@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPT6: (2017-11-23 )
MSTTVIILAAGKGTRMRSQLPKVLQPLAGRPLLGHVIKTAKQLLAENIITIYGHGGDHVKKTFAQENIQWVEQAEQLGTGHAVQMTLPVLPKDGISLILYGDVPLARQTTLEQLIEASNKTGIGMITLHVDNPTGYGRIVRQDGKIQAIVEHKDATEAQRQIQEINTGIYCVSNAKLHEWLPKLSNENAQGEYYLTDIVAMAVADGLEIASIQPELAFEVEGVNDRLQLAALEREFQKQQAKELMQQGVTFADPARFDLRGTVKVGHDVRIDVNVIIEGDCELGDFVEIGAGCILKNTTIAAGTKVQAYSVFDGAVVGENTQIGPFARLRPGAKLANEVHIGNFVEVKNTTIGLGSKANHFTYLGDAEIGAESNIGAGTITCNYDGANKHKTTIGDAVFIGSNSSLVAPVTIGNGATVGAGSVITKDVAEQSLSFERAQQISKANYQRPQKLKK
Atome Classification :
(25 SA)
.........10........20........30........40........50........60....------....70........80........90..--......100.......110.......--120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230...---....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430..-.....440....---...450..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
T
T
V
I
I
L
AAGKG
T
R
M
R
S
Q
L
P
K
V
L
Q
P
LAGR
P
L
L
G
H
V
I
K
T
A
K
Q
L
L
A
EN
I
I
T
I
Y
GHG
G
D
H
V
K
K
T
F
A
Q
------
E
N
I
Q
W
V
E
Q
A
E
QLGTG
H
A
V
Q
M
T
LPVLPKD--G
I
S
L
I
L
YGDVPL
A
R
Q
T
T
L
E
Q
L
I
E
ASN--KT
G
I
G
M
I
T
L
H
VDNPTGY
G
R
IVR-QDG
K
I
Q
A
I
V
EHK
D
A
T
E
A
Q
R
Q
I
Q
E
INT
G
I
Y
CVSN
A
K
L
H
E
W
L
P
K
LSNENAQGE
Y
Y
L
T
D
I
V
A
M
A
V
ADG
L
E
I
A
SIQ
P
E
L
A
F
E
VEGVN
D
R
L
Q
L
A
A
L
E
R
E
---
F
Q
K
Q
Q
A
K
E
L
M
QQGVTFADP
A
R
F
D
L
R
G
T
V
K
VG
H
D
V
R
I
D
V
N
V
I
I
EGDCELG
D
F
V
E
IGA
G
C
I
L
KN
T
T
IAAG
T
K
V
Q
A
Y
S
VFD
G
A
VVGENTQIG
P
F
ARLRPG
A
K
L
ANEVHIG
N
F
V
E
V
K
N
T
T
I
GLGSKA
N
H
F
T
Y
LGDAEIGAESNIG
A
G
T
I
T
C
NYDGANKHKTTIG
D
A
V
F
IGSNS
S
L
V
A
P
V
T
IGNGATVGA
G
S
V
I
T
K
D
V
A
E
QSL
S
-
F
E
R
A
Q
Q
I
S
K
ANY---QR
P
Q
KLKK
1
PsiBlast_PDB
86.46
99%
-121
- C3 -
-
5VMK
4
?
A:
[10-458]
-
S
T
T
V
I
I
L
A
A
G
K
G
T
R
M
R
S
Q
L
P
K
V
L
Q
P
L
A
G
R
P
L
L
G
H
V
I
K
T
A
K
Q
L
L
A
E
N
I
I
T
I
Y
G
H
G
G
D
H
V
K
K
T
F
A
Q
------
E
N
I
Q
W
V
E
Q
A
E
Q
L
G
T
G
H
A
V
Q
M
T
L
P
V
L
P
K
D
--
G
I
S
L
I
L
Y
G
D
V
P
L
V
R
Q
T
T
L
E
Q
L
I
E
V
S
N
--
K
T
G
I
G
M
I
T
L
H
V
D
N
P
T
G
Y
G
R
I
V
R
-
Q
D
G
K
I
Q
A
I
V
E
H
K
D
A
T
E
A
Q
R
Q
I
Q
E
I
N
T
G
I
Y
C
V
S
N
A
K
L
H
E
W
L
P
K
L
S
N
E
N
A
Q
G
E
Y
Y
L
T
D
I
V
A
M
A
V
A
D
G
L
E
I
A
S
I
Q
P
E
L
A
F
E
V
E
G
V
N
D
R
L
Q
L
A
A
L
E
R
E
---
F
Q
K
Q
Q
A
K
E
L
M
Q
Q
G
V
T
F
A
D
P
A
R
F
D
L
R
G
T
V
K
V
G
H
D
V
R
I
D
V
N
V
I
I
E
G
N
C
E
L
G
D
F
V
E
I
G
A
G
C
I
L
K
N
T
T
I
A
A
G
T
K
V
Q
A
Y
S
V
F
D
G
A
V
V
G
E
N
T
Q
I
G
P
F
A
R
L
R
P
G
A
K
L
A
N
E
V
H
I
G
N
F
V
E
V
K
N
T
T
I
G
L
G
S
K
A
N
H
F
T
Y
L
G
D
A
E
I
G
A
E
S
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
H
K
T
T
I
G
D
A
V
F
I
G
S
N
S
S
L
V
A
P
V
T
I
G
N
G
A
T
V
G
A
G
S
V
I
T
K
D
V
A
E
Q
S
L
S
-
F
E
R
A
Q
Q
I
S
K
A
N
Y
---
Q
R
P
Q
----
21
PsiBlast_CBE
83.25
99%
-130
- C3 -
-
5VMK
4
?
B:
[11-457]
--
T
T
V
I
I
L
A
A
G
K
G
T
R
M
R
S
Q
L
P
K
V
L
Q
P
L
A
G
R
P
L
L
G
H
V
I
K
T
A
K
Q
L
L
A
E
N
I
I
T
I
Y
G
H
G
G
D
H
V
K
K
T
F
A
Q
------
E
N
I
Q
W
V
E
Q
----
G
T
G
H
A
V
Q
M
T
L
P
V
L
-----
G
I
S
L
I
L
Y
G
D
V
P
L
V
R
Q
T
T
L
E
Q
L
I
E
V
S
N
--
K
T
G
I
G
M
I
T
L
H
V
D
N
P
T
G
Y
G
R
I
V
R
-
Q
D
G
K
I
Q
A
I
V
E
H
K
D
A
T
E
A
Q
R
Q
I
Q
E
I
N
T
G
I
Y
C
V
S
N
A
K
L
H
E
W
L
P
----------
Y
Y
L
T
D
I
V
A
M
A
V
A
D
G
L
E
I
A
S
I
Q
P
E
L
A
F
E
V
E
G
V
N
D
R
L
Q
L
A
A
L
E
R
E
---
F
Q
K
Q
Q
A
K
E
L
M
Q
Q
G
V
T
F
A
D
P
A
R
F
D
L
R
G
T
V
K
V
G
H
D
V
R
I
D
V
N
V
I
I
E
G
N
C
E
L
G
D
F
V
E
I
G
A
G
C
I
L
K
N
T
T
I
A
A
G
T
K
V
Q
A
Y
S
V
F
D
G
A
V
V
G
E
N
T
Q
I
G
P
F
A
R
L
R
P
G
A
K
L
A
N
E
V
H
I
G
N
F
V
E
V
K
N
T
T
I
G
L
G
S
K
A
N
H
F
T
Y
L
G
D
A
E
I
G
A
E
S
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
H
K
T
T
I
G
D
A
V
F
I
G
S
N
S
S
L
V
A
P
V
T
I
G
N
G
A
T
V
G
A
G
S
V
I
T
K
D
V
A
E
Q
S
L
S
-
F
E
R
A
Q
Q
I
S
K
A
N
Y
---
Q
R
P
-----
126
HHSearch
78.14
96%
-57
- C3 -
-
5VMK
4
?
A:
[10-458]
-
S
T
T
V
I
I
L
A
A
G
K
G
T
R
M
R
S
Q
L
P
K
V
L
Q
P
L
A
G
R
P
L
L
G
H
V
I
K
T
A
K
Q
L
L
A
E
N
I
I
T
I
Y
G
H
G
G
D
H
V
K
K
T
F
A
Q
------
E
N
I
Q
W
V
E
Q
A
E
Q
L
G
T
G
H
A
V
Q
M
T
L
P
V
L
P
K
D
--
G
I
S
L
I
L
Y
G
D
V
P
L
V
R
Q
T
T
L
E
Q
L
I
E
V
S
N
--
K
T
G
I
G
M
I
T
L
H
V
D
N
P
T
G
Y
G
R
I
V
R
-
Q
D
G
K
I
Q
A
I
V
E
H
K
D
A
T
E
A
Q
R
Q
I
Q
E
I
N
T
G
I
Y
C
V
S
N
A
K
L
H
E
W
L
P
K
L
S
N
E
N
A
Q
G
E
Y
Y
L
T
D
I
V
A
M
A
V
A
D
G
L
E
I
A
S
I
Q
P
---
E
L
A
F
E
V
E
G
V
N
D
R
L
Q
L
A
A
L
E
R
E
F
Q
K
Q
Q
A
K
E
L
M
Q
Q
G
V
T
F
A
D
P
A
R
F
D
L
R
G
T
V
K
V
G
H
D
V
R
I
D
V
N
V
I
I
E
G
N
C
E
L
G
D
F
V
E
I
G
A
G
C
I
L
K
N
T
T
I
A
A
G
T
K
V
Q
A
Y
S
V
F
D
G
A
V
V
G
E
N
T
Q
I
G
P
F
A
R
L
R
P
G
A
K
L
A
N
E
V
H
I
G
N
F
V
E
V
K
N
T
T
I
G
L
G
S
K
A
N
H
F
T
Y
L
G
D
A
E
I
G
A
E
S
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
H
K
T
T
I
G
D
A
V
F
I
G
S
N
S
S
L
V
A
P
V
T
I
G
N
G
A
T
V
G
A
G
S
V
I
T
K
D
V
A
E
Q
S
L
S
-
F
E
R
A
Q
Q
I
S
K
A
N
Y
---
Q
R
P
Q
----
17
PsiBlast_PDB
75.73
57%
-127
- C3 -
-
4FCE
4
GLMU_YERPE
A:
[11-452]
----
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
P
L
A
G
K
P
M
V
Q
H
V
I
D
A
A
M
K
L
G
A
Q
H
V
H
L
V
Y
G
H
G
G
E
L
L
K
K
T
-----------
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
H
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
D
T
L
Q
R
L
L
A
A
K
P
--
E
G
G
I
G
L
L
T
V
K
L
D
N
P
S
G
Y
G
R
I
V
R
-
E
N
G
D
V
V
G
I
V
E
H
K
D
A
S
D
A
Q
R
E
I
N
E
I
N
T
G
I
L
V
A
N
G
R
D
L
K
R
W
L
S
L
L
D
N
N
N
A
Q
G
E
F
Y
I
T
D
I
I
A
L
A
H
A
D
G
K
K
I
A
T
V
H
P
T
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
A
L
E
R
V
---
F
Q
T
E
Q
A
E
K
L
L
L
A
G
V
M
L
L
D
P
S
R
F
D
L
R
G
E
L
T
H
G
R
D
I
T
I
D
T
N
V
I
I
E
G
H
V
I
L
G
D
R
V
R
I
G
T
G
C
V
L
K
N
C
V
I
G
D
D
S
E
I
S
P
Y
T
V
L
E
D
A
R
L
D
A
N
C
T
V
G
P
F
A
R
L
R
P
G
A
E
L
A
E
G
A
H
V
G
N
F
V
E
I
K
K
A
R
L
G
K
G
S
K
A
G
H
L
S
Y
L
G
D
A
E
I
G
A
G
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
A
N
G
A
T
I
G
A
G
T
T
V
T
R
D
V
A
E
N
E
L
V
-
I
S
R
V
K
Q
V
H
I
Q
G
W
-----------
20
PsiBlast_PDB
75.72
55%
-118
- C3 -
-
2OI6
3
GLMU_ECOLI
A:
[5-453]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
V
----
11
PsiBlast_PDB
75.69
56%
-126
- C3 -
-
4E1K
2
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
14
PsiBlast_PDB
75.67
56%
-125
- C3 -
-
4KPX
3
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
127
HHSearch
75.55
56%
-116
- C3 -
-
2OI6
3
GLMU_ECOLI
B:
[4-454]
N
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
V
K
---
5
PsiBlast_PDB
75.54
56%
-122
- C3 -
-
2V0J
4
GLMU_HAEIN
A:
[7-452]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
-----
15
PsiBlast_PDB
75.51
56%
-122
- C3 -
-
4KPZ
2
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
7
PsiBlast_PDB
75.48
56%
-126
- C3 -
-
2V0L
4
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
8
PsiBlast_PDB
75.46
56%
-121
- C3 -
-
2VD4
4
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
3
PsiBlast_PDB
75.41
56%
-122
- C3 -
-
2V0H
4
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
16
PsiBlast_PDB
75.37
56%
-123
- C3 -
-
4KQL
3
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
19
PsiBlast_PDB
75.34
55%
-119
- C3 -
-
2OI5
2
GLMU_ECOLI
A:
[5-452]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
-----
13
PsiBlast_PDB
75.33
56%
-123
- C3 -
-
4KNX
3
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
10
PsiBlast_PDB
75.20
56%
-123
- C3 -
-
2W0W
2
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
24
PsiBlast_CBE
75.13
55%
-117
* C3 *
-
2OI6
3
GLMU_ECOLI
B:
[5-454]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
V
K
---
6
PsiBlast_PDB
75.13
56%
-125
- C3 -
-
2V0K
4
GLMU_HAEIN
A:
[7-453]
---
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
T
A
H
Q
L
G
S
E
N
I
H
L
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
------
E
Q
V
N
W
V
L
Q
T
E
Q
L
G
T
A
H
A
V
Q
Q
A
A
P
F
F
K
D
N
--
E
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
A
K
P
--
E
N
G
I
A
L
L
T
V
N
L
D
N
P
T
G
Y
G
R
I
I
R
-
E
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
T
D
V
M
E
V
E
G
A
N
N
R
L
Q
L
A
A
L
E
R
Y
---
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
R
F
D
L
R
G
T
L
E
H
G
K
D
V
E
I
D
V
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G
C
V
L
K
N
V
V
I
G
N
D
V
E
I
K
P
Y
S
V
L
E
D
S
I
V
G
E
K
A
A
I
G
P
F
S
R
L
R
P
G
A
E
L
A
A
E
T
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
-
I
T
R
V
A
Q
R
H
I
Q
G
W
---
Q
R
P
I
----
25
PsiBlast_CBE
74.79
55%
-117
- C3 -
-
2OI5
2
GLMU_ECOLI
B:
[5-452]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
-----
23
PsiBlast_CBE
74.77
55%
-117
- C3 -
-
2OI7
3
GLMU_ECOLI
A:
[5-452]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
-----
22
PsiBlast_CBE
73.87
55%
-113
- C3 -
-
2OI7
3
GLMU_ECOLI
B:
[5-452]
-
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
A
A
N
E
L
G
A
A
H
V
H
L
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
------
D
N
L
N
W
V
L
Q
A
E
Q
L
G
T
G
H
A
M
Q
Q
A
A
P
F
F
A
D
D
--
E
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
A
K
P
--
Q
G
G
I
G
L
L
T
V
K
L
D
D
P
T
G
Y
G
R
I
T
R
-
E
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
H
P
Q
R
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
R
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
-----
46
PsiBlast_CBE
59.08
39%
-19
- C3 -
-
3ST8
3
GLMU_MYCTU
A:
[13-472]
--
T
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
P
Q
R
L
I
V
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
G
L
S
A
L
P
D
D
YA
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
T
H
R
A
V
S
A
A
V
T
V
L
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
Q
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
H
V
D
D
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
E
L
A
S
E
---
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
T
T
W
I
D
V
D
V
T
I
G
R
D
T
V
I
H
P
G
T
Q
L
L
G
R
T
Q
I
G
G
R
C
V
V
G
P
D
T
T
L
T
D
V
A
V
G
D
G
A
S
V
-
V
R
T
H
G
S
S
S
S
I
G
D
G
A
A
V
G
P
F
T
Y
L
R
P
G
T
A
L
G
A
D
G
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
-
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
K
R
P
-----
53
PsiBlast_CBE
48.06
56%
-116
- C3 -
-
3TWD
1
GLMU_ECOLI
A:
[4-221]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
---
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
-
I
S
R
V
P
Q
T
Q
K
E
G
W
---
R
R
P
-----
143
HHSearch
46.01
56%
-114
- C3 -
-
3TWD
1
GLMU_ECOLI
A:
[19-220]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
M
L
R
D
P
A
R
F
D
L
R
G
T
L
T
H
G
R
D
V
E
I
D
T
N
V
I
I
E
G
N
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
A
R
L
R
P
G
A
E
L
L
E
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
-
W
---
R
R
------