@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPG1: (2017-11-21 )
MVDKRTKQTRKKQQSISEKPSLAFDMWRFYLLWAVVLLCFVVLIARAFYVQVINKDFLQNKANANILRTERIEAMRGVISDRHGVPLAISSPIMKIVIDPRDYFETKHLYDQITAELKQDPNNRKLKRQLPDKNLNLDELADVVGVDRADLKKQMNARPRSRYLVLKKEVPPQQADLIMKGNFQGVYAEKTYKRYYPQPQPNAQIIGLTNSEGQGIEGLEMQLNKQLSGVDGEQKIIRDKRGNRLKVSEVIREGEPGENITLSIDSRLQYIMYRELTAAGVANNARSATAIAVDVKTGEILAMTSWPSYNPNDKNGLSNKDAMRNRGAIDMFEPGSTMKPFTISAALETGQYTPNTIVNTSPGSMRLGWHTIRDTHNYGALTVSGVIIKSSNVGSAKIALSLPKETLPSFFNRVGFGKRSAVRFPGESSGLVLPVNKLNSSQIGTMAYGYGLNATILQLAQGYAMLANHGVKMPLSLHKLDQPPKGEQVLNPKIADQVLLMLEQVTMPGGTAKQANIPGYRVGGKTGTAHKLRADGKGYSNNEYRALFAGVAPISDPRLAVIVVVENPQGRYYGGLVAAPVFARIMQESLRLMNVPLDKPLNTPENPIRR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.....--...100....-...110..-----.....---120.......130.......140.......150.......160...--------....170.......180.......190.......200.......----210---....----.....220.......230.......240.......-250.....--...260.......270.......280.......290.......300.......310.......320........330.......340.......350.......360.......370..-.-.-...-----380.......390.......400.......410.......420.......430.......440.......450.......460.......470.-......480.-------...------...490.......500.......-----------510--------.-......520..-----.....530.......--540.......550-........560......-.570...---.....580..--.....590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVD
K
R
T
K
Q
T
R
K
K
Q
Q
S
ISEKP
S
L
A
F
D
M
W
R
F
Y
L
L
W
A
V
V
L
L
C
F
V
V
L
I
A
R
A
F
Y
V
Q
V
I
N
K
D
F
L
QNKANAN
I
L
R
T
E
R
I
E
A
M
R
G
V
I
SDRHGV
P
L
AISS
P
I
M
K
I
--
V
ID
P
R
D
Y
F
E
T
-
K
H
L
Y
D
Q
I
T
-----
A
E
L
KQ---DPN
N
R
K
L
K
R
QLPDKNL
N
L
D
E
L
A
D
V
VGV
D
R
A
D
L
K
K
Q
MNARPR
S
R
Y
L
V
--------
L
KKEVPPQQA
D
L
I
M
KGNFQ
G
V
Y
AE
K
T
Y
K
RYYPQPQPN
A
Q
I
I
G
L
T----N-----SEGQ----GIE
G
L
E
M
Q
L
N
K
QLSGVD
G
E
Q
K
I
I
R
DKRGN
R
L
K
V
S
E
-
V
I
-REGEP--G
E
N
I
T
L
S
I
D
S
R
L
Q
Y
I
M
Y
R
E
L
TAAGVANNARS
A
T
A
I
A
V
D
VKT
G
E
I
L
A
M
TSWPSYNPNDKNGLS
N
K
D
-
A
MRNRGA
I
D
M
FEPGSTMK
P
F
T
I
S
A
A
LETGQYTPN
T
I
V
NTSPG
S
M
R
L
G
W
H
T
IRD-T-H-NY
G
-----
A
L
T
V
S
G
V
I
I
KSSNVG
S
A
K
I
A
L
SL
P
K
E
T
L
P
S
F
F
N
R
VGFGKRS
A
V
RFPGESS
G
L
V
L
P
VNKLNSSQIG
T
M
A
YGYGL
N
A
T
I
L
Q
L
A
Q
G
Y
A
M
L
A
NHGVKM-P
L
S
L
H
KLDQP-------PKG------EQVL
N
P
K
I
A
D
Q
V
L
L
M
L
E
Q
VTMPG-----------GTA--------K-QANIP
G
Y
R
VGG-----KTGT
A
H
K
L
RADGKGY--SNN
E
Y
R
A
L
F
AGV--APISDP
R
L
A
V
I
V
V
V
ENP-QG
R
-
Y
YG---
G
L
V
A
A
P
V
F
A
R
--
I
M
Q
E
S
L
R
L
MNVPLDKPLNTPENPIRR
6
PsiBlast_PDB
74.73
41%
-27
- C2 -
-
5DF8
5
?
A:
[36-543]
----------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
4
PsiBlast_PDB
74.73
41%
-29
- C2 -
-
4KQR
9
FTSI_PSEAE
A:
[36-543]
----------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
7
PsiBlast_PDB
74.58
41%
-31
- C2 -
-
5DF9
2
?
A:
[38-543]
------------------------------------------------------------------
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
23
PsiBlast_CBE
74.53
41%
-30
- C2 -
-
4KQR
6
FTSI_PSEAE
B:
[38-543]
------------------------------------------------------------------
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
5
PsiBlast_PDB
74.45
41%
-29
- C2 -
-
5DF7
3
?
A:
[35-543]
---------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
3
PsiBlast_PDB
74.37
41%
-28
- C2 -
-
4KQQ
4
FTSI_PSEAE
A:
[36-543]
----------------------------------------------------------------
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
2
PsiBlast_PDB
74.32
41%
-27
- C2 -
-
4KQO
3
FTSI_PSEAE
A:
[35-543]
---------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
38
Fugue
74.31
42%
-29
- C2 -
-
3OC2
-
?
A:
[35-545]
---------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
------------------------------------
M
T
A
K
E
R
W
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
R
E
F
I
Y
--------
L
V
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
-
V
S
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
-------------
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
------
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
----------
1
PsiBlast_PDB
74.10
41%
-28
- C2 -
-
3OCN
1
?
A:
[35-543]
---------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
----------
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
22
PsiBlast_CBE
73.58
41%
-34
- C2 -
-
5DF7
4
?
B:
[42-543]
----------------------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
-------------------
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
24
PsiBlast_CBE
73.38
41%
-34
- C2 -
-
4KQQ
4
FTSI_PSEAE
B:
[42-543]
----------------------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
----------------
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
21
PsiBlast_CBE
73.32
41%
-31
- C2 -
-
5DF8
5
?
B:
[42-543]
----------------------------------------------------------------------
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
-------------------
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
25
PsiBlast_CBE
72.78
41%
-31
- C2 -
-
4KQO
3
FTSI_PSEAE
B:
[43-543]
-----------------------------------------------------------------------
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
--
W
A
N
P
K
E
L
M
T
A
-
K
E
R
W
P
Q
L
A
-----
A
A
L
G
Q
---
D
---
T
K
L
-------------
F
A
D
R
I
---------
E
Q
N
A
E
R
E
F
I
Y
L
V
----------
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
----
D
-----
V
D
D
R
----
G
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
-----------------
V
T
-
K
N
A
K
P
--
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
-
Q
P
A
-
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
G
T
L
Q
I
G
R
Y
T
I
R
D
V
S
-
R
-
N
S
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
-
P
L
S
M
T
R
V
D
R
V
-------
P
D
G
------
V
Q
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
-----------
G
G
V
--------
F
-
R
A
Q
V
P
G
Y
H
A
A
G
-----
K
S
G
T
A
R
K
V
S
V
G
T
K
G
Y
--
R
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
S
K
A
G
-
Y
F
G
---
G
L
V
S
A
P
V
F
S
K
--
V
M
A
G
A
L
R
L
M
N
V
P
P
D
------------
18
PsiBlast_PDB
67.62
26%
-
- C2 -
-
1PMD
-
PBPX_STRPN
A:
[76-620]
---------------------------------------------------------------------------
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
YA
V
I
D
E
N
Y
K
S
A
T
G
K
I
L
Y
V
E
K
T
QFN
K
V
A
E
V
F
H
KYL
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
N
L
K
-----------
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
--------
I
K
K
E
L
E
A
A
E
V
--------
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
QLHE
N
-----
E
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
Q
V
S
-
Q
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
-
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
-
W
-
D
V
N
E
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
---
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
NDQ
T
A
R
K
S
Q
K
------
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
TDPVYGTMYNH
S
T
G
--------
K
P
T
V
T
V
P
G
Q
N
V
A
L
-----
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
--
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
-
E
-
H
-
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
------------------
10
PsiBlast_PDB
65.21
35%
7
- C2 -
-
5KSH
2
PBP2_NEIGO
A:
[12-532]
-----------------------------------------------------
T
Y
N
F
L
K
E
Q
G
D
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
--------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
-----
I
D
G
K
----
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
-
S
P
-
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
-
R
P
G
R
A
D
S
E
-
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
P
--
Y
K
I
G
P
S
P
V
R
D
-
T
-
H
-
V
Y
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
-------
P
Q
G
------
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
T
E
P
G
-----------
G
T
G
--------
T
-
A
G
A
V
D
G
F
D
V
G
A
-----
K
T
G
T
T
R
K
L
-
V
N
G
R
-
Y
--
V
D
N
K
H
V
G
T
F
I
G
F
--
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
-
T
A
H
G
Y
Y
G
---
G
V
V
A
G
S
P
F
K
K
--
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
--------
11
PsiBlast_PDB
64.30
35%
1
- C2 -
-
3EQU
1
PBP2_NEIGO
A:
[24-534]
---------------------------------------------------------------
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
--------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
-----
I
D
G
K
----
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
-
S
P
-
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
-
R
P
G
R
A
D
S
E
-
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
P
--
Y
K
I
G
P
S
P
V
R
D
-
T
-
H
-
V
Y
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
-------
P
Q
G
------
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
T
E
P
G
-----------
G
T
G
--------
T
-
A
G
A
V
D
G
F
D
V
G
A
-----
K
T
G
T
A
---------------
K
H
V
A
T
F
I
G
F
--
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
-
T
A
H
G
Y
Y
G
---
G
V
V
A
G
P
P
F
K
K
--
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
--------
9
PsiBlast_PDB
64.06
35%
8
- C2 -
-
3EQV
1
PBP2_NEIGO
A:
[14-534]
-----------------------------------------------------
T
Y
N
F
L
K
E
Q
G
D
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-------------------------------------------------------------------------------------------------------------------
E
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
-----
I
D
G
K
----
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
-
S
P
-
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
-
R
P
G
R
A
D
S
E
-
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
P
--
Y
K
I
G
P
S
P
V
R
D
-
T
-
H
-
V
Y
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
R
P
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
-
P
L
S
F
E
K
Q
A
V
A
-------
P
Q
G
------
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
T
E
P
G
-----------
G
T
G
--------
T
-
A
G
A
V
D
G
F
D
V
G
A
-----
K
T
G
T
A
R
K
------------
N
K
H
V
G
T
F
I
G
F
--
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
-
T
A
H
G
Y
Y
G
---
G
V
V
A
G
S
P
F
K
K
--
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
--------
17
PsiBlast_PDB
63.38
26%
0
- C- -
-
1QMF
2
PBPX_STRPN
A:
[23-584]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
---------------------------------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
-----
E
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
--------------------
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
-
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
-
W
-
D
V
N
E
G
LT
G
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
---
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
NDQ
T
A
R
K
S
Q
K
------
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
TDPVYGTMYNH
S
T
G
--------
K
P
T
V
T
V
P
G
Q
N
V
A
L
-----
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
--
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
-
E
-
H
-
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
------------------
16
PsiBlast_PDB
62.51
26%
0
- C- -
-
1QME
-
PBPX_STRPN
A:
[23-583]
----------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
---------------------------------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
-----
E
D
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
----------------------
R
T
M
D
--
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
-
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
-
W
-
D
V
N
E
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
N
I
V
N
I
A
Q
---
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
NDQ
T
A
R
K
S
Q
K
------
E
I
V
G
N
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
G
TDPVYGTMYNH
S
T
G
--------
K
P
T
V
T
V
P
G
Q
N
V
A
L
-----
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
--
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
-
E
-
H
-
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
------------------
20
PsiBlast_PDB
62.25
25%
48
- C2 -
-
5U47
-
?
A:
[28-581]
-----------------------------------------------------------------------
V
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--------