLIQAGYQHDKHAMVQAMTGYEFFDAMPESIKPGMADVFLLATEAFSTPANNPDMPAGLMDEHERYDWKKSQLHSRVMQQASKSMASRYFSVPPKEFMFISRKFIGAYTFMTVIDAKTNVRRMIRNFA
Atome Classification :
(20 SA)
-.........10........20.......-.30........40........50.....-...60........-70........80.......-.---90........100..--.....110......-.120.-.-.-----...--.-130----------------------.--------......-..140.......---150.......160.---..--....-.170.......180.......190.......200.......210----------.......220-........230..--.--.--...240.......250.......260...---...---...270....--...280.......290.......---300..-.....310.......320--........330.......340.------......350....-...360.-......370.......380.......390.......400.......410.....--..420......-.430.......440.......450.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MSNQ
N
D
K
L
K
S
L
K
TS
S
M
D
R
R
L
S
I
A
K
A
S
LL-AGTRWATA
S
A
S
S
L
FS
S
E
E
E
K
E
K
K
R
K
K
A
M
-
S
E
Q
A
N
Y
L
V
S
E
I
G
K
-
L
K
G
S
I
V
K
I
G
Q
M
M
A
L
Y
G
EHF-
L
---
P
E
E
I
T
Q
A
L
N
TLNN
Q
T
--
V
A
LNWPAI
K
P
H
L
Q
E
-
Q
L
G
S
K-L-N-----
D
L
T
--I-D------------------------H--------EPIGTA-
S
L
A
Q
V
H
C
ATRKS---DG
L
E
L
V
L
K
I
QY-PG---VA--N
A
I
D
-
S
D
M
S
L
F
K
N
M
L
K
L
T
R
MVPQT
R
E
F
D
Q
W
F
D
E
V
R
E
M
M
H
R
EV
N
Y
H
V
E
A
A
----------
T
T
R
R
F
A
E
RL--KDDE
R
Y
I
V
P
T
I
V
D
--
E
--Y--CTD
Q
V
L
C
M
T
F
ERGVPINS
P
V
M
L
SL--
P
Q
E
---
R
R
N
---QLG
E
A
S
L
E
I
A
--
V
R
E
I
F
E
W
GEMQTDPNFG
N
Y
L
V
RL---GNGQD-IQ
D
K
I
V
L
L
D
F
G
A
I
R
Q
F
D
---
E
H
L
L
S
V
A
R
N
L
I
Q
AGYQ
H
D
K
H
A
M
------
V
Q
A
MT
G
Y
E
F
F
D
AM-
P
E
SIKPG-
M
A
D
V
F
L
L
A
T
E
AFSTPANNPDMPA
G
L
M
D
E
H
E
RY
D
W
K
K
S
Q
L
H
S
R
V
M
Q
Q
A
S
K
S
M
A
S
R
--YFSV
P
P
K
E
F
M
F
-
I
S
R
K
F
I
G
A
Y
T
F
M
T
V
IDA
K
T
N
V
R
R
M
I
R
NFA
26
HHSearch
80.13
28%
-16
- C2 -
-
4PED
-
COQ8A_HUMAN
A:
[4-383]
------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
-
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
-
D
D
A
F
I
---
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
L
G
P
N
-
W
-
R
D
K
---
L
E
Y
--
F
-
E
------------------------
E
--------
R
P
F
A
A
A
-
S
I
G
Q
V
H
L
A
R
M
K
G
----
G
R
E
V
A
M
K
I
Q
Y
-
P
G
---
V
A
--
Q
S
I
N
-
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
F
P
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
E
A
A
----------
C
A
R
K
F
R
D
L
L
--
K
G
H
P
F
F
Y
V
P
E
I
V
D
--
E
--
L
--
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
L
S
----
Q
E
---
I
R
N
---
E
I
C
Y
N
I
L
V
L
C
--
L
R
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
D
P
---
Q
------
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
---
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
D
R
E
T
V
------
R
A
K
S
I
E
M
K
F
L
T
G
Y
-
E
V
K
V
M
E
D
A
H
L
D
A
I
L
I
L
G
E
A
F
A
S
D
--------------
E
P
F
D
F
G
T
Q
S
T
-
T
E
K
I
H
N
L
I
P
V
M
L
R
H
--
R
L
V
-
P
P
P
E
E
T
Y
S
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
E
A
Y
1
PsiBlast_PDB
76.74
26%
-1
- C2 -
-
4PED
-
COQ8A_HUMAN
A:
[6-372]
--------------------------------------------------------------
A
E
R
I
V
R
T
L
C
K
-
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
D
A
F
-
I
---
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
L
G
P
N
-
W
-
R
-----
D
K
L
EY
F
-
E
------------------------
E
--------
R
P
F
A
A
A
-
S
I
G
Q
V
H
L
A
-
R
M
K
---
G
G
R
E
V
A
M
K
I
Q
Y
-
P
G
---
V
A
--
Q
S
I
N
-
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
F
P
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
E
A
A
----------
C
A
R
K
F
R
D
L
L
--
K
G
H
P
F
F
Y
V
P
E
I
V
D
--
E
--
L
--
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
L
S
----
Q
E
---
I
R
N
---
E
I
C
Y
N
I
L
V
L
C
--
L
R
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
--------
D
P
-
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
---
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
G
Y
E
V
------
K
V
M
E
D
A
-
H
L
D
A
I
L
I
L
G
E
A
F
A
S
--------------
D
E
P
F
D
F
G
T
Q
S
T
T
E
K
I
H
N
L
I
P
V
M
L
R
H
R
--
L
V
P
-
P
P
E
E
T
Y
S
-
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
-----------
2
PsiBlast_PDB
67.16
29%
-13
- C2 -
-
5I35
1
COQ8A_HUMAN
A:
[7-318]
---------------------------------------------------------------
E
R
I
V
R
T
L
C
K
-
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
D
A
F
-
I
---
N
P
H
L
A
K
I
F
E
R
V
R
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-
D
L
G
P
N
-
W
-
R
-----
D
K
L
EY
F
-
E
------------------------
E
--------
R
P
F
A
A
A
-
S
I
G
Q
V
H
L
A
-
R
M
K
---
G
G
R
E
V
A
M
K
I
Q
Y
-
P
G
---
V
A
--
Q
S
I
N
-
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
F
P
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
E
A
A
----------
C
A
R
K
F
R
D
L
L
--
K
G
H
P
F
F
Y
V
P
E
I
V
D
--
E
--
L
--
C
S
P
H
V
L
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
L
S
----
Q
E
---
I
R
N
---
E
I
C
Y
N
I
L
V
L
C
--
L
R
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
--------
D
P
-
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
---
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
G
Y
E
V
------
K
V
M
E
D
A
-
H
L
D
A
I
L
I
L
G
E
A
F
A
S
-----------------------------------------------------------------------------------
19
Fugue
40.36
13%
-39
- C2 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
--------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
-
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
E
P
S
P
K
T
-
E
D
N
E
G
V
L
L
T
E
K
L
K
-
P
V
D
Y
E
Y
R
E
E
V
------------------------------------------------------------
H
W
A
--
T
-
H
------------------------
Q
--------
L
R
L
G
R
G
-
S
F
G
E
V
H
R
M
E
D
K
Q
---
T
G
F
Q
C
A
V
K
K
V
R
------
L
E
--
V
F
R
A
-
E
E
L
M
A
C
A
G
L
--------
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
W
V
N
I
F
M
E
L
L
----------
E
G
G
S
L
G
Q
L
V
--
K
E
Q
G
---------------------------------------
C
L
--
P
E
D
---
R
A
L
---
Y
Y
L
G
Q
A
L
E
-
G
--
L
E
Y
L
H
S
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
----
S
D
G
S
-----
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
IPG
T
E
T
H
M
A
P
E
V
V
L
G
R
S
C
D
A
K
V
D
V
W
------
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
-
G
P
L
C
L
K
I
A
S
E
----
P
P
P
V
R
E
I
P
P
S
C
----------
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
--
V
S
A
A
E
L
G
G
K
V
N
-
R
A
L
Q
Q
V
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
------
21
Fugue
40.20
24%
-167
* C3 *
-
1DPJ
-
IPA3_YEAST
B:
[2-30]
----------------------------------
T
D
Q
Q
K
V
S
E
I
F
Q
S
S
K
E
K
L
Q
G
D
A
K
V
V
-
S
D
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
40.19
21%
-68
- C2 -
-
4KS7
2
A:
[29-172]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
G
E
G
-
S
T
G
I
V
C
L
A
R
E
K
H
---
S
G
R
Q
V
A
V
K
M
M
D
-
L
R
---
K
Q
--
Q
R
R
E
--------------------------------------
L
L
F
N
E
V
V
----------
I
M
R
D
Y
Q
---------
H
F
N
V
V
E
M
Y
K
--
S
--
Y
L
V
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
V
R
L
-
N
E
E
---
Q
I
A
---
T
V
C
E
A
V
L
Q
A
---
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
----------
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
---
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
38.63
16%
-26
- C2 -
-
2F57
1
B:
[17-194]
----------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
--
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
-
V
V
S
P
G
D
P
R
E
Y----
L
A
N
--
F
-----------------------------------
I
K
I
G
E
G
-
S
T
G
I
V
C
I
A
T
E
K
H
---
T
G
K
Q
V
A
V
K
K
M
D
-
L
R
---
K
Q
--
Q
R
R
E
--------------------------------------
L
L
F
N
E
V
V
----------
I
M
R
D
Y
H
-------
H
D
N
V
V
D
M
Y
S
S
Y
--
L
--
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
-
N
E
E
---
Q
I
A
---
T
V
C
L
S
V
L
R
A
---
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
----------
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
38.44
20%
-44
- C2 -
-
4L67
-
A:
[26-169]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
G
E
G
-
S
T
G
I
V
C
I
A
T
V
R
S
---
S
G
K
L
V
A
V
K
K
M
D
-
L
R
---
K
Q
--
Q
R
R
E
--------------------------------------
L
L
F
N
E
V
V
----------
I
M
R
D
Y
Q
-------
H
E
--
N
V
V
E
M
Y
N
--
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
-
N
E
E
---
Q
I
A
---
A
V
C
L
A
V
L
Q
A
---
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
----------
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
37.32
15%
-31
- C2 -
-
3BKB
6
A:
[120-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
G
R
G
-
N
F
G
E
V
F
S
G
R
L
R
A
---
D
N
T
L
V
A
V
K
S
C
R
-
E
T
---
L
P
--
P
D
L
K
-
A
------------------------------------
K
F
L
Q
E
A
R
----------
I
L
K
Q
Y
S
-------
H
P
--
N
I
V
R
L
I
G
VC
T
--
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
--
A
R
L
---
R
V
K
---
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
----------
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
36.69
15%
-33
* C2 *
-
3CBL
3
A:
[120-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
I
G
R
G
-
N
F
G
E
V
F
S
G
R
L
R
A
---
D
N
T
L
V
A
V
K
S
C
R
-
E
T
---
L
P
--
P
D
L
K
-
A
------------------------------------
K
F
L
Q
E
A
R
----------
I
L
K
Q
Y
S
-------
H
P
--
N
I
V
R
L
I
G
VC
T
--
Q
--
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
--
A
R
L
---
R
V
K
---
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
----------
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
35.40
19%
-35
- C2 -
-
2X4F
3
MYLK4_HUMAN
B:
[94-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--------
E
I
L
G
G
G
---
G
Q
V
H
K
C
E
E
T
A
---
T
G
L
K
L
A
A
K
I
I
K
-
T
R
---
G
M
--
K
D
K
E
--------------------------------------
E
V
K
N
E
I
S
----------
V
M
N
Q
L
D
-------
H
A
--
N
L
I
Q
L
Y
D
--
A
F
E
S
--
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
--
Y
N
L
---
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
---
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
---
R
D
-----
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
---
P
--------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
34.26
13%
-61
- C2 -
-
1GH6
-
RB_HUMAN
B:
[379-772]
--
M
N
T
I
Q
Q
L
M
M
I
L
N
S
A
S
D
Q
P
S
E
N
L
I
S
Y
F
N
-
N
C
T
V
---
N
P
K
E
S
I
L
K
R
V
K
D
I
G
Y
I
F
K
E
K
F
-
A
K
A
V
G
A
G
C
V
A
I
G
S
-
Q
R
Y
K
L
G
V
R
--
L
Y
Y
R
V
M
E
S
M
-
L
---
K
S
E
E
E
R
L
S
I
Q
N
F
S
K
L
--
L
N
-----------------------------
D
--
N
-
I
------------------------
F
--------
H
M
S
L
L
A
-
C
A
L
E
V
V
M
A
T
Y
S
R
---
S
T
T
D
L
----
S
F
-
P
W
---
I
L
--
N
V
L
N
L
K
A
F
D
F
Y
K
V
I
E
S
F
I
K
A
--------------------------
E
G
N
----------
L
T
R
E
M
I
K
H
L
--
E
R
C
E
H
R
I
M
E
S
------------------
L
A
W
L
S
D
----
S
P
L
F
D
L
I
--
K
Q
S
---
K
L
V
---
P
R
G
S
T
S
L
S
L
F
--
Y
K
K
V
Y
R
L
A
Y
L
R
L
N
T
L
C
E
R
L
L
S
------
E
H
P
E
-
L
E
H
I
I
W
T
L
F
Q
H
T
L
Q
N
E
Y
---
E
L
M
-------------
R
D
R
H
------------------------------
L
D
Q
I
M
M
C
S
M
Y
G
I
C
K
V
K
N
I
D
L
K
F
K
I
I
V
T
A
Y
K
D
L
P
H
A
V
Q
E
T
F
K
R
V
L
I
K
E
E
E
Y
D
-----------
S
I
I
V
F
-
Y
N
S
V
F
M
Q
R
------------
L
K
T
N
I
L
Q
Y
A
29
HHSearch
33.83
15%
9
- C2 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-252]
-----------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
W
-
A
A
A
K
E
F
Y
Q
K
--
Y
-
D
------------------------
P
K-------
D
V
I
G
R
G
-
V
S
S
V
V
R
R
C
V
H
R
A
---
T
G
H
E
F
A
V
K
I
M
E
-
V
T
---
A
E
--
R
L
S
P
-
E
Q
L
E
E
-----------------------
V
R
E
------
A
T
R
R
E
T
H
----------
I
L
R
Q
V
A
------
G
H
P
H
I
I
T
L
I
D
S
Y
--
E
--
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
AL
S
E
K
---
E
T
R
---
S
I
M
R
S
L
L
E
A
---
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
---
P
--------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
33.66
13%
-18
- C2 -
-
4AW2
4
MRCKA_RAT
A:
[12-245]
-----------------------------------------------------------------------------
F
I
L
D
G
P
A
Q
T
N
G
-
Q
C
F
-
S
---
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
--
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
-
F
-
T
S
K
---
V
K
Q
--
M
-
R
------------------------
L
HREDFEIL
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
K
N
---
A
D
K
V
F
A
M
K
I
L
N
-
K
W
---
E
M
--
L
K
-
R
-
A
E
T
A
---------------------------------
C
F
R
E
E
R
D
----------
V
L
V
N
-------
G
D
S
K
W
I
T
T
L
H
Y
A
F
--
Q
--
D
--
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
--
D
R
L
P
E
E
M
A
R
---
F
Y
L
A
E
M
V
I
A
---
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
----------
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
---
E
--------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
33.25
17%
-45
- C2 -
-
4JXF
2
PLK4_HUMAN
A:
[13-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
L
G
K
G
-
S
F
A
G
V
Y
R
A
E
S
I
H
---
T
G
L
E
V
A
I
K
M
I
D
-
K
K
---
A
M
--
Y
K
A
-----
G
------------------------
M
V
Q
------
R
V
Q
N
E
V
K
----------
I
H
C
Q
L
K
-------
H
P
S
--
I
L
E
L
Y
N
Y
F
E
--
D
--
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
--
K
P
F
---
S
E
N
---
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
----------
N
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
---
M
P
-------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
32.55
16%
-18
- C2 -
-
1VZO
-
KS6A5_HUMAN
A:
[60-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
T
G
-
A
Y
G
K
V
F
L
V
R
K
I
S
GHD
T
G
K
L
Y
A
M
K
V
L
K
-
K
A
---
T
I
--
V
Q
K
A
-
K
T
T
---------------------------------
E
H
T
R
T
E
R
Q
----------
V
L
E
H
I
R
------
Q
S
P
F
L
--
V
T
L
H
Y
A
F
Q
--
T
--
E
T
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
R
E
---
R
F
---
T
E
H
---
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
L
G
I
I
Y
R
D
I
K
L
E
N
I
L
L
D
S
----------
N
G
H
V
V
L
T
D
F
G
L
S
K
E
F
V
---
A
--------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
32.47
17%
-24
- C2 -
-
4UW0
-
?
A:
[222-378]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
H
--
W
-
Q
------------------------
N
--------
Q
P
Y
A
G
A
-
G
L
A
H
K
R
S
R
R
Y
F
F
----
G
E
D
Y
V
C
K
F
F
Y
-
Y
D
---
M
P
--
H
G
I
L
--
T
A
E
E
--------------------
S
Q
R
N
K
H
------
E
L
H
N
E
I
K
----------
F
L
T
Q
P
P
--------
A
G
F
D
A
P
A
V
L
A
--
H
--
G
E
N
A
Q
S
G
W
L
V
M
E
K
L
P
G
R
L
L
S
D
M
L
A
A
G
E
---
E
I
---
D
R
E
---
K
I
L
G
S
L
L
R
S
---
L
A
A
L
E
K
K
G
F
W
H
D
D
V
R
P
W
N
V
M
V
D
A
----------
R
Q
H
A
R
L
I
D
F
G
S
I
V
T
T
P
---
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
31.93
12%
31
- C2 -
-
3V5W
1
ARBK1_HUMAN
A:
[91-361]
-------------------------------------------------------
K
Y
E
K
L
E
T
E
E
E
R
V
A
R
S
R
E
-
I
F
D
S
Y
I
M
--
K
E
L
L
A
C
-
S
H
P
-
F
---
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
QV
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
-
N
L
R
G
D
-
V
-
F
Q
K
---
F
I
E
--
S
-
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
MNDFSV
H
--------
R
I
I
G
R
G
-
G
F
G
E
V
Y
G
C
R
K
A
D
---
T
G
K
M
Y
A
M
K
C
L
D
-
K
K
---
R
I
--
K
M
K
---------------------------------------
Q
G
E
T
L
A
L
----------
N
E
R
I
M
L
S
L
V
ST
G
D
C
P
F
I
V
C
M
S
Y
A
F
--
H
--
T
--
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
---
V
F
---
S
E
A
---
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
----------
H
G
H
V
R
I
S
D
L
G
L
A
C
D
F
S
---
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
31.66
14%
-4
- C2 -
-
5J87
1
BTK_HUMAN
B:
[22-165]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
T
G
-
Q
F
G
V
V
K
Y
G
K
W
R
G
----
Q
Y
D
V
A
I
K
M
I
K
-
E
G
---
S
M
S
E
D
E
F
I
-
E
----------------------------------------
E
A
K
----------
V
M
M
N
L
S
-------
H
E
K
--
L
V
Q
L
Y
G
VC
T
--
K
--
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
--
H
R
F
---
Q
T
Q
---
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
----------
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
31.21
10%
10
- C3 -
-
2VOS
3
FOLC_MYCTU
A:
[22-487]
D
E
I
A
S
L
L
Q
V
E
H
L
L
D
Q
R
W
R
I
D
P
S
L
T
R
I
S
A
L
M
D
L
L
G
S
P
Q
R
S
Y
P
S
I
H
I
A
----------------
G
T
N
G
K
T
S
V
A
R
M
V
D
A
L
V
T
A
L
H
R
R
T
G
R
T
T
S
P
H
-
L
QSP
V
E
R
I
S
I
D
G
K
P
I
S
P
A
Q
--
Y
V
A
T
Y
R
E
I
E
P
L
V
-
A
-
L
I
D
Q
Q
-
S
-
Q
-----
A
S
P
--
A
M
S
------------------------
K
--------
F
E
V
L
T
A
M
A
F
A
A
F
A
D
--------
A
P
V
D
V
A
V
V
E
V
G
M
G
G
RWD
A
T
--
N
V
I
N
-
A
P
V
A
V
I
T
P
-
I
S
I
D
H
V
D
Y
L
G
A
D
I
A
G
I
A
G
E
K
A
G
I
I
T
R
A
P
S
P
D
T
V
A
V
I
G
R
QV
P
K
V
M
E
V
L
L
A
E
S
V
R
A
--
D
A
S
V
A
R
E
D
S
E
F
A
V
--
L
--
R
--
R
Q
I
A
V
G
G
Q
V
L
Q
L
Q
G
L
G
G
V
Y
S
D
I
Y
L
--
P
L
H
---
G
E
H
---
Q
A
H
N
A
V
L
A
L
A
--
S
V
E
A
F
F
-
G
A
Q
L
D
G
D
A
V
R
A
G
F
A
A
V
T
S
P
G
R
L
E
R
M
R
S
A
P
T
V
F
I
D
-
A
A
---
H
N
---
P
A
G
A
S
A
L
A
Q
T
L
A
H
E
F
D
F
R
F
L
V
G
------
V
L
S
V
L
G
D
K
D
V
D
G
I
-
L
A
A
L
E
P
--
V
F
D
S
V
V
V
T
H
N
G
S
P
R
A
L
D
V
E
A
L
A
L
A
A
G
E
R
F
G
P
D
R
V
R
T
A
E
N
L
R
D
A
I
D
V
A
T
S
L
V
D
D
A
A
A
D
P
D
V
A
G
R
T
G
I
V
-
I
T
----
G
S
V
V
T
A
G
A
A
R
T
L
F
G
R
D
P
Q
-----