@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNY0: (2017-11-18 )
MLTIVQEALTFDDVLLLPAYSTVLPKDVSLKTRLTRGIYLNIPLVSAAMDTVTESRMAIAMAQNGGIGILHKNMDIAAQAAEVRRVKKFEAGMVKDPITVSPETTVRELIAITSANNISGVPVVKDGKVVGIVTGRDTRFETNLEQPVSNIMTGQDRLVTVREGESKENIQALLQKHRIEKVLVVGESNELKGLITVTDFRKAESYPNSCKDDLGRLRVGAAVGTGADTPSRVEALVEAGVDVIVVDTAHGHSAGVIERVRWVKQNFPQVQVIGGNIATGDAALALLDAGADAVKVGIGPGSICTTRIVAGIGMPQISAIDSVASALKDQIPLIADGGIRFSGDMAKAIGAGASTIMVGSLLAGTEEAPGEVEFFQGRYYKAYRGMGSLGAMAGATGSADRYFQDSKAGAEKLVPEGIEGRVPYKGPMGNIVHQMMGGLRSSMGYTGSAVIEDLRQNAKFVKITSAGMSESHVHDVTITKEAPNYRVG
Atome Classification :
(53 SA)
-------------......-...10........20..-......30......-..40........50........60........70........80........90........100.......110.......120..-.---...----.130.......140.......150.....-..160.......170.......180.......190.......200.......210........220.......230.......240.......250.......260.....-..270.......280.......290.......300.......310.......320....-..-.-.-330........340.......350.......360.......370.......380.......390.......400------.........410.......420.......430.......440.......450....-----..-----.460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------M
L
T
I
V
Q
-
E
ALTFD
D
V
L
L
LPA
Y
S
TV-LPKDV
S
L
K
T
R
LTR
G
-
I
Y
L
NI
P
L
V
S
A
A
M
D
T
V
TES
R
M
A
I
A
M
AQNG
G
I
G
I
L
HKNM
D
I
A
A
Q
A
A
E
V
R
R
V
K
K
FEAGMVKD
P
I
TVSP
E
T
T
V
R
E
L
I
A
I
TSANNISG
V
P
V
V-K---DG
K
----
V
V
G
I
VTGRDTRFET
N
L
E
Q
P
V
S
N
IMTGQ
D
R
-
L
V
T
V
REGE
S
K
E
N
I
Q
A
L
L
Q
K
HRI
E
K
V
L
V
VGESNE
L
K
G
L
I
T
V
T
D
F
R
K
A
ESYP
N
S
C
K
-
D
D
L
G
R
L
R
V
G
A
AVGTGAD
T
P
S
R
V
E
A
L
V
EAGV
D
V
I
V
V
DTAHGHS
A
G
V
I
E
R
V
R
W
V
K
QNF-P
Q
V
Q
V
IGGNIAT
G
D
A
A
L
A
L
L
DAGA
D
A
V
K
VGIGPG
S
I
C
T
T
R
I
V
AGIGM
P
Q
I
S
A
I
-
D
S
V
A
S
-
A
L
-
K
-D-Q-I
P
L
IADG
G
I
R
FSG
D
M
A
K
A
IGAG
A
S
T
I
M
V
G
S
L
LAGTEEAPGE
V
E
FFQGR
Y
Y
K
A
Y
RGMGSLGAMAGATGSAD--------RYFQDSKA
G
A
E
KLVPEGIEGRVPYKG
P
M
G
N
I
V
H
Q
M
M
G
G
L
R
S
SMGYT
G
S
A
V
I
E
D
L
RQ-----NA-----
K
F
V
K
I
TSAGMSES
H
V
H
D
V
T
ITKEAPNYRVG
3
PsiBlast_PDB
92.52
70%
-92
- C1 -
-
4DQW
4
?
A:
[21-486]
-------------
M
L
R
I
S
Q
-
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
-
E
---
Q
G
E
----
L
V
G
I
V
T
G
R
D
L
R
V
K
P
N
A
G
D
T
V
A
A
I
M
T
P
K
D
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
-
G
-
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
-----------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
-----------------------
21
PsiBlast_CBE
87.41
70%
-96
- C1 -
-
4DQW
3
?
B:
[21-486]
-------------
M
L
R
I
S
Q
-
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
-
E
---
Q
G
E
----
L
V
G
I
V
T
G
R
D
L
R
V
-----
D
T
V
A
A
I
M
T
P
K
D
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
-
G
-
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
-----------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
-----------------------
122
HHSearch
86.32
62%
-32
- C1 -
-
4FXS
2
?
A:
[3-486]
-------------
M
L
R
I
A
K
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
-
T
E--
N
N
E
----
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
L
T
K
S
V
A
A
V
M
T
P
K
E
R
-
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
-
A
D
A
A
G
-
V
A
N
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
G
S
--
S
D
--------
R
Y
F
Q
T
----
A
D
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
5
PsiBlast_PDB
84.40
59%
-31
- C1 -
-
4FXS
2
?
A:
[4-486]
--------------
L
R
I
A
K
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
E
---
N
N
E
----
L
V
G
I
I
T
G
R
D
V
R
F
V
T
D
L
T
K
S
V
A
A
V
M
T
P
K
E
R
-
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
K
G
S
S
D
--------
R
Y
F
Q
T
----
A
D
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
130
HHSearch
83.73
77%
-73
- C1 -
-
5AHM
1
?
A:
[22-398]
--------------
L
R
I
S
Q
-
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
-----------------------
E
T
A
K
-
A
K
T
Y
-------------------------------------------
P
-
L
--
A
S
K
----------------------
D
E
---------------------------
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
G
T
-
G
-
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
--------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
123
HHSearch
83.72
54%
-32
- C1 -
-
1ZFJ
1
IMDH_STRPY
A:
[4-490]
-------------
D
T
K
F
L
K
-
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
-
L
P
N
E
V
D
L
K
T
K
L
A
D
N
-
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
-
E
TLA
N
R
K
----
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
P
I
S
E
H
M
T
S
--
E
H
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
-
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
-
Y
D
A
A
A
-
V
A
R
E
-
Y
-
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
------------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
--
10
PsiBlast_PDB
82.34
52%
-26
- C1 -
-
1ZFJ
1
IMDH_STRPY
A:
[7-490]
----------------
F
L
K
-
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
-
L
P
N
E
V
D
L
K
T
K
L
A
D
N
-
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
-
E
TLA
N
R
K
----
L
V
G
I
I
T
N
R
D
M
R
F
I
S
D
Y
N
A
P
I
S
E
H
M
T
S
E
-
H
-
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
-
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
-
A
R
-
E
-
Y
-
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
--
K
K
----------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
-----
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
--
7
PsiBlast_PDB
82.18
54%
-17
* C1 *
-
3TSB
-
?
A:
[30-510]
----------------
F
V
K
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
-
N
NLD
E
R
K
----
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
G
S
K
D
--------
R
Y
F
Q
E
---
G
N
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
--
137
HHSearch
79.90
65%
-74
- C1 -
-
4FO4
2
?
A:
[6-366]
-------------
M
L
R
I
A
K
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
-------------------------------------------------------------------------------------------------
Q
V
K
I
S
--
G
G
L
R
------------------------------------
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
-
A
D
A
A
G
-
V
A
N
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
--------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
G
8
PsiBlast_PDB
79.28
54%
-26
- C1 -
-
3TSD
1
?
A:
[30-497]
----------------
F
V
K
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
-
N
NLD
E
R
K
----
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
--
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
-----------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
---------------
135
HHSearch
79.14
60%
-102
- C1 -
-
5UZS
9
?
C:
[4-360]
-------------
M
A
R
I
L
K
-
T
A
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
-
L
P
N
E
V
S
L
K
T
Q
L
T
K
K
-
I
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
N
M
T
I
E
D
Q
A
R
E
V
D
---------------------------
R
----------------------------------------------------------------------
V
K
R
S
G
--------------------------------------
G
L
L
C
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
-
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
L
T
A
V
-
M
D
C
A
E
-
E
G
-
K
-
L
-
G
-
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
L
G
A
M
A
K
--------------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
-----
N
A
-----
N
F
V
V
Q
T
S
A
G
F
R
E
S
H
P
H
D
I
N
I
T
K
E
A
P
N
Y
S
--
4
PsiBlast_PDB
79.04
70%
-91
- C1 -
-
5AHN
1
?
A:
[1-467]
-------------
M
L
R
I
S
Q
-
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
----------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
-
G
-
T
G
V
P
L
I
A
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G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
---------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
----------------------
120
HHSearch
78.87
71%
-91
- C1 -
-
5AHN
1
?
A:
[1-467]
-------------
M
L
R
I
S
Q
-
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
-
L
P
K
D
V
S
L
K
T
R
L
T
R
G
-
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
K
H
----------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
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R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
G
T
-
G
-
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
---------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
----------------------
136
HHSearch
78.57
65%
-73
- C1 -
-
4X3Z
3
?
A:
[6-363]
-------------
M
L
R
I
A
K
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
-------------------------------------------------------------------------------------------------
Q
V
K
I
S
--
G
G
L
R
------------------------------------
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
-
A
D
A
A
G
-
V
A
N
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
---------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
143
HHSearch
78.41
62%
-61
- C1 -
-
4MZ1
4
?
C:
[5-382]
---------------
K
I
V
K
-
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
-
L
P
K
E
V
K
I
H
T
K
L
T
K
N
-
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
---------------------------
S
------------------------------------------------
E
-
S
G
G
I
------
K
-------
K
R
K
E
Y
P
D
A
N
K
D
---------------------------
N
F
G
R
L
R
V
G
A
A
--
I
G
V
G
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
-
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
-
D
E
C
V
E
-
E
A
-
N
K
F
-
G
-
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
K
--------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
-----
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
-
134
HHSearch
77.92
60%
-77
- C1 -
-
5UZC
7
?
C:
[5-360]
--------------
A
R
I
L
K
-
T
A
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
-
L
P
N
E
V
S
L
K
T
Q
L
T
K
K
-
I
Q
L
N
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
N
M
T
I
E
D
Q
A
R
E
V
D
---------------------------
R
----------------------------------------------------------------------
V
K
R
S
G
--------------------------------------
G
L
L
C
G
A
S
I
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
-
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
L
T
A
V
-
M
D
C
A
E
-
E
G
-
K
K
L
-
G
-
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
E
I
Y
Q
G
R
S
Y
K
V
Y
R
G
M
G
S
L
G
A
M
A
---------------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
E
N
L
Y
E
-----
N
A
-----
N
F
V
V
Q
T
S
A
G
F
R
E
S
H
P
H
D
I
N
I
T
K
E
A
P
N
Y
S
--
140
HHSearch
77.69
62%
-66
- C1 -
-
5UQG
3
?
E:
[27-403]
----------------
I
V
K
-
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
-
L
P
K
E
V
K
I
H
T
K
L
T
K
N
-
I
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
------
S
----------------------------------------------------------------------------
K
E
Y
P
--
D
A
---
N
K
D
-
N
F
------------------------------------
G
R
L
R
V
G
A
A
I
G
--
V
G
Q
M
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
-
P
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
-
D
E
C
V
E
-
E
A
-
N
K
F
-
G
-
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
K
--------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
Q
K
-----
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
-
133
HHSearch
75.88
56%
-69
- C1 -
-
5UPX
2
?
A:
[7-384]
--------------
T
K
F
A
K
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
N
D
V
D
L
S
V
E
M
A
P
S
-
L
K
L
N
V
P
I
W
S
A
G
M
D
T
I
T
E
A
K
M
A
I
A
I
A
R
Q
G
G
I
G
V
V
H
K
N
M
S
I
E
Q
Q
A
E
E
I
E
K
V
K
R
S
E
----------------------------------------------------------------------------
S
G
G
I
-
K
D
--
K
V
---
I
--------
E
F
P
N
S
A
------------------------
K
-
D
K
H
G
R
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
-
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
-
Y
D
C
A
T
-
V
A
R
E
-
F
-
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
E
H
G
----
D
--------
R
Y
F
Q
A
D
---
A
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
-----
E
A
-----
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
--
121
HHSearch
75.68
40%
0
- C- -
-
1NF7
1
IMDH2_HUMAN
B:
[26-514]
-----------------
C
G
-
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
-----------------------------------
G
I
I
S
S
R
D
I
D
F
L
-
E
H
D
C
F
L
E
E
I
M
T
K
R
E
D
-
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
-
Y
K
V
S
E
-
Y
A
R
R
-
F
-
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
---------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
S
Y
E
K
R
L
F
----
9
PsiBlast_PDB
75.50
52%
-25
- C1 -
-
3USB
3
?
A:
[30-493]
----------------
F
V
K
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
-
L
P
R
E
V
S
V
K
T
V
L
S
E
S
-
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
-
N
NLD
E
R
K
----
L
V
G
I
I
T
N
R
D
M
R
F
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-----------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
132
HHSearch
75.30
65%
-71
- C1 -
-
4FEZ
5
?
B:
[7-366]
--------------
L
R
I
A
K
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
-
L
P
N
T
A
D
L
R
T
R
L
T
K
N
-
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
S
---------------------------------------------------------------------------------------------------
K
P
------------------------
N
A
C
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
-
A
D
A
A
G
-
V
A
N
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
--------------------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
----------------------
11
PsiBlast_PDB
68.78
48%
-63
- C1 -
-
2CU0
1
IMDH_PYRHO
A:
[16-480]
-----------------------
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
-
E
P
K
D
V
D
V
S
T
R
I
T
P
N
-
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
R
A
E
---------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
G
E
L
L
V
A
A
A
V
-
S
P
F
D
I
K
R
A
I
E
-
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
-
A
M
V
A
D
-
R
A
-
Q
-
E
-
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
--
M
K
------------------
Y
M
K
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
127
HHSearch
68.60
48%
-63
- C1 -
-
2CU0
1
IMDH_PYRHO
A:
[9-480]
---------------
E
K
A
I
-
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
-
E
P
K
D
V
D
V
S
T
R
I
T
P
N
-
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
R
A
E
---------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
G
E
L
L
V
A
A
A
--
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
-
A
M
V
A
D
-
R
A
-
Q
E
Y
-
G
-
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
--------------------
Y
M
K
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-----
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
13
PsiBlast_PDB
65.92
76%
-74
- C1 -
-
5AHM
1
?
A:
[113-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
-
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
-
A
N
V
A
A
-
A
L
-
E
-
G
-
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
--------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
R
T
-----
Q
P
-----
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
31
PsiBlast_CBE
63.75
40%
-21
- C1 -
-
1NFB
2
IMDH2_HUMAN
B:
[28-498]
--------------------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
-
D
---
T
G
R
MGS----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
-
Y
K
V
S
E
Y
A
R
-
R
-
F
-
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
---------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
MMYSG
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
35
PsiBlast_CBE
63.69
40%
-18
- C1 -
-
1B3O
2
IMDH2_HUMAN
B:
[28-498]
--------------------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
D
R
V
R
-----------
C
G
I
P
I
T
-
D
---
T
G
R
MG
S
R
L
V
G
I
I
-----------------
I
M
T
K
R
E
D
-
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
-
Y
K
V
S
E
Y
A
R
-
R
-
F
-
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
------------------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
32
PsiBlast_CBE
63.61
40%
-20
- C1 -
-
1NFB
2
IMDH2_HUMAN
A:
[28-498]
--------------------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
-
D
---
T
G
R
MGS----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
-
Y
K
V
S
E
Y
A
R
-
R
-
F
-
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
---------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
36
PsiBlast_CBE
63.34
40%
-77
- C1 -
-
1B3O
2
IMDH2_HUMAN
A:
[28-498]
--------------------
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
-
T
A
D
Q
V
D
L
T
S
A
L
T
K
K
-
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
------------------------------------------------------------------------------------------------------------------------------
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
-------------
R
P
Q
A
T
A
V
-
Y
K
V
S
E
Y
A
R
-
R
-
F
-
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
------------------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
-----
K
F
E
K
R
T
S
S
A
Q
--------------------
110
PsiBlast_CBE
62.55
39%
-37
- C1 -
-
4AF0
2
?
B:
[60-537]
----------------------
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
-
P
A
S
D
V
S
L
Q
S
K
A
T
K
N
-
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
K
Y
E
N
---------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
Q
T
Y
-
P
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
-
Y
A
V
A
E
F
A
S
-
R
-
F
-
G
-
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
H
T
-----GLDNAATA
R
Y
F
--
S
E
A
D
A
V
K
-
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
G
I
K
S
V
S
E
L
H
S
-----
C
A
RSGSL
R
F
E
L
R
T
A
S
----------------------
14
PsiBlast_PDB
62.32
66%
-66
- C1 -
-
4FO4
2
?
A:
[95-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
G
23
PsiBlast_CBE
61.63
66%
-64
- C1 -
-
4QNE
2
?
B:
[95-365]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
22
PsiBlast_CBE
61.33
66%
-70
- C1 -
-
4X3Z
2
?
B:
[95-365]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
24
PsiBlast_CBE
61.25
66%
-68
- C1 -
-
4IX2
1
?
D:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
17
PsiBlast_PDB
61.03
66%
-61
- C1 -
-
4QNE
2
?
A:
[95-365]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
-
26
PsiBlast_CBE
61.02
66%
-66
- C1 -
-
4IX2
1
?
B:
[95-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
15
PsiBlast_PDB
61.01
66%
-65
- C1 -
-
4IX2
1
?
A:
[95-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
18
PsiBlast_PDB
60.91
66%
-64
- C1 -
-
4X3Z
3
?
A:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
27
PsiBlast_CBE
60.88
66%
-62
- C1 -
-
4FO4
2
?
B:
[95-364]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
--
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
--
25
PsiBlast_CBE
58.73
66%
-62
- C1 -
-
4IX2
1
?
C:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
86
PsiBlast_CBE
58.60
59%
-68
- C1 -
-
4MYA
4
?
A:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
----------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
20
PsiBlast_PDB
58.14
55%
-53
- C1 -
-
5UPX
2
?
A:
[77-384]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
M
S
I
E
Q
Q
A
E
E
I
E
K
V
----
K
R
S
E
S
G
G
---
I
K
D
--
K
V
I
E
F
P
N
S
A
K
-
D
K
H
G
R
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
-
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
-
Y
D
C
A
T
-
V
A
-
R
-
E
F
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
--
E
H
G
--
D
--------
R
Y
F
Q
---
A
D
A
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
-----
E
A
-----
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
--
85
PsiBlast_CBE
57.56
59%
-70
- C1 -
-
4MYA
3
?
B:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
16
PsiBlast_PDB
57.40
66%
-79
- C1 -
-
4QQ3
1
?
A:
[95-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
-
A
N
-
E
-
Y
-
G
-
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
-----------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
R
T
-----
K
A
-----
Q
F
V
R
I
S
G
A
----------------------
109
PsiBlast_CBE
57.07
59%
-79
- C1 -
-
5UPY
7
?
A:
[95-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
A
A
A
A
V
G
I
T
N
D
T
F
V
R
V
E
K
L
I
E
A
G
V
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
I
N
K
I
S
E
I
R
Q
T
F
-
K
D
V
V
I
V
A
G
N
V
A
T
A
E
G
A
R
A
L
F
E
V
G
V
D
I
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
I
T
A
I
-
Y
D
C
A
T
-
V
A
-
R
-
E
F
G
-
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
L
A
G
T
D
E
S
P
G
E
T
E
I
F
Q
G
R
Q
F
K
T
Y
R
G
M
G
S
L
A
A
M
--
E
H
G
----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
S
V
A
D
I
I
F
Q
L
V
G
G
I
R
S
G
M
G
Y
T
G
S
P
D
L
R
H
L
R
E
-----
E
A
-----
A
F
V
R
M
T
G
A
G
L
R
E
S
H
P
H
D
I
Q
I
T
K
E
A
P
N
Y
S
--
96
PsiBlast_CBE
56.86
59%
-69
- C1 -
-
4MY8
4
?
C:
[116-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
75
PsiBlast_CBE
56.20
59%
-69
- C1 -
-
4QM1
3
?
B:
[116-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
--
97
PsiBlast_CBE
55.97
59%
-72
- C1 -
-
4MY8
7
?
B:
[116-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-------------------
98
PsiBlast_CBE
55.64
59%
-68
- C1 -
-
4MY8
9
?
A:
[116-367]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
G
S
K
---------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
------------------
73
PsiBlast_CBE
54.54
59%
-73
- C1 -
-
4QM1
3
?
D:
[116-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
---------
76
PsiBlast_CBE
53.57
59%
-73
- C1 -
-
4QM1
3
?
A:
[116-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
--
E
K
-------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
---------
74
PsiBlast_CBE
53.38
59%
-72
- C1 -
-
4QM1
3
?
C:
[116-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
-
A
R
-
K
-
H
-
G
-
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
-----------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
R
E
-----
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
----------
112
PsiBlast_CBE
52.71
60%
-40
- C1 -
-
5K4Z
2
?
A:
[111-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
G
D
D
A
W
E
R
A
M
A
L
R
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
K
V
L
D
M
V
H
R
L
K
T
T
V
G
D
E
I
E
V
V
G
G
N
V
A
T
R
A
A
A
A
A
L
V
E
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
-
C
A
-
P
-
H
-
G
-
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
S
P
G
E
L
I
L
V
N
G
K
Q
F
K
S
Y
R
G
M
G
S
L
G
A
M
Q
---------------------------
L
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
T
V
I
H
Q
L
V
G
G
L
R
A
A
M
G
Y
T
G
S
A
T
I
E
E
L
Q
Q
------
A
-----
Q
F
V
Q
I
T
A
A
G
L
--------------------
114
Fugue
50.92
41%
18
- C1 -
-
1B3O
2
IMDH2_HUMAN
A:
[10-498]
TSYVPDDGLT
A
Q
Q
L
F
N
C
--G
D
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
-F
T
A
D
Q
V
D
L
T
S
A
L
T
K
-K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
D
------------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
-
P
N
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
R
P
------
Q
A
T
A
V
Y
K
V
S
E
Y
A
-
R
R
F
----------
G
-
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
------------------------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
-----
M
M
-----
Y
S
G
E
L
K
F
E
K
R
T
S
S
A
Q
---------------