@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPC7: (2017-11-20 )
MSLSRIRLASLHDKVISAEQAAQFIENGMTVGMSGFTRAGEAKAVPQALVELAKKNPLKITLITGASLGNDLDKQLTEAGVLSRRMPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNQQLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKVIVEINTSLSESFEGLHDIYIPTYRPTRTPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTHDSPSTVTPLDDETQGIANHLIAFFEKEVAEGHLPKNLGPLQAGIGSIANAVLTGLKDSNFEDLIMYSEVLQDCTFELIDAGKMKFASGSSITLSAKCGEKVFGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEFDIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSIAKGGDISSIVPMVSHVDHSEHDVDILVTEQGLADLRGLAPRERARAIIDNCVHPLYRDALNDYFDRACAKGGHTPHLLREALSWHANFEETGQMLQPTPVAKSA
Atome Classification :
(32 SA)
.........10........20........30........40........50..-----..-----....60........70........80........90........100.......110.......120........130.......140.......150.......160......-.170.......180..--.....190....------...200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300..---.....310.......320.....----..330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......--470.........480.......490.......500..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSLS
R
I
R
L
A
S
L
H
D
K
VI
S
A
E
Q
A
A
Q
F
I
ENG
M
T
VGMSGFTRAGEA
K
A
V
P
Q
A
L
V
E
L
A
-----KK-----N
P
L
K
I
T
L
I
TGASLG
N
D
L
D
K
Q
L
T
E
A
G
V
L
SRRMPF
Q
V
D
N
T
L
R
R
AINNG
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
M
R
N
Q-QLKRPD
V
A
V
I
E
A
I
A
ITEDG
G
I
I
PTTSVGNSA
S
F
A
I
F
A
E
K
V
I
V
E
IN
T
S
L
-
S
E
S
F
E
G
L
H
DIYIPTYR--PTRTPI
P
L
T
K
V
D
------ERIG
T
T
A
I
Q
IDP
A
K
I
V
G
I
V
F
NDTHDSPSTVTPLD
D
E
T
Q
G
I
A
N
H
L
I
A
F
F
E
K
E
V
AEGHLPKNL
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
L
TGLKDS
N
F
E
D
L
I
M
Y
S
E
V
L
Q
D
C
T
F
E
L
I
DAG
K
M
K
---FASG
S
S
I
T
L
SAKCG
E
K
V
FG
N
I
E
A
----
Y
K
D
K
L
V
L
R
P
Q
E
ISN
H
P
E
L
V
R
R
LGI
I
G
IN
T
A
L
E
F
D
I
YGNVNS
T
H
V
C
G
T
K
M
M
NGIGGSGDFARN
A
H
L
A
I
F
V
T
K
SIAKGG
D
I
S
S
I
V
P
M
V
S
HVDHSEH
D
V
D
I
L
V
TEQ
G
L
A
D
L
RGLA
P
R
E
R
A
R
A
I
I
D
N
C
V
H
P
L
Y
R
D
A
L
N
D
Y
F
D
R
A
C
A--K--GGH
T
P
H
L
L
R
E
A
L
S
WHA
N
F
E
ETGQMLQPTPVAKSA
1
PsiBlast_PDB
99.18
77%
-85
- C4 -
-
2G39
7
?
A:
[5-495]
----
R
V
R
L
P
S
L
L
D
K
V
M
S
A
A
E
A
A
D
L
I
Q
D
G
M
T
V
G
M
S
G
F
T
R
A
G
E
A
K
A
V
P
Q
A
L
A
M
R
A
-----
K
E
-----
R
P
L
R
I
S
L
M
T
G
A
S
L
G
N
D
L
D
K
Q
L
T
E
A
G
V
L
A
R
R
M
P
F
Q
V
D
S
T
L
R
K
A
I
N
A
G
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
L
R
N
H
-
Q
L
K
L
P
D
I
A
V
I
E
A
A
A
I
T
E
Q
G
H
I
V
P
T
T
S
V
G
N
S
A
S
F
A
I
F
A
K
Q
V
I
V
E
I
N
L
A
H
-
S
T
N
L
E
G
L
H
D
I
Y
I
P
T
Y
R
--
P
T
R
T
P
I
P
L
T
R
V
D
------
D
R
I
G
S
T
A
I
P
I
P
P
E
K
I
V
A
I
V
I
N
D
Q
P
D
S
P
S
T
V
L
P
P
D
G
E
T
Q
A
I
A
N
H
L
I
D
F
F
K
R
E
V
D
A
G
R
M
S
N
S
L
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
M
C
G
L
I
E
S
P
F
E
N
L
T
M
Y
S
E
V
L
Q
D
S
T
F
D
L
I
D
A
G
K
L
R
---
F
A
S
G
S
S
I
T
L
S
P
R
R
N
A
D
V
F
G
N
L
E
R
----
Y
K
D
K
L
V
L
R
P
Q
E
I
S
N
H
P
E
V
V
R
R
L
G
I
I
G
I
N
T
A
L
E
F
D
I
Y
G
N
V
N
S
T
H
V
G
G
T
K
M
M
N
G
I
G
G
S
G
D
F
A
R
N
A
H
L
A
I
F
V
T
K
S
I
A
K
G
G
N
I
S
S
V
V
P
M
V
S
H
V
D
H
T
E
H
D
V
D
I
L
V
T
E
Q
G
L
A
D
L
R
G
L
A
P
R
E
R
A
R
V
I
I
E
N
C
V
H
P
S
Y
Q
A
P
L
L
D
Y
F
E
A
A
C
A
--
K
--
G
G
H
T
P
H
L
L
R
E
A
L
A
W
H
L
N
L
E
E
R
G
H
M
L
---------
44
HHSearch
92.89
78%
-50
- C4 -
-
2G39
7
?
A:
[3-496]
--
R
D
R
V
R
L
P
S
L
L
D
K
V
M
S
A
A
E
A
A
D
L
I
Q
D
G
M
T
V
G
M
S
G
F
T
R
A
G
E
A
K
A
V
P
Q
A
L
A
M
R
A
-----
K
E
-----
R
P
L
R
I
S
L
M
T
G
A
S
L
G
N
D
L
D
K
Q
L
T
E
A
G
V
L
A
R
R
M
P
F
Q
V
D
S
T
L
R
K
A
I
N
A
G
E
V
M
F
I
D
Q
H
L
S
E
T
V
E
Q
L
R
N
H
-
Q
L
K
L
P
D
I
A
V
I
E
A
A
A
I
T
E
Q
G
H
I
V
P
T
T
S
V
G
N
S
A
S
F
A
I
F
A
K
Q
V
I
V
E
I
N
L
A
H
-
S
T
N
L
E
G
L
H
D
I
Y
I
P
T
Y
R
--
P
T
R
T
P
I
P
L
T
R
V
D
------
D
R
I
G
S
T
A
I
P
I
P
P
E
K
I
V
A
I
V
I
N
D
Q
P
D
S
P
S
T
V
L
P
P
D
G
E
T
Q
A
I
A
N
H
L
I
D
F
F
K
R
E
V
D
A
G
R
M
S
N
S
L
G
P
L
Q
A
G
I
G
S
I
A
N
A
V
M
C
G
L
I
E
S
P
F
E
N
L
T
M
Y
S
E
V
L
Q
D
S
T
F
D
L
I
D
A
G
K
L
R
F
A
S
G
S
S
I
T
L
S
P
R
R
N
---
A
D
V
F
G
N
L
E
R
----
Y
K
D
K
L
V
L
R
P
Q
E
I
S
N
H
P
E
V
V
R
R
L
G
I
I
G
I
N
T
A
L
E
F
D
I
Y
G
N
V
N
S
T
H
V
G
G
T
K
M
M
N
G
I
G
G
S
G
D
F
A
R
N
A
H
L
A
I
F
V
T
K
S
I
A
K
G
G
N
I
S
S
V
V
P
M
V
S
H
V
D
H
T
E
H
D
V
D
I
L
V
T
E
Q
G
L
A
D
L
R
G
L
A
P
R
E
R
A
R
V
I
I
E
N
C
V
H
P
S
Y
Q
A
P
L
L
D
Y
F
E
A
A
C
A
--
K
--
G
G
H
T
P
H
L
L
R
E
A
L
A
W
H
L
N
L
E
E
R
G
H
M
L
A
--------
45
HHSearch
70.73
49%
15
- C4 -
-
4EU9
1
SCACT_ACEAC
A:
[2-506]
--
T
E
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
-----
E
A
A
H
D
R
G
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
N
Y
G
-
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
N
P
M
-
L
E
G
I
H
D
I
W
D
G
N
------
V
S
G
V
P
T
R
D
I
V
PIVRAD
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
----
E
A
A
E
E
I
N
N
R
M
D
F
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
NS
F
--
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
P
S
S
------
4
PsiBlast_PDB
69.93
48%
25
- C4 -
-
4EU3
-
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
10
PsiBlast_PDB
69.79
48%
26
- C4 -
-
5DW6
4
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
15
PsiBlast_PDB
69.71
48%
27
- C4 -
-
4EUB
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
25
PsiBlast_CBE
69.68
48%
27
- C4 -
-
4EU5
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
9
PsiBlast_PDB
69.67
48%
28
- C4 -
-
5DW5
4
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
31
PsiBlast_CBE
69.65
48%
25
- C4 -
-
4EU8
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
A
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
33
PsiBlast_CBE
69.60
48%
27
- C4 -
-
4EUB
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
22
PsiBlast_CBE
69.38
48%
27
- C4 -
-
5DW5
4
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
14
PsiBlast_PDB
69.34
48%
26
- C4 -
-
4EU8
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
A
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
21
PsiBlast_CBE
69.29
48%
27
- C4 -
-
5DW6
4
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
6
PsiBlast_PDB
69.27
48%
28
- C4 -
-
4EU5
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
29
PsiBlast_CBE
69.07
48%
27
- C4 -
-
4EU9
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
13
PsiBlast_PDB
68.97
48%
27
- C4 -
-
4EUD
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
23
PsiBlast_CBE
68.82
48%
27
- C4 -
-
4EU7
2
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
32
PsiBlast_CBE
68.80
48%
28
- C4 -
-
4EUC
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
16
PsiBlast_PDB
68.71
48%
26
- C4 -
-
4EUC
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
A
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
34
PsiBlast_CBE
68.67
48%
26
- C4 -
-
5DDK
4
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
A
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
30
PsiBlast_CBE
68.63
48%
25
- C4 -
-
4EUD
2
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
11
PsiBlast_PDB
68.51
48%
28
- C4 -
-
4EU9
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
28
PsiBlast_CBE
68.40
48%
26
- C4 -
-
4EUA
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
24
PsiBlast_CBE
68.30
48%
28
- C4 -
-
4EU6
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
3
PsiBlast_PDB
68.19
48%
27
- C4 -
-
5E5H
7
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
-
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
12
PsiBlast_PDB
68.15
48%
26
- C4 -
-
4EUA
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
E
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
17
PsiBlast_PDB
68.14
48%
27
- C4 -
-
5DDK
4
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
A
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
8
PsiBlast_PDB
68.09
48%
27
- C4 -
-
4EU7
2
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
7
PsiBlast_PDB
67.67
48%
28
- C4 -
-
4EU6
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
5
PsiBlast_PDB
67.45
48%
27
- C4 -
-
4EU4
1
SCACT_ACEAC
A:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
26
PsiBlast_CBE
66.90
48%
27
- C4 -
-
4EU4
1
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
S
K
V
C
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
EAAHD
R
G
-----
E
K
Y
Q
I
S
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
R
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
S
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
L
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------
35
PsiBlast_CBE
65.81
48%
28
- C4 -
-
5E5H
5
SCACT_ACEAC
B:
[4-503]
----
R
I
R
N
V
A
L
R
-
K
V
-
P
A
E
T
A
S
E
L
I
K
H
G
D
V
V
G
T
S
G
F
T
G
A
G
Y
P
K
E
V
P
K
A
L
A
Q
R
M
E
A
A
H
D
R
G
-----
E
K
Y
Q
I
-
L
I
T
G
A
S
T
G
P
Q
L
D
G
E
L
A
K
A
N
G
V
Y
F
R
S
P
F
N
T
D
A
T
M
R
N
R
I
N
A
G
E
T
E
Y
F
D
N
H
L
G
Q
V
A
G
R
A
V
Q
G
-
N
Y
G
K
F
N
I
A
L
V
E
A
T
A
I
T
E
D
G
G
I
V
P
T
S
S
V
G
N
S
Q
T
F
L
N
L
A
E
K
V
I
I
E
V
N
E
W
Q
-
N
P
M
L
E
G
I
H
D
I
W
D
G
N
V
S
GV
P
T
R
D
I
V
P
I
V
-
A
D
------
Q
R
V
G
G
P
V
L
R
V
N
P
D
K
I
A
A
I
V
R
T
N
D
R
D
R
N
A
P
F
A
A
P
D
E
T
A
K
A
I
A
G
Y
L
L
D
F
F
G
H
E
V
K
Q
N
R
L
P
P
-
L
L
P
L
Q
S
G
V
G
N
V
A
N
A
V
L
E
G
L
K
E
G
P
F
E
N
L
V
G
Y
S
E
V
I
Q
D
G
M
L
A
M
L
D
S
G
R
M
R
---
I
A
S
A
S
S
F
S
L
S
P
E
A
A
E
E
I
N
N
R
M
D
F
----
F
R
S
K
I
I
L
R
Q
Q
D
V
S
N
S
P
G
I
I
R
R
L
G
C
I
A
M
N
G
M
I
E
A
D
I
Y
G
N
V
N
S
T
R
V
M
G
S
K
M
M
N
G
I
G
G
S
G
D
F
A
R
S
S
Y
L
S
I
F
L
S
P
S
T
A
K
G
G
K
I
S
A
I
V
P
M
A
A
H
V
D
H
I
M
Q
D
A
Q
I
F
V
T
E
Q
G
L
A
D
L
R
G
L
S
P
V
Q
R
A
R
E
I
I
S
K
C
A
H
P
D
Y
R
P
M
L
Q
D
Y
F
D
R
A
-
K
--
N
SF
G
K
H
T
P
H
L
L
T
E
A
L
S
W
H
Q
R
F
I
D
T
G
T
M
L
---------