@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPG3: (2017-11-21 )
MHTSTTSTVPLEPWIAQQLQQATQGYWHKDQIPQSEIKRILTDSRHAESGDAFLALKGERFDAHNFVAQVAANGCQVAIVERPIDAEIAQLVVADTRLALGQLGAYRREQNAQLKVIALTGSSGKTTTKEMLGSILSRLAPTLINRGNLNNDLGVPMMLLELRKEHQYAVMELGANHQGEIDYTSKIVQPHVAGILNIGTAHLGEFGGRDGICRAKSEIYRHILPQGVAIVPQQDDFTAEIREAAKSHQIMSFGAGGDVFATEIELLPQSANFQLHTPQGSSFVRLPFAGEHNVQNATAAVAFALALGVSLEDIVKGLEQAQGAKGRLNFIQKAPHLFIDDTYNANPTSMRAAAQVLLQQNGIKVMVMGDIGELGDSSWQEHHDLGRDLAGLPLDHIVAVGQFASAALEGAGLHSTKLKAFQTQAEALPFLINLIQTHQPQSMSFLFKGSRFTHMETLMADLMEKL
Atome Classification :
(20 SA)
.........10........20........-30........40........50........60........70........80...-.-....90....-----....100.......110........120.......130.......140--.-.---.-...-----.-..150....--...160-----.......170.......180.......190.......200.....-..210.......220.......230.......240-.......250.---..-.---...260.....-..270.-........-280.......290.---......300.......310.......320.......330-----.----------...-.-..340.......350.....----..-360--.....-....370.......380..-.....390.......400---------..------.-----......410...---....420------.......430.......-440.......450...--....460....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MHTSTTSTVPL
E
P
W
I
A
Q
Q
L
Q
Q
A
T
QGYWHK-DQI
P
Q
S
E
I
K
R
I
L
TDSRHAESG
D
A
F
L
A
L
KGERF
D
A
H
N
F
V
A
Q
V
A
ANG
C
Q
V
A
I
V
ERPI-
D
-
A
E
I
A
Q
L
V
V
A
D
-----
T
R
L
A
L
G
Q
L
G
A
Y
RREQ-NA
Q
L
K
V
I
A
L
TGSSGK
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
-
T
---
L
-INR-----G-NLNNDLG
V
P
--
M
M
L
L
E
L
-----
R
K
EH
Q
Y
A
V
M
ELGANHQGEID
Y
T
S
K
IV
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
EFG-GRDGIC
R
A
K
S
E
I
Y
R
H
ILPQ
G
V
A
IVPQQD
D
F
T
A
E
I
R
-
E
A
A
K
SH
Q
I
M
SF---GA-G---G
D
V
F
A
T
E
I
ELL-PQS--A-
N
F
Q
L
HTPQ-GS
S
F
V
RLPFAGEHN---V
Q
N
A
T
A
A
V
A
F
A
L
A
LGV
S
L
E
D
I
V
K
G
L
E
Q
AQGAKG
R
L
N
F
I
Q
-----K----------AP
H
-
L
-
F
I
DDTYNAN
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
-Q----NG
I
K
V
-
M
V
MGD
I
G
ELGD
S
S
W
Q
E
H
H
D
-
L
G
R
D
L
AGL
P
L
D
H
I
V
A
V
-----------
G
Q
------
F
-----
A
S
A
A
LEGAGLH
S
---
T
K
L
K
A
F
Q
------
T
Q
A
E
A
L
P
F
L
I
N
L
I
Q
THQ-PQS
M
S
F
L
FKGSR
F
T
H
M
--
E
T
L
M
A
D
L
M
E
KL
1
PsiBlast_PDB
94.45
98%
-113
- C1 -
-
4ZIY
4
?
A:
[15-473]
------
S
T
V
P
L
E
P
W
T
A
Q
Q
L
Q
Q
A
T
Q
G
Y
W
H
K
-
D
Q
I
P
Q
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
-
D
-
A
E
I
A
Q
L
V
V
A
D
-----
T
R
L
A
L
G
Q
L
G
A
Y
R
R
E
Q
-
N
A
Q
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
-
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
---
F
G
-
G
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G
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A
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Y
R
H
I
L
P
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A
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Q
D
D
F
T
A
E
I
R
-
E
A
A
K
S
H
Q
I
M
S
F
---
G
A
-
G
---
G
D
V
F
A
T
E
I
E
L
L
-
P
Q
S
--
A
-
N
F
Q
L
H
T
P
Q
-
G
S
S
F
V
R
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
-----
K
----------
T
P
H
-
L
-
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
-
Q
----
N
G
I
K
V
-
M
V
M
G
D
I
G
E
L
---
S
W
Q
E
H
H
D
-
L
G
R
D
L
A
E
L
P
L
D
H
I
V
A
V
-----------
G
Q
------
F
-----
A
S
A
A
L
E
G
--------
T
K
L
K
A
F
Q
------
T
Q
A
E
A
L
P
F
L
I
N
L
I
Q
T
H
---
Q
S
M
S
F
L
F
K
G
S
R
F
T
H
M
--
E
T
L
M
A
D
L
M
E
K
-
2
PsiBlast_PDB
94.33
98%
-106
- C1 -
-
4QDI
4
?
A:
[15-471]
--------
V
P
L
E
P
W
T
A
Q
Q
L
Q
Q
A
T
Q
G
Y
W
H
K
-
D
Q
I
P
Q
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
-
D
-
A
E
I
A
Q
L
V
V
A
D
-----
T
R
L
A
L
G
Q
L
G
A
Y
R
R
E
Q
-
N
A
Q
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
-
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
E
F
G
-
G
R
D
G
I
C
R
A
K
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Y
R
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L
P
Q
G
V
A
I
V
P
Q
Q
D
D
F
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A
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R
-
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A
A
K
S
H
Q
I
M
S
F
---
G
E
-
G
---
G
D
V
F
A
T
E
I
E
L
L
-
P
Q
S
--
A
-
N
F
Q
L
H
T
P
Q
-
G
S
S
F
V
R
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
-----
K
----------
A
P
H
-
L
-
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
-
Q
----
N
G
I
K
V
-
M
V
M
G
D
I
G
E
L
G
D
S
S
W
Q
E
H
H
D
-
L
G
R
D
L
A
E
L
P
L
D
H
I
V
A
V
-----------
G
Q
------
F
-----
A
S
A
A
L
E
G
A
G
L
H
S
---
T
K
L
K
A
F
Q
------
T
Q
A
E
A
L
P
F
L
I
N
L
I
Q
T
H
Q
-
P
Q
S
M
S
F
L
F
K
G
S
R
F
T
H
M
--
E
T
L
M
A
D
L
M
E
K
-
32
HHSearch
94.05
98%
-103
- C1 -
-
4QDI
4
?
A:
[15-471]
--------
V
P
L
E
P
W
T
A
Q
Q
L
Q
Q
A
T
Q
G
Y
W
H
K
-
D
Q
I
P
Q
T
E
I
K
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
I
-
D
-
A
E
I
A
Q
L
V
V
A
D
-----
T
R
L
A
L
G
Q
L
G
A
Y
R
R
E
Q
-
N
A
Q
L
K
V
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
S
R
L
A
----
P
-
T
---
L
-
I
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
M
M
L
L
E
L
-----
R
K
E
H
Q
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
E
F
G
-
G
R
D
G
I
C
R
A
K
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Y
R
H
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P
Q
G
V
A
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D
D
F
T
A
E
I
R
-
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A
A
K
S
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---
G
E
-
G
---
G
D
V
F
A
T
E
I
E
L
L
-
P
Q
S
--
A
-
N
F
Q
L
H
T
P
Q
-
G
S
S
F
V
R
L
P
F
A
G
E
H
N
---
V
Q
N
A
T
A
A
V
A
F
A
L
A
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
L
N
F
I
Q
-----
K
----------
A
P
H
-
L
-
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
----
L
Q
-
Q
----
N
G
I
K
V
-
M
V
M
G
D
I
G
E
L
G
D
S
S
W
Q
E
H
H
D
-
L
G
R
D
L
A
E
L
P
L
D
H
I
V
A
V
-----------
G
Q
------
F
-----
A
S
A
A
L
E
G
A
G
L
H
S
---
T
K
L
K
A
F
Q
------
T
Q
A
E
A
L
P
F
L
I
N
L
I
-
Q
T
H
Q
P
Q
S
M
S
F
L
F
K
G
S
R
F
T
H
M
--
E
T
L
M
A
D
L
M
E
K
-
34
HHSearch
65.35
40%
-59
- C1 -
-
1GG4
-
B:
[502-947]
-----------
I
S
V
T
L
S
Q
L
T
D
I
L
N
G
E
L
Q
----
G
A
D
I
T
L
D
A
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
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G
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R
F
D
A
H
D
F
A
D
Q
A
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A
G
G
A
G
A
L
L
V
S
R
P
L
-
D
-
I
D
L
P
Q
L
I
V
K
D
-----
T
R
L
A
F
G
E
L
A
A
W
V
R
Q
Q
-
V
P
-
A
R
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V
A
L
T
G
S
S
G
K
T
S
V
K
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M
T
A
A
I
L
S
Q
C
G
----
N
-
T
---
L
-
Y
T
A
-----
G
-
N
L
N
N
D
I
G
V
P
--
M
T
L
L
R
L
-----
T
P
E
Y
D
Y
A
V
I
E
L
G
A
N
H
Q
G
E
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A
W
T
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S
L
T
R
P
E
A
A
L
V
N
N
L
A
---------
S
L
A
G
V
A
K
A
K
G
E
I
F
S
G
L
P
E
N
G
I
A
I
M
N
A
D
N
N
D
W
L
N
W
Q
-
S
V
I
G
S
R
K
V
W
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F
---
S
P
-
N
AAN
S
D
F
T
A
T
N
I
H
V
T
-
S
H
G
--
T
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E
F
T
L
Q
T
P
T
-
G
S
V
D
V
L
L
P
L
P
G
R
H
N
---
I
A
N
A
L
A
A
A
A
L
S
M
S
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
L
F
P
I
Q
-----
L
A---------
E
N
Q
-
L
-
L
L
D
D
S
Y
N
A
N
V
G
S
M
T
A
A
V
Q
V
L
----
A
E
-
M
----
P
G
Y
R
V
-
L
V
V
G
D
M
A
E
L
G
A
E
S
E
A
C
H
V
Q
-
V
G
E
A
A
K
A
A
G
I
D
R
V
L
S
V
-----------
G
K
------
Q
-----
S
H
A
I
S
T
A
S
G
-------
V
G
E
H
F
A
------
D
K
T
A
L
I
T
R
L
K
L
L
I
A
E
---
Q
Q
V
I
T
I
L
V
K
G
S
R
S
A
A
M
--
E
E
V
V
R
A
L
Q
---
37
HHSearch
62.43
42%
-31
- C1 -
-
4CVK
5
?
A:
[2-451]
----------
L
E
P
L
R
L
S
Q
L
T
V
A
L
D
A
R
L
I
----
G
E
D
A
V
F
S
A
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
-
A
-
A
P
L
P
Q
L
L
V
R
D
-----
T
R
A
A
L
G
R
L
G
A
L
N
R
R
K
-
F
T
-
G
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
-
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
-------
F
G
-
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
L
D
D
K
A
F
D
T
W
K
-
A
R
A
S
G
R
P
L
L
T
F
---
S
L
-
D
RPQ
A
D
F
R
A
A
D
L
Q
R
D
A
R
G
C
--
M
-
G
F
R
L
Q
G
V
A
-
G
E
A
Q
V
Q
L
N
L
L
G
R
H
N
---
V
A
N
A
L
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
-----
T
A---------
S
G
L
-
R
-
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
----
S
G
-
F
----
S
G
R
T
V
-
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
A
G
K
-
V
S
A
L
Y
A
V
-----------
G
P
------
L
-----
M
A
H
A
V
Q
A
F
G
A
------
T
G
R
H
F
A
------
D
Q
A
S
L
I
G
A
L
A
T
-----
E
-
D
P
T
T
T
I
L
I
K
G
S
R
S
A
A
M
--
D
K
V
V
A
A
L
C
---
3
PsiBlast_PDB
61.87
40%
-61
- C1 -
-
1GG4
-
MURF_ECOLI
A:
[27-447]
----------------------------------------
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
K
G
E
R
F
D
A
H
D
F
A
D
Q
A
K
A
G
G
A
G
A
L
L
V
S
R
P
L
-
D
-
I
D
L
P
Q
L
I
V
K
D
-----
T
R
L
A
F
G
E
L
A
A
W
V
R
Q
Q
--
V
P
A
R
V
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
S
Q
C
G
----
N
-
T
---
L
-
Y
T
A
-----
G
-
N
L
N
N
D
I
G
V
P
--
M
T
L
L
R
L
-----
T
P
E
Y
D
Y
A
V
I
E
L
G
A
N
H
Q
G
E
I
A
W
T
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
---------
S
L
A
G
V
A
K
A
K
G
E
I
F
S
G
L
P
E
N
G
I
A
I
M
N
A
D
N
N
D
W
L
N
W
Q
-
S
V
I
G
S
R
K
V
W
R
F
S
PN
A
A
-
N
---
S
D
F
T
A
T
N
I
H
V
T
-
S
H
G
--
T
-
E
F
T
L
Q
T
P
T
-
G
S
V
D
V
L
L
P
L
P
G
R
H
N
---
I
A
N
A
L
A
A
A
A
L
S
M
S
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
L
F
P
I
Q
-----
L
----------
A
E
N
Q
L
-
L
L
D
D
S
Y
N
A
N
V
G
S
M
T
A
A
V
Q
V
L
----
A
E
-
M
----
P
G
Y
R
V
-
L
V
V
G
D
M
A
E
L
G
A
E
S
E
A
C
H
V
Q
-
V
G
E
A
A
K
A
A
G
I
D
R
V
L
S
V
-----------
G
K
QS----
H
-----
A
I
S
T
A
S
G
V
G
E
H
F
---
A
D
K
T
A
L
I
------
T
R
---
L
K
L
L
I
-----
A
E
-
Q
Q
V
I
T
I
L
V
K
G
S
R
S
A
A
M
--
E
E
V
V
R
A
L
Q
---
38
HHSearch
61.49
42%
-11
- C1 -
-
4CVM
5
?
A:
[2-451]
----------
L
E
P
L
R
L
S
Q
L
T
V
A
L
D
A
R
L
I
----
G
E
D
A
V
F
S
A
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
-
A
D
A
P
L
P
Q
L
L
V
R
D
-----
T
R
A
A
L
G
R
L
G
A
L
N
R
R
K
-
F
T
-
G
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
-
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
G
T
A
H
V
---
G
-
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
L
D
D
K
A
F
D
T
W
K
-
A
R
A
S
G
R
P
L
L
T
F
---
S
L
-
D
RPQ
A
D
F
R
A
A
D
L
Q
R
D
A
R
G
C
--
M
-
G
F
R
L
Q
G
V
A
-
G
E
A
Q
V
Q
L
N
L
L
G
R
H
N
---
V
A
N
A
L
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
-----
T
A---------
S
G
L
-
R
-
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
----
S
G
-
F
----
S
G
R
T
V
-
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
A
G
K
-
V
S
A
L
Y
A
V
-----------
G
P
------
L
-----
M
A
H
A
V
Q
A
F
G
A
------
T
G
R
H
F
A
------
D
Q
A
S
L
I
G
A
L
A
T
-----
E
-
D
P
T
T
T
I
L
I
K
G
S
R
S
A
A
M
--
D
K
V
V
A
A
L
C
---
5
PsiBlast_PDB
56.96
42%
-3
- C1 -
-
4CVM
5
?
A:
[28-450]
----------------------------------------
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
A
D
-
A
P
L
P
Q
L
L
V
R
D
-----
T
R
A
A
L
G
R
L
G
A
L
N
R
R
K
-
F
T
G
-
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
-
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
G
T
A
H
V
---
G
-
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
L
D
D
K
A
F
D
T
W
K
-
A
R
A
S
G
R
P
L
L
T
F
---
S
L
-
D
RPQ
A
D
F
R
A
A
D
L
Q
R
D
-
A
R
G
--
C
M
G
F
R
L
Q
G
V
A
-
G
E
A
Q
V
Q
L
N
L
L
G
R
H
N
---
V
A
N
A
L
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
-----
T
----------
A
S
G
-
L
R
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
----
S
G
-
F
----
S
G
R
T
V
-
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
A
G
-
K
V
S
A
L
Y
A
V
-----------
G
P
------
L
-----
M
A
H
A
V
Q
A
F
G
A
T
G
------
R
H
F
A
------
D
Q
A
S
----
L
I
G
A
L
A
T
E
D
-
P
T
T
-
T
I
L
I
K
G
S
R
S
A
A
M
--
D
K
V
V
A
A
L
----
4
PsiBlast_PDB
56.56
42%
-4
- C1 -
-
4CVK
5
?
A:
[28-450]
----------------------------------------
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
A--
A
P
L
P
Q
L
L
V
R
D
-----
T
R
A
A
L
G
R
L
G
A
L
N
R
R
K
-
F
T
G
-
P
L
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
A
GDAE
S
-
V
---
L
-
A
T
R
-----
G
-
N
L
N
N
D
L
G
V
P
--
L
T
L
L
Q
L
-----
A
P
Q
H
R
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
-------
F
G
-
G
P
E
K
I
V
E
A
K
G
E
I
L
E
G
L
A
A
D
G
T
A
V
L
N
L
D
D
K
A
F
D
T
W
K
-
A
R
A
S
G
R
P
L
L
T
F
---
S
L
-
D
RPQ
A
D
F
R
A
A
D
L
Q
R
D
-
A
R
G
--
C
M
G
F
R
L
Q
G
V
A
-
G
E
A
Q
V
Q
L
N
L
L
G
R
H
N
---
V
A
N
A
L
A
A
A
A
A
A
H
A
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
A
V
A
Q
L
-----
T
----------
A
S
G
-
L
R
V
I
D
D
S
Y
N
A
N
P
A
S
M
L
A
A
I
D
I
L
----
S
G
-
F
----
S
G
R
T
V
-
L
V
L
G
D
M
G
-----
A
E
Q
A
H
R
E
-
V
G
A
Y
A
A
G
-
K
V
S
A
L
Y
A
V
-----------
G
P
------
L
-----
M
A
H
A
V
Q
A
F
G
A
T
G
------
R
H
F
A
------
D
Q
A
S
----
L
I
G
A
L
A
T
E
D
-
P
T
T
-
T
I
L
I
K
G
S
R
S
A
A
M
--
D
K
V
V
A
A
L
----
35
HHSearch
55.13
27%
-62
- C1 -
-
3ZM6
1
?
A:
[1-454]
-----------
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
-
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
-
G
S
L
L
L
A
P
A
D
P
I
V
E
D
Y
L
-
P
I
--
D
K
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
---
L
E
Q
A
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
A---------
N
G
A
-
D
-
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
----
S
A
-
I
PANE
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
------
D
-----
I
A
Q
L
A
Q
L
A
S
Q
M
F
PI-
G
H
V
Y
Y
F
K
K
T
EDQD
Q
F
E
D
L
V
K
Q
V
K
E
S
L
-----
G
A
H
D
Q
I
L
L
K
G
S
N
S
M
N
L
--
A
K
L
V
E
S
L
E
N
--
6
PsiBlast_PDB
55.05
31%
-71
- C1 -
-
3ZL8
2
?
A:
[7-355]
--------------------------------------
R
R
F
V
L
N
S
K
E
V
R
E
G
D
V
F
V
A
V
K
G
K
R
F
D
G
H
D
F
I
D
E
A
L
R
N
G
A
Y
A
I
I
A
E
R
K
T
-
V
-
N
S
D
R
I
F
L
V
E
S
-----
S
V
D
T
L
A
K
L
-
A
R
E
K
L
G
-
N
F
S
G
T
V
V
G
V
T
G
S
S
G
K
T
T
T
K
E
I
L
Y
N
L
L
K
N
K
R
----
S
-
V
---
F
-
K
T
P
-----
G
-
N
M
N
T
E
Y
G
L
P
--
L
S
I
L
N
D
-----
Y
K
G
E
E
I
L
V
L
E
M
A
A
S
R
P
G
D
I
A
H
L
C
K
I
A
P
P
D
V
A
V
L
L
N
V
G
S
A
H
L
E
F
F
G
-
T
R
E
R
I
M
E
T
K
M
E
I
I
K
H
S
K
E
N
A
I
A
V
T
L
F
D
D
---
P
D
L
R
K
E
V
P
R
Y
R
N
T
L
F
F
---
G
K
E
G
---
G
D
S
V
L
K
D
W
W
Y
Y
-
E
G
S
T
I
A
-
E
F
E
A
F
-----
D
S
L
F
T
V
K
L
S
G
Y
W
N
G
G
Q
L
L
N
I
A
A
S
L
C
V
M
R
T
L
G
E
T
V
D
--
I
F
D
L
A
S
L
K
T
V
P
G
R
F
N
V
R
E
-----
K
----------
K
G
V
-
L
-
I
V
D
D
T
Y
N
A
S
P
E
A
F
Q
T
S
I
E
A
L
----
L
R
-
F
----
P
G
K
K
F
-
A
V
V
G
A
M
K
E
L
G
E
R
S
K
E
F
H
E
E
-
L
G
E
R
L
---------------------------------------------------------------------------------------------------------------
39
HHSearch
53.33
28%
-43
- C1 -
-
3ZL8
2
?
A:
[2-422]
---------------------------------
K
D
L
L
T
R
R
F
V
L
N
S
K
E
V
R
E
G
D
V
F
V
A
V
K
G
K
R
F
D
G
H
D
F
I
D
E
A
L
R
N
G
A
Y
A
I
I
A
E
R
K
T
-
V
-
N
S
D
R
I
F
L
V
E
S
-----
S
V
D
T
L
A
K
L
A
R
E
K
L
G
N
-
F
S
-
G
T
V
V
G
V
T
G
S
S
G
K
T
T
T
K
E
I
L
Y
N
L
L
K
N
K
R
----
S
-
V
---
F
-
K
T
P
-----
G
-
N
M
N
T
E
Y
G
L
P
--
L
S
I
L
N
D
-----
Y
K
G
E
E
I
L
V
L
E
M
A
A
S
R
P
G
D
I
A
H
L
C
K
I
A
P
P
D
V
A
V
L
L
N
V
G
S
A
H
L
E
F
F
G
-
T
R
E
R
I
M
E
T
K
M
E
I
I
K
H
S
K
E
N
A
I
A
V
T
L
F
D
D
P
D
L
R
K
E
V
-
P
R
--
Y
R
N
T
L
F
F
---
G
K
-
E
G--
G
D
S
V
L
K
D
W
W
Y
Y
-
E
G
S
--
T
-
I
A
E
F
E
A
---
F
D
S
L
F
T
V
K
L
S
G
Y
W
N
G
G
Q
L
L
N
I
A
A
S
L
C
V
M
R
T
L
G
E
T
V
D
I
--
F
D
L
A
S
L
K
T
V
P
G
R
F
N
V
R
E
-----
K
----------
K
G
V
-
L
-
I
V
D
D
T
Y
N
A
S
P
E
A
F
Q
T
S
I
E
A
L
----
L
R
-
F
----
P
G
K
K
F
-
A
V
V
G
A
M
K
E
L
G
E
R
S
K
E
F
H
E
E
-
L
G
E
R
L
N
V
L
D
G
V
Y
V
F
L
S
-----------
E
P
------
E
-----
A
E
W
I
K
S
K
--------
K
I
I
L
K
S
D
------
D
P
E
K
I
A
K
D
L
A
-----
T
R
V
K
K
G
D
V
V
L
F
K
A
S
R
A
V
R
I
--
E
R
V
L
E
M
F
E
K
E
-
36
HHSearch
51.65
27%
-61
- C1 -
-
2AM1
2
?
A:
[1-454]
-----------
M
K
L
T
I
H
E
I
A
Q
V
V
G
A
K
N
D
I
-
S
I
F
E
D
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
-
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
-
G
S
L
L
L
A
P
A
D
P
I
V
E
D
Y
L
-
P
I
--
D
K
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
---
L
E
Q
A
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
A---------
N
G
A
-
D
-
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
----
S
A
-
I
PANE
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
------
D
-----
I
A
Q
L
A
Q
L
A
S
Q
M
F
PI-
G
H
V
Y
Y
F
K
K
T
EDQD
Q
F
E
D
L
V
K
Q
V
K
E
S
L
-----
G
A
H
D
Q
I
L
L
K
G
S
N
S
M
N
L
--
A
K
L
V
E
S
L
E
N
--
8
PsiBlast_PDB
51.49
30%
-74
- C1 -
-
3ZM6
1
?
A:
[24-388]
-----------------------------------
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
D
P
I
V
E
D
Y
L
-
P
I
D
K
--
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
L
E
-
Q
A
--
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
----------
A
N
G
-
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
IP
A
N
-
E
----
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
---------------------------------------------------------------------------------------
7
PsiBlast_PDB
49.03
30%
-74
- C1 -
-
3ZM5
1
?
A:
[24-388]
-----------------------------------
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
D
P
I
V
E
D
Y
L
-
P
I
D
K
--
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
L
E
-
Q
A
--
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
----------
A
N
G
-
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
-
E
----
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
---------------------------------------------------------------------------------------
9
PsiBlast_PDB
47.69
29%
-74
- C1 -
-
2AM1
2
?
A:
[24-388]
-----------------------------------
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
D
P
I
V
E
D
Y
L
-
P
I
D
K
--
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
L
E
-
Q
A
--
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
----------
A
N
G
-
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
IP
A
N
-
E
----
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
---------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.33
29%
-78
- C1 -
-
2AM2
1
?
A:
[24-388]
-----------------------------------
T
Q
L
E
K
A
E
F
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
T
L
S
E
K
E
V
---
S
N
H
P
Y
I
L
V
D
D
-----
V
L
T
A
F
Q
S
L
A
S
Y
Y
L
E
K
-
T
T
-
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
S
T
R
Y
----
K
-
T
---
Y
-
K
T
Q
-----
G
-
N
Y
N
N
E
I
G
L
P
--
Y
T
V
L
H
M
-----
P
E
G
T
E
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
A
D
G
M
A
S
G
S
L
L
L
A
P
-
A
D
P
I
V
E
D
Y
L
-
P
I
D
K
--
K
V
V
R
F
---
G
Q
-
G
---
A
E
L
E
I
T
D
L
V
E
R
-
K
D
S
--
L
-
T
F
K
A
N
F
L
E
-
Q
A
--
L
D
L
P
V
T
G
K
Y
N
---
A
T
N
A
M
I
A
S
Y
V
A
L
Q
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
K
-----
A
----------
A
N
G
-
A
D
I
L
S
D
V
Y
N
A
N
P
T
A
M
K
L
I
L
E
T
F
S
A
I
P
A
N
-
E
----
G
G
K
K
I
-
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
Q
L
H
N
Q
-
M
I
L
S
L
S
P
D
V
L
D
I
V
I
F
Y
-----------
G
E
---------------------------------------------------------------------------------------
42
HHSearch
42.11
21%
1
- C1 -
-
4BUB
1
MURE_THEMA
B:
[1-461]
-------------
M
N
I
S
T
I
V
S
N
L
K
D
L
I
L
E
V
R
A
P
Y
D
L
E
I
T
G
V
S
N
H
S
S
K
V
K
K
G
D
L
F
I
C
R
R
G
E
--
D
S
H
E
I
I
P
E
V
M
E
K
G
A
V
A
V
V
V
E
R
E
I
-
D
-
L
D
F
P
Y
I
Q
V
F
D
-----
S
R
Y
F
E
A
K
V
A
S
L
F
F
E
D
P
W
K
D
V
L
T
F
G
V
T
G
T
N
G
K
T
T
T
T
M
M
I
Y
H
M
L
T
S
L
G
----
E
-
R
G
S
V
L
-
T
T
A
V
K
R
I
L
G
N
S
Y
Y
D
D
I
T
T
P
D
A
I
T
I
L
S
A
M
K
E
N
R
E
G
G
G
K
F
F
A
L
E
V
S
S
H
A
L
--
V
Q
Q
R
V
E
G
V
R
F
D
V
G
I
F
T
N
I
S
R
D
H
L
D
F
H
G
-
T
F
E
N
Y
L
K
A
K
L
H
L
F
D
L
L
K
D
D
G
V
A
V
L
N
E
S
L
A
D
A
F
--
N
-
R
---
K
S
R
K
I
T
F
---
G
T
-
S
KN-
A
D
Y
R
L
G
N
I
E
V
S
-
W
E
G
--
T
-
Q
F
V
L
E
T
P
D
-
G
L
L
K
V
F
T
R
A
I
G
D
F
N
---
A
Y
N
A
A
A
A
I
A
A
L
H
Q
L
G
Y
D
P
K
D
L
A
S
S
L
E
T
F
T
G
V
E
G
R
F
E
V
V
R
-----
G
AKK-------
I
G
L
-
N
-
V
V
V
D
-
F
A
H
S
P
D
A
L
E
K
L
L
K
N
V
----
R
K
-
I
S---
Q
G
R
V
I
-
V
V
F
G
A
G
G
N
S
D
----
R
G
K
R
P
M
M
S
E
V
A
S
K
L
-
A
D
V
V
I
L
T
-----------
T
D
------
D
PRGED
P
E
Q
I
M
E
D
L
I
K
G
I
DKR
K
P
Y
L
V
L
F
------
D
R
R
E
A
I
E
T
A
L
T
I
A
-----
N
R
G
D
S
V
V
I
A
G
R
G
H
E
R
Y
--
Q
I
I
--------
48
HHSearch
32.46
19%
-8
- C1 -
-
1GQY
1
MURC_HAEIN
B:
[76-473]
-------------------------------------------------------------------------
E
G
A
S
V
V
V
V
S
S
A
I
-
K
-
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
-----
R
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
----
L
D
P
---
T
-
F
V
N
-----
G
-
G
----
L
V
K
S
--
A
G
K
N
A
H
-----
L
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
-----
S
F
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
V
-
G
R
Q
V
I
T
Y
---
G
F
-
S
EQ-
A
D
Y
R
I
E
D
Y
E
Q
T
-
G
F
Q
--
G
-
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
---
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
N
----------
G
K
V
-
R
-
L
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
----
R
E
G
W
----
G
D
K
R
I
V
M
I
F
Q
P
-
H
R
Y
S
R
T
R
-
D
L
F
D
D
-
F
V
Q
V
L
S
-
Q
-
V
D
A
L
I
M
L
D
VYAAGEAPIV
G
A
------
D
-----
S
K
S
L
C
R
S
I
R
N
L
G
K--
V
D
P
I
L
V
S
------
D
T
S
Q
L
G
D
V
L
D
-----
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
----
54
HHSearch
31.54
21%
-8
- C1 -
-
4HV4
2
MURC_YERPE
B:
[122-480]
--------------------------------------------------------------------------------------------------------------------------
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
----
L
-
D
---
P
T
F
V
N
-----
G
-
G
----
L
V
K
A
--
A
G
T
H
A
R
-----
L
G
S
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
-----
F
L
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
-------
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
-
P
R
V
-
G
R
H
I
T
T
Y
---
G
F
-
S
DD-
A
D
V
Q
I
A
S
Y
R
Q
E
-
G
P
Q
--
G
-
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
---
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
-----
N
F
P
LAPVNGK
E
G
S
A
-
M
-
L
V
D
D
-
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
----
R
A
G
W
----
P
D
K
R
I
-
V
M
L
F
Q
P
H
R
Y
T
R
T
R
-
D
L
Y
D
D
-
F
A
N
V
L
S
Q
--
V
D
V
L
L
M
L
D
VYAA------
G
E
PPIPGA
D
-----
S
R
A
L
C
R
T
I
R
N
R
G
K--
L
D
P
I
L
V
P
------
D
S
E
S
A
P
E
M
L
A
Q
I
L
-----
N
G
E
D
L
I
L
V
Q
G
A
G
N
I
G
----
K
I
A
R
K
L
A
E
--