@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPU3: (2017-11-23 )
MREIILISFLGPDQPNQFTRLMQVLSVHSLQILDVGQAVIHNQLTLGIVVASENETATALAMKEILILAHDIGLTVRFKPISGAEYDQWVSEGGRTRYIVTALAPELTAAHLQAVTQIVSSQGFNIETVTRLSGRVDLEKDSTLPRRACVQFGLSSGPTLDAQAMRAACLLLSSELNIDVAVQEDNAYRRNRRLVCFDMDSTLIEQEVIDELALEAGVGEQVAEITERAMQGELDFQQSFRARVALLKGLDASVLPKIAERLTITEGAERLISTLKVLGYKTAILSGGFQYFAEYLQAKLGIDEVHANVLDVQDGVVTGEVKGVIVDGARKAELLRELANKLGISLEQAMAVGDGANDLPMLAIAGLGVAYRAKPLVRQNANQAISSVGLDGVLYLLGMHDKDLSRA
Atome Classification :
(23 SA)
.........10........20........30........40........50-......-..60........70........--80........90........100.......110.......120.......130...--....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.-......270.......280.......290.......300.--......310.......320..-----.....330.......340.......350.......----360.......370.......380.......390.......400.....----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
E
I
I
L
I
S
F
LGPDQ
P
N
Q
F
T
R
L
M
Q
V
L
S
V
H
S
L
Q
I
L
D
V
G
Q
A
V
I
HNQ
L
T
L
G
I
V
V
A-SENE
T
A
-
T
A
L
A
M
K
E
I
L
I
L
A
HDI
G
L
T
V
R
F
K
--PISG
A
E
Y
D
Q
W
V
SEGG
R
T
R
Y
I
V
T
ALA
P
E
L
T
A
A
H
L
Q
A
V
T
Q
I
V
S
SQGF
N
I
E
T
V
T
RLS
G
R
--
V
DLEKDSTL
P
R
R
A
C
V
Q
FGLSSGPT
L
D
A
Q
A
M
R
A
A
C
L
L
LSSEL
N
I
D
V
A
VQEDNAYRRN
R
R
L
V
C
FDM
D
S
T
L
I
E
Q
E
V
I
D
E
L
A
L
EAGV
G
E
Q
V
A
E
I
T
E
R
A
MQGE
L
D
F
Q
Q
S
F
R
A
R
V
A
L
L
KGL
D
A
S
V
L
P
K
I
A
E
R
LT-I
T
E
G
A
E
R
L
I
S
T
L
K
V
LGY
K
T
A
I
LS
G
G
F
Q
Y
F
A
E
Y
L
Q
A
KL
G
I
D
--
E
V
HA
N
V
L
DVQD
G
V
V
TGEV
K
G
V
-----
I
VDG
A
R
K
A
E
L
L
R
E
L
A
N
KLGI
S
L
E
Q
A
MAVGDGANDL----
P
M
L
A
I
AGLG
V
A
YRA
K
P
L
V
R
Q
N
A
N
Q
A
I
S
S
V
G
L
D
G
V
L
Y
L
LGMHDKDLSRA----
76
HHSearch
82.79
40%
-24
- C2 -
-
5JLP
3
SERB_MYCA1
A:
[2-391]
-
K
V
S
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
D
G
P
A
L
R
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
--
R
S
D
D
V
-----
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
------------
Y
P
V
I
G
L
E
L
R
V
S
V
P
P
G
-
A
D
G
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
T
R
G
E
I
E
A
-----
5
PsiBlast_PDB
82.68
40%
-53
- C2 -
-
5JMA
3
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
6
PsiBlast_PDB
82.13
39%
-54
- C2 -
-
5IT4
-
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
-
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
N
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
95
Fugue
82.02
39%
-18
- C2 -
-
3P96
1
SERB_MYCA1
A:
[9-404]
P
K
V
S
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
C
P
A
D
V
A
D
-
G
P
A
L
R
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
--
R
-----
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
--
P
----------
V
I
G
L
E
L
R
V
S
-
V
P
P
G
A
D
E
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
T
R
G
E
I
E
A
A
D
A
I
D
3
PsiBlast_PDB
81.96
40%
-45
- C2 -
-
5JLP
3
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
1
PsiBlast_PDB
81.78
40%
-46
- C2 -
-
3P96
1
SERB_MYCA1
A:
[13-392]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
-
E
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
75
HHSearch
81.76
40%
-22
- C2 -
-
5IS2
-
SERB_MYCA1
A:
[2-391]
-
K
V
S
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
D
G
P
A
L
R
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
--
R
S
D
D
V
-----
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
------------
Y
P
V
I
G
L
E
L
R
V
S
V
P
P
G
-
A
D
G
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
-
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
T
R
G
E
I
E
A
-----
4
PsiBlast_PDB
81.22
40%
-48
- C2 -
-
5JLR
3
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
8
PsiBlast_PDB
81.20
39%
-48
- C2 -
-
5JJB
1
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
G
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
9
PsiBlast_PDB
80.99
39%
-47
- C2 -
-
5IT0
-
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
N
G
A
N
N
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
2
PsiBlast_PDB
80.65
40%
-46
- C2 -
-
5IS2
-
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
P
V
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
-
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
S
G
G
F
R
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
7
PsiBlast_PDB
79.32
39%
-46
- C2 -
-
5T41
1
SERB_MYCA1
A:
[5-384]
----
V
L
I
T
V
T
G
V
D
Q
P
G
V
T
A
T
L
F
E
V
L
S
R
H
G
V
E
L
L
N
V
E
Q
V
V
I
R
H
R
L
T
L
G
V
L
V
C
-
C
P
A
D
V
A
-
D
G
P
A
L
R
------
H
D
V
E
A
A
I
R
K
V
G
L
D
V
S
I
E
R
S
D
D
V
P
I
I
R
E
P
S
T
H
T
I
F
V
L
G
R
P
I
T
A
A
A
F
G
A
V
A
R
E
V
A
A
L
G
V
N
I
D
L
I
R
G
V
S
D
Y
PV
I
G
L
E
L
R
V
S
V
P
------------
P
G
A
D
G
-
A
L
R
T
A
L
N
R
V
S
S
E
E
H
V
D
V
A
V
E
D
Y
T
L
E
R
R
A
K
R
L
I
V
F
D
V
D
S
T
L
V
Q
G
E
V
I
E
M
L
A
A
K
A
G
A
E
G
Q
V
A
A
I
T
D
A
A
M
R
G
E
L
D
F
A
Q
S
L
Q
Q
R
V
A
T
L
A
G
L
P
A
T
V
I
D
E
V
A
G
Q
L
E
-
L
M
P
G
A
R
T
T
L
R
T
L
R
R
L
G
Y
A
C
G
V
V
A
G
G
F
A
R
I
I
E
P
L
A
E
E
L
M
L
D
--
Y
V
A
A
N
E
L
E
I
V
D
G
T
L
T
G
R
V
V
G
P
-----
I
I
D
R
A
G
K
A
T
A
L
R
E
F
A
Q
R
A
G
V
P
M
A
Q
T
V
A
V
G
D
G
A
N
D
I
----
D
M
L
A
A
A
G
L
G
I
A
F
N
A
K
P
A
L
R
E
V
A
D
A
S
L
S
H
P
Y
L
D
T
V
L
F
L
L
G
V
------------
77
HHSearch
69.39
37%
-119
- C2 -
-
3N28
-
SERB_VIBCH
A:
[26-321]
--------------------------------------------------------------------------------------------
F
V
T
Q
L
A
K
K
R
A
S
W
I
V
F
G
H
Y
L
T
P
A
Q
F
E
D
M
D
F
F
T
N
R
F
N
A
I
L
D
M
---------
W
---------
K
V
G
R
Y
E
V
A
L
M
--
D
----
G
E
L
T
S
E
H
E
T
I
L
K
A
L
E
L
D
Y
A
R
I
Q
D
V
P
D
L
T
K
P
G
L
I
V
L
D
M
D
S
T
A
I
Q
I
E
C
I
D
E
I
A
K
L
A
G
V
G
E
E
V
A
E
V
T
E
R
A
M
Q
G
E
L
D
F
E
Q
S
L
R
L
R
V
S
K
L
K
D
A
P
E
Q
I
L
S
Q
V
R
E
T
L
P
-
L
M
P
E
L
P
E
L
V
A
T
L
H
A
F
G
W
K
V
A
I
A
S
G
G
F
T
Y
F
S
D
Y
L
K
E
Q
L
S
L
D
--
Y
A
Q
S
N
T
L
E
I
V
S
G
K
L
T
G
Q
V
L
G
E
-----
V
V
S
A
Q
T
K
A
D
I
L
L
T
L
A
Q
Q
Y
D
V
E
I
H
N
T
V
A
V
G
D
G
A
N
D
L
----
V
M
M
A
A
A
G
L
G
V
A
Y
H
A
K
P
K
V
E
A
K
A
Q
T
A
V
R
F
A
G
L
G
G
V
V
C
I
L
S
A
A
L
V
A
Q
Q
K
-----
97
Fugue
69.05
33%
-143
- C2 -
-
4EZE
-
?
A:
[21-317]
-
Q
S
M
S
I
I
Y
F
I
T
T
Q
D
I
D
T
F
Q
K
K
L
Q
E
T
L
F
F
P
L
L
F
D
K
R
Y
A
A
L
I
N
---------------------------------------------------------
T
A
Y
L
K
L
T
L
P
A
E
C
L
T
--------------------------------------------------------
P
E
F
Y
R
Y
L
R
E
L
S
L
Q
W
Q
F
D
F
F
I
K
P
Q
P
--
L
P
A
N
G
I
I
A
F
D
M
D
S
T
F
I
A
E
E
G
V
D
E
I
A
R
E
L
G
M
S
T
Q
I
T
A
I
T
Q
Q
A
M
E
G
K
L
D
F
N
A
S
F
T
R
R
I
G
M
L
K
G
T
P
K
A
V
L
N
A
V
C
D
R
M
T
-
L
S
P
G
L
L
T
I
L
P
V
I
K
A
K
G
F
K
T
A
I
I
S
G
G
L
D
I
F
T
Q
R
L
K
A
R
Y
Q
L
D
--
Y
A
F
S
N
T
V
E
I
R
D
N
V
L
T
D
N
I
T
L
P
-----
I
M
N
A
A
N
K
K
Q
T
L
V
D
L
A
A
R
L
N
I
A
T
E
N
I
I
A
C
G
D
G
A
N
D
L
----
P
M
L
E
H
A
G
T
G
I
A
W
K
A
K
P
V
V
R
E
K
I
H
H
Q
I
N
Y
H
G
F
E
L
L
L
F
L
I
E
D
E
L
----------
10
PsiBlast_PDB
67.53
46%
-120
- C2 -
-
3N28
-
SERB_VIBCH
A:
[91-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
D
Y
A
R
I
Q
D
V
P
D
L
T
K
P
G
L
I
V
L
D
M
D
S
T
A
I
Q
I
E
C
I
D
E
I
A
K
L
A
G
V
G
E
E
V
A
E
V
T
E
R
A
M
Q
G
E
L
D
F
E
Q
S
L
R
L
R
V
S
K
L
K
D
A
P
E
Q
I
L
S
Q
V
R
E
T
L
P
-
L
M
P
E
L
P
E
L
V
A
T
L
H
A
F
G
W
K
V
A
I
A
S
G
G
F
T
Y
F
S
D
Y
L
K
E
Q
L
S
L
D
--
Y
A
Q
S
N
T
L
E
I
V
S
G
K
L
T
G
Q
V
L
G
E
-----
V
V
S
A
Q
T
K
A
D
I
L
L
T
L
A
Q
Q
Y
D
V
E
I
H
N
T
V
A
V
G
D
G
A
N
D
L
----
V
M
M
A
A
A
G
L
G
V
A
Y
H
A
K
P
K
V
E
A
K
A
Q
T
A
V
R
F
A
G
L
G
G
V
V
C
I
L
--------------
79
HHSearch
67.30
45%
-106
- C2 -
-
1L7M
-
SERB_METJA
A:
[3-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
K
L
I
L
F
D
F
D
S
T
L
V
N
N
E
T
I
D
E
I
A
R
E
A
G
V
E
E
E
V
K
K
I
T
K
E
A
M
E
G
K
L
N
F
E
Q
S
L
R
K
R
V
S
L
L
K
D
L
P
I
E
K
V
E
K
A
I
K
R
I
T
-
P
T
E
G
A
E
E
T
I
K
E
L
K
N
R
G
Y
V
V
A
V
V
S
G
G
F
D
I
A
V
N
K
I
K
E
K
L
G
L
D
--
Y
A
F
A
N
R
L
I
V
K
D
G
K
L
T
G
D
V
E
G
E
-----
V
L
K
E
N
A
K
G
E
I
L
E
K
I
A
K
I
E
G
I
N
L
E
D
T
V
A
V
G
D
G
A
N
D
I
----
S
M
F
K
K
A
G
L
K
I
A
F
C
A
K
P
I
L
K
E
K
A
D
I
C
I
E
K
R
D
L
R
E
I
L
K
Y
I
--------------
96
Fugue
67.08
34%
-107
- C2 -
-
3N28
-
SERB_VIBCH
A:
[3-325]
L
D
A
L
-------------------------------------------------------------------
T
T
L
P
I
K
K
H
T
A
--
L
L
N
R
F
P
E
T
R
F
V
T
Q
L
A
K
K
R
A
S
W
I
V
F
G
H
Y
L
T
P
A
Q
F
E
D
M
D
F
F
T
N
R
F
N
A
I
L
D
M
W
K
V
G
R
Y
E
--
V
A
L
M
D
G
E
----------------------
L
T
S
E
H
E
T
I
L
K
A
L
E
L
D
Y
A
R
I
Q
D
V
P
D
L
T
K
P
G
L
I
V
L
D
M
D
S
T
A
I
Q
I
E
C
I
D
E
I
A
K
L
A
G
V
G
E
E
V
A
E
V
T
E
R
A
M
Q
G
E
L
D
F
E
Q
S
L
R
L
R
V
S
K
L
K
D
A
P
E
Q
I
L
S
Q
V
R
E
T
L
P
-
L
M
P
E
L
P
E
L
V
A
T
L
H
A
F
G
W
K
V
A
I
A
S
G
G
F
T
Y
F
S
D
Y
L
K
E
Q
L
S
L
D
--
Y
A
Q
S
N
T
L
E
I
V
S
G
K
L
T
G
Q
V
L
G
E
-----
V
V
S
A
Q
T
K
A
D
I
L
L
T
L
A
Q
Q
Y
D
V
E
I
H
N
T
V
A
V
G
D
G
A
N
D
L
----
V
M
M
A
A
A
G
L
G
V
A
Y
H
A
K
P
K
V
E
A
K
A
Q
T
A
V
R
F
A
G
L
G
G
V
V
C
I
L
S
A
A
L
V
A
Q
Q
K
L
SWK-
13
PsiBlast_PDB
67.01
44%
-106
- C2 -
-
1L7M
-
SERB_METJA
A:
[3-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
K
L
I
L
F
D
F
D
S
T
L
V
N
N
E
T
I
D
E
I
A
R
E
A
G
V
E
E
E
V
K
K
I
T
K
E
A
M
E
G
K
L
N
F
E
Q
S
L
R
K
R
V
S
L
L
K
D
L
P
I
E
K
V
E
K
A
I
K
R
I
T
-
P
T
E
G
A
E
E
T
I
K
E
L
K
N
R
G
Y
V
V
A
V
V
S
G
G
F
D
I
A
V
N
K
I
K
E
K
L
G
L
D
--
Y
A
F
A
N
R
L
I
V
K
D
G
K
L
T
G
D
V
E
G
E
-----
V
L
K
E
N
A
K
G
E
I
L
E
K
I
A
K
I
E
G
I
N
L
E
D
T
V
A
V
G
D
G
A
N
D
I
----
S
M
F
K
K
A
G
L
K
I
A
F
C
A
K
P
I
L
K
E
K
A
D
I
C
I
E
K
R
D
L
R
E
I
L
K
Y
I
--------------
80
HHSearch
66.39
45%
-105
- C2 -
-
1F5S
-
SERB_METJA
A:
[2-210]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
K
K
K
L
I
L
F
D
F
D
S
T
L
V
N
N
E
T
I
D
E
I
A
R
E
A
G
V
E
E
E
V
K
K
I
T
K
E
A
M
E
G
K
L
N
F
E
Q
S
L
R
K
R
V
S
L
L
K
D
L
P
I
E
K
V
E
K
A
I
K
R
I
T
-
P
T
E
G
A
E
E
T
I
K
E
L
K
N
R
G
Y
V
V
A
V
V
S
G
G
F
D
I
A
V
N
K
I
K
E
K
L
G
L
D
--
Y
A
F
A
N
R
L
I
V
K
D
G
K
L
T
G
D
V
E
G
E
-----
V
L
K
E
N
A
K
G
E
I
L
E
K
I
A
K
I
E
G
I
N
L
E
D
T
V
A
V
G
D
G
A
N
D
I
----
S
M
F
K
K
A
G
L
K
I
A
F
C
A
K
P
I
L
K
E
K
A
D
I
C
I
E
K
R
D
L
R
E
I
L
K
Y
I
--------------
98
Fugue
66.29
44%
-104
* C2 *
-
1F5S
-
SERB_METJA
A:
[2-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
K
K
K
L
I
L
F
D
F
D
S
T
L
V
N
N
E
T
I
D
E
I
A
R
E
A
G
V
E
E
E
V
K
K
I
T
K
E
A
M
E
G
K
L
N
F
E
Q
S
L
R
K
R
V
S
L
L
K
D
L
P
I
E
K
V
E
K
A
I
K
R
I
T
-
P
T
E
G
A
E
E
T
I
K
E
L
K
N
R
G
Y
V
V
A
V
V
S
G
G
F
D
I
A
V
N
K
I
K
E
K
L
G
L
D
--
Y
A
F
A
N
R
L
I
V
K
D
G
K
L
T
G
D
V
E
G
E
-----
V
L
K
E
N
A
K
G
E
I
L
E
K
I
A
K
I
E
G
I
N
L
E
D
T
V
A
V
G
D
G
A
N
D
I
----
S
M
F
K
K
A
G
L
K
I
A
F
C
A
K
P
I
L
K
E
K
A
D
I
C
I
E
K
R
D
L
R
E
I
L
K
Y
I
K
-------------
14
PsiBlast_PDB
65.97
44%
-106
- C2 -
-
1L7N
1
SERB_METJA
A:
[3-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
K
L
I
L
F
D
F
D
S
T
L
V
N
N
E
T
I
D
E
I
A
R
E
A
G
V
E
E
E
V
K
K
I
T
K
E
A
M
E
G
K
L
N
F
E
Q
S
L
R
K
R
V
S
L
L
K
D
L
P
I
E
K
V
E
K
A
I
K
R
I
T
-
P
T
E
G
A
E
E
T
I
K
E
L
K
N
R
G
Y
V
V
A
V
V
S
G
G
F
D
I
A
V
N
K
I
K
E
K
L
G
L
D
--
Y
A
F
A
N
R
L
I
V
K
D
G
K
L
T
G
D
V
E
G
E
-----
V
L
K
E
N
A
K
G
E
I
L
E
K
I
A
K
I
E
G
I
N
L
E
D
T
V
A
V
G
D
G
A
N
D
I
----
S
M
F
K
K
A
G
L
K
I
A
F
C
A
K
P
I
L
K
E
K
A
D
I
C
I
E
K
R
D
L
R
E
I
L
K
Y
I
--------------
23
PsiBlast_CBE
39.49
33%
-21
- C2 -
-
1L8O
1
SERB_HUMAN
B:
[17-197]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
F
D
V
D
S
T
V
I
R
E
E
G
I
D
E
L
A
K
I
C
G
V
E
D
A
V
S
E
M
T
R
R
A
M
G
G
A
V
P
F
K
A
A
L
T
E
R
L
A
L
I
Q
P
S
R
E
Q
V
Q
R
L
I
A
E
Q
P
P
H
L
T
P
G
I
R
E
L
V
S
R
L
Q
E
R
N
V
Q
V
F
L
I
S
G
G
F
R
S
I
V
E
H
V
A
S
K
L
N
I
P
AT
N
V
F
A
N
R
L
K
F
---
Y
F
N
G
E
Y
A
G
F
DETQP
T
A
E
S
G
G
K
G
K
V
I
K
F
L
K
E
K
F
--
H
F
K
K
I
I
M
I
G
D
G
A
T
D
M
EACP
P
A
D
A
F
I
G
F
G
-------------------------------------------
19
PsiBlast_PDB
38.14
33%
-28
- C2 -
-
1L8O
1
SERB_HUMAN
A:
[17-197]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
F
D
V
D
S
T
V
I
R
E
E
G
I
D
E
L
A
K
I
C
G
V
E
D
A
V
S
E
M
T
R
R
A
M
G
G
A
V
P
F
K
A
A
L
T
E
R
L
A
L
I
Q
P
S
R
E
Q
V
Q
R
L
I
A
E
Q
P
P
H
L
T
P
G
I
R
E
L
V
S
R
L
Q
E
R
N
V
Q
V
F
L
I
S
G
G
F
R
S
I
V
E
H
V
A
S
K
L
N
I
P
AT
N
V
F
A
N
R
L
K
F
---
Y
F
N
G
E
Y
A
G
F
DETQP
T
A
E
S
G
G
K
G
K
V
I
K
F
L
K
E
K
F
--
H
F
K
K
I
I
M
I
G
D
G
A
T
D
M
E
A
C
P
P
A
D
A
F
I
G
F
G
-------------------------------------------