@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPD8: (2017-11-21 )
MAQYIYTMNRVSKMVPPKREILKDISLSFFPGAKIGVLGLNGAGKSTLLRIMAGVDKDFSGEARAQPGIKIGYLEQEPPLDPTKDVRGNVEDGVREALDALERLDQVFAEYADPDADFDALAKEQEKLESIIHAWDAHNLNNQLEIAADALNLPAWDADVTKLSGGERRRVALCRLLLSKPDMLLLDEPTNHLDAESVSWLERFLKDFPGTIVAITHDRYFLDNVAEWILELDRGHGIPYQGNYTSWLEQKNARLEQEQKQEESFAKALKKELEWVRQNAKGQQKKNKARMERFEELNSREFQQRNETSEIYIPPGPRLGNKVVEVENISKSFGDRLLYENLSFTVPPAAIVGIVGPNGAGKTTLFRMMTGEQKPDTGTVTLGDSVKVAYVGQIRDTLDDNKTVWEEVSGGLDILKVGDYEIASRAYIGRFNFKGQDQQKRVGELSGGERNRLQLAKILQQGANVILLDEPSNDLDVETLRALEDAILVFPGTVMVVSHDRWFLDRIATHILSFEDEQPEFYTGNYTEFEAYRRAKLGDDAQPHRKKYKKISG
Atome Classification :
(20 SA)
.........10......-..20........30........40........50...-.....60......-..70........--80-------........---------90....--....100.......110.--...------...120.--.-.....130.......140.......150...--....160------.......170.......180.......190....---...200...---...---.210-........220.......230.......240.......250.......260.......270.......280.......290----.......300.......310.......320.......330...--...-.340.......350----........360.......370......------.380..---------.----------....390......-----------.-----400----....-----------------------------------------------------...-------------------.410------------------------...--.--------------..-.-.--.--420--------------------------.......-------..430....-...440.......450.......460.......470......----.480.......490--.----........500.......510.....-..--520.......530.......540........550.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
Q
Y
I
Y
T
M
N
R
V
S
K
MVP
P
-
K
R
E
I
L
K
DISLSFFPG
A
K
I
G
V
L
GLNGA
G
K
S
T
L
L
R
I
M
AG-VDKDFSGEARAQP-G
I
K
I
G
Y
LEQEPP--LD-------
P
T
K
D
VRG
N
---------
V
E
D
G
V
R
--
E
A
L
D
A
L
E
R
L
D
Q
V
F
A
EYAD--PDA------
D
F
D
A
L
A
K
--
E
-
Q
E
K
L
E
S
I
I
H
A
W
DAHNLNN
Q
L
E
I
AADALNLPA--WDADVTK------LSGG
E
R
R
R
V
A
L
C
R
L
L
LSKP
D
M
L
L
LDEPTNHLD
A
E
---
S
V
S
W
L
E
R
F
L
---
K
DF---P
G
T
--
I
V
A
I
THD
R
Y
F
L
D
N
V
A
E
W
I
L
E
LDRGHGIPYQG
N
Y
T
S
W
L
E
Q
K
N
A
R
L
E
Q
E
Q
K
Q
E
E
S
F
A
K
A
L
K
K
E
L
E
W
V
R
Q
NAKGQ
Q
K
K
N
K
A
R
M
E
----
R
F
E
E
L
N
S
R
E
F
Q
QRNET
S
E
I
YIPPGPRLG
N
K
V
V
E
V
E
N
I
S
K
S
F
G
D
--
R
L
L
-YENLSFTVPP
A
A
I
-----
V
G
I
VGPNGAGK
T
T
L
F
R
MMTGEQKPDT
G
------
T
V
TLGD---------
S
----------
V
K
V
A
Y
V
G
Q
I
R
D
TL-----------D-----DN-----
K
T
V
W
-----------------------------------------------------
E
E
V-------------------SG--------------------------G
L
D
--
I
--------------
L
K
-V-G--D--
Y
----------------------------
E
I
A
S
R
A
Y
-------
I
G
RFNFKG
Q
-
D
Q
Q
K
R
V
GELSGGE
R
N
R
L
Q
L
A
K
I
L
QQGA
N
V
I
L
LDEPSNDL
D
V
E
----
T
L
R
A
L
E
D
A
I
L
V
F----P----
G
T
V
M
V
V
SH
D
R
W
F
L
D
R
I
A
T
H
I
LSFEDE-QP--EFYTGN
Y
T
E
F
E
A
Y
R
R
AKLGDDA-
Q
P
H
R
K
K
Y
KKISG
24
HHSearch
95.66
71%
-49
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[2-553]
-
A
Q
F
V
Y
T
M
H
R
V
G
K
V
V
P
P
-
K
R
H
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
-
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
I
K
I
G
Y
L
P
Q
E
P
Q
--
L
N
-------
P
E
H
T
V
R
E
S
---------
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
--
P
D
A
------
D
F
D
K
L
A
A
--
E
-
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
------
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
---
H
D
F
---
E
G
T
--
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
----
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
-
I
D
D
L
S
F
S
I
P
K
G
A
I
-----
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
------
T
I
T
L
G
E
---------
T
----------
V
K
L
A
S
V
D
Q
F
R
D
S
M
-----------
D
-----
N
S
-----
K
T
V
W
-----------------------------------------------------
E
E
V
-------------------
S
G
--------------------------
G
L
D
--
I
--------------
M
K
-
I
-
G
--
N
--
T
----------------------------
E
M
P
S
R
A
Y
-------
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
----
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
-
D
-
E
G
KV
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
G
A
D
A
L
E
P
K
R
I
K
Y
K
R
I
--
1
PsiBlast_PDB
95.31
71%
-47
- C1 -
-
3J5S
-
ETTA_ECOLI
D:
[2-554]
-
A
Q
F
V
Y
T
M
H
R
V
G
K
V
V
P
P
-
K
R
H
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
-
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
I
K
I
G
Y
L
P
Q
E
P
Q
--
L
N
-------
P
E
H
T
V
R
E
S
---------
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
--
P
D
A
------
D
F
D
K
L
A
A
--
E
-
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
------
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
---
H
D
F
---
E
G
T
--
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
----
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
R
L
G
D
K
V
L
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V
S
N
L
R
K
S
Y
G
D
--
R
L
L
-
I
D
D
L
S
F
S
I
P
K
G
A
I
-----
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
------
T
I
T
L
G
E
---------
T
----------
V
K
L
A
S
V
D
Q
F
R
D
S
M
-----------
D
-----
N
S
-----
K
T
V
W
-----------------------------------------------------
E
E
V
-------------------
S
G
--------------------------
G
L
D
--
I
--------------
M
K
-
I
-
G
--
N
--
T
----------------------------
E
M
P
S
R
A
Y
-------
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
----
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
--
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
G
A
D
A
L
E
P
K
R
I
K
Y
K
R
I
A
-
2
PsiBlast_PDB
94.91
70%
-73
- C1 -
-
4FIN
6
ETTA_ECOLI
A:
[2-548]
-
A
Q
F
V
Y
T
M
H
R
V
G
K
V
V
P
P
-
K
R
H
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
-
I
D
K
D
I
E
G
E
A
R
P
Q
P
-
D
I
K
I
G
Y
L
P
Q
E
P
Q
--
L
N
-------
P
E
H
T
V
R
E
S
---------
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
--
P
D
A
------
D
F
D
K
L
A
A
--
E
-
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
I
A
N
------
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
---
H
D
F
---
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G
T
--
V
V
A
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D
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Y
F
L
D
N
V
A
G
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L
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G
N
Y
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L
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Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
----
R
F
E
E
L
N
S
T
E
Y
Q
K
R
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T
N
E
L
F
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P
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P
R
L
G
D
K
V
L
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V
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N
L
R
K
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Y
G
D
--
R
L
L
-
I
D
D
L
S
F
S
I
P
K
G
A
I
-----
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
------
T
I
T
L
G
E
---------
T
----------
V
K
L
A
S
V
D
Q
F
R
D
S
M
-----------
D
-----
N
S
-----
K
T
V
W
-----------------------------------------------------
E
E
V
-------------------
S
G
--------------------------
G
L
D
--
I
--------------
M
K
-
I
-
G
--
N
--
T
----------------------------
E
M
P
S
R
A
Y
-------
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
----
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
--
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
K
R
T
L
G
A
D
A
L
E
P
K
R
I
-------
36
HHSearch
52.35
26%
8
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[435-978]
------
D
L
C
N
C
E
F
S
L
A
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
-
G
Q
V
D
--
G
F
P
T
Q
E
E
-
C
R
T
V
Y
V
E
H
D
I
D
G
--
T
H
-------
S
D
T
S
V
L
D
F
---------
V
F
E
S
G
V
--
G
------------------------------------------------------
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
------
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
---
N
T
C
---
G
I
T
--
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
-------
K
-----
A
Y
E
---
E
L
S
N
T
D
L
-------------------
E
-
F
--
K
F
P
E
P
G
-----
Y
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
-
I
T
D
I
N
F
Q
C
S
L
S
S
R
-----
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
------
E
V
Y
T
H
E
---------
N
----------
C
R
I
A
Y
I
K
Q
H
A
F
A
H
IESHLDKT
P
S
E
Y
-----
I
Q
W
R
F
Q
T
G
E
D
R
ETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
-------------------
G
M
--------------------------
K
S
E
R
-
W
V
P
M
M
SVD-------
N
A
-
W
I
P
--
R
--
G
ELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRPLT
R
K
E
I
E
E
H
-------
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
----
S
L
G
A
L
S
K
A
L
K
E
F
----
E
----
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
-
D
-
G
R
--
M
T
P
--------------------------------
13
PsiBlast_PDB
49.59
28%
-51
- C1 -
-
4HLU
1
ECFA2_THEMA
A:
[19-235]
---------------
P
L
-
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
-
L
I
E
P
T
S
G
D
V
L
Y
D
G
-
E
R
K
K
G
Y
--------------------
E
I
R
R
N
---------
I
--
G
I
----
A
F
Q
Y
P
E
--
D
Q
F
F
A
E
R
V
-------------
F
D
E
V
A
------------
F
A
V
K
N
F
Y
P
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
F
K
DRVPFF
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
---
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
---
G
K
T
--
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
-
F
D
G
T
R
M
E
F
L
E
K
Y
D
P
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
49.09
22%
17
- C1 -
-
3J16
1
RLI1_YEAST
B:
[102-542]
-------------------------------
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
-
K
Q
K
P
N
L
G
R
F
-------------
D
D
P
P
E
W
Q
E
-------
I
I
K
Y
F
R
G
S
EL
Q
N
Y
F
T
K
M
L
E
D
D
I
K
---
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
--
P
V
Q
------
K
V
G
E
L
L
K
L
R
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
K
--------------
R
D
I
E
K
------
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
---
L
A
P
---
T
K
Y
--
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
---
Y
G
V
P
S
V
Y
G
V
V
T
L
--------------
P
A
S
V
R
E
G
I
N
I
F
L
D
G
---
H
I
P
A
E
N
L
R
F
R
T
E
A
L
----
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
------------
S
L
K
K
T
Q
G
D
--
F
V
L
N
V
E
E
G
E
F
S
--
D
S
E
I
-----
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
P
KFPG
T
----------
V
R
Q
L
F
F
K
K
I
R
G
Q
F
-----------------
L
N
-----
P
Q
F
Q
-----------------------------------------------------
T
D
V
-------------------
V
K
--------------------------
P
L
R
--
I
--------------
D
D
-
I
-
I
--
D
--
Q
----------------------------
E
----------------------------
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
----
K
----
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------------------------------------------
16
PsiBlast_PDB
48.25
22%
17
- C1 -
-
4CRM
2
RLI1_YEAST
P:
[102-542]
-------------------------------
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
-
K
Q
K
P
N
L
G
R
F
-------------
D
D
P
P
EW
Q
E
-------
I
I
K
Y
F
R
G
S
ELQNYFTKM
L
E
D
D
I
K
---
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
--
P
V
Q
------
K
V
G
E
L
L
K
LR
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
K
--------------
R
D
I
E
K
------
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
QRL
N
A
A
Q
I
I
R
S
L
---
L
A
P
---
T
K
Y
--
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
---
Y
G
V
P
S
V
Y
G
V
V
T
L
--------------
P
A
S
V
R
E
G
I
N
I
F
L
D
G
---
H
I
P
A
E
N
L
R
F
R
T
E
A
L
----
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
------------
S
L
K
K
T
Q
G
D
--
F
V
L
N
V
E
E
G
E
F
S
--
D
S
E
I
-----
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
QDIPKL
N
V
S
M
K
P
QKIAPKFPG
T
----------
V
R
Q
L
F
F
K
K
I
R
G
Q
F
-----------------
L
N
-----
P
Q
F
Q
-----------------------------------------------------
T
D
V
-------------------
V
K
--------------------------
P
L
R
--
I
--------------
D
D
-
I
-
I
--
D
--
Q
----------------------------
E
----------------------------
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
QRII
C
S
K
V
I
R
R
F
I
L
H
N
----
K
----
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------------------------------------------
39
HHSearch
48.18
26%
17
- C1 -
-
2IX8
-
A:
[1429-1975]
------
D
L
C
N
C
E
F
S
L
A
Y
G
A
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
-
G
Q
V
D
--
G
F
P
T
Q
E
E
-
C
R
T
V
Y
V
E
H
D
I
D
G
--
T
H
-------
S
D
T
S
V
L
D
F
---------
V
F
E
S
G
V
--
G
------------------------------------------------------
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
------
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
---
N
T
C
---
G
I
T
--
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
--------
A
----
K
A
Y
E
---
E
L
S
N
T
D
------------------
L
E
----
F
K
F
P
E
P
G
-----
Y
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
-
I
T
D
I
N
F
Q
C
S
L
S
S
R
-----
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
------
E
V
Y
T
H
E
---------
N
----------
C
R
I
A
Y
I
K
Q
H
A
F
A
H
IESHLDKT
P
S
E
Y
I
Q
W
R
F
Q
T
-----
G
-
D
R
-----------------------------------------------------
E
T
M
DRANRQINENDAEAMN
K
I
F
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
GMKSE
R
W
V
P
M
M
SVD
N
A
W
I
-
P
--
R
--
G
ELVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFRPLT
R
K
E
I
E
E
H
-------
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
----
S
L
G
A
L
S
K
A
L
K
E
F
----
E
----
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
-
D
-
G
R
--
M
T
P
S
G
H
-----------------------------
45
HHSearch
47.50
25%
10
- C1 -
-
1YQT
2
?
A:
[25-480]
--------
E
D
C
V
H
R
Y
G
V
--
N
A
F
V
L
Y
R
L
P
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
-
Q
L
I
P
N
L
C
G
D
N
D
S
W
D
G
V
I
R
A
F
R
G
N
E
L
Q
N
-
Y
F
E
K
L
K
N
GE
I
R
P
V
V
K
P
Q
---------
Y
V
D
L
I
P
--
K
------
A
V
-------
K
------------------------
G
K
V
I
E
L
L
K
K
A
---
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
V-
L
E
R
E
I
Q
H
------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
---
Q
R
L
N
A
A
R
A
I
---
R
R
L
S
E
E
G
K
S
--
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
-
H
V
V
Y
G
E
P
G
V
Y
-
G
I
F
S
Q
P
K
G
T
R
N
-------
G
I
N
----
E
F
L
R
--
G
Y
L
K
D
--
E
N
V
R
F
---
R
P
Y
E
I
----
K
F
T
K
T
----
G
E
R
--------
V
E
---
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
---
S
F
R
-
L
E
V
E
P
G
E
I
K
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
I
E
W
D
---------------------
L
T
V
A
Y
K
P
Q
Y
I
K
A
------------
D
-----
Y
E
-----
G
T
V
Y
-----------------------------------------------------
E
L
L
-------------------
S
K
--------------------------
I
D
A
--
S
--------------
K
--
L
----
N
--
S
----------------------------
N
F
Y
K
T
E
L
-------
L
K
P
L
G
I
I
D
--
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
-
G
-
E
P
--
G
----------------------------------
7
PsiBlast_PDB
47.01
26%
35
- C1 -
-
1YQT
2
?
A:
[47-482]
--------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
D
-
G
V
----------------------
I
R
A
F
R
G
N
---------
E
L
Q
N
Y
F
--
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
LI
P
K
A
VKGK
V
I
E
L
L
K
K
A
D
--
E
-
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
V
-----------------
L
E
R
E
I
Q
H
------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
---
S
E
E
---
G
K
S
--
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
---
Y
G
E
P
--
G
V
Y
G
I
F
S
Q
P
K
G
T
R
-------------------
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
----
P
Y
E
----
I
K
F
T
K
T
G
E
R
V
E
I
E
-------
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
S
--
F
R
L
--
E
V
E
P
G
E
I
K
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
I
E
W
-----------
D
----------
L
T
V
A
Y
K
P
Q
Y
I
K
A
------------
D
-----
Y
E
-----
G
T
V
Y
-----------------------------------------------------
E
L
L
-------------------
S
K
---------------------------
I
D
--
A
--------------
S
K
-
L
-
N
--
S
N
F
Y
----------------------------
K
T
E
L
L
K
P
-------
L
G
I
I
D
L
-----
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
E
-
P
G
--
K
Y
---------------------------------
10
PsiBlast_PDB
46.50
26%
18
- C1 -
-
3BK7
2
?
A:
[117-548]
--------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
----------------------
Q
L
I
P
N
--
L
C
-------
E
D
N
D
S
W
D
N
---------
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
--
K
P
Q
------
Y
V
D
L
L
P
K
--
A
V
K
G
K
V
R
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
----
L
D
R
E
L
H
Q
------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
---
A
N
E
---
G
K
A
--
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
---
Y
G
E
P
--
G
V
Y
G
I
F
S
K
P
K
G
T
R
-------------------
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
R
V
D
V
E
R
-
E
T
--------------
L
V
E
Y
P
R
L
V
K
D
Y
G
---------
S
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
V
E
W
-----------
D
----------
L
T
V
A
Y
K
P
Q
Y
I
K
A
------------
E
-----
Y
E
-----
G
T
V
Y
-----------------------------------------------------
E
L
L
-------------------
S
------------------------------------------------
K
-
I
-
D
--
S
--
S
----------------------------
K
L
N
S
N
F
Y
K
T
E
LLKP
L
G
I
I
D
L
-----
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
E
----------------------------------------
12
PsiBlast_PDB
46.20
28%
-44
- C1 -
-
4ZIR
2
ECFA2_THEMA
A:
[18-234]
---------------
P
L
-
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
-
L
I
E
P
T
S
G
D
V
L
Y
D
G
-
E
--
K
G
Y
--------------------
E
I
R
R
N
---------
I
--
G
I
----
A
F
Q
Y
P
E
--
D
Q
F
F
A
E
R
V
-------------
F
D
E
V
A
------------
F
A
V
K
N
F
Y
P
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
F
K
DRVPFF
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
---
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
---
G
K
T
--
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
-
F
D
G
T
R
M
E
F
L
E
K
Y
D
P
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.60
23%
40
- C1 -
-
3OZX
2
?
A:
[28-464]
-----------------------------------
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
-----
G
D
P
-
N
S
K
V
G
K
D
E
V
L
K
R
--
F
--------
R
G
K
E
I
Y
N
Y
---------
F
K
E
L
Y
S
--
N
E
L
K
I
V
H
K
I
Q
--
Y
V
E
Y
A
S
--
K
F
L
-----------------
K
G
T
V
N
E
I
L
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
L
----
W
N
K
D
A
N
I
------
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
---
E
R
M
N
M
A
K
A
I
---
R
E
L
---
L
K
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
-
H
I
I
Y
G
E
S
S
V
Y
------------
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
N
F
L
K
G
Y
L
P
--
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
-------------
L
K
T
K
M
K
W
T
K
I
I
----
K
K
L
G
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
------------------
I
-----
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
D
E
G
------
S
V
T
P
E
K
---------
Q
----------
I
L
S
Y
K
P
Q
R
I
F
P
N
Y
-----------
D
-----
G
T
-----
V
Q
Q
Y
-----------------------------------------------------
L
E
--------------------
N
A
--------------------------
S
K
D
--
A
--------------
L
S
-
T
-
S
--
S
--
W
F
F
E
-------------------------
E
V
T
K
R
L
N
-------
L
H
R
L
-------
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
----
K
----
A
V
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
E
--
P
--
E
----------------------------------
14
PsiBlast_PDB
44.70
28%
-49
- C- -
-
2YZ2
-
ECFA2_THEMA
A:
[17-233]
---------------
P
L
-
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
-
L
I
E
P
T
S
G
D
V
L
Y
D
G
-
E
R
K
K
G
Y
--------------------
E
I
R
R
N
---------
I
--
G
I
----
A
F
Q
Y
P
E
--
D
Q
F
F
A
E
R
V
-------------
F
D
E
V
A
------------
F
A
V
K
N
F
Y
P
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
F
K
DRVPFF
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
---
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
---
G
K
T
--
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
-
F
D
G
T
R
M
E
F
L
E
K
Y
D
P
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.68
26%
26
- C1 -
-
5LW7
-
?
B:
[103-534]
--------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
----------------------
Q
L
I
P
N
--
L
C
-------
E
D
N
D
S
W
D
N
---------
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
--
K
P
Q
------
Y
V
D
L
L
P
K
--
A
V
K
G
K
V
R
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
----
L
D
R
E
L
H
Q
------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
QRL
K
V
A
R
V
I
R
R
L
---
A
N
E
---
G
K
A
--
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
---
Y
G
E
P
--
G
V
Y
G
I
F
S
K
P
K
G
T
R
-------------------
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
PYEI
R
F
T
K
L
S
E
R
V
D
V
E
R
-
E
T
--------------
L
V
E
Y
P
R
L
V
K
D
Y
G
---------
S
F
K
L
E
V
E
P
G
E
I
RKGEV
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
V
E
W
-----------
D
----------
L
T
V
A
Y
K
P
Q
Y
I
K
A
------------
E
-----
Y
E
-----
G
T
V
Y
-----------------------------------------------------
E
L
L
-------------------
S
------------------------------------------------
K
-
I
-
D
--
S
--
S
----------------------------
K
L
N
S
N
F
Y
KTELLKP
L
G
I
I
D
L
-----
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
MEKN
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
E
----------------------------------------
8
PsiBlast_PDB
44.45
26%
26
- C1 -
-
3J15
2
?
B:
[103-534]
--------------------------------
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
----------------------
Q
L
I
P
N
--
L
C
-------
E
D
N
D
S
W
D
N
---------
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
--
K
P
Q
------
Y
V
D
L
L
P
K
--
A
V
K
G
K
V
R
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
----
L
D
R
E
L
H
Q
------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
---
A
N
E
---
G
K
A
--
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
---
Y
G
E
P
--
G
V
Y
G
I
F
S
K
P
K
G
T
R
-------------------
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
R
V
D
V
E
R
-
E
T
--------------
L
V
E
Y
P
R
L
V
K
D
Y
G
---------
S
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
------
K
V
E
W
-----------
D
----------
L
T
V
A
Y
K
P
Q
Y
I
K
A
------------
E
-----
Y
E
-----
G
T
V
Y
-----------------------------------------------------
E
L
L
-------------------
S
------------------------------------------------
K
-
I
-
D
--
S
--
S
----------------------------
K
L
N
S
N
F
Y
K
T
E
LLKP
L
G
I
I
D
L
-----
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
----
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
E
----------------------------------------
50
HHSearch
43.64
27%
-25
- C1 -
-
4YER
2
?
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
I
V
V
E
N
L
V
K
K
F
G
D
--
F
E
A
-
V
K
G
V
S
F
S
V
K
K
G
E
I
-----
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
------
K
A
W
V
A
G
---------
H
DVLKE
P
R
E
V
R
R
K
I
G
I
V
F
Q
D
Q
S
L
------------
D
-----
R
E
-----
L
T
A
Y
-----------------------------------------------------
E
N
M
-------------------
Y
I
--------------------------
H
G
K
--
I
--------------
Y
G
-
Y
-
G
G
E
K
--
L
----------------------------
K
K
R
I
L
E
L
-------
L
E
F
V
E
L
L
E
--
F
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
----
T
R
A
H
M
W
E
Y
I
S
K
M
----
K
K
EHN
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
-
H
-
G
K
--
I
I
A
L
G
T
P
T
E
L
K
R
M
----------------------
5
PsiBlast_PDB
43.45
29%
-71
- C1 -
-
2IW3
1
EF3A_YEAST
A:
[546-743]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
A
------
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
---
N
T
C
---
G
I
T
--
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
--------
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
-
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
K
----
A
I
V
K
V
T
N
M
E
F
Q
Y
----------
P
G
-----------------
T
S
--
K
P
Q
-
I
T
D
I
N
F
Q
C
S
L
S
S
R
-----
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
------
E
V
Y
T
H
E
---------
N
----------
C
R
I
A
Y
I
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
42.14
24%
-19
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-222]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
-
S
K
D
I
N
L
D
I
H
E
G
E
F
-----
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
------
D
L
F
I
G
E
---------
K
RMNDTPPAE-
R
G
V
G
M
V
F
Q
S
Y
A
L
------------
Y
-----
P
H
-----
L
S
V
A
-----------------------------------------------------
E
N
M
-------------------
S
F
--------------------------
G
L
K
--
L
--------------
A
G
-
A
-
K
--
K
E
V
I
----------------------------
N
Q
R
V
N
Q
V
-------
A
E
V
L
Q
L
A
H
--
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
----
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
----
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
-
A
-
G
R
--
V
A
Q
V
G
K
P
L
E
L
Y
------------------------
48
HHSearch
42.14
24%
-20
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[3-222]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
--
V
V
V
-
S
K
D
I
N
L
D
I
H
E
G
E
F
-----
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
------
D
L
F
I
G
E
---------
K
RMNDTPPAE-
R
G
V
G
M
V
F
Q
S
Y
A
L
------------
Y
-----
P
H
-----
L
S
V
A
-----------------------------------------------------
E
N
M
-------------------
S
F
--------------------------
G
L
K
--
L
--------------
A
G
-
A
-
K
--
K
E
V
I
----------------------------
N
Q
R
V
N
Q
V
-------
A
E
V
L
Q
L
A
H
--
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
----
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
----
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
-
A
-
G
R
--
V
A
Q
V
G
K
P
L
E
L
Y
------------------------