@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPI8: (2017-11-21 )
MIEPVTAMTTLSNSVSKPDIDDVNIKSIQTLVTPAELKSELPLSDVASQTVLKGRETIRNILDGSDKCLFVVIGPCSIHDPKAAHEYADRLKALSEKVKDTLYLVMRVYFEKPRTTIGWKGLINDPDMNDSFNIEKGLRIGRKLLLDLNEKGLPCATEALDPNSPQYYQDLISWSAIGARTTESQTHREMSSGLSSPVGFKNGTDGGLTVATNAMQSVKYGHSFLGLNEDGQVSIINTKGNPYAHVVLRGGNGKPNYDAGSVAEAENALAKAKVSSKIMIDASHANSNKDPYLQPLVLKNITEQILDGNKSIVGIMVESHLKGGRQDIPDNLCDLEYGKSVTDGCIDWETTEKTLLEMHKALKEVLPNR
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIEPV
T
A
M
T
T
L
SNSVSKPDIDDV
N
I
K
S
I
Q
T
LV
T
P
A
E
L
K
SELP
L
S
D
V
A
S
Q
T
V
L
K
G
R
E
T
I
R
N
I
LDGSD
K
C
L
F
V
V
IGPCSIHD
P
K
A
A
H
E
Y
A
D
R
L
K
A
L
S
E
K
V
K
D
T
L
Y
L
V
M
R
V
Y
FEKPRTTIGWKGLINDPDMNDSF
N
I
E
K
G
L
R
I
G
R
K
L
L
L
DLNEKGLPCATEALDPNS
P
Q
Y
Y
Q
D
L
I
S
W
SAIGARTT
E
S
Q
T
H
R
E
M
S
SGLSSPVGFKNGTDG
G
L
T
V
A
T
N
A
M
Q
S
V
K
YG
H
S
FLGLNEDG
Q
V
S
I
I
NTKGN
P
Y
A
H
V
V
L
RGGNGKPNYDAG
S
V
A
E
A
E
N
A
L
A
K
AKVS
S
K
I
M
I
D
ASHANSNKDPY
L
Q
P
L
V
L
K
N
I
T
E
Q
I
LDGNK
S
I
V
G
I
M
V
E
S
H
LKGGRQDIPDNLC
D
L
EYGKSVTDGCIDW
E
T
T
E
K
T
L
L
E
M
H
K
A
L
K
E
VLPNR
4
PsiBlast_PDB
94.62
54%
-88
- C4 -
-
5CKS
1
AROG_ECOLI
A:
[7-347]
--------------------
D
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
--
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
------
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
32
PsiBlast_CBE
93.73
54%
-84
- C4 -
-
5CKS
3
AROG_ECOLI
B:
[7-347]
--------------------
D
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
114
HHSearch
93.41
54%
-79
- C4 -
-
1KFL
-
AROG_ECOLI
F:
[2-350]
----------------
N
Y
Q
N
D
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
-
S
G
E
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
--
132
Fugue
93.22
54%
-79
- C4 -
-
1QR7
1
AROG_ECOLI
A:
[8-350]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
------
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
--
31
PsiBlast_CBE
93.20
54%
-82
- C4 -
-
5CKS
2
AROG_ECOLI
C:
[7-347]
--------------------
D
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
---
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
118
HHSearch
93.12
53%
-79
- C4 -
-
1N8F
1
AROG_ECOLI
A:
[8-350]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
-
S
G
E
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
A
R
R
G
--
3
PsiBlast_PDB
93.10
54%
-81
- C4 -
-
1N8F
1
AROG_ECOLI
A:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
21
PsiBlast_CBE
92.91
54%
-80
- C4 -
-
1QR7
1
AROG_ECOLI
D:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
-----
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
1
PsiBlast_PDB
92.87
54%
-80
- C4 -
-
1QR7
1
AROG_ECOLI
A:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
------
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
25
PsiBlast_CBE
92.40
54%
-81
- C4 -
-
1GG1
1
AROG_ECOLI
C:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
---
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
2
PsiBlast_PDB
92.35
54%
-80
- C4 -
-
1GG1
1
AROG_ECOLI
A:
[7-346]
---------------------
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
-----
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
29
PsiBlast_CBE
92.28
54%
-82
- C4 -
-
1N8F
1
AROG_ECOLI
B:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
28
PsiBlast_CBE
92.21
54%
-84
- C4 -
-
1N8F
1
AROG_ECOLI
C:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
30
PsiBlast_CBE
92.15
54%
-85
- C4 -
-
5CKS
1
AROG_ECOLI
D:
[7-347]
--------------------
D
D
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
27
PsiBlast_CBE
91.88
54%
-82
- C4 -
-
1N8F
1
AROG_ECOLI
D:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
Q
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
22
PsiBlast_CBE
91.79
54%
-80
- C4 -
-
1QR7
1
AROG_ECOLI
C:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
------
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
26
PsiBlast_CBE
91.71
54%
-81
- C4 -
-
1GG1
1
AROG_ECOLI
B:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
E
S
G
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
23
PsiBlast_CBE
91.63
54%
-81
- C4 -
-
1QR7
1
AROG_ECOLI
B:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
------
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
24
PsiBlast_CBE
91.53
54%
-82
- C4 -
-
1GG1
1
AROG_ECOLI
D:
[8-346]
----------------------
L
R
I
K
E
I
K
E
L
L
P
P
V
A
L
L
E
K
F
P
A
T
E
N
A
A
N
T
V
A
H
A
R
K
A
I
H
K
I
L
K
G
N
D
D
R
L
L
V
V
I
G
P
C
S
I
H
D
P
V
A
A
K
E
Y
A
T
R
L
L
A
L
R
E
E
L
K
D
E
L
E
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
M
D
N
S
F
Q
I
N
D
G
L
R
I
A
R
K
L
L
L
D
I
N
D
S
G
L
P
A
A
G
E
F
L
D
M
I
T
P
Q
Y
L
A
D
L
M
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
T
I
K
V
A
I
D
A
I
N
A
A
G
A
P
H
C
F
L
S
V
T
K
W
G
H
S
A
I
V
N
T
S
G
N
G
D
C
H
I
I
L
R
G
G
K
-
E
P
N
Y
S
A
K
H
V
A
E
V
K
E
G
L
N
K
A
G
L
P
A
Q
V
M
I
D
F
S
H
A
N
S
S
K
Q
F
K
K
Q
M
D
V
C
A
D
V
C
Q
Q
I
A
G
G
E
K
A
I
I
G
V
M
V
E
S
H
L
V
E
G
N
Q
S
L
---
E
-
P
L
A
Y
G
K
S
I
T
D
A
C
I
G
W
E
D
T
D
A
L
L
R
Q
L
A
N
A
V
K
------
116
HHSearch
91.35
53%
-78
- C4 -
-
5DCB
3
?
C:
[3-349]
---------------
H
H
Y
P
T
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
S
V
T
K
A
G
H
S
A
I
V
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
K
-
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
-----
E
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
R
M
A
R
-
115
HHSearch
91.04
53%
-75
- C4 -
-
5D04
7
?
D:
[4-349]
----------------
H
Y
P
T
D
D
I
K
I
K
E
V
K
E
L
L
P
P
I
A
H
L
Y
E
L
P
I
S
K
E
A
S
G
L
V
H
R
T
R
Q
E
I
S
D
L
V
H
G
R
D
K
R
L
L
V
I
I
G
P
C
S
I
H
D
P
K
A
A
L
E
Y
A
E
R
L
L
K
L
R
K
Q
Y
E
N
E
L
L
I
V
M
R
V
Y
F
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
H
L
D
G
T
F
D
I
N
F
G
L
R
Q
A
R
S
L
L
L
S
L
N
N
M
G
M
P
A
S
T
E
F
L
D
M
I
T
P
Q
Y
Y
A
D
L
I
S
W
G
A
I
G
A
R
T
T
E
S
Q
V
H
R
E
L
A
S
G
L
S
C
P
V
G
F
K
N
G
T
D
G
N
L
K
I
A
I
D
A
I
G
A
A
S
H
S
H
H
F
L
S
V
T
K
A
G
H
S
A
I
A
H
T
G
G
N
P
D
C
H
V
I
L
R
G
G
-
K
E
P
N
Y
D
A
E
H
V
S
E
A
A
E
Q
L
R
A
A
G
V
T
D
K
L
M
I
D
C
S
H
A
N
S
R
K
D
Y
T
R
Q
M
E
V
A
Q
D
I
A
A
Q
L
E
Q
D
G
G
N
I
M
G
V
M
V
E
S
H
L
V
E
G
R
Q
D
K
P
-----
E
V
Y
G
K
S
I
T
D
A
C
I
G
W
G
A
T
E
E
L
L
A
L
L
A
G
A
N
K
K
R
M
A
R
-
101
PsiBlast_CBE
88.84
50%
-71
* C4 *
-
1OFO
1
AROG_YEAST
A:
[22-363]
---------------------
D
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
G
--
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
---
A
G
L
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
-----
113
HHSearch
88.31
50%
-66
- C4 -
-
1OF8
4
AROG_YEAST
B:
[23-367]
----------------------
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
-
G
-
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
--
K
A
G
L
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
R
R
E
V
-
105
PsiBlast_CBE
88.22
50%
-68
- C4 -
-
1OF8
4
AROG_YEAST
B:
[23-363]
----------------------
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
G
--
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
--
K
A
G
L
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
-----
106
PsiBlast_CBE
87.92
50%
-69
- C4 -
-
1OF8
4
AROG_YEAST
A:
[23-363]
----------------------
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
G
--
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
------
L
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
-----
104
PsiBlast_CBE
87.79
50%
-70
- C4 -
-
1OFA
3
AROG_YEAST
A:
[23-363]
----------------------
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
G
--
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
I
P
---
A
G
L
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
-----
103
PsiBlast_CBE
87.29
50%
-69
- C4 -
-
1OFA
4
AROG_YEAST
B:
[23-363]
----------------------
V
R
I
L
G
Y
D
P
L
A
S
P
A
L
L
Q
V
Q
I
P
A
T
P
T
S
L
E
T
A
K
R
G
R
R
E
A
I
D
I
I
T
G
K
D
D
R
V
L
V
I
V
G
P
C
S
I
H
D
L
E
A
A
Q
E
Y
A
L
R
L
K
K
L
S
D
E
L
K
G
D
L
S
I
I
M
R
A
Y
L
E
K
P
R
T
T
V
G
W
K
G
L
I
N
D
P
D
V
N
N
T
F
N
I
N
K
G
L
Q
S
A
R
Q
L
F
V
N
L
T
N
I
G
L
P
I
G
S
E
M
L
D
T
I
S
P
Q
Y
L
A
D
L
V
S
F
G
A
I
G
A
R
T
T
E
S
Q
L
H
R
E
L
A
S
G
L
S
F
P
V
G
F
K
N
G
T
D
G
T
L
N
V
A
V
D
A
C
Q
A
A
A
H
S
H
H
F
M
G
V
T
K
H
G
V
A
A
I
T
T
T
K
G
N
E
H
C
F
V
I
L
R
G
G
K
K
G
T
N
Y
D
A
K
S
V
A
E
A
K
A
Q
L
P
A
G
--
S
N
G
L
M
I
D
Y
S
H
G
N
S
N
K
D
F
R
N
Q
P
K
V
N
D
V
V
C
E
Q
I
A
N
G
E
N
A
I
T
G
V
M
I
E
S
N
I
N
E
G
N
Q
G
--------
K
Y
G
V
S
I
T
D
A
C
I
G
W
E
T
T
E
D
V
L
R
K
L
A
A
A
V
R
Q
-----