@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP98: (2017-11-20 )
MTSLAHHATENRSVAEFTEQAYLNYAMYVIMDRALPHISDGLKPVQRRIVYAMSELGLKSSGKPKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLIEGQGNWGSPDDPKSFAAMRYTEAKLSAYSELLLSELGQGTSEWQDNFDGSLKEPITLPARVPNILLNGTTGIAVGMATDIPPHNLREVVKGTIALIRNPQTSDEKLAEYIPAPDLPTKAEIITPPEELLKIQTTGRGSYRMRAVYTIEKNEIVITELPYQVSGSKVITQIADQMQAKKLPLVVDVRDESDHENPTRLVIVLRSNRIDAEAVMSHLFATTDLESSYRVNLNMIGEDGRPQVKSIRRILLEWIEIRKKTVTRRLQYHLNRIEKRLHILAGLLIAYLDIDTVIRIIREEDQPKPVLMEHFNIDEIQAEAILELKLRHLAKLEEMEIRHEQDELSAKAAIIREQLENPESLKNLIISELKEDAKKFGDERRSPIVARAEAVQIKEQDLMPAETVTVVLSEAGWVRAAKGADVDAENLNYRAGDQYLSHAVGKTNQRVYFLDETGRSYALPISNLPSARGLGDPLSSKLSPASGVSFIQVYLDDDESELIAASSAGYGFKTQTKQLDTNAKAGKTFLTVPDKAKALPLISAQNMTHLAVLSSAGRLLILDLAELPNLNKGKGNKLIQLEGKEQILSMTTLNLDEIIQVVAGQQHLKLKGDDLQKYMGKRASKGQLLPRGYQKANKLLIQR
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.-.-.....120.......130.......140.......150.......160.......170.......180.......190.......200...----....----210.......220.......230.......240.......250------.-----..-....260.......270.......280.......290.-......300.......310.......320.......330.......340........350.......360.......370.......380.......390.......--------------------------400-.---.---....---...410------.........420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640-...-....650.......660.......670.....------..680----.........690.......700.......710.......720.......730.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSLAHHATENR
S
V
A
E
F
T
E
Q
A
Y
L
N
Y
A
M
Y
V
I
M
D
RAL
P
H
I
S
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
ELGLKSSGKPK
K
S
A
R
T
V
G
D
V
L
GKYHPHG
D
S
A
C
Y
E
A
M
V
L
MAQPFSYRYPLIEGQGNWGSP-D-D
P
K
S
F
A
A
M
R
Y
T
E
A
K
L
S
A
Y
S
E
L
L
L
S
E
LGQ
G
T
S
E
WQDNFDGSLKE
P
I
TLPARV
P
N
I
L
LNGTT
G
I
A
V
GMATDI
P
P
H
N
L
R
E
V
V
K
G
T
I
A
L
I
RNPQT----
S
D
E
K
----
L
A
E
YIPAPDLPTKA
E
I
IT
P
P
E
E
L
L
K
I
Q
TTGRG
S
Y
R
M
R
A
V
Y
T
I
E------K-----N
E
-
I
V
I
T
ELPYQVS
G
S
K
V
I
T
Q
I
A
D
Q
M
QAKKL
P
L
V
V
D
VRDES-DHENP
T
R
L
V
I
V
L
RSNRI
D
A
E
A
V
M
S
H
L
F
ATTDLES
S
Y
R
V
N
L
N
M
IGEDG-
R
P
Q
V
K
S
I
R
R
I
L
L
E
W
I
E
I
R
K
K
T
V
T
R
R
L
Q
Y
H
L
N
R
I
E
K
R
L
H
I
L
A
G
L
L
I
A
Y
L
D
I
D
T
V
I
R
I
I
RE--------------------------E---D---Q---PK
P
V
---
L
M
E
H--------F
N
I
D
E
I
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
E
I
R
H
E
Q
D
E
L
S
A
K
A
A
I
I
R
E
Q
LE
N
P
E
S
L
K
N
L
I
I
S
E
L
K
E
D
A
K
K
F
G
D
ERRS
P
I
V
A
R
A
E
A
V
Q
IKEQDLMPA
E
T
V
T
V
V
LSEAG
W
V
R
AAKGADVDAENLNYRA
G
D
Q
Y
L
S
H
AVGKTN
Q
R
V
Y
F
LDETGR
S
Y
A
LPISNLPSARGLGD
P
L
S
SKLSPASG
V
S
F
I
Q
V
Y
LDDDES
E
L
I
A
ASSAGYGFKTQTKQLDTNAKAG
K
T
F
L
TVPDKAKA
L
P
L
ISAQN-
M
T
H
-
L
A
V
L
SSAG
R
L
L
I
L
D
L
A
ELPNLNKGKGN
K
L
I
Q
L------EGK------EQ
I
L
S
MTTL
N
L
D
E
I
I
Q
V
VAGQ
Q
H
L
KLK
G
D
D
L
Q
K
Y
M
G
KRASKGQLL
P
R
G
Y
Q
K
A
N
K
L
LIQR
113
HHSearch
90.89
58%
-74
- C5 -
-
1ZVU
-
PARC_ECOLI
A:
[28-740]
-------------------------------
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
----------
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
W
G
A
P
-
D
-
D
P
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
S
E
L
L
L
S
E
L
G
Q
G
T
A
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
Q
A
A
I
A
L
I
D
Q
P
K
T
----
T
L
D
Q
----
L
L
D
I
V
Q
G
P
D
Y
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
E
N
G
R
G
S
V
R
M
R
A
V
W
K
K
E
------
D
-----
G
A
-
V
V
I
S
A
L
P
H
Q
V
S
G
A
R
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
D
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
Y
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
N
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
L
T
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
G
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
Q
A
Y
G
D
D
R
R
S
P
L
Q
E
R
E
E
A
K
A
M
S
E
H
D
M
L
P
S
E
P
V
T
I
V
L
S
Q
M
G
W
V
R
S
A
K
G
---------------
F
K
A
A
V
K
G
K
S
N
Q
P
V
V
F
V
D
S
T
G
R
S
Y
A
I
D
P
I
T
L
P
S
A
R
---
E
P
L
T
G
K
L
T
L
P
P
G
A
T
V
D
H
M
L
M
E
S
D
D
Q
K
L
L
M
A
S
D
A
G
Y
G
F
V
C
T
F
N
D
L
V
A
R
N
R
A
G
K
A
L
I
T
L
P
E
N
A
H
V
M
P
P
V
V
I
E
D
A
S
D
M
-
L
L
A
I
T
Q
A
G
R
M
L
M
F
P
V
S
D
L
P
Q
L
S
K
G
K
G
N
K
I
I
N
I
------
P
S
A
E
A
A
R
GE
D
G
L
A
Q
L
Y
V
L
P
P
Q
S
T
L
T
I
H
V
G
K
R
K
I
K
L
R
P
E
E
L
Q
K
V
T
G
E
R
G
R
R
G
T
L
M
R
G
L
Q
R
I
-
D
R
V
E
I
D
-
1
PsiBlast_PDB
90.27
57%
-72
- C5 -
-
1ZVU
-
PARC_ECOLI
A:
[28-739]
-------------------------------
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
----------
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
W
G
A
P
-
D
-
D
P
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
S
E
L
L
L
S
E
L
G
Q
G
T
A
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
Q
A
A
I
A
L
I
D
Q
P
K
T
----
T
L
D
Q
----
L
L
D
I
V
Q
G
P
D
Y
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
E
N
G
R
G
S
V
R
M
R
A
V
W
K
K
E
------
D
-----
G
A
-
V
V
I
S
A
L
P
H
Q
V
S
G
A
R
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
D
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
Y
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
N
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
L
T
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
G
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
Q
A
Y
G
D
D
R
R
S
P
L
Q
E
R
E
E
A
K
A
M
S
E
H
D
M
L
P
S
E
P
V
T
I
V
L
S
Q
M
G
W
V
R
S
A
K
G
---------------
F
K
A
A
V
K
G
K
S
N
Q
P
V
V
F
V
D
S
T
G
R
S
Y
A
I
D
P
I
T
L
P
S
A
R
---
E
P
L
T
G
K
L
T
L
P
P
G
A
T
V
D
H
M
L
M
E
S
D
D
Q
K
L
L
M
A
S
D
A
G
Y
G
F
V
C
T
F
N
D
L
V
A
R
N
R
A
G
K
A
L
I
T
L
P
E
N
A
H
V
M
P
P
V
V
I
E
D
-
A
S
D
M
L
L
A
I
T
Q
A
G
R
M
L
M
F
P
V
S
D
L
P
Q
L
S
K
G
K
G
N
K
I
I
N
I
P
S
A
E
A
A
R
G
E
------
D
G
L
A
Q
L
Y
V
L
P
P
Q
S
T
L
T
I
H
V
G
K
R
K
I
K
L
R
P
E
E
L
Q
K
V
T
G
E
R
G
R
R
G
T
L
M
-
R
G
L
Q
R
I
D
R
V
E
I
--
22
PsiBlast_CBE
80.83
69%
-82
- C6 -
-
5EIX
1
?
G:
[251-727]
---------
E
R
L
A
L
H
E
F
T
E
N
A
Y
L
N
Y
S
M
Y
V
I
M
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
N
A
S
A
K
F
K
K
S
A
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
G
D
G
Q
G
N
W
G
A
P
-----
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
A
E
L
L
L
S
E
L
G
Q
G
T
V
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
K
A
A
I
T
L
I
E
Q
P
K
T
----
T
L
D
E
----
L
L
D
I
V
Q
G
P
D
F
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
Q
N
G
R
G
S
V
R
M
R
A
V
W
S
K
E
------
D
-----
G
A
-
V
V
I
T
A
L
P
H
Q
V
S
G
A
K
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
E
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
H
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
T
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
I
S
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
A
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
D
A
F
G
D
D
R
R
S
P
L
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.96
69%
-82
- C6 -
-
5EIX
1
?
B:
[251-727]
---------
E
R
L
A
L
H
E
F
T
E
N
A
Y
L
N
Y
S
M
Y
V
I
M
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
N
A
S
A
K
F
K
K
S
A
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
G
D
G
Q
G
N
W
G
A
P
-----
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
A
E
L
L
L
S
E
L
G
Q
G
T
V
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
K
A
A
I
T
L
I
E
Q
P
K
T
----
T
L
D
E
----
L
L
D
I
V
Q
G
P
D
F
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
Q
N
G
R
G
S
V
R
M
R
A
V
W
S
K
E
------
D
-----
G
A
-
V
V
I
T
A
L
P
H
Q
V
S
G
A
K
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
E
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
H
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
T
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
I
S
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
A
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
D
A
F
G
D
D
R
R
S
P
L
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
79.82
69%
-80
- C6 -
-
5EIX
2
?
A:
[248-727]
------
D
M
A
E
R
L
A
L
H
E
F
T
E
N
A
Y
L
N
Y
S
M
Y
V
I
M
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
N
A
S
A
K
F
K
K
S
A
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
G
D
G
Q
G
N
W
G
A
P
-----
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
A
E
L
L
L
S
E
L
G
Q
G
T
V
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
K
A
A
I
T
L
I
E
Q
P
K
T
----
T
L
D
E
----
L
L
D
I
V
Q
G
P
D
F
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
Q
N
G
R
G
S
V
R
M
R
A
V
W
S
K
E
------
D
-----
G
A
-
V
V
I
T
A
L
P
H
Q
V
S
G
A
K
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
E
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
H
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
T
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
I
S
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
A
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
D
A
F
G
D
D
R
R
S
P
L
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.74
69%
-80
- C6 -
-
5EIX
2
?
A:
[251-727]
---------
E
R
L
A
L
H
E
F
T
E
N
A
Y
L
N
Y
S
M
Y
V
I
M
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
N
A
S
A
K
F
K
K
S
A
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
G
D
G
Q
G
N
W
G
A
P
-----
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
A
E
L
L
L
S
E
L
G
Q
G
T
V
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
K
A
A
I
T
L
I
E
Q
P
K
T
----
T
L
D
E
----
L
L
D
I
V
Q
G
P
D
F
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
Q
N
G
R
G
S
V
R
M
R
A
V
W
S
K
E
------
D
-----
G
A
-
V
V
I
T
A
L
P
H
Q
V
S
G
A
K
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
E
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
H
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
T
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
I
S
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
A
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
D
A
F
G
D
D
R
R
S
P
L
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.30
69%
-83
- C6 -
-
5EIX
2
?
J:
[251-726]
---------
E
R
L
A
L
H
E
F
T
E
N
A
Y
L
N
Y
S
M
Y
V
I
M
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
N
A
S
A
K
F
K
K
S
A
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
G
D
G
Q
G
N
W
G
A
P
-----
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
A
E
L
L
L
S
E
L
G
Q
G
T
V
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
K
A
A
I
T
L
I
E
Q
P
K
T
----
T
L
D
E
----
L
L
D
I
V
Q
G
P
D
F
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
Q
N
G
R
G
S
V
R
M
R
A
V
W
S
-------------------
I
T
A
L
P
H
Q
V
S
G
A
K
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
S
-
D
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
E
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
-
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
H
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
T
--------------------------
E
---
D
---
E
---
P
K
P
A
---
L
M
S
R
--------
F
G
I
S
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
A
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
D
A
F
G
D
D
R
R
S
P
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.88
42%
-66
- C6 -
-
4Z2E
1
?
B:
[8-486]
----------
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
-
D
-
G
-
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
-
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
-----------------
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
R
E
G
-
V
R
F
V
I
---
R
D
-
A
S
A
N
V
I
L
N
N
L
F
K
M
T
Q
M
Q
T
N
F
G
F
N
M
L
A
I
-
Q
N
G
-
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
--------------------------
S
---
E
T
D
A
E
---
A
Q
A
E
---
L
M
S
K
--------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.00
42%
-6
- C6 -
-
4Z2C
1
?
B:
[8-486]
----------
N
V
N
L
T
K
E
M
K
A
S
F
I
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
M
N
E
L
G
V
T
P
D
K
P
H
K
K
S
A
R
I
T
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
W
W
S
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
M
-
D
-
G
-
D
S
A
A
A
Q
R
Y
T
E
A
R
M
S
K
I
A
L
E
M
L
R
D
I
N
K
N
T
V
D
F
V
D
N
Y
D
A
N
E
R
E
P
L
V
L
P
A
R
F
P
N
L
L
V
N
G
A
T
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
G
E
T
I
D
A
V
K
L
V
M
D
N
P
E
V
----
T
T
K
D
----
L
M
E
V
L
P
G
P
D
F
P
T
G
A
-
L
V
M
G
K
S
G
I
H
K
A
Y
E
T
G
K
G
S
I
V
L
R
S
R
T
E
I
E
T
T
KTG-
R
-----
E
R
-
I
V
V
T
E
F
P
Y
M
V
N
K
T
K
V
H
E
H
I
V
R
L
V
Q
E
K
R
I
E
G
I
T
A
V
R
D
E
S
-
N
R
E
G
-
V
-
F
V
I
E
V
K
R
D
--
S
A
N
V
I
L
N
N
L
F
K
M
T
-
M
Q
T
N
F
G
F
N
M
L
A
I
-
Q
N
G
-
I
P
K
I
L
S
L
R
Q
I
L
D
A
Y
I
E
H
Q
K
E
V
V
V
R
R
T
R
F
D
K
E
K
A
E
A
R
A
H
I
L
E
G
L
L
I
A
L
D
H
I
D
E
V
I
R
I
I
R
A
--------------------------
S
---
E
T
D
A
E
---
A
Q
A
E
---
L
M
S
K
--------
F
K
L
S
E
R
Q
S
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
Q
S
E
Y
D
D
L
L
A
L
I
A
D
L
A
D
I
L
A
K
P
E
R
V
S
Q
I
I
K
D
E
L
D
E
V
K
R
K
F
S
D
K
R
R
T
E
L
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
62.75
44%
-1
- C6 -
-
5IWI
10
GYRA_STAAN (first)
A:
[8-489]
--------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
-
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
K
-
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
------
E
RGGG-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
T
D
K
V
---
A
M
E
S
---
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.46
43%
1
- C6 -
-
5IWI
10
GYRA_STAAN (first)
A:
[11-487]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
RGGG-
R
-----
Q
R
-
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
-
V
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
M
E
S
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
62.43
43%
2
- C6 -
-
5CDN
6
GYRA_STAAN (first)
C:
[3-479]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
R
GG
G
-
R
-----
Q
R
-
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
-
V
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
M
E
S
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.43
43%
1
- C6 -
-
5CDQ
6
GYRA_STAAN
A:
[3-479]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
R
GG
G
-
R
-----
Q
R
-
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
-
V
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
M
E
S
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.43
43%
2
- C6 -
-
5CDP
4
GYRA_STAAN
A:
[4-480]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
E
RGGG-
R
-----
Q
R
-
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
-
V
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
M
E
S
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.40
43%
3
- C6 -
-
5CDM
7
GYRA_STAAN
A:
[4-480]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
A
V
I
E
ERGG
G
-
R
-----
Q
R
-
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
T
-
S
L
R
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
-
V
N
G
-
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
M
E
S
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.18
44%
3
- C6 -
-
5NPP
10
?
D:
[213-689]
-----------
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
-
D
-
G
D
G
A
-
A
A
M
R
Y
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
----
S
I
A
E
----
L
M
E
D
I
E
G
P
D
F
P
T
-
A
G
L
I
L
G
K
S
G
I
R
R
A
Y
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T
G
R
G
S
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Q
M
R
S
R
A
V
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E
ERGGG-
R
-----
Q
R
-
I
V
V
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F
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K
A
R
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K
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K
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D
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-
S
L
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V
R
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V
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K
D
-
A
N
A
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N
N
L
Y
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Q
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P
L
Q
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F
G
V
N
M
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A
L
-
V
N
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L
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N
L
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A
L
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V
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R
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Y
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L
R
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A
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D
R
A
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I
L
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G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
--------------------------
S
---
D
---
T
---
D
K
V
A
MES
L
Q
Q
R
--------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
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R
D
K
I
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A
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Y
N
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L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------