@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNZ3: (2017-11-18 )
MVKQRTLNRVVKASGIGLHSGQKVMINFIPHTVDGGIVFRRIDLDPPVDIPANALLIQEAFMCSNLVTGDIKVGTIEHVMSAIASLGIDNLIVEVSASEVPIMDGSAGPFIYLLMQGGLREQDAPKKFIKILKPVEALIDDKKAIFSPHNGFQLNFTIDFDHPAFAKEYQSATIDFSTETFVYEVSEARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFADEFVRHKILDAVGDLYLLGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDEKDCPIPYVSVT
Atome Classification :
(59 SA)
.........10........20........30........40........50........60.......-.70........80........90........100.......110.......120.......130.......140.......150.......160...--....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MV
K
Q
R
T
L
N
R
V
V
K
ASGIGLHSG
Q
K
V
M
I
N
FIPHTVDG
G
I
V
F
R
RIDLDPPVDIPA
N
A
L
L
I
Q
E
A
F
M
C
SNLVT-GDIKV
G
T
I
E
H
V
M
S
A
I
A
SLGI
D
N
L
I
V
E
VSASEVPIMDGSAG
P
F
I
Y
L
L
MQGGLREQD
A
P
K
K
F
I
K
I
L
K
P
V
E
A
L
IDD
K
K
A
IFSPHN
G
F
Q
L
N
F
T
I
DFDH
P
A
F
--
A
K
E
YQS
A
T
I
DFST
E
T
F
V
Y
E
VSEART
F
G
F
M
K
D
L
D
Y
L
KANN
L
A
LGASLDNAIGVDDTGVV
N
E
E
G
L
R
F
A
D
E
F
V
R
H
K
I
L
D
A
V
G
D
L
Y
L
L
G
H
Q
I
I
A
K
FDGYKSGH
A
L
N
N
Q
L
L
R
N
VQSDPSN
Y
E
I
V
T
FDDEKDCPIPYVSVT
31
PsiBlast_CBE
78.72
58%
-95
- C11 -
-
4FW4
2
LPXC_PSEAE
D:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
35
PsiBlast_CBE
78.60
58%
-99
- C11 -
-
4FW3
1
LPXC_PSEAE
C:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
32
PsiBlast_CBE
78.54
58%
-94
- C11 -
-
4FW4
2
LPXC_PSEAE
C:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
34
PsiBlast_CBE
78.15
58%
-98
- C11 -
-
4FW3
2
LPXC_PSEAE
D:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
36
PsiBlast_CBE
78.07
58%
-99
- C11 -
-
4FW3
1
LPXC_PSEAE
B:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
42
PsiBlast_CBE
78.05
58%
-101
- C11 -
-
5U3B
2
?
B:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
-----
T
Q
Q
A
S
V
D
F
--
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
26
PsiBlast_CBE
77.91
58%
-92
- C11 -
-
4FW6
3
LPXC_PSEAE
C:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
23
PsiBlast_CBE
77.71
58%
-97
- C11 -
-
4FW7
2
LPXC_PSEAE
C:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
21
PsiBlast_CBE
77.68
58%
-94
- C11 -
-
5N8C
1
LPXC_PSEAE
B:
[2-298]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
20
PsiBlast_PDB
77.66
58%
-100
- C11 -
-
5U3B
2
?
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
--
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
14
PsiBlast_PDB
77.50
58%
-96
- C11 -
-
4OKG
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
12
PsiBlast_PDB
77.50
58%
-95
- C11 -
-
4LCG
1
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
9
PsiBlast_PDB
77.45
58%
-97
- C11 -
-
3U1Y
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
4
PsiBlast_PDB
77.40
58%
-101
- C11 -
-
4FW5
2
LPXC_PSEAE
A:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
15
PsiBlast_PDB
77.39
58%
-92
- C11 -
-
5DRQ
1
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
11
PsiBlast_PDB
77.36
58%
-94
- C11 -
-
4LCF
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
5
PsiBlast_PDB
77.34
58%
-97
- C11 -
-
4FW6
5
LPXC_PSEAE
A:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
1
PsiBlast_PDB
77.34
58%
-93
- C11 -
-
5N8C
1
LPXC_PSEAE
A:
[2-298]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
16
PsiBlast_PDB
77.33
58%
-93
- C11 -
-
5DRR
1
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
6
PsiBlast_PDB
77.30
58%
-97
- C11 -
-
4FW7
5
LPXC_PSEAE
A:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
30
PsiBlast_CBE
77.28
58%
-101
- C11 -
-
4FW5
2
LPXC_PSEAE
B:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
13
PsiBlast_PDB
77.26
58%
-95
- C11 -
-
4LCH
1
LPXC_PSEAE
A:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
2
PsiBlast_PDB
77.25
58%
-97
- C11 -
-
4FW3
2
LPXC_PSEAE
A:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
18
PsiBlast_PDB
77.24
58%
-97
- C11 -
-
5VWM
4
?
A:
[98-394]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
28
PsiBlast_CBE
77.19
58%
-93
- C11 -
-
4FW5
2
LPXC_PSEAE
D:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
24
PsiBlast_CBE
77.09
58%
-94
- C11 -
-
4FW7
7
LPXC_PSEAE
B:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
33
PsiBlast_CBE
77.07
58%
-98
- C11 -
-
4FW4
2
LPXC_PSEAE
B:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
29
PsiBlast_CBE
77.04
58%
-93
- C11 -
-
4FW5
2
LPXC_PSEAE
C:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
39
PsiBlast_CBE
76.84
58%
-98
- C11 -
-
2VES
1
LPXC_PSEAE
C:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
17
PsiBlast_PDB
76.84
58%
-98
- C11 -
-
5UPG
8
LPXC_PSEAE
A:
[2-298]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
27
PsiBlast_CBE
76.81
58%
-95
- C11 -
-
4FW6
6
LPXC_PSEAE
B:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
40
PsiBlast_CBE
76.59
58%
-94
- C11 -
-
2VES
1
LPXC_PSEAE
B:
[1-288]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
------------
8
PsiBlast_PDB
76.58
58%
-94
- C11 -
-
3P3E
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
3
PsiBlast_PDB
76.51
58%
-96
- C11 -
-
4FW4
1
LPXC_PSEAE
A:
[4-300]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
70
HHSearch
76.44
59%
-52
- C11 -
-
4OKG
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
RG
R
--
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
7
PsiBlast_PDB
76.27
58%
-89
- C11 -
-
2VES
1
LPXC_PSEAE
A:
[1-294]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
------
10
PsiBlast_PDB
76.24
58%
-96
- C11 -
-
3UHM
3
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
19
PsiBlast_PDB
76.17
58%
-99
- C11 -
-
4J3D
1
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
38
PsiBlast_CBE
76.05
58%
-95
- C11 -
-
3U1Y
2
LPXC_PSEAE
B:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
37
PsiBlast_CBE
76.03
58%
-94
- C11 -
-
4OKG
1
LPXC_PSEAE
B:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
----------
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
43
PsiBlast_CBE
75.27
58%
-91
- C11 -
-
5U39
1
?
A:
[4-290]
-
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
------------
53
PsiBlast_CBE
75.22
50%
-31
- C11 -
-
4IS9
2
LPXC_ECOLI
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
71
HHSearch
74.41
51%
-31
- C11 -
-
3PS3
4
?
A:
[1-299]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
--
45
PsiBlast_CBE
74.25
52%
-29
- C11 -
-
3NZK
2
?
A:
[6-302]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
----
72
HHSearch
74.21
51%
-34
- C11 -
-
3P3G
3
?
A:
[1-299]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
--
69
HHSearch
74.21
59%
-49
- C11 -
-
3UHM
3
LPXC_PSEAE
A:
[1-297]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
RG
R
--
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
54
PsiBlast_CBE
74.16
50%
-32
- C11 -
-
3PS3
4
?
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
41
PsiBlast_CBE
74.14
58%
-89
- C11 -
-
4J3D
1
LPXC_PSEAE
B:
[1-296]
M
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
V
K
-
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
44
PsiBlast_CBE
74.13
52%
-26
- C11 -
-
3NZK
1
?
B:
[6-302]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
----
57
PsiBlast_CBE
74.07
50%
-35
- C11 -
-
3P3G
3
?
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
50
PsiBlast_CBE
73.92
50%
-34
- C11 -
-
4MQY
3
LPXC_ECOLI
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
47
PsiBlast_CBE
73.62
50%
-30
- C11 -
-
4MDT
1
LPXC_ECOLI
C:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
-
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
56
PsiBlast_CBE
73.59
50%
-31
- C11 -
-
3PS1
3
?
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
55
PsiBlast_CBE
73.47
50%
-34
- C11 -
-
3PS2
5
?
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
51
PsiBlast_CBE
73.42
50%
-32
- C11 -
-
4ISA
20
LPXC_ECOLI
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
48
PsiBlast_CBE
73.27
50%
-31
- C11 -
-
4MDT
1
LPXC_ECOLI
B:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
52
PsiBlast_CBE
72.42
50%
-29
- C11 -
-
4IS9
2
LPXC_ECOLI
B:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
49
PsiBlast_CBE
72.32
50%
-29
- C11 -
-
4MDT
1
LPXC_ECOLI
A:
[1-297]
M
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
--
D
S
S
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
----
46
PsiBlast_CBE
71.43
50%
-29
- C11 -
-
4MDT
1
LPXC_ECOLI
D:
[4-296]
---
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
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