@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPN2: (2017-11-22 )
MAGNSIGQLFRVTTCGESHGVGLMAIVDGVPPGLALTEEDLQKDLDRRKPGTSKFATQRKEPDQVEIISGVFEGKTTGTPIGLLIRNTDQKSKDYGNIAQTFRPGHADYTYTQKYGFRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGILIRGHVTQIGNEVAEKLDWNEVPNNPFFCGDVDAVPRFEALVKSLREQGTSCGAKLEILAEKVPVGWGEPVFDRLDADIAHAMMSINAVKGVEIGDGFAVAGQFGHETRDELTSHGFLANHAGGILGGISSGQTIRVAIALKPTASITTPGKTINLNREDTDVLTKGRHDPCVGVRATPIAEAMLAIVLMDHFLRHRAQNADVVPPFVPIEP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.------------....-..-.-----------------100-----.......110.......120.-......130.......140.......150.......160..------.----...-------.170.......180.......190.......200.......210-----.------.......--220.--.-.....230.......240.......250.......260..--..----...--270.......280.......290.......300.......-310.......320.......330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAGNS
I
G
Q
L
F
R
V
T
TCGESHG
V
G
L
M
A
I
VDGVPPGLAL
T
E
E
D
L
Q
K
D
L
D
RRKPGT
S
K
F
ATQRKEPD
Q
V
E
I
I
S
G
V
FEGKTTG
T
P
I
G
L
L
I
RNTDQKS------------
K
D
Y
G
-
N
I
-
A
-----------------
Q
TF-----RPGHAD
Y
T
Y
T
Q
KYGFRDYRGG-GR
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
I
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
KL-------DWNEVPNNPFFCGDVDA
V
P
R
F
E
A
L
V
K
S
L
R
EQGTSCG
A
K
L
E
I
L
A
------
E
------KVPVGWG--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
VK
G
V
EIGD
G
F
A
V
AGQFGHE
T
R
D
E
L
T--SH----GFL--ANHAGGILGGISSG
Q
T
I
R
V
A
I
A
LKPTASITTPG
K
T
I
NLNR-ED
T
D
V
L
TKGRHDPCVGVRA
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
RAQNADVVPPFVPIEP
1
PsiBlast_PDB
86.57
99%
-94
- C3 -
-
4LJ2
-
?
A:
[1-363]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K
S
------------
K
------------------------------------------------
R
D
Y
R
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
S
I
T
------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
26
HHSearch
84.94
99%
-90
- C3 -
-
4LJ2
-
?
B:
[1-363]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K
S
------------
K
------------------------------------------------
R
D
Y
R
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
S
I
T
T
----------------
T
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
3
PsiBlast_PDB
84.86
99%
-96
- C3 -
-
4OB9
-
?
A:
[1-363]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K
------------------------------------------------------------------
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
25
HHSearch
84.24
99%
-94
- C3 -
-
4OB9
-
?
B:
[1-363]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K
------------------------------------------------------------------
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
2
PsiBlast_PDB
83.12
99%
-104
- C3 -
-
4O90
1
?
A:
[1-351]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
------------------------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
-----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
------------
4
PsiBlast_PDB
82.65
99%
-106
- C3 -
-
5WUY
-
?
A:
[1-352]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
----------
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
K
----------------------------------------------------------------------
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
----------------
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
---------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
-----------
21
PsiBlast_CBE
82.02
99%
-105
- C3 -
-
4O90
2
?
B:
[1-351]
M
A
G
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
------------------------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
N
E
V
------
A
----
E
K
L
-------
D
W
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
------
K
V
P
V
G
W
G
--
E
P
V
F
--
D
-
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
--
S
H
----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
-----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
------------
29
HHSearch
71.43
43%
-40
- C3 -
-
1UMF
-
AROC_HELPY
A:
[1-364]
--
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
------
R
S
IKTNQ
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
--
28
HHSearch
71.11
43%
-40
- C3 -
-
1UM0
2
AROC_HELPY
D:
[1-364]
--
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
------
R
SIKTNQ
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
--
6
PsiBlast_PDB
69.62
44%
-43
- C3 -
-
1UMF
-
AROC_HELPY
A:
[2-348]
---
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
IKTN
Q
------
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
------------------
24
PsiBlast_CBE
69.46
44%
-46
- C3 -
-
1UM0
2
AROC_HELPY
B:
[2-348]
---
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
RSIKTN
Q
------
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
------------------
5
PsiBlast_PDB
69.45
44%
-43
- C3 -
-
1UM0
2
AROC_HELPY
A:
[2-348]
---
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
IKTN
Q
------
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
------------------
22
PsiBlast_CBE
69.09
44%
-42
- C3 -
-
1UM0
2
AROC_HELPY
D:
[2-348]
---
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
RSIKTN
Q
------
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
------------------
23
PsiBlast_CBE
69.04
44%
-44
- C3 -
-
1UM0
2
AROC_HELPY
C:
[2-348]
---
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
A
R
S
------------
K
D
Y
D
-
N
I
-
K
-----------------
N
L
F
-----
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
G
I
K
------
A
----
K
N
Y
-------
D
F
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
RSIKTN
Q
------
K
L
P
I
G
L
G
--
Q
G
L
Y
--
A
-
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
--
Q
K
----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
-
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
------------------
36
HHSearch
66.57
36%
-10
- C3 -
-
2QHF
2
AROC_MYCTU
A:
[1-379]
--------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
R
M
T
F
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-------------
K
W
E
T
V
M
A
A
DPVD
P
A
E
L
A
D
VARNAPL
T
R
P
-----
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
S
A
------
P
----
Y
-
E
G
P
P
P
R
AE
D
L
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
------
L
------
G
L
P
V
G
L
G
SF
T
S
G
---
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
--
P
G
PDGV
V
R
S
--
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
------
30
HHSearch
65.93
44%
-64
* C3 *
-
1SQ1
-
AROC_CAMJE
A:
[1-358]
--
M
N
T
F
G
T
R
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
-----------------------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
T
F
V
------
S
----
N
L
K
EEEF---
D
F
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
K
V
------
S
------
G
M
L
I
G
L
G
--
E
V
L
Y
--
D
-
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
K
--
D
G
----
K
F
L
--
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
----------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
N
L
N
N
L
K
N
A
-----
35
HHSearch
65.76
36%
-12
- C3 -
-
1ZTB
-
AROC_MYCTU
A:
[1-379]
--------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
-
P
-------------
K
W
E
T
V
M
A
A
DPVD
P
A
E
L
A
D
VARNAPL
T
R
P
-----
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
S
A
------
P
----
Y
-
E
G
P
P
P
RAE
D
L
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
------
L
------
G
L
P
V
G
L
G
SF
T
S
G
---
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
--
P
G
PDGV
V
R
S
--
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
-
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
------
8
PsiBlast_PDB
64.75
43%
-62
- C3 -
-
1SQ1
-
AROC_CAMJE
A:
[2-353]
---
N
T
F
G
T
R
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
-----------------------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
T
F
V
------
S
NLKE
E
E
F
-------
D
F
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
K
V
------
S
------
G
M
L
I
G
L
G
--
E
V
L
Y
--
D
-
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
K
--
D
G
----
K
F
L
--
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
----------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
N
L
N
----------
14
PsiBlast_PDB
64.30
34%
-32
- C3 -
-
4BAI
-
AROC_MYCTU
A:
[2-367]
---------
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
-----------
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
WETVMAADPVD
P
A
E
L
A
-
D
V
-
A
-----------------
R
N
A
PLTRP
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
S
A
PYE
G
P
P
P
----
R
A
E
-------
D
L
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
------
L
------
G
L
P
V
G
L
G
--
S
F
T
S
GD
H
-
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
P
G
P
D
----
G
V
V
RS
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
-
G
D
E
A
V
A
I
H
Q
----
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
------------------
12
PsiBlast_PDB
64.07
34%
-14
- C3 -
-
2O12
1
AROC_MYCTU
A:
[1-362]
--------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
WETVMAADPVD
P
A
E
L
A
-
D
V
-
A
-----------------
R
N
A
PLTRP
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
A
S
A
PYE
G
P
P
P
----
R
A
E
-------
D
L
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
------
L
------
G
L
P
V
G
L
G
--
S
F
T
S
GD
H
-
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
P
G
P
D
----
G
V
V
RS
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
-
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
-----------------------