@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP49: (2017-11-19 )
MYEPYPVPEQVREQKLSRYSSLWTFAKQDLRLLLFFLIIAGLVGLGIGYFWSCIFIAFVVFFTLQLRSLYLVNDWIANNPYDVPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDRAQSSLVALAEAVVLIDDQHQIEWWNPAAERLLGISPLDRGRNLLTILRQPTFIEYFNNIDQAPDGIKLHSNLDDDRYVQVKLTRFGGESRLLVAYDVTRMHNLEQMRKDFVDNISHELRTPLTVLSGYIETFTDQEDINPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKKIAKNQIIEMPSLMNQLFDDAQAYNADYGHTLNLHIDSHCDLIGSDMEIASAFSNLITNAIKYTPKGGTITIGWHDDGEHAYFSVQDTGIGINPKHLPRLTERFYRVDSDRSRQTGGTGLGLAIVKHVLMQQGAYLDVQSKENEGSTFTAVFPKERLYNMT
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80..--......90........100.......110.......120.......130.......140.......150...-..-..-160.......170.......180....--...190.......200...-----...--------.210.......220-----.------.......230.......240.......250---..-.--....260......-..270.......280......------.290.......300.......310----.-----.......--.320---...---......--330.......-340.......350.......-----360.......370.......380.......390.......400.......410.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MYEPYPV
P
E
Q
V
R
E
Q
K
L
S
R
Y
S
S
L
W
T
F
A
K
Q
D
L
R
L
L
L
F
F
L
I
I
A
G
L
V
G
L
G
I
G
Y
F
W
S
C
I
F
I
A
F
V
V
F
F
T
L
Q
L
R
S
L
Y
L
V
N
D
W
IANNPYDV--PPNL
N
G
I
W
G
A
L
L
F
N
V
Y
R
A
Q
R
Q
E
R
I
V
Q
A
E
M
V
G
L
I
D
R
A
Q
S
S
L
V
A
L
A
E
A
V
V
L
IDDQHQ
I
E
W
WN
P
A
A
E
R
L
LGISPL-DR-G
R
-
N
L
L
T
I
LRQ
P
T
F
I
E
Y
F
N
N
IDQAPD
G
I
K
L--HSNLDDD
R
Y
V
Q
V
K
L
T
RFGG-----E
S
R
--------
L
L
V
A
Y
D
V
T
R
M
H
N
L
------
E
------
Q
M
R
K
D
F
V
D
N
I
S
H
E
LR
T
P
L
T
V
L
S
G
Y
I
E
TFTD---QE-D--I
N
P
R
W
-
K
R
A
F
D
Q
M
-
Q
S
Q
T
K
R
M
N
A
L
V
N
D
L
L
L
L
SNLE------NNKKI
A
K
N
QII
E
M
P
S
L
M
N
Q
L
F
D
------
D
-----
A
Q
AYNAD--YG-----
H
T
L
---
N
L
H
IDS--HCDLIGS
D
M
E
-
I
A
S
A
F
S
N
L
I
T
N
A
I
K
YTPKG
G
-----
T
I
T
I
G
WHDDG
E
H
A
Y
F
S
V
Q
DTGIGI
N
P
K
H
L
P
R
L
T
E
R
F
Y
RVDSDRSRQTGGT
G
L
G
L
A
I
V
K
H
V
L
M
QQG
A
Y
L
D
V
QSKENEG
S
T
F
T
A
VF
P
K
E
R
LYNMT
51
HHSearch
87.38
28%
-
- C4 -
-
4I5S
-
?
B:
[35-434]
-----------------------------------------------------------
Y
K
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
-
E
C
-
N
I
L
D
I
L
D
D
D
S
Y
-
T
-
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
ESGFI
S
G
L
--------
I
A
V
L
H
D
A
T
E
Q
E
K
E
------
E
------
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
---
G
A
-
L
--
T
E
S
V
A
-
P
S
F
I
K
V
S
-
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
I
D
------
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
------
R
-----
F
D
Q
I
Q
S
Q
--
Q
-------
E
I
---
I
R
D
Y
P
D
K
-
S
V
W
I
E
I
D
T
D
K
-
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
-----
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
------
T
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
Y
E
------
1
PsiBlast_PDB
81.76
31%
-
- C4 -
-
4I5S
-
?
A:
[65-432]
-----------------------------------------------------------------------------------------
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
-
Q
A
-
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
-
Y
N
D
L
I
T
K
T
P
E
-
I
V
L
--
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
-
R
F
A
L
-----
N
R
R
ESGFIS
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
------
E
------
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
GAL
T
E
-
S
--
V
A
P
S
F
I
K
V
S
L
D
E
-----
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----------
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
-----
Q
Q
S
T
------
E
-----
I
I
R
---
D
Y
P
D
K
S
--
V
W
I
E
I
D
T
D
-
K
-
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
-----
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
--------
41
Fugue
78.13
26%
-
- C4 -
-
4I5S
-
?
A:
[37-432]
---
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
--------------------------------------------------------
H
Y
T
D
K
L
--
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
-
Q
A
L
E
C
-
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
--
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
-----
E
S
G
FIS
G
L
---
I
A
V
L
H
D
A
T
E
Q
E
K
E
------
E
------
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
---
G
A
-
L
--
T
E
S
V
A
-
P
S
F
I
K
V
S
-
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
------
L
D
V
-----
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
------
R
-----
F
D
Q
I
Q
S
Q
--
Q
S
-----
T
E
I
---
I
R
D
Y
P
D
--
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
-----
K
V
T
I
T
M
Q
T
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
--------
53
HHSearch
66.36
33%
26
- C4 -
-
4U7O
1
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
K-
D
P
E
V
A
-
P
G
F
L
K
V
T
-
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
-----
F
D
M
I
L
K
K
--
D
D
NPA
K
Y
Y
T
I
---
K
R
E
F
T
K
R
-
D
L
W
V
E
I
D
T
D
K
-
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
4
PsiBlast_PDB
65.78
34%
15
- C4 -
-
4ZKI
-
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
-
N
P
A
--
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
3
PsiBlast_PDB
64.62
34%
22
- C4 -
-
4U7O
1
?
A:
[25-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
D
N
P
A
--
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
52
HHSearch
63.19
33%
30
- C4 -
-
5C93
1
?
A:
[3-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
W
K
--
D
P
E
V
A
-
P
G
F
L
K
V
T
-
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
-----
F
D
M
I
L
K
K
--
D
D
NPA
K
Y
Y
T
I
---
K
R
E
F
T
K
R
-
D
L
W
V
E
I
D
T
D
K
-
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
2
PsiBlast_PDB
63.04
34%
-
- C4 -
-
4U7N
-
?
A:
[386-610]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
D
N
-----
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
5
PsiBlast_PDB
62.95
34%
23
- C4 -
-
5C93
1
?
A:
[3-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
------
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
D
N
P
A
--
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
58
HHSearch
62.94
29%
27
- C4 -
-
4JAV
1
?
A:
[3-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
------
E
R
L
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
---
S
L
-
G
EL
D
L
S
T
L
-
K
E
F
L
E
V
I
-
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
------
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
------
A
-----
I
K
E
F
A
S
S
--
H
N
-----
V
N
V
---
L
F
E
S
N
V
PC
P
V
E
A
Y
I
D
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
--
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
------
18
PsiBlast_PDB
61.33
30%
32
- C4 -
-
3DGE
2
?
A:
[14-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
-
D
--
L
S
T
-
L
-
K
E
F
L
E
V
I
-
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
--
S
A
V
N
A
I
K
E
------
F
-----
A
S
S
H
N
V
N
V
L
F
E
-----
S
N
V
---
P
C
P
V
E
A
--
Y
I
D
----
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
PD
K
Y
V
K
V
I
L
D
E
K
D
G
G
--
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-----
43
Fugue
61.04
22%
-115
- C4 -
-
1ID0
1
A:
[1-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
H
P
V
A
P
L
L
D
N
L
T
S
------
A
-----
L
N
K
V
Y
Q
R
--
K
G
-----
V
N
I
---
S
L
D
I
S
P
--
E
I
S
F
V
G
E
Q
N
D
-
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
L
E
F
V
-----
E
I
S
A
R
Q
--
T
D
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
L
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
H
-----
57
HHSearch
60.46
29%
21
- C4 -
-
2C2A
1
?
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
---
S
L
-
G
EL
D
L
S
T
L
-
K
E
F
L
E
V
I
-
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
------
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
------
A
-----
I
K
E
F
A
S
S
--
H
N
-----
V
N
V
---
L
F
E
S
N
V
PC
P
V
E
A
Y
I
D
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
--
Y
V
K
V
I
L
D
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-----
19
PsiBlast_PDB
59.99
30%
26
- C4 -
-
4JAV
1
?
A:
[7-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
K
R
I
------
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
-
D
--
L
S
T
-
L
-
K
E
F
L
E
V
I
-
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
--
S
A
V
N
A
I
K
E
------
F
-----
A
S
S
H
N
V
N
V
L
F
E
-----
S
N
V
---
P
C
P
V
E
A
--
Y
I
D
----
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
--
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
------
68
HHSearch
59.83
26%
-2
- C4 -
-
4BIV
2
CPXA_ECOLI
A:
[76-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
M
------
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
---
R
S
-
G
------
E
-
S
K
E
L
E
R
I
-
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
------
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
------
N
-----
A
A
F
E
A
E
Q
--
M
G
-----
K
S
L
---
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
N
P
N
A
-
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
R
----
67
HHSearch
58.53
26%
-7
- C4 -
-
4BIX
-
CPXA_ECOLI
B:
[76-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
M
------
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
---
R
S
-
G
--
E
-----
S
K
E
L
E
R
I
-
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
------
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
------
N
-----
A
A
F
E
A
E
Q
--
M
G
-----
K
S
L
---
T
V
N
F
P
P
G
-
P
W
P
L
Y
G
N
P
N
A
-
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
--
T
-----
K
I
E
V
G
F
A
V
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
-----
12
PsiBlast_PDB
58.28
30%
41
- C4 -
-
4JAS
1
?
A:
[13-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
------
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
-
D
--
L
S
T
-
L
-
K
E
F
L
E
T
I
-
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
--
S
A
V
N
A
I
K
E
------
F
-----
A
S
S
H
N
V
N
V
L
F
E
-----
S
N
V
---
P
C
P
V
E
A
--
Y
I
D
----
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
--
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-----
13
PsiBlast_PDB
57.57
30%
20
- C4 -
-
4JAU
1
?
A:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
K
R
I
------
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
LG
E
L
-
D
--
L
S
T
-
L
-
K
E
F
L
E
T
I
-
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
--
S
A
V
N
A
I
K
E
------
F
-----
A
S
S
H
N
V
N
V
L
F
E
-----
S
N
V
---
P
C
P
V
E
A
--
Y
I
D
----
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
--
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
-------
22
PsiBlast_CBE
57.32
34%
22
- C4 -
-
4U7O
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
D
N
P
A
--
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
23
PsiBlast_CBE
57.23
34%
16
- C4 -
-
5C93
1
?
B:
[14-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
-----------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
D
N
P
A
--
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
S
--
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
21
PsiBlast_CBE
56.01
34%
17
- C4 -
-
4ZKI
1
?
B:
[37-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
---
G
A
-
W
--
K
D
P
E
V
-
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
---------------
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
------
R
F
D
M
I
L
K
K
D
------
K
Y
-----
Y
T
I
---
K
R
E
F
T
K
--
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
-----
V
V
T
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
------
20
PsiBlast_PDB
55.73
30%
24
- C4 -
-
2C2A
1
?
A:
[7-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
K
R
I
------
D
------
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
-
D
--
L
S
T
-
L
-
K
E
F
L
E
V
I
-
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
KS
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
--
S
A
V
N
A
I
K
E
------
F
-----
A
S
S
H
N
V
N
V
L
F
E
-----
S
N
V
---
P
C
P
V
E
A
--
Y
I
D
----
P
T
R
-
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
K
D
G
G
--
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-----
14
PsiBlast_PDB
40.30
35%
47
- C4 -
-
3SL2
1
A:
[4-150]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
V
R
F
M
S
L
I
I
D
R
F
E
------
M
-----
T
K
E
Q
--
E
--
F
I
-----
R
N
L
PDR
D
L
Y
V
E
I
--
D
Q
D
------
K
-
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
H
V
---
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
--------