@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPX3: (2017-11-23 )
MTQQAQTIQGSIVAIVTPMLKDGGVDWKSLEKLVEWHIEQGTNSIVAVGTTGEASTLSMEEHTQVIKEIIRVANKRIPIIAGTGANSTREAIELTKAAKDLGADAALLVTPYYNKPTQEGLYQHYKAIAEAVELPLILYNVPGRTGVDLSNDTAVRLAEIPNIVGIKDATGDVPRGKALIDALNGKMAVYSGDDETAWELMLLGADGNISVTANIAPKAMSEVCAVAIAKDEQQAKTLNNKIANLHNILFCESNPIPVKWALHEMGLIDTGIRLPLTPLAEQYREPLRNALKDAGII
Atome Classification :
(66 SA)
.......--..10........20........30........40........50........60........70...-.....80........90........100....-...110.......120.......130.......140.......150......-.160.......170---.......180.......190..----.....200.......210.......220.......230.......240--........250.......260......-.270-.....-...280.......290.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQQAQT--IQ
G
S
I
V
A
I
V
T
P
M
L
KDGGV
D
W
K
S
L
E
K
L
V
E
W
H
I
EQGTN
S
I
V
A
V
GTTGEASTL
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
VAN-KRI
P
I
I
A
GTGANS
T
R
E
A
I
E
L
T
K
A
A
K
DLGA
D
A
A
-
L
L
VTPYYNKP
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
VEL
P
L
I
L
Y
NVPGRTGVDLSND
T
A
V
R
L
A-EIP
N
I
VGIKDATGD---VPR
G
K
A
L
I
D
ALNG
K
M
A
V
Y
SGDD----E
T
A
W
E
L
M
L
L
GADG
N
I
S
V
T
ANI
A
P
K
A
M
S
E
V
C
A
V
AIAK
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
CESNPI
P
V
K
W
A
L
H
EMGLI-DT-G-IRLPL-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
DAGII
24
PsiBlast_CBE
97.48
100%
-101
- C3 -
-
3TDF
1
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
28
PsiBlast_CBE
97.15
100%
-100
- C3 -
-
3PUL
5
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
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E
K
L
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E
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I
E
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G
T
N
S
I
V
A
V
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T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
5
PsiBlast_PDB
96.93
100%
-97
- C3 -
-
3TAK
3
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
1
PsiBlast_PDB
96.59
100%
-104
- C3 -
-
3PUD
4
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
6
PsiBlast_PDB
96.56
100%
-97
- C3 -
-
3TCE
2
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
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E
K
L
V
E
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I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
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G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
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N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
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M
L
L
G
A
D
G
N
I
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V
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A
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K
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M
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E
V
C
A
V
A
I
A
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E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
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P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
30
PsiBlast_CBE
96.53
100%
-97
- C3 -
-
3PUD
3
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
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T
N
S
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A
V
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E
A
S
T
L
S
M
E
E
H
T
Q
V
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K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
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V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
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I
L
Y
N
V
P
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N
D
T
A
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L
A
-
E
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D
A
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---
V
P
R
G
K
A
L
I
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A
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Y
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D
D
----
E
T
A
W
E
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M
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A
D
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K
A
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E
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C
A
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A
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E
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Q
A
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T
L
N
N
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---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
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A
L
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I
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D
T
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G
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I
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L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
26
PsiBlast_CBE
96.49
100%
-98
- C3 -
-
3TAK
5
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
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-
K
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E
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Q
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K
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Y
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A
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R
L
A
-
E
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D
---
V
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R
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K
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A
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Y
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D
D
----
E
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A
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K
A
M
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E
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C
A
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A
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A
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Q
A
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T
L
N
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---
I
A
N
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H
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F
C
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N
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A
E
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Y
R
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P
L
R
N
A
L
K
D
A
G
I
I
152
HHSearch
96.24
100%
-99
- C3 -
-
3TAK
5
?
B:
[2-291]
---------
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
29
PsiBlast_CBE
96.21
100%
-98
- C3 -
-
3PUE
4
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
10
PsiBlast_PDB
96.21
100%
-99
- C3 -
-
4DXV
1
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
4
PsiBlast_PDB
96.16
100%
-100
- C3 -
-
3RK8
7
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
8
PsiBlast_PDB
95.75
100%
-98
- C3 -
-
3U8G
-
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
2
PsiBlast_PDB
95.54
100%
-101
- C3 -
-
3PUE
2
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
3
PsiBlast_PDB
95.53
100%
-100
- C3 -
-
3PUL
4
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
9
PsiBlast_PDB
95.49
100%
-98
- C3 -
-
3UQN
2
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
153
HHSearch
95.45
100%
-99
- C3 -
-
3U8G
-
?
A:
[2-291]
---------
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
27
PsiBlast_CBE
95.44
100%
-101
- C3 -
-
3RK8
7
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
7
PsiBlast_PDB
95.35
100%
-97
- C3 -
-
3TDF
1
?
A:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
22
PsiBlast_CBE
95.17
100%
-100
- C3 -
-
3UQN
2
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
25
PsiBlast_CBE
94.53
100%
-100
- C3 -
-
3TCE
2
?
B:
[1-291]
------
T
--
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
N
-
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
---
V
P
R
G
K
A
L
I
D
A
L
N
G
K
M
A
V
Y
S
G
D
D
----
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
-
G
-
I
R
L
P
L
-
T
P
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
151
HHSearch
84.11
61%
-103
- C3 -
-
3S8H
1
DAPA_PSEAE
B:
[2-290]
---------
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
-
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
V
P
N
I
I
G
I
K
E
A
T
G
D
---
L
Q
R
A
K
E
V
I
E
R
V
G
K
D
F
L
V
Y
S
G
D
D
----
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
-
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
-
35
PsiBlast_CBE
82.96
60%
-107
- C3 -
-
3PUO
3
DAPA_PSEAE
B:
[2-291]
---------
I
A
G
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
V
R
R
V
V
D
Q
V
K
-
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
L
P
E
T
V
E
R
L
S
-
K
V
P
N
I
I
G
I
K
E
A
T
G
D
---
L
Q
R
A
K
E
V
I
E
R
V
G
K
D
F
L
V
Y
S
G
D
D
----
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
P
E
-
G
-
I
R
L
P
L
-
T
W
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
39
PsiBlast_CBE
81.72
54%
-96
- C3 -
-
4PFM
4
?
B:
[1-292]
-----
H
M
--
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
-
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
-
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
V
P
N
I
I
G
V
-
D
A
T
G
D
---
V
A
R
V
K
Q
L
R
D
L
C
G
N
D
F
L
L
Y
S
G
D
D
----
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
---
I
K
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
-
S
Q
-
G
D
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
-
148
HHSearch
81.56
50%
-99
- C3 -
-
3FLU
8
DAPA_NEIMB
A:
[5-296]
----
F
T
M
--
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
-
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
-
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
N
---
I
G
S
N
I
E
L
I
N
R
A
P
E
G
F
V
V
L
S
G
D
D
----
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
---
L
I
P
I
Y
D
T
M
F
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
-
E
P
-
H
-
V
R
L
P
L
-
V
P
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
-
45
PsiBlast_CBE
81.24
51%
-97
- C3 -
-
1YXD
2
DAPA_ECOLI
B:
[2-292]
---------
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
-
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
N
---
L
T
R
V
N
Q
I
K
E
L
V
S
D
D
F
V
L
L
S
G
D
D
----
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
-
A
T
-
D
T
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
156
HHSearch
81.20
54%
-97
- C3 -
-
4PFM
4
?
A:
[1-292]
-----
H
M
--
I
N
G
S
I
V
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
I
A
V
V
G
Q
T
V
K
F
A
S
-
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
-
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
L
P
E
T
I
A
Q
L
V
-
E
V
P
N
I
I
G
V
-
D
A
T
G
D
---
V
A
R
V
K
Q
L
R
D
L
C
G
N
D
F
L
L
Y
S
G
D
D
----
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
---
I
K
G
L
F
S
A
L
F
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
-
D
-
I
R
L
P
L
-
T
E
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
-
46
PsiBlast_CBE
81.17
51%
-95
- C3 -
-
1YXD
1
DAPA_ECOLI
A:
[2-292]
---------
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
-
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
K
E
A
T
G
N
---
L
T
R
V
N
Q
I
K
E
L
V
S
D
D
F
V
L
L
S
G
D
D
----
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
-
A
T
-
D
T
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
59
PsiBlast_CBE
80.94
50%
-98
- C3 -
-
5T25
2
DAPA_ECOLI
B:
[2-293]
------
M
--
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
-
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
-
E
A
T
G
N
---
L
T
R
V
N
Q
I
K
E
L
V
S
D
D
F
V
L
L
S
G
D
D
----
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
-
A
T
-
D
T
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
61
PsiBlast_CBE
80.86
50%
-99
- C3 -
-
5T26
2
DAPA_ECOLI
B:
[2-294]
-----
H
M
--
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
-
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
-
E
A
T
G
N
---
L
T
R
V
N
Q
I
K
E
L
V
S
D
D
F
V
L
L
S
G
D
D
----
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
-
A
T
-
D
T
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
53
PsiBlast_CBE
80.85
50%
-100
- C3 -
-
3I7Q
5
DAPA_ECOLI
B:
[2-292]
---------
F
T
G
S
I
V
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
A
D
-
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
L
P
E
T
V
G
R
L
A
-
K
V
K
N
I
I
G
I
R
E
A
T
G
N
---
L
T
R
V
N
Q
I
K
E
L
V
S
D
D
F
V
L
L
S
G
D
D
----
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
-
A
T
-
D
T
L
R
L
P
M
-
T
P
I
T
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L