@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPV1: (2017-11-23 )
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINTSVACVEQIVNEGRTAYGINTGFGLLASTKIAPEDLEKLQRSLVLSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVIDALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGESKARYKGEWLPAVEALKIAGLEPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARIHEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAEQGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMMDRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWYMADNVCGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRFFAPDIEQASELLASGCLNELLIPKLLPSLSEV
Atome Classification :
(20 SA)
.........10........20--........--.30........40........50........60........70........80.......---.90........100.......110.......120.......130.......140.......150.......160--....-...-.170.......180.......190.......200.......210.......220.......230.......240.-......250.......260.------.....--------------.270------------....--------.----...280.......290.......300.......310......-.320.--......330.......340.......350.......360...-.-...370..-.--.---....380.......390.......400.......--410.......420.......430.......440.......450---.--.---------...-..460.......470..-.....480--------......-..490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MELLIQPGKL
T
L
A
D
L
R
Q
AYL---N
P
I
K
V
K
LD--ESA
S
S
AI
N
T
S
V
A
C
V
E
Q
I
V
NEGR
T
A
Y
GINTGFGLLASTKI
A
P
E
D
L
E
K
L
Q
R
S
L
V
L
S
HAAGV
G
---
E
A
L
D
D
A
M
V
R
L
I
I
L
L
K
A
N
S
L
A
R
G
F
S
G
I
R
R
K
V
I
D
A
L
L
A
L
INAE
V
Y
PHIPLKGSVGASGD
L
A
P
L
A
H
M
S
L
V
L
LGESK---ARYK-GEW-L
P
A
V
E
A
L
KIAGLEP
I
S
L
A
A
KE
G
L
A
L
LNGTQ
V
S
T
A
Y
A
L
R
G
L
F
E
A
E
D
L
F
A
A
A
T
V
CGGL
S
V
E
A
M
LGSRAPF
D
A
R
I
H
E
V-RGQRG
Q
I
D
V
A
A
A
Y
R
D
LLT
D
S
------
S
E
I
S
R
--------------
S
H
E
-------------
E
CGK--------V----QDPYSLRC
Q
P
Q
V
M
G
A
C
L
T
Q
I
R
Q
A
A
E
V
L
E
I
E
ANAVSDN
P
L
V
F
A
-EQGDV--ISGGNFHAE
P
V
A
M
AAD
N
L
A
L
A
I
A
E
IG
S
L
S
E
R
R
I
S
M
M
M
D
R
H
M
S
-Q-LP
P
F
L
-
V
A-N--G---GVNS
G
F
M
I
A
Q
V
T
A
A
A
LASDNKALAHPASVDSLPT--SANQED
H
V
SMAPNAG
K
R
L
W
Y
M
A
DN
V
C
G
I
L
A
V
E
W
L
G
ACQGL
D
F
R
---
E
--G---------LKS-SP
K
L
E
Q
A
R
K
I
L
R
DQVPY-YSEDRFF---------AP
D
I
E
Q
-
A
S
E
L
L
A
S
G
C
L
N
E
L
L
I
P
K
L
L
P
S
LSEV
4
PsiBlast_PDB
99.32
79%
-96
- C5 -
-
1B8F
1
HUTH_PSEPU
A:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
2
PsiBlast_PDB
99.14
79%
-95
- C5 -
-
1GK3
1
HUTH_PSEPU
A:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
A
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
6
PsiBlast_PDB
99.07
78%
-96
- C5 -
-
1EB4
1
HUTH_PSEPU
A:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
A
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
1
PsiBlast_PDB
98.93
79%
-94
- C5 -
-
1GK2
1
HUTH_PSEPU
A:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
22
PsiBlast_CBE
98.68
79%
-93
- C5 -
-
1GK2
1
HUTH_PSEPU
C:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
5
PsiBlast_PDB
98.62
78%
-97
- C5 -
-
1GKJ
1
HUTH_PSEPU
A:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
F
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
23
PsiBlast_CBE
98.57
79%
-93
- C5 -
-
1GK2
1
HUTH_PSEPU
B:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
21
PsiBlast_CBE
98.08
79%
-92
- C5 -
-
1GK2
1
HUTH_PSEPU
D:
[2-509]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
A
S
G
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
G
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
3
PsiBlast_PDB
75.44
79%
-41
- C5 -
-
1GKM
3
HUTH_PSEPU
A:
[2-507]
-
E
L
T
L
K
P
G
T
L
T
L
A
Q
L
R
A
I
H
A
---
A
P
V
R
L
Q
L
D
--
A
S
A
A
P
A
I
D
A
S
V
A
C
V
E
Q
I
I
A
E
D
R
T
A
Y
G
I
N
T
G
F
G
L
L
A
S
T
R
I
A
S
H
D
L
E
N
L
Q
R
S
L
V
L
S
H
A
A
G
I
G
---
A
P
L
D
D
D
L
V
R
L
I
M
V
L
K
I
N
S
L
S
R
G
F
S
G
I
R
R
K
V
I
D
A
L
I
A
L
V
N
A
E
V
Y
P
H
I
P
L
K
G
S
V
G
M
D
-
D
L
A
P
L
A
H
M
S
L
V
L
L
G
E
G
K
---
A
R
Y
K
-
G
Q
W
-
L
S
A
T
E
A
L
A
V
A
G
L
E
P
L
T
L
A
A
K
E
G
L
A
L
L
N
G
T
Q
A
S
T
A
Y
A
L
R
G
L
F
Y
A
E
D
L
Y
A
A
A
I
A
C
G
G
L
S
V
E
A
V
L
G
S
R
S
P
F
D
A
R
I
H
E
A
-
R
G
Q
R
G
Q
I
D
T
A
A
C
F
R
D
L
L
G
D
S
------
S
E
V
S
L
--------------
S
H
K
-------------
N
A
D
K
--------
V
----
Q
D
P
Y
S
L
R
C
Q
P
Q
V
M
G
A
C
L
T
Q
L
R
Q
A
A
E
V
L
G
I
E
A
N
A
V
S
D
N
P
L
V
F
A
-
A
E
G
D
V
--
I
S
G
G
N
F
H
A
E
P
V
A
M
A
A
D
N
L
A
L
A
I
A
E
I
G
S
L
S
E
R
R
I
S
L
M
M
D
K
H
M
S
-
Q
-
L
P
P
F
L
-
V
E
-
N
--
G
---
G
V
N
S
G
F
M
I
A
Q
V
T
A
A
A
L
A
S
E
N
K
A
L
S
H
P
H
S
V
D
S
L
P
T
--
S
A
N
Q
E
D
H
V
S
M
A
P
A
A
G
K
R
L
W
E
M
A
E
N
T
R
G
V
L
A
I
E
W
L
G
A
C
Q
G
L
D
L
R
---
K
--
G
---------
L
K
T
-
S
A
K
L
E
K
A
R
Q
A
L
R
S
E
V
A
H
-
Y
D
R
D
R
F
F
---------
A
P
D
I
E
K
-
A
V
E
L
L
A
K
G
S
L
T
G
L
L
P
A
G
V
L
P
S
L
---
34
HHSearch
64.45
35%
-46
* C5 *
-
2O6Y
-
TALY_RHOS4
B:
[10-522]
-
A
V
E
L
D
R
-
H
I
D
L
D
Q
A
H
A
V
A
S
---
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
---
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
F--
L
D
R
D
-
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
-------
S
A
R
V
V
--------------
R
H
V
IAERRLDAGDIGT
E
P
E
A
--------
G
----
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
V
F
P
P
D
G
S
V
P
A
--
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
R
G
-
L
P
P
F
L
-
H
R
G
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
-
G
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
---
C
GS
G
L--------
D
G
V
-
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
A
A
-
L
A
T
H
L
L
Q
Q
S
P
---------------
8
PsiBlast_PDB
61.40
35%
-42
- C5 -
-
3KDY
-
TAM_STRGL
A:
[48-524]
------------------------------------------
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
A
M
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
---
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
---
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
Y
---
V
L
R
D
-
G
R
P
-
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
GLTVE
H
A
D
L
R
R
E
L
Q
-----------
K
D
K
-------------
E
A
G
K
D
V
Q
R
S
EIY
L
----
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
--
E
G
K
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
S
G
D
--
P
---
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
A
S
T
Q
S
V
P
S
--
N
G
D
N
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
--
G
---------
L
---
S
P
A
A
K
A
T
Y
E
A
V
R
R
L
V
P
T
-
L
G
V
D
R
Y
M
---------
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
-----------------
12
PsiBlast_PDB
61.02
35%
-44
- C5 -
-
2OHY
-
TAM_STRGL
A:
[48-524]
------------------------------------------
S
R
E
I
F
E
G
I
A
E
Q
N
I
P
I
Y
G
V
T
T
G
Y
G
E
M
I
Y
M
Q
V
D
K
S
K
E
V
E
L
Q
T
N
L
V
R
S
H
S
A
G
V
G
---
P
L
F
A
E
D
E
A
R
A
I
V
A
A
R
L
N
T
L
A
K
G
H
S
A
V
R
P
I
I
L
E
R
L
A
Q
Y
L
N
E
G
I
T
P
A
I
P
E
I
G
S
L
G
---
D
L
A
P
L
S
H
V
A
S
T
L
I
G
E
G
Y
---
V
L
R
D
-
G
R
P
-
V
E
T
A
Q
V
L
A
E
R
G
I
E
P
L
E
L
R
F
K
E
G
L
A
L
I
N
G
T
S
G
M
T
G
L
G
S
L
V
V
G
R
A
L
E
Q
A
Q
Q
A
E
I
V
T
A
L
L
I
E
A
V
R
G
S
T
S
P
F
L
A
E
G
H
D
I
A
R
P
H
E
G
Q
I
D
T
A
A
N
M
R
A
L
M
R
G
S
GLTVE
H
A
D
L
R
R
E
L
Q
-----------
K
D
K
-------------
E
A
G
K
D
V
Q
R
S
EIY
L
----
Q
K
A
Y
S
L
R
A
I
P
Q
V
V
G
A
V
R
D
T
L
Y
H
A
R
H
K
L
R
I
E
L
N
S
A
N
D
N
P
L
F
F
--
E
G
K
E
I
--
F
H
G
A
N
F
H
G
Q
P
I
A
F
A
M
D
F
V
T
I
A
L
T
Q
L
G
V
L
A
E
R
Q
I
N
R
V
L
N
R
H
L
S
-
Y
G
L
P
E
F
L
-
V
S
G
D
--
P
---
G
L
H
S
G
F
A
G
A
Q
Y
P
A
T
A
L
V
A
E
N
R
T
I
G
-
P
A
S
T
Q
S
V
P
S
--
N
G
D
N
Q
D
V
V
S
M
G
L
I
S
A
R
N
A
R
R
V
L
S
N
N
N
K
I
L
A
V
E
Y
L
A
A
A
Q
A
V
D
I
S
GRF
D
--
G
---------
L
---
S
P
A
A
K
A
T
Y
E
A
V
R
R
L
V
P
T
-
L
G
V
D
R
Y
M
---------
A
D
D
I
E
L
-
V
A
D
A
L
S
R
G
-----------------
36
HHSearch
58.54
30%
-17
- C5 -
-
2NYN
-
PAL_ANAVT
B:
[25-563]
-
N
V
I
I
G
N
Q
K
L
T
I
N
D
V
A
R
V
A
R
---
N
G
T
L
V
S
L
T
NN
T
D
I
L
Q
G
I
Q
A
S
C
D
Y
I
N
N
A
V
E
S
G
-----------------
I
S
R
E
Q
A
S
E
L
Q
T
N
L
V
W
F
L
K
T
G
A
G
---
N
K
L
P
L
A
D
V
R
A
A
M
L
L
R
A
N
S
H
M
R
G
A
S
G
I
R
L
E
L
I
K
R
M
E
I
F
L
N
A
G
V
T
P
Y
V
Y
E
F
G
S
I
G
---
D
L
V
P
L
S
Y
I
T
G
S
L
I
G
L
D
P
SFK
V
D
F
N
-
G
K
E
-
M
D
A
P
T
A
L
R
Q
L
N
L
S
P
L
T
L
L
P
K
E
G
L
A
M
M
N
G
T
S
V
M
T
G
I
A
A
N
C
V
Y
D
T
Q
I
L
T
A
I
A
M
G
V
H
A
L
D
I
Q
A
L
N
G
T
N
Q
S
F
H
P
F
I
H
N
S
-
K
P
H
P
G
Q
L
W
A
A
D
Q
M
I
S
L
L
A
N
-------
S
Q
L
V
R
--------------
D
E
L
DGK----------------------
I
----
Q
D
R
Y
S
L
R
C
L
P
Q
Y
L
G
P
I
V
D
G
I
S
Q
I
A
K
Q
I
E
I
E
I
N
S
V
T
D
N
P
L
I
D
V
-
D
N
Q
A
S
--
Y
H
G
G
N
F
L
G
Q
Y
V
G
M
G
M
D
H
L
R
Y
Y
I
G
L
L
A
K
H
L
D
V
Q
I
A
L
L
A
S
P
E
F
S
N
G
-
L
P
P
S
L
-
L
G
-
N
RE
R
---
K
V
N
M
G
L
K
G
L
Q
I
C
G
N
S
I
M
P
L
L
T
F
Y
G
N
S
I
-
A
D
R
F
P
T
HA
E
Q
F
N
Q
N
I
N
S
Q
G
Y
T
S
A
T
L
A
R
R
S
V
D
I
F
Q
N
Y
V
A
I
A
L
M
F
G
V
Q
A
V
D
L
R
---
T
--
Y
KKTGHYDAR
A
C
L
-
S
P
A
T
E
R
L
Y
S
A
V
R
H
V
V
G
Q
K
P
T
S
D
R
P
Y
IWNDNEQGL
D
E
H
I
A
R
I
S
A
D
I
A
A
G
G
V
-
I
V
Q
A
V
Q
D
I
L
------
14
PsiBlast_PDB
57.32
35%
1
- C5 -
-
2O6Y
-
TALY_RHOS4
A:
[18-510]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
---
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVIAE
R
R
L
D
AGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
18
PsiBlast_PDB
55.38
35%
-22
- C5 -
-
2O7E
3
TALY_RHOS4
A:
[18-508]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
F
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVI
A
E
R
R
LDAGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
16
PsiBlast_PDB
55.08
35%
-23
- C5 -
-
2O7D
3
TALY_RHOS4
A:
[18-508]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVI
A
E
R
R
LDAGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
19
PsiBlast_PDB
54.96
35%
-24
- C5 -
-
2O7F
3
TALY_RHOS4
A:
[18-508]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
F
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVI
A
E
R
R
LDAGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
17
PsiBlast_PDB
54.88
35%
-23
- C5 -
-
2O78
3
TALY_RHOS4
A:
[18-508]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
F
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVI
A
E
R
R
LDAGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
15
PsiBlast_PDB
54.66
35%
-23
- C5 -
-
2O7B
3
TALY_RHOS4
A:
[18-508]
-------------
D
L
D
Q
A
H
A
V
A
S
G
G
A
R
I
V
L
A
--
P
P
A
R
D
R
C
R
A
S
E
A
R
L
G
A
V
I
R
E
A
R
H
V
Y
G
L
T
T
G
F
G
P
L
A
N
R
L
I
S
G
E
N
V
R
T
L
Q
A
N
L
V
H
H
L
A
S
G
V
G
---
P
V
L
D
W
T
T
A
R
A
M
V
L
A
R
L
V
S
I
A
Q
G
A
S
G
A
S
E
G
T
I
A
R
L
I
D
L
L
N
S
E
L
A
P
A
V
P
S
R
G
T
V
G
M
D
-
D
L
T
P
L
A
H
M
V
L
C
L
Q
G
R
G
D
---
F
L
D
R
D
G
T
R
-
L
D
G
A
E
G
L
R
R
G
R
L
Q
P
L
D
L
S
H
R
D
A
L
A
L
V
N
G
T
S
A
M
T
G
I
A
L
V
N
A
H
A
C
R
H
L
G
N
W
A
V
A
L
T
A
L
L
A
E
C
L
R
G
R
T
E
A
W
A
A
A
L
S
D
L
-
R
P
H
P
G
Q
K
D
A
A
A
R
L
R
A
R
V
D
G
S
------
A
R
V
V
R
HVI
A
E
R
R
LDAGDIG
T
E
P
-------------
E
A
G
--------------
Q
D
A
Y
S
L
R
C
A
P
Q
V
L
G
A
G
F
D
T
L
A
W
H
D
R
V
L
T
I
E
L
N
A
V
T
D
N
P
-
V
F
P
-
P
D
G
S
V
P
A
L
H
G
G
N
F
M
G
Q
H
V
A
L
T
S
D
A
L
A
T
A
V
T
V
L
A
G
L
A
E
R
Q
I
A
R
L
T
D
E
R
L
N
-
R
G
L
P
P
F
L
H
R
G
-
P
--
A
---
G
L
N
S
G
F
M
G
A
Q
V
T
A
T
A
L
L
A
E
M
R
A
T
G
-
P
A
S
I
H
S
I
S
T
--
N
A
A
N
Q
D
V
V
S
L
G
T
I
A
A
R
L
C
R
E
K
I
D
R
W
A
E
I
L
A
I
L
A
L
C
L
A
Q
A
A
E
L
R
CG-
S
--
G
---------
L
D
G
V
S
P
A
G
K
K
L
V
Q
A
L
R
E
Q
F
P
P
-
L
E
T
D
R
P
L
---------
G
Q
E
I
----------------------------
20
PsiBlast_PDB
54.14
31%
-25
- C5 -
-
4C5U
-
?
A:
[49-516]
-------------------------
V
K
V
A
L
E
A-
E
Q
C
R
A
R
V
E
T
C
S
S
W
V
Q
R
K
A
E
D
G
A
D
I
Y
G
V
T
T
G
F
G
A
C
S
S
R
R
T
--
N
R
L
S
E
L
Q
E
S
L
I
R
C
L
L
A
G
V
F
T
KV
D
E
L
P
A
T
A
T
R
S
A
M
L
L
R
L
N
S
F
T
Y
G
C
S
G
I
R
W
E
V
M
E
A
L
E
K
L
L
N
S
N
V
S
P
K
V
P
L
R
G
S
V
S
A
S
G
D
L
I
P
L
A
Y
I
A
G
L
L
I
G
K
P
S
V
I
-
A
R
I
G
-
D
D
V
E
V
P
A
P
E
A
L
S
R
V
G
L
R
P
F
K
L
Q
A
K
E
G
L
A
L
V
N
G
T
S
F
A
T
A
V
A
S
T
V
M
Y
D
A
N
V
L
L
L
L
V
E
T
L
C
G
M
F
C
E
V
I
F
G
R
E
E
F
A
H
P
L
I
H
K
V
-
K
P
H
P
G
Q
I
E
S
A
E
L
L
E
W
L
L
R
S
S
P
F
----
Q
E
L
S
R
--------------
E
Y
Y
-------------
S
I
D
K
--------
L
KKPK
Q
D
R
A
A
L
R
S
S
P
Q
W
L
A
P
L
V
Q
T
I
R
D
A
T
T
T
V
E
T
E
V
N
S
A
N
D
N
P
I
I
D
H
-
A
N
D
R
A
--
L
H
-----
G
S
A
V
G
F
Y
M
D
Y
V
R
I
A
V
A
G
L
G
K
L
L
F
A
Q
F
T
E
L
M
I
E
Y
Y
S
-
N
-
G
L
P
G
N
-
L
S
-
L
--
G
PDL
S
V
D
Y
G
L
K
G
L
D
I
A
M
A
A
Y
S
S
E
L
Q
Y
L
A
N
P
V
T
T
H
V
H
S
A
--
E
Q
H
N
Q
D
I
N
S
L
A
L
I
S
A
R
K
T
E
E
A
L
D
I
L
K
L
M
I
A
S
H
L
T
A
M
C
Q
A
V
D
L
R
---
Q
----------------------------------------------------------------------------------