@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNZ4: (2017-11-18 )
MASFEFIEDELNDGNGQARFTVFGVGGGGGNAVQHMVQSDIQGVKFVCANTDKQALDCMNAPFKIQLGEQSTRGLGAGANPEVGQVAAEESREIIRQHLEGTDMVFVTAGMGGGTGTGAAPVVAEVAKEMGILTVGVVTTPFNFEGRRRQKSAERGIEALEAHVDSLIIIPNQRLLSVYGDISMKDAYKKADDVLLNAVRSIFDLVVNRGHINLDFADLKTAMSTRGYAMMGAGLGRGEDRARQAAEQAIRSPLLDNVNIINAKGVLINITGGDDITLRETEIITDVVNQIVDLDEGEIFYGTVFDPDARDELRVTVIATGLTRNAADAEPRTRNTVSHTSTQSVDEDDVPAINKRQNAENDVNNAPSSTPRSSPMSIQDYLKNQQRK
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170....-...-180--........190.......200....-...210..--.--....220.......230.......240.......250.......260.......270.......280.......290.......300....---...-310.......320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
S
F
E
F
I
E
D
ELNDGNG
Q
A
R
F
T
V
F
G
VGGG
G
G
N
A
V
Q
H
M
V
Q
SDIQ
G
V
K
F
V
C
ANTD
K
Q
A
L
D
CMNA
P
F
K
I
Q
LGEQSTRGLGAGANP
E
V
G
Q
V
A
A
E
E
S
R
E
I
I
R
Q
HLEGT
D
M
V
F
V
T
AGMGGGTGTG
A
A
P
V
V
A
E
V
A
K
EMG
I
L
T
V
G
V
V
TTPFNFEGRRR
Q
K
S
A
E
R
G
I
E
A
L
E
A
HV
D
S
L
I
I
IPN
Q
R
L
L
-
S
V
Y-G-D--I
S
M
K
D
A
Y
K
K
A
D
D
V
L
L
N
A
V
R
S
I
F
D
L
V
-VNRG
H
I
N
L
--
D
--
F
A
D
L
K
T
A
M
STRG
Y
A
M
MGAGLGR
G
E
D
R
A
R
Q
A
A
E
Q
A
I
RSPLLDN
V
N
I
I
NAK
G
V
L
I
N
ITGG
D
D
I
T
L
R
E
T
E
I
I
T
D
V
V
N
Q
I
VDLDEG
E
I
F
Y
G
T
VFD---PDA-RD
E
L
R
V
T
V
I
A
TGLTRNAADAEPRTRNTVSHTSTQSVDEDDVPAINKRQNAENDVNNAPSSTPRSSP
M
S
I
Q
D
Y
L
K
N
QQRK
85
HHSearch
91.67
43%
-121
- C3 -
-
1W59
-
FTSZ1_METJA
A:
[34-347]
-------------
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
-
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
-----------------------------------------------------------
86
HHSearch
90.98
43%
-127
- C3 -
-
2VAP
1
FTSZ1_METJA
A:
[34-347]
-------------
Q
Q
T
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
P
-
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
Q
S
R
I
E
F
T
-----------------------------------------------------------
70
PsiBlast_CBE
90.04
44%
-130
- C3 -
-
1W5B
1
FTSZ1_METJA
A:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
83
HHSearch
89.89
57%
-72
- C3 -
-
1OFU
1
FTSZ_PSEAE
B:
[11-317]
----------------
T
A
V
I
K
V
I
G
V
G
G
G
G
G
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
-
T
I
L
-
G
K
D
--
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
-
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
E
-
H
A
T
V
K
V
G
T
V
I
D
---
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
L
G
-----------------------------------------------------------------
72
PsiBlast_CBE
89.58
44%
-126
- C3 -
-
1W5A
1
FTSZ1_METJA
A:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
66
PsiBlast_CBE
89.55
44%
-121
- C3 -
-
1W5E
1
FTSZ1_METJA
B:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
80
HHSearch
89.22
50%
-131
- C3 -
-
1RQ2
-
FTSZ_MYCTU
B:
[11-316]
----------------
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
----------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
G
------
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
-
D
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
D
-----------------------------------------------------------------
60
PsiBlast_CBE
89.11
44%
-122
- C3 -
-
1W5E
1
FTSZ1_METJA
H:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
71
PsiBlast_CBE
88.94
44%
-129
- C3 -
-
1W5A
1
FTSZ1_METJA
B:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
61
PsiBlast_CBE
88.79
44%
-121
- C3 -
-
1W5E
1
FTSZ1_METJA
G:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
68
PsiBlast_CBE
88.77
44%
-131
- C3 -
-
2VAP
1
FTSZ1_METJA
A:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
75
PsiBlast_CBE
88.21
44%
-125
* C3 *
-
1FSZ
1
FTSZ1_METJA
A:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
65
PsiBlast_CBE
88.13
44%
-118
- C3 -
-
1W5E
1
FTSZ1_METJA
C:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
89
HHSearch
88.03
53%
-81
- C3 -
-
4E6E
-
?
A:
[5-313]
------------
P
Q
N
Y
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
E
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
E
L
T
R
----
G
A
N
P
D
V
G
R
K
A
A
E
D
H
R
E
E
I
E
E
V
L
K
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
N
I
A
R
S
L
G
A
L
T
I
G
V
V
T
R
P
F
S
F
E
G
K
R
R
A
T
Q
A
E
A
G
I
A
M
L
R
E
E
V
D
T
L
I
V
I
P
N
D
R
L
L
-----
D
R
Q
--
V
S
V
L
D
A
F
K
A
A
D
Q
V
L
L
S
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
S
V
M
S
G
A
G
S
A
L
M
G
I
G
S
A
R
G
D
D
R
A
V
A
A
A
E
M
A
I
S
S
P
L
L
E
-
A
S
I
D
G
A
H
G
V
L
L
S
I
Q
G
G
S
D
L
G
L
F
E
I
N
E
A
A
Q
L
V
A
N
S
A
A
A
-
E
A
N
I
I
F
G
A
V
I
D
---
D
A
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
64
PsiBlast_CBE
87.94
44%
-120
- C3 -
-
1W5E
1
FTSZ1_METJA
D:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
59
PsiBlast_CBE
87.94
44%
-119
- C3 -
-
1W5E
1
FTSZ1_METJA
I:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
67
PsiBlast_CBE
87.90
44%
-118
- C3 -
-
1W5E
1
FTSZ1_METJA
A:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
63
PsiBlast_CBE
87.86
44%
-121
- C3 -
-
1W5E
1
FTSZ1_METJA
E:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
69
PsiBlast_CBE
87.60
44%
-124
- C3 -
-
1W5B
1
FTSZ1_METJA
B:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
W
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
62
PsiBlast_CBE
87.59
44%
-123
- C3 -
-
1W5E
1
FTSZ1_METJA
F:
[37-340]
----------------
K
A
K
I
T
V
V
G
C
G
G
A
G
N
N
T
I
T
R
L
K
M
E
G
I
E
G
A
K
T
V
A
I
N
T
D
A
Q
Q
L
I
R
T
K
A
D
K
K
I
L
I
G
K
K
L
T
R
G
L
G
A
G
G
N
P
K
I
G
E
E
A
A
K
E
S
A
E
E
I
K
A
A
I
Q
D
S
D
M
V
F
I
T
C
G
L
G
G
G
T
G
T
G
S
A
P
V
V
A
E
I
S
K
K
I
G
A
L
T
V
A
V
V
T
L
P
F
V
M
E
G
K
V
R
M
K
N
A
M
E
G
L
E
R
L
K
Q
H
T
D
T
L
V
V
I
P
N
E
K
L
F
-
E
I
V
-
P
-
N
--
M
P
L
K
L
A
F
K
V
A
D
E
V
L
I
N
A
V
K
G
L
V
E
L
I
-
T
K
D
G
L
I
N
V
--
D
--
F
A
D
V
K
A
V
M
N
N
G
G
L
A
M
I
G
I
G
E
S
D
S
E
K
R
A
K
E
A
V
S
M
A
L
N
S
P
L
L
D
-
V
D
I
D
G
A
T
G
A
L
I
H
V
M
G
P
E
D
L
T
L
E
E
A
R
E
V
V
A
T
V
S
S
R
L
D
-
P
N
A
T
I
I
Y
G
A
T
I
D
---
E
N
L
-
E
N
T
V
R
V
L
L
V
I
T
G
V
------------------------------------------------------------------
79
HHSearch
87.08
51%
-73
- C3 -
-
2Q1Y
1
FTSZ_MYCTU
A:
[8-312]
----------------
L
A
V
I
K
V
V
G
I
G
G
G
G
V
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
G
-
D
A
A
--
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
-
D
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
88
HHSearch
86.82
56%
-60
- C3 -
-
5MN4
2
FTSZ_STAAU
A:
[1-304]
-----------------
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
-
D
K
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
-
D
V
N
M
I
F
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
78
HHSearch
84.75
47%
-59
- C3 -
-
4M8I
1
FTSZ_STAEQ
A:
[17-327]
----------------
L
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
G
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
S
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
-
D
K
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
-
D
V
N
M
I
F
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
E
D
K
P
S
S
------------------------------------------------------------
21
PsiBlast_CBE
82.71
57%
-63
- C3 -
-
1OFU
1
FTSZ_PSEAE
B:
[25-316]
------------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
-
T
I
L
-
G
K
D
--
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
-
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
-
E
H
A
T
V
K
V
G
T
V
I
D
---
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
L
------------------------------------------------------------------
2
PsiBlast_PDB
82.23
57%
-64
- C3 -
-
1OFU
1
FTSZ_PSEAE
A:
[25-316]
------------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
-
T
I
L
-
G
K
D
--
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
-
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
-
E
H
A
T
V
K
V
G
T
V
I
D
---
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
L
------------------------------------------------------------------
77
HHSearch
82.12
47%
-63
- C3 -
-
3WGL
1
FTSZ_STAAM
B:
[13-316]
----------------
L
A
T
L
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
-
D
K
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
G
--
A
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
-
D
V
N
M
I
F
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
D
-----------------------------------------------------------------
76
HHSearch
82.02
47%
-74
- C3 -
-
2VXY
1
FTSZ_BACSU
A:
[11-316]
----------------
L
A
S
I
K
V
I
G
V
G
G
G
G
N
N
A
V
N
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
-
E
I
V
-
D
K
N
--
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
-
D
V
N
M
I
F
G
S
V
I
N
---
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
I
-----------------------------------------------------------------
1
PsiBlast_PDB
80.92
57%
-65
- C3 -
-
2VAW
1
FTSZ_PSEAE
A:
[25-316]
------------------------------
N
A
V
N
H
M
A
K
N
N
V
E
G
V
E
F
I
C
A
N
T
D
A
Q
A
L
K
N
I
A
A
R
T
V
L
Q
L
G
P
G
V
T
K
G
L
G
A
G
A
N
P
E
V
G
R
Q
A
A
L
E
D
R
E
R
I
S
E
V
L
E
G
A
D
M
V
F
I
T
T
G
M
G
G
G
T
G
T
G
A
A
P
I
I
A
E
V
A
K
E
M
G
I
L
T
V
A
V
V
T
R
P
F
P
F
E
G
R
K
R
M
Q
I
A
D
E
G
I
R
A
L
A
E
S
V
D
S
L
I
T
I
P
N
E
K
L
L
-
T
I
L
-
G
K
D
--
A
S
L
L
A
A
F
A
K
A
D
D
V
L
A
G
A
V
R
G
I
S
D
I
I
-
K
R
P
G
M
I
N
V
--
D
--
F
A
D
V
K
T
V
M
S
E
M
G
M
A
M
M
G
T
G
C
A
S
G
P
N
R
A
R
E
A
T
E
A
A
I
R
N
P
L
L
E
D
V
N
L
Q
G
A
R
G
I
L
V
N
I
T
A
G
P
D
L
S
L
G
E
Y
S
D
V
G
N
I
I
E
Q
F
A
S
-
E
H
A
T
V
K
V
G
T
V
I
D
---
A
D
M
-
R
D
E
L
H
V
T
V
V
A
T
G
L
------------------------------------------------------------------
10
PsiBlast_PDB
80.46
56%
-57
- C3 -
-
5H5H
1
?
A:
[22-307]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
3
PsiBlast_PDB
80.32
56%
-56
- C3 -
-
4DXD
2
FTSZ_STAAU
A:
[36-321]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
14
PsiBlast_PDB
80.08
55%
-66
- C3 -
-
5MN6
1
FTSZ_STAAU
A:
[18-304]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
--------
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
4
PsiBlast_PDB
79.69
56%
-54
- C3 -
-
3VO8
1
FTSZ_STAAM
A:
[32-317]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
29
PsiBlast_CBE
79.02
55%
-58
- C3 -
-
3WGM
1
FTSZ_STAAM
B:
[32-314]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
-------------------------------------------------------------------
36
PsiBlast_CBE
78.91
53%
-63
- C3 -
-
2RHL
1
FTSZ_BACSU
A:
[19-306]
----------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
-
E
I
V
D
K
-
N
--
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
-
G
S
V
I
N
---
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
L
-----------------------------------------------------------------
11
PsiBlast_PDB
78.91
56%
-62
- C3 -
-
5H5I
1
?
A:
[22-307]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
6
PsiBlast_PDB
78.83
56%
-51
- C3 -
-
3VOA
1
FTSZ_STAAM
A:
[21-307]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
16
PsiBlast_PDB
78.77
56%
-55
- C3 -
-
4M8I
1
FTSZ_STAEQ
A:
[36-321]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
G
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
S
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
53
PsiBlast_CBE
78.75
51%
-44
- C3 -
-
1RQ7
1
FTSZ_MYCTU
A:
[25-315]
------------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
-----
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
--
G
-
D
AA
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
-
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
20
PsiBlast_PDB
78.67
55%
-58
- C3 -
-
3WGM
1
FTSZ_STAAM
A:
[32-314]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
-------------------------------------------------------------------
35
PsiBlast_CBE
78.66
53%
-61
- C3 -
-
2RHL
1
FTSZ_BACSU
B:
[19-308]
----------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
-
E
I
V
D
K
-
N
--
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
-
G
S
V
I
N
---
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
L
E
N
---------------------------------------------------------------
23
PsiBlast_CBE
78.65
56%
-54
- C3 -
-
3VO8
1
FTSZ_STAAM
B:
[32-317]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
8
PsiBlast_PDB
78.63
56%
-51
- C3 -
-
5H5G
1
?
A:
[21-307]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
7
PsiBlast_PDB
78.54
56%
-50
- C3 -
-
3VOB
2
FTSZ_STAAM
A:
[21-307]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
52
PsiBlast_CBE
78.43
51%
-42
- C3 -
-
4KWE
1
FTSZ_MYCTU
A:
[25-315]
------------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
--
G
-
D
AA
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
-
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
48
PsiBlast_CBE
78.26
51%
-38
- C3 -
-
2Q1Y
1
FTSZ_MYCTU
A:
[22-312]
------------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
--
G
-
D
AA
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
-
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
34
PsiBlast_CBE
78.25
53%
-62
- C3 -
-
2RHO
1
FTSZ_BACSU
A:
[19-306]
----------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
-
E
I
V
D
K
-
N
--
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
K
G
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
-
G
S
V
I
N
---
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
L
-----------------------------------------------------------------
24
PsiBlast_CBE
78.23
56%
-63
- C3 -
-
5H5G
1
?
B:
[21-307]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
13
PsiBlast_PDB
77.91
55%
-49
- C3 -
-
5MN4
2
FTSZ_STAAU
A:
[18-304]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
49
PsiBlast_CBE
77.87
51%
-47
- C3 -
-
2Q1X
1
FTSZ_MYCTU
A:
[22-312]
------------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
-------
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
--
G
-
D
AA
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
-
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
33
PsiBlast_CBE
77.68
53%
-66
- C3 -
-
2RHO
1
FTSZ_BACSU
B:
[19-305]
----------------------------------
R
M
I
E
N
E
V
Q
G
V
E
Y
I
A
V
N
T
D
A
Q
A
L
N
L
S
K
A
E
V
K
M
Q
I
G
A
K
L
T
R
G
L
G
A
G
A
N
P
E
V
G
K
K
A
A
E
E
S
K
E
Q
I
E
E
A
L
K
G
A
D
M
V
F
V
T
A
G
M
G
G
G
T
G
T
G
A
A
P
V
I
A
Q
I
A
K
D
L
G
A
L
T
V
G
V
V
T
R
P
F
T
F
E
G
R
K
R
Q
L
Q
A
A
G
G
I
S
A
M
K
E
A
V
D
T
L
I
V
I
P
N
D
R
I
L
-
E
I
V
D
K
-
N
--
T
P
M
L
E
A
F
R
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
T
P
G
L
I
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
--
S
A
L
M
G
I
G
I
A
T
G
E
N
R
A
A
E
A
A
K
K
A
I
S
S
P
L
L
E
-
A
A
I
D
G
A
Q
G
V
L
M
N
I
T
G
G
T
N
L
S
L
Y
E
V
Q
E
A
A
D
I
V
A
S
A
S
D
Q
D
V
N
M
I
F
-
G
S
V
I
N
---
E
N
L
-
K
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
28
PsiBlast_CBE
77.65
55%
-62
- C3 -
-
5MN6
1
FTSZ_STAAU
B:
[18-304]
----------------------------------
R
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
A
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
S
G
E
V
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
T
-
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------
56
PsiBlast_CBE
77.60
51%
-40
- C3 -
-
1RLU
2
FTSZ_MYCTU
A:
[25-315]
------------------------------
N
A
V
N
R
M
I
E
Q
G
L
K
G
V
E
F
I
A
I
N
T
D
A
Q
A
L
L
M
S
D
A
D
V
K
L
D
V
G
R
D
S
T
R
G
L
G
A
G
A
D
P
E
V
G
R
K
A
A
E
D
A
K
D
E
I
E
E
L
L
R
G
A
D
M
V
F
V
T
A
G
E
G
G
G
T
G
T
G
G
A
P
V
V
A
S
I
A
R
K
L
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
K
R
R
S
N
Q
A
E
N
G
I
A
A
L
R
E
S
C
D
T
L
I
V
I
P
N
D
R
L
L
-
Q
M
--
G
-
D
AA
V
S
L
M
D
A
F
R
S
A
D
E
V
L
L
N
G
V
Q
G
I
T
D
L
I
-
T
T
P
G
L
I
N
V
--
D
--
F
A
D
V
K
G
I
M
S
G
A
G
T
A
L
M
G
I
G
S
A
R
G
E
G
R
S
L
K
A
A
E
I
A
I
N
S
P
L
L
E
-
A
S
M
E
G
A
Q
G
V
L
M
S
I
A
G
G
S
D
L
G
L
F
E
I
N
E
A
A
S
L
V
Q
D
A
A
H
P
D
-
A
N
I
I
F
G
T
V
I
D
---
D
S
L
-
G
D
E
V
R
V
T
V
I
A
A
G
F
------------------------------------------------------------------
19
PsiBlast_PDB
77.59
55%
-57
- C3 -
-
3WGL
1
FTSZ_STAAM
A:
[32-315]
-----------------------------------
M
I
D
H
G
M
N
N
V
E
F
I
A
I
N
T
D
G
Q
A
L
N
L
S
K
A
E
S
K
I
Q
I
G
E
K
L
T
R
G
L
G
A
G
A
N
P
E
I
G
K
K
A
A
E
E
S
R
E
Q
I
E
D
A
I
Q
G
A
D
M
V
F
V
T
S
G
M
G
G
G
T
G
T
G
A
A
P
V
V
A
K
I
A
K
E
M
G
A
L
T
V
G
V
V
T
R
P
F
S
F
E
G
R
K
R
Q
T
Q
A
A
A
G
V
E
A
M
K
A
A
V
D
T
L
I
V
I
P
N
D
R
L
L
-
D
I
V
D
K
-
S
--
T
P
M
M
E
A
F
K
E
A
D
N
V
L
R
Q
G
V
Q
G
I
S
D
L
I
-
A
V
G
A
--
N
L
--
D
--
F
A
D
V
K
T
I
M
S
N
Q
G
S
A
L
M
G
I
G
V
S
S
G
E
N
R
A
V
E
A
A
K
K
A
I
S
S
P
L
L
E
-
T
S
I
V
G
A
Q
G
V
L
M
N
I
T
G
G
E
S
L
S
L
F
E
A
Q
E
A
A
D
I
V
Q
D
A
A
D
E
D
V
N
M
I
F
-
G
T
V
I
N
---
P
E
L
-
Q
D
E
I
V
V
T
V
I
A
T
G
F
------------------------------------------------------------------