@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP90: (2017-11-20 )
MRKIIHIDMDAFYASVELRERPDLRHLPVVISSHHPRAVIAAASYPAREFGLRSAMSMSQARKLCPQVVIIEPNFEKYRAISAQIHSIFQQYTTLIEPLSLDEAYLDVTENLKQIASATEVAMHIREDIFRQTGLTASAGVAPNKFLAKVASDWNKPNGLFVIKPSQVASFIQDLPLKKIPGVGKVTQEKLQQLELHTLGDLQKIEEAVLVHHFGKYGQQLYLYAQGIDNRPVQAERARQQISKETTFDSDFTLAQCQSYWHGLAEKVWQSLEKKQLNARGVNIKLKLKNFQTLQHSKSFKNPIHSQQDLIQVLFLLLNEMHIPENFQFRLIGVLGFINYKLKLTTFSCLYGECCFFIQKNKF
Atome Classification :
(26 SA)
-------------------------------------------------------------------.........10........20........30.-..-.------------------------------....40........50........60........70.-.......80........90........100.......110...----------------------------------.--------------------...120.......130.......140.......150.......160...--....170...-....180.......190.......200.......210....-...220.......230.......240.......250-.-......260.......270...-------.--...280.......290---------------........300.----....---..310.......320...--....330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------M
R
K
I
I
H
ID
M
D
A
F
Y
A
S
V
E
LRERPDLRHL
P
V
V
IS-SH-H------------------------------P
R
A
V
I
A
AASY
P
A
R
E
F
G
L
R
S
A
M
S
M
S
Q
A
R
KLCP
Q
V
V
I
IE-P
N
F
E
K
Y
R
A
I
S
A
Q
I
H
S
I
F
Q
Q
Y
T
T
L
IEPLS
L
D
E
A
Y
L
D
V
T
E
N
L
K
Q
I
----------------------------------
A
--------------------
S
A
T
E
V
A
M
H
I
R
E
D
I
F
R
QTGLTASAGVA
P
N
K
F
L
A
K
V
A
S
DWNKPN
G
L
F
V
I
K
P
--
S
Q
V
A
S
F
I
Q
DL-PLKKIPGV
G
K
V
T
Q
E
K
L
Q
Q
L
E
L
H
TLG
D
L
Q
K
I
E
E
A
V
L
V
H
H
F
G
K-YG
Q
Q
L
Y
L
Y
A
QGIDNRP
V
Q
A
E
R
A
R
Q
Q
I
SKETTFDSD
F
-
T
-
L
A
Q
C
Q
S
Y
W
H
G
L
A
E
K
V
W
Q
S
L
E
K
K-------Q--LNARG
V
N
I
K
L
K
LK
N
-
F
---------------
Q
T
L
Q
H
S
K
SFKNP----IH
S
Q
---
Q
D
L
I
Q
V
L
F
L
L
L
N
EMHIPE--N
F
Q
F
R
L
I
G
V
L
G
F
I
N
Y
K
L
K
L
T
T
F
S
C
L
Y
G
E
C
C
F
F
I
QKNKF
54
HHSearch
71.37
26%
-9
- C1 -
-
3OSN
3
POLI_HUMAN
A:
[27-414]
-------------------------------------------------------------------
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
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E
M
I
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N
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E
L
K
D
K
P
L
G
V
Q
-
Q
----------------------------------
K
Y
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
M
N
V
R
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A
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K
C
P
Q
L
V
L
V
N
G
E
D
L
T
R
Y
R
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M
S
Y
K
V
T
E
L
L
E
E
F
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P
V
V
E
R
L
G
F
D
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N
F
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L
T
E
M
V
E
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HVYNN
Q
S
I
N
LLD
V
L
H
I
R
L
L
--------------------
V
G
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
N
Q
Q
T
V
L
L
P
--
E
S
C
Q
H
L
I
H
S
L
N
H
I
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I
P
G
I
G
Y
K
T
A
K
C
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A
L
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D
L
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F
S
P
K
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L
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K
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L
G
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A
Q
R
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Q
K
L
S
F
G
E
D
N
S
P
V
I
L
S
G
P
P
Q
S
F
S
E
E
D
S
F
K
K
C
S
-
S
-
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
-------
G
--
R
K
P
H
T
V
R
L
I
I
R
R
Y
S
S
E
K
H
Y
------------
G
R
E
S
R
Q
C
P
I
P
S
H
VIQK---
Y
D
V
M
T
P
M
V
D
I
L
M
K
L
F
R
N
-
M
V
N
V
KM
P
F
H
L
T
L
L
S
V
C
F
C
N
L
K
-----------------------
47
HHSearch
71.36
44%
13
- C1 -
-
5C5J
5
?
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
-
G
S
R
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
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A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
-
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-------
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
-
F
---------------
Q
Q
T
T
Q
E
H
--
V
W
P
----
R
L
N
K
---
A
D
L
I
A
T
A
R
K
T
W
D
E
-
R
R
-
G
--
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------------
45
HHSearch
69.51
45%
10
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[2-339]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
-
G
S
R
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
-
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-------
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
-
F
---------------
Q
Q
T
T
Q
E
H
V
W
--
P
----
R
L
N
K
---
A
D
L
I
A
T
A
R
K
T
W
D
E
-
R
R
-
G
--
G
R
G
V
R
L
V
G
L
H
V
T
L
-------------------------
28
PsiBlast_CBE
69.02
46%
9
- C1 -
-
4IRK
3
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
9
PsiBlast_PDB
68.87
46%
13
- C1 -
-
4Q44
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
5
PsiBlast_PDB
68.70
47%
8
- C1 -
-
4R8U
1
?
B:
[1-312]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
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I
A
I
G
G
S
R
-
E
------------------------------
R
R
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Y
P
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S
A
M
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M
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P
-
G
R
F
D
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I
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Y
T
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E
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L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
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A
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E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
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F
L
A
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I
A
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D
M
N
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P
N
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P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
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A
A
K
L
E
A
M
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L
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K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
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E
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Q
G
I
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E
R
D
V
N
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R
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G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
1
PsiBlast_PDB
68.69
47%
9
- C1 -
-
4IR1
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
10
PsiBlast_PDB
68.62
46%
7
- C1 -
-
4Q45
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
25
PsiBlast_CBE
68.20
47%
14
- C1 -
-
4R8U
1
DPO4_ECOLI
A:
[2-313]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
VKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
22
PsiBlast_CBE
68.13
47%
9
- C1 -
-
4Q43
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
21
PsiBlast_CBE
68.12
47%
11
- C1 -
-
5C5J
5
?
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
8
PsiBlast_PDB
68.05
46%
10
- C1 -
-
4IRK
5
DPO4_ECOLI
B:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
6
PsiBlast_PDB
67.78
46%
11
- C1 -
-
4IRC
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
3
PsiBlast_PDB
67.25
47%
16
- C1 -
-
4Q43
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
VKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
2
PsiBlast_PDB
67.24
47%
13
- C1 -
-
4IR9
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
24
PsiBlast_CBE
66.96
47%
16
- C1 -
-
4IR1
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
7
PsiBlast_PDB
66.94
46%
14
- C1 -
-
4IRD
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
26
PsiBlast_CBE
66.74
46%
13
- C1 -
-
4Q45
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
23
PsiBlast_CBE
66.20
47%
10
- C1 -
-
4IR9
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
43
HHSearch
65.83
30%
0
- C1 -
-
3GQC
-
REV1_HUMAN
D:
[417-827]
--------------------------------------------------------------------
S
C
I
M
H
V
D
M
D
C
F
F
V
S
V
G
I
R
N
R
P
D
L
K
G
K
P
V
A
V
T
-
S
N
-
R
GTGRAPLRPGAN
P
Q
L
E
W
Q
Y
Y
Q
NANGIDSVL
S
R
A
E
I
A
S
C
S
Y
E
A
R
Q
L
G
I
K
N
G
M
F
F
G
H
A
K
Q
L
C
P
N
L
Q
A
V
P
-
Y
D
F
H
A
Y
K
E
V
A
Q
T
L
Y
E
T
L
A
S
Y
T
H
N
I
E
A
V
S
C
D
E
A
L
V
D
I
T
E
I
L
A
E
T
----------------------------------
K
L-------------------
T
P
D
E
F
A
N
A
V
R
M
E
I
K
D
Q
T
K
C
A
A
S
V
G
I
G
S
N
I
L
L
A
R
M
A
T
R
K
A
K
P
D
G
Q
Y
H
L
K
P
--
E
E
V
D
D
F
I
R
G
Q
-
L
V
T
N
L
P
G
V
G
H
S
M
E
S
K
L
A
S
L
G
I
K
T
C
G
D
L
Q
Y
M
T
M
A
K
L
Q
K
E
F
G
P
K
T
G
Q
M
L
Y
R
F
C
R
G
L
D
D
R
P
V
R
T
E
K
E
R
K
S
V
S
A
E
I
N
Y
G
I
R
F
-
T
Q
P
K
E
A
E
A
F
L
L
S
L
S
E
E
I
Q
R
R
L
E
A
T
-------
G
--
M
K
G
K
R
L
T
L
K
I
M
V
R
K
-
P
GAPVETAKFGGH
G
I
C
D
N
I
A
R
T
V
T
L
D
Q
A
----
T
D
N
A
---
K
I
I
G
K
A
M
L
N
M
F
H
T
-
M
K
L
N
--
I
S
D
M
R
G
V
G
I
H
V
N
Q
L
V
P
T
---------------------
27
PsiBlast_CBE
65.81
46%
11
- C1 -
-
4Q44
3
DPO4_ECOLI
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
4
PsiBlast_PDB
65.56
47%
15
- C1 -
-
5C5J
2
?
F:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
LAKVKPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
30
PsiBlast_CBE
65.32
46%
14
- C1 -
-
4IRC
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
29
PsiBlast_CBE
64.55
46%
15
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[3-314]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
-
E
------------------------------
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
-
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
----------------------------------
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
-
W
S
E
C
E
A
----
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
KPD
L
--
L
I
A
R
Q
-
G
V
K
L
K
F
D
D
-
F
---------------
Q
--
Q
T
T
Q
E
H
V
W
P
----
R
L
N
K
---
A
D
L
I
------------------------------------------------------
68
Fugue
63.91
35%
42
- C1 -
-
2OH2
3
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
RNL
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
G
-
S
----------------------------------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
-
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
---------------
T
--------------------
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
N
-
K
-
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
-------
R
--
L
K
G
R
T
V
T
I
K
L
K
N
V
N
-
F
---------------
E
V
K
T
R
A
S
T
V
S
S
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
A
D
--
F
P
H
P
L
R
L
R
L
M
G
V
R
I
S
S
F
P
--------------------
70
Fugue
61.59
34%
35
- C1 -
-
2W7O
3
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
RNL
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
G
-
S
----------------------------------
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
-
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
----------------------------------
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
N
-
K
-
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
-------
R
--
L
K
G
R
T
V
T
I
K
L
K
N
V
N
-
F
---------------
E
V
K
T
R
A
S
T
V
S
S
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
A
D
--
F
P
H
P
L
R
L
R
L
M
G
V
R
I
S
S
F
P
N
E
------------------