@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPA7: (2017-11-20 )
MEKAMLAKRIIPCLDVDNGRVVKGVQFLDIRDAGDPVEVARRYNEQGADEITFLDITATHHGRDTTYRTVERMAETVFVPLTVGGGVRKVEDIRALLNAGADKVSINSAAVFNPEFVQEASQHFGAQCIVVAIDAKKTGDNKWEIFTHGGRKPTGIDAIEWAVKMADYGAGELLITSMGADGTKAGYDIALMRAINDRVTIPTIASGGVGNLQHLADGILQGGADAVLAASIFHFGQYTIPEAKQYLAEQGIEMRL
Atome Classification :
(23 SA)
.........10........20-........--.30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
K
A
M
L
A
K
RII
P
C
L
DVDN
G
R
--
V
V
K
G
V
Q
F
L
--
D
IRDAG
D
P
V
E
V
A
R
R
YNEQGAD
E
I
T
F
L
D
I
T
ATHHGRD
T
T
Y
R
T
V
E
R
M
A
E
T
V
F
V
P
L
TVGGGV
R
K
V
E
D
I
R
A
L
L
NAGA
D
K
V
SINSAAVF
N
P
E
F
V
Q
E
A
S
Q
HFG
A
Q
C
I
V
V
A
I
DAKKTGDNK
W
E
I
F
THGGRKPTG
I
D
A
I
E
W
A
V
K
MADYGAG
E
L
L
I
T
SMGADGTKAG
Y
D
I
A
L
M
R
AINDRVT
I
P
T
IASGGVG
N
L
Q
H
L
A
D
G
I
L
QGG
A
D
A
V
L
A
A
S
I
F
H
FGQYT
I
P
E
A
K
Q
Y
L
A
EQGIEMRL
93
HHSearch
93.23
59%
-110
* C2 *
-
1KA9
-
HIS6_THET8
F:
[2-250]
----
S
L
A
K
R
I
V
P
C
L
D
V
H
A
G
R
--
V
V
K
G
V
N
F
V
--
N
L
R
D
A
G
D
P
V
E
A
A
R
A
Y
D
E
A
G
A
D
E
L
V
F
L
D
I
S
A
T
H
E
E
R
A
I
L
L
D
V
V
A
R
V
A
E
R
V
F
I
P
L
T
V
G
G
G
V
R
S
L
E
D
A
R
K
L
L
L
S
G
A
D
K
V
S
V
N
S
A
A
V
R
R
P
E
L
I
R
E
L
A
D
H
F
G
A
Q
A
V
V
L
A
I
D
A
R
W
R
G
-
D
F
P
E
V
H
V
A
G
G
R
V
P
T
G
L
H
A
V
E
W
A
V
K
G
V
E
L
G
A
G
E
I
L
L
T
S
M
D
R
D
G
T
K
E
G
Y
D
L
R
L
T
R
M
V
A
E
A
V
G
V
P
V
I
A
S
G
G
A
G
R
M
E
H
F
L
E
A
F
-
Q
A
G
A
E
A
A
L
A
A
S
V
F
H
F
G
E
I
P
I
P
K
L
K
R
Y
L
A
E
K
G
V
H
V
R
-
2
PsiBlast_PDB
92.08
59%
-107
- C2 -
-
1KA9
-
HIS6_THET8
F:
[3-251]
-----
L
A
K
R
I
V
P
C
L
D
V
H
A
G
R
--
V
V
K
G
V
N
F
V
--
N
L
R
D
A
G
D
P
V
E
A
A
R
A
Y
D
E
A
G
A
D
E
L
V
F
L
D
I
S
A
T
H
E
E
R
A
I
L
L
D
V
V
A
R
V
A
E
R
V
F
I
P
L
T
V
G
G
G
V
R
S
L
E
D
A
R
K
L
L
L
S
G
A
D
K
V
S
V
N
S
A
A
V
R
R
P
E
L
I
R
E
L
A
D
H
F
G
A
Q
A
V
V
L
A
I
D
A
R
W
R
G
D
F
P
-
E
V
H
V
A
G
G
R
V
P
T
G
L
H
A
V
E
W
A
V
K
G
V
E
L
G
A
G
E
I
L
L
T
S
M
D
R
D
G
T
K
E
G
Y
D
L
R
L
T
R
M
V
A
E
A
V
G
V
P
V
I
A
S
G
G
A
G
R
M
E
H
F
L
E
A
-
F
Q
A
G
A
E
A
A
L
A
A
S
V
F
H
F
G
E
I
P
I
P
K
L
K
R
Y
L
A
E
K
G
V
H
V
R
L
83
HHSearch
91.83
66%
-107
- C2 -
-
4EVZ
-
?
B:
[1-249]
----
M
L
A
K
R
I
I
P
C
L
D
V
K
D
G
R
--
V
V
K
G
V
N
F
E
--
N
L
R
D
A
G
D
P
V
E
L
A
A
R
Y
D
E
E
G
A
D
E
L
V
F
L
D
I
T
----
G
R
E
T
M
L
E
V
V
E
R
T
A
E
Q
V
F
I
P
L
T
V
G
G
G
I
R
S
V
E
D
A
S
R
L
L
R
A
G
A
D
K
V
S
I
N
T
A
A
V
K
N
P
E
L
I
T
E
A
A
E
E
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
G
-
G
G
W
E
V
F
T
H
G
G
R
K
P
T
G
L
D
A
V
E
W
A
R
K
V
V
E
L
G
A
G
E
I
L
L
T
S
M
D
R
D
G
T
K
A
G
Y
D
L
E
L
T
R
A
V
S
E
A
V
S
V
P
V
I
A
S
G
G
A
G
E
L
E
H
F
A
E
V
F
E
L
E
G
A
D
A
A
L
A
A
S
I
F
H
F
G
E
I
T
I
R
E
V
K
A
Y
L
R
E
R
G
I
E
V
--
1
PsiBlast_PDB
91.09
66%
-99
- C2 -
-
4EVZ
-
?
A:
[1-251]
----
M
L
A
K
R
I
I
P
C
L
D
V
K
D
G
R
--
V
V
K
G
------
N
L
R
D
A
G
D
P
V
E
L
A
A
R
Y
D
E
E
G
A
D
E
L
V
F
L
D
I
T
A
S
H
E
G
R
E
T
M
L
E
V
V
E
R
T
A
E
Q
V
F
I
P
L
T
V
G
G
G
I
R
S
V
E
D
A
S
R
L
L
R
A
G
A
D
K
V
S
I
N
T
A
A
V
K
N
P
E
L
I
T
E
A
A
E
E
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
G
G
G
-
W
E
V
F
T
H
G
G
R
K
P
T
G
L
D
A
V
E
W
A
R
K
V
V
E
L
G
A
G
E
I
L
L
T
S
M
D
R
D
G
T
K
A
G
Y
D
L
E
L
T
R
A
V
S
E
A
V
S
V
P
V
I
A
S
G
G
A
G
E
L
E
H
F
A
E
V
F
E
L
E
G
A
D
A
A
L
A
A
S
I
F
H
F
G
E
I
T
I
R
E
V
K
A
Y
L
R
E
R
G
I
E
V
R
L
4
PsiBlast_PDB
89.41
50%
-121
- C2 -
-
2A0N
1
HIS6_THEMA
A:
[13-262]
----
M
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
10
PsiBlast_PDB
89.28
49%
-130
- C2 -
-
4EWN
1
HIS6_THEMA
D:
[2-250]
-----
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
------
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
V
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
V
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
6
PsiBlast_PDB
89.14
50%
-121
- C2 -
-
1THF
-
HIS6_THEMA
D:
[1-250]
----
M
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
5
PsiBlast_PDB
88.50
50%
-122
- C2 -
-
2WJZ
-
HIS6_THEMA
A:
[1-250]
----
M
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
7
PsiBlast_PDB
87.76
49%
-120
- C2 -
-
1VH7
-
HIS6_THEMA
A:
[4-252]
-----
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
9
PsiBlast_PDB
87.74
49%
-113
- C2 -
-
5TQL
-
HIS6_THEMA
A:
[24-272]
-----
L
A
K
R
I
I
A
S
L
D
V
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
24
PsiBlast_CBE
87.62
50%
-125
- C2 -
-
3ZR4
1
HIS6_THEMA
C:
[1-250]
----
M
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
G
-----------
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
8
PsiBlast_PDB
87.23
49%
-117
- C2 -
-
1GPW
-
HIS6_THEMA
A:
[1-250]
----
M
L
A
K
R
I
I
A
C
L
N
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
84
HHSearch
86.90
49%
-116
- C2 -
-
1GPW
-
HIS6_THEMA
A:
[1-249]
----
M
L
A
K
R
I
I
A
C
L
N
V
K
D
G
R
--
V
V
K
G
T
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
D
-
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
A
F
-
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
-
23
PsiBlast_CBE
86.70
50%
-122
- C2 -
-
3ZR4
2
HIS6_THEMA
E:
[1-250]
----
M
L
A
K
R
I
I
A
C
L
D
V
K
D
G
R
--
V
V
K
-----------
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
V
F
L
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
S
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
A
I
D
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
S
G
G
A
G
K
M
E
H
F
L
E
-
A
F
L
A
G
A
D
A
A
L
A
A
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
85
HHSearch
84.22
43%
-112
- C2 -
-
5D38
-
?
B:
[3-251]
-----
L
A
K
R
I
D
A
A
L
I
M
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
I
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
F
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
D
-
G
E
F
M
V
F
T
Y
S
G
T
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
R
G
A
G
K
M
E
H
F
L
E
A
F
-
L
A
G
A
D
A
A
K
A
D
S
V
F
H
S
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
15
PsiBlast_PDB
83.73
45%
-113
- C2 -
-
5D2W
1
?
A:
[3-251]
-----
L
A
K
R
I
I
A
A
L
I
V
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
G
G
A
G
K
M
E
H
F
L
E
A
F
L
-
A
G
A
D
A
A
K
A
N
S
V
L
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
11
PsiBlast_PDB
83.07
45%
-108
- C2 -
-
2RKX
-
?
A:
[1-250]
----
M
L
A
K
R
I
I
A
A
L
I
V
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
G
G
A
G
K
M
E
H
F
L
E
A
F
L
-
A
G
A
D
A
A
K
A
N
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
16
PsiBlast_PDB
82.82
44%
-110
- C2 -
-
5D32
-
?
A:
[2-250]
-----
L
A
K
R
I
D
A
A
L
I
V
K
D
G
R
--
V
V
E
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
T
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
R
G
A
G
K
M
E
H
F
L
E
A
F
L
-
A
G
A
D
A
A
K
A
D
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
19
PsiBlast_PDB
82.36
44%
-109
- C2 -
-
5D30
-
?
A:
[3-251]
-----
L
A
K
R
I
D
A
A
L
I
M
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
R
G
A
G
K
M
E
H
F
L
E
A
F
L
-
A
G
A
D
A
A
K
A
D
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
20
PsiBlast_PDB
82.33
44%
-110
- C2 -
-
5D2X
1
?
A:
[3-251]
-----
L
A
K
R
I
D
A
A
L
I
M
K
D
G
R
--
V
V
K
G
S
N
F
E
--
N
L
R
D
S
G
D
P
V
E
L
G
K
F
Y
S
E
I
G
I
D
E
L
S
F
W
D
I
T
A
S
V
E
K
R
K
T
M
L
E
L
V
E
K
V
A
E
Q
I
D
I
P
F
T
V
G
G
G
I
H
D
F
E
T
A
S
E
L
I
L
R
G
A
D
K
V
E
I
N
T
A
A
V
E
N
P
S
L
I
T
Q
I
A
Q
T
F
G
S
Q
A
V
V
V
Y
I
A
A
K
R
V
-
D
G
E
F
M
V
F
T
Y
S
G
K
K
N
T
G
I
L
L
R
D
W
V
V
E
V
E
K
R
G
A
G
E
I
V
L
G
S
I
D
R
L
G
T
K
S
G
Y
D
T
E
M
I
R
F
V
R
P
L
T
T
L
P
I
I
A
H
R
G
A
G
K
M
E
H
F
L
E
A
F
L
-
A
G
A
D
A
A
K
A
D
S
V
F
H
F
R
E
I
D
V
R
E
L
K
E
Y
L
K
K
H
G
V
N
V
R
L
3
PsiBlast_PDB
79.01
53%
1
- C2 -
-
1H5Y
2
HIS6_PYRAE
A:
[3-253]
-----
M
A
L
R
I
I
P
C
L
D
I
D
G
G
A
KV
V
V
K
G
V
N
F
Q
--
G
I
R
E
V
G
D
P
V
E
M
A
V
R
Y
E
E
E
G
A
D
E
I
A
I
L
D
I
T
A
A
P
E
G
R
A
T
F
I
D
S
V
K
R
V
A
E
A
V
S
I
P
V
L
V
G
G
G
V
R
S
L
E
D
A
T
T
L
F
R
A
G
A
D
K
V
S
V
N
T
A
A
V
R
N
P
Q
L
V
A
L
L
A
R
E
F
G
S
Q
S
T
V
V
A
I
D
A
K
W
N
G
E
Y
-
Y
E
V
Y
V
K
G
G
R
E
A
T
G
L
D
A
V
K
W
A
K
E
V
E
E
L
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
G
L
G
Y
D
V
E
L
I
R
R
V
A
D
S
V
R
I
P
V
I
A
S
G
G
A
G
R
V
E
H
F
Y
E
-
A
A
A
A
G
A
D
A
V
L
A
A
S
L
F
H
F
R
V
L
S
I
A
Q
V
K
R
Y
L
K
E
R
G
V
E
V
R
I
22
PsiBlast_CBE
78.57
53%
2
- C2 -
-
1H5Y
2
HIS6_PYRAE
B:
[3-253]
-----
M
A
L
R
I
I
P
C
L
D
I
D
G
G
A
KV
V
V
K
G
V
N
F
Q
--
G
I
R
E
V
G
D
P
V
E
M
A
V
R
Y
E
E
E
G
A
D
E
I
A
I
L
D
I
T
A
A
P
E
G
R
A
T
F
I
D
S
V
K
R
V
A
E
A
V
S
I
P
V
L
V
G
G
G
V
R
S
L
E
D
A
T
T
L
F
R
A
G
A
D
K
V
S
V
N
T
A
A
V
R
N
P
Q
L
V
A
L
L
A
R
E
F
G
S
Q
S
T
V
V
A
I
D
A
K
W
N
G
E
Y
-
Y
E
V
Y
V
K
G
G
R
E
A
T
G
L
D
A
V
K
W
A
K
E
V
E
E
L
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
G
L
G
Y
D
V
E
L
I
R
R
V
A
D
S
V
R
I
P
V
I
A
S
G
G
A
G
R
V
E
H
F
Y
E
-
A
A
A
A
G
A
D
A
V
L
A
A
S
L
F
H
F
R
V
L
S
I
A
Q
V
K
R
Y
L
K
E
R
G
V
E
V
R
I
89
HHSearch
76.46
53%
6
- C2 -
-
1H5Y
2
HIS6_PYRAE
B:
[2-252]
----
H
M
A
L
R
I
I
P
C
L
D
I
D
G
G
A
--
K
V
V
V
K
G
V
N
F
Q
G
I
R
E
V
G
D
P
V
E
M
A
V
R
Y
E
E
E
G
A
D
E
I
A
I
L
D
I
T
A
A
P
E
G
R
A
T
F
I
D
S
V
K
R
V
A
E
A
V
S
I
P
V
L
V
G
G
G
V
R
S
L
E
D
A
T
T
L
F
R
A
G
A
D
K
V
S
V
N
T
A
A
V
R
N
P
Q
L
V
A
L
L
A
R
E
F
G
S
Q
S
T
V
V
A
I
D
A
K
W
N
G
-
E
Y
Y
E
V
Y
V
K
G
G
R
E
A
T
G
L
D
A
V
K
W
A
K
E
V
E
E
L
G
A
G
E
I
L
L
T
S
I
D
R
D
G
T
G
L
G
Y
D
V
E
L
I
R
R
V
A
D
S
V
R
I
P
V
I
A
S
G
G
A
G
R
V
E
H
F
Y
E
A
A
-
A
A
G
A
D
A
V
L
A
A
S
L
F
H
F
R
V
L
S
I
A
Q
V
K
R
Y
L
K
E
R
G
V
E
V
R
-