@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPY0: (2017-11-23 )
MSDTHIPLPERLRPRDLSEIIGQDHLLGEHAPLRQMIDQGHLPSIIFWGPPGVGKTTIALLLAQAIDRPFVSLSALNTGVKELREVIAESGDLLTPVVFIDEIHRFNKSQQDALLGAVEKGKITLIGATTENPSFEVNSALLSRCQVYTLNSLDSEAIQTLLNNALQNDKFLKERYIHIEEYDALLQFAAGDARKALNLLDLIASTFEPEVENTITNAVVVKVAQQNIARYDKSGEQHYDLVSAFIKSIRGSDPDAALYWMARMLKGGEDPVFIARRMLIAASEDIGNSNPNALLLAGECFRSVQAVGMPEARIILGQTAVYLATSAKSNSTYLAINKALELAEKTANLPVPLHLRNAPTKLMKQQGYGINYLYPHDYPEHFVLQDYLPPELKGTKLYESARNKREVEGERLQQRRWQQEQ
Atome Classification :
(20 SA)
------.........10........20........30........40...-......50........60.....-----.-----.-----.--70...----------------------..------.-.-.80.-....------------------.---..----90-----.----....-----------.----...-----------100.......110.......120.........130.......140.......150.......160.......170.----..-.....180.......190.......200.......210.........220-.-......230.......240.....--..250.......260....-....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380....-...390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------MSDTHIPLPERL
R
P
R
D
L
S
E
I
IGQDHLLGE
H
A
P
L
R
Q
M
I
DQG-HL
P
-
S
I
I
F
WGPPGV
G
K
T
T
I
A
L
L
L
A
Q
A
I-----D-----R-----P--
F
V
S
L
S
----------------------
A
L
------
N
-
T
-
G
V
K
E
-
L
R
E
V
------------------
I
---AE----S------G----D
L
L
T
-----------
P
----
V
V
F
-----------
I
D
E
I
H
R
FNKS
Q
Q
D
A
L
L
G
AVEK--G
K
I
T
L
I
G
ATTENPSF
E
V
N
S
A
L
L
SR
C
Q
V
Y
T
LNSL
D
S
E
A
I
Q
T
L
L
N
N
A
LQN
D
K
F
-
L
----
K
E
-
R
Y
I
H
I
E
E
Y
D
A
L
L
Q
FAAG
D
A
R
K
A
L
N
L
L
D
L
I
A
S
TFEP
E
--
V
E
N
T
I
T
N
A
V
V
V
K
-
V
-
A
Q
Q
N
I
A
RYDKSG
E
Q
H
Y
D
L
V
S
A
F
I
K
--
S
I
RGSDP
D
A
A
L
Y
W
M
-
A
R
M
L-KGGE
D
P
V
F
I
A
R
R
M
L
I
AASEDIGNSNP
N
A
L
L
L
A
G
E
C
F
R
S
V
Q
A
VGMP
E
A
R
I
I
L
GQ
T
A
V
Y
L
A
TSAKSN
S
T
Y
L
A
I
N
K
A
L
E
L
A
E
K
TANL
P
V
P
L
H
LRNA
P
T
K
L
M
K
QQGYG
I
N
YLYPHDYPEH
F
V
L
Q
D-YLPPELKG
T
K
L
Y
E
S
ARNKREV
E
G
E
R
L
Q
Q
R
RWQQEQ
1
PsiBlast_PDB
72.63
43%
1
- C2 -
-
3PVS
-
RARA_ECOLI
A:
[14-437]
-----------
Q
P
L
A
A
R
M
R
P
E
N
L
A
Q
Y
I
G
Q
Q
H
L
L
A
A
G
K
P
L
P
R
A
I
E
A
G
-
H
L
H
-
S
M
I
L
W
G
P
P
G
T
G
K
T
T
L
A
E
V
I
A
R
Y
A
-----
N
-----
A
-----
D
--
V
E
R
I
S
----------------------
A
V
------
T
-
S
-
G
V
K
E
-
I
R
E
A
------------------
I
---
E
R
----
A
------
R
----
Q
N
R
N
-----------
A
G
R
R
T
I
L
F
-----------
V
D
E
V
H
R
F
------
A
F
L
P
H
I
E
D
--
G
T
I
T
F
I
G
A
T
T
E
N
P
S
F
E
L
N
S
A
L
L
S
R
A
R
V
Y
L
L
K
S
L
S
T
E
D
I
E
Q
V
L
T
Q
A
M
E
-
D
K
T
-
R
GYGG
Q
D
-
I
V
L
P
D
E
T
R
R
A
I
A
E
L
V
N
G
D
A
R
R
A
L
N
T
L
E
M
M
A
D
M
A
E
V
D
DS
G
K
R
V
L
K
P
E
L
L
T
E
-
I
-
A
G
E
R
S
A
R
---
K
G
D
R
F
Y
D
L
I
S
A
L
H
K
--
S
V
R
G
S
A
P
D
A
A
L
Y
W
Y
-
A
R
I
I
-
T
A
G
G
D
P
L
Y
V
A
R
R
C
L
A
I
A
S
E
D
V
G
N
A
D
P
R
A
M
Q
V
A
I
A
A
W
D
C
F
T
R
V
G
P
A
E
G
E
R
A
I
A
Q
A
I
V
Y
L
A
C
A
P
K
S
N
A
V
Y
T
A
F
K
A
A
L
A
D
A
R
E
R
P
D
Y
D
V
P
V
H
L
R
N
A
P
T
----------
E
Y
R
Y
A
H
D
E
A
N
A
Y
A
A
G
E
V
Y
F
P
P
E
I
A
Q
T
R
Y
Y
F
P
--
T
N
R
G
L
E
G
K
I
G
E
K
L
A
W
L
A
E
Q
101
HHSearch
52.28
27%
-18
* C1 *
-
2CHG
1
RFCS_ARCFU
C:
[4-221]
----------
F
E
I
W
V
E
K
Y
R
P
R
T
L
D
E
V
V
G
Q
D
E
V
I
Q
---
R
L
K
G
Y
V
E
R
K
-
N
I
P
-
H
L
L
F
S
G
P
P
G
T
G
K
T
A
T
A
I
A
L
A
R
D
L
-----
F
-----
G
ENWRD
N
--
F
I
E
M
N
----------------------
A
S
------
D
-
E
R
G
I
D
V
-
V
R
H
K
------------------
I
---
K
E
----
F
ARTA--
P
IG--
G
A
P
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
A
D
A
Q
A
A
L
R
R
T
M
E
M
YS
K
S
C
R
F
I
L
S
C
N
Y
--
V
S
R
I
I
E
P
I
Q
S
R
C
A
V
F
R
F
K
P
V
P
K
E
A
M
K
K
R
L
L
E
I
C
E
K
E
G
----------
V
K
I
T
E
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
R
K
A
I
N
A
L
Q
G
A
A
A
I
G
E
-------
V
V
D
A
D
T
I
Y
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.76
29%
-18
- C1 -
-
1IQP
1
RFCS_PYRFU
A:
[14-233]
------------
P
W
V
E
K
Y
R
P
Q
R
L
D
D
I
V
G
Q
E
H
I
V
K
R
---
L
K
H
Y
V
K
T
G
-
S
M
P
-
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
F
GENW
R
-----
H
-----
N
--
F
L
E
L
N
----------------------
A
S
------
D
E
R
-
G
I
N
V
-
I
R
E
K
------------------
V
---
K
E
----
F
A
R
TKPI
G
----
G
A
S
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
Q
D
A
Q
Q
A
L
R
R
T
M
E
M
--
F
S
S
N
V
R
F
I
L
S
C
N
Y
S
S
K
I
I
E
P
I
Q
S
R
C
A
I
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
E
G
L
E
L
----
T
E
------
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
-------
L
D
K
K
I
T
D
E
N
V
F
M
-
V
-
A
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
HHSearch
51.44
26%
-5
- C1 -
-
1SXJ
2
RFC3_YEAST
C:
[12-285]
----------
N
L
P
W
V
E
K
Y
R
P
E
T
L
D
E
V
Y
G
Q
N
E
V
I
T
---
T
V
R
K
F
V
D
E
G
-
K
L
P
-
H
L
L
F
Y
G
P
P
G
T
G
K
T
S
T
I
V
A
L
A
R
E
I
-----
Y
-----
G
KN
Y
S
N
M
--
V
L
E
L
N
----------------------
A
S
------
D
-
D
R
G
I
D
V
-
V
R
N
Q
------------------
I
---
K
D
----
F
A
S
TRQI
F
----
S
K
G
F
-----------
K
----
L
I
I
-----------
L
D
E
A
D
A
M
T
N
A
A
Q
N
A
L
R
R
V
I
E
R
Y
T
K
N
T
R
F
C
V
L
A
N
Y
--
A
H
K
L
T
P
A
L
L
S
Q
C
T
R
F
R
F
Q
P
L
P
Q
E
A
I
E
R
R
I
A
N
V
L
V
H
E
K
----------
L
K
L
S
P
N
A
E
K
A
L
I
E
L
S
N
G
D
M
R
R
V
L
N
V
L
Q
S
C
K
A
T
L
D
N
P
--
D
E
D
E
I
S
D
D
V
I
Y
E
C
C
------------
G
A
P
R
P
S
D
L
K
A
V
L
K
--
S
I
L
E
D
D
W
G
T
A
H
Y
T
L
-
N
K
V
R
S
A
K
G
L
A
L
I
D
L
I
E
G
I
V
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
50.47
27%
-10
- C1 -
-
1IQP
1
RFCS_PYRFU
E:
[11-277]
---------
L
E
K
P
W
V
E
K
Y
R
P
Q
R
L
D
D
I
V
G
Q
E
H
I
V
K
---
R
L
K
H
Y
V
K
T
G
-
S
M
P
-
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
-----
F
GENWR
H
-----
N
--
F
L
E
L
N
----------------------
A
S
------
D
-
E
R
G
I
N
V
-
I
R
E
K
------------------
V
---
K
E
----
F
ARTKPI
G
----
G
A
S
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
Q
D
A
Q
Q
A
L
R
R
T
M
E
M
FS
S
N
V
R
F
I
L
S
C
N
Y
S
--
S
K
I
I
E
P
I
Q
S
R
C
A
I
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
E
G
----------
L
E
L
T
E
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
L
D
K
-------
K
I
T
D
E
N
V
F
M
V
A
------------
S
R
A
R
P
E
D
I
R
E
M
M
L
--
L
A
L
K
G
N
F
L
K
A
R
E
K
L
-
R
E
I
L
L
K
Q
G
L
S
G
E
D
V
L
V
Q
M
H
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
49.11
26%
-28
- C1 -
-
2CHG
1
RFCS_ARCFU
A:
[9-219]
---------------
E
K
Y
R
P
R
T
L
D
E
V
V
G
Q
D
E
V
I
Q
R
---
L
K
G
Y
V
E
R
K
-
N
I
P
-
H
L
L
F
S
G
P
P
G
T
G
K
T
A
T
A
I
A
L
A
R
D
L
FGENW
R
-----
D
-----
N
--
F
I
E
M
N
----------------------
A
S
------
D
E
R
-
G
I
D
V
-
V
R
H
K
------------------
I
---
K
E
----
F
A
R
T
API
G
----
G
A
P
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
A
D
A
Q
A
A
L
R
R
T
M
E
M
--
Y
S
K
S
C
R
F
I
L
S
C
N
Y
V
S
R
I
I
E
P
I
Q
S
R
C
A
V
F
R
F
K
P
V
P
K
E
A
M
K
K
R
L
L
E
I
C
E
K
E
G
V
----------
K
I
T
E
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
R
K
A
I
N
A
L
Q
G
A
A
A
I
G
E
V
V
--
D
A
D
T
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
48.22
27%
-8
- C1 -
-
1IQP
1
RFCS_PYRFU
C:
[11-277]
---------
L
E
K
P
W
V
E
K
Y
R
P
Q
R
L
D
D
I
V
G
Q
E
H
I
V
K
---
R
L
K
H
Y
V
K
T
G
-
S
M
P
-
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
-----
F
GENWR
H
-----
N
--
F
L
E
L
N
----------------------
A
S
------
D
-
E
R
G
I
N
V
-
I
R
E
K
------------------
V
---
K
E
----
F
ARTKPI
G
----
G
A
S
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
Q
D
A
Q
Q
A
L
R
R
T
M
E
M
FS
S
N
V
R
F
I
L
S
C
N
Y
S
--
S
K
I
I
E
P
I
Q
S
R
C
A
I
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
E
G
----------
L
E
L
T
E
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
L
D
K
-------
K
I
T
D
E
N
V
F
M
V
A
------------
S
R
A
R
P
E
D
I
R
E
M
M
L
--
L
A
L
K
G
N
F
L
K
A
R
E
K
L
-
R
E
I
L
L
K
Q
G
L
S
G
E
D
V
L
V
Q
M
H
-----------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
47.17
24%
28
- C1 -
-
1IQP
1
RFCS_PYRFU
A:
[2-327]
SEEI
R
E
V
K
V
L
E
K
P
W
V
E
K
Y
R
P
Q
R
L
D
D
I
V
G
Q
E
H
I
V
K
R
---
L
K
H
Y
V
K
T
G
-
S
M
P
-
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
L
F
GENW
R
-----
H
-----
N
--
F
L
E
L
N
----------------------
A
S
D-----
E
-
R
-
G
I
N
V
-
I
R
E
K
------------------
V
---
K
E
----
F
------
A
----
R
T
K
P
IGGAS
F
-----
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
Q
D
A
Q
Q
A
L
R
R
T
M
E
M
--
F
S
S
N
V
R
F
I
L
S
C
N
Y
S
S
K
I
I
E
P
I
Q
S
R
C
A
I
F
R
F
R
P
L
R
D
E
D
I
A
K
R
L
R
Y
I
A
E
N
E
G
L
----------
E
L
T
E
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
L
-------
D
K
K
I
T
D
E
N
V
F
M
-
V
-----------
A
S
R
A
R
P
E
D
I
R
E
M
M
L
--
L
A
L
K
G
N
F
L
K
A
R
E
K
L
-
R
E
I
L
-
L
K
Q
G
---
L
S
G
E
D
V
L
V
Q
M
H
K
E
V
F
N
L
P
-------------
I
E
E
P
K
K
V
L
L
A
D
K
I
G
E
Y
N
F
R
L
V
E
G
A
N
E
I
I
Q
L
E
A
L
L
A
Q
F
T
L
I
G
K
K
----------------------------------------------------------------------------
4
PsiBlast_PDB
46.92
25%
-32
- C1 -
-
1SXJ
2
RFC3_YEAST
C:
[12-266]
----------
N
L
P
W
V
E
K
Y
R
P
E
T
L
D
E
V
Y
G
Q
N
E
V
I
---
T
T
V
R
K
F
V
D
E
G
-
K
L
P
-
H
L
L
F
Y
G
P
P
G
T
G
K
T
S
T
I
V
A
L
A
R
E
I
-----
Y
-----
G
-----
K
--
N
Y
S
N
M
----------------------
V
L
E
L
N
AS
D
D
-
R
-
G
I
D
V
-
V
R
N
Q
------------------
I
K
D
F
A
S
----
T
------
R
----
Q
I
F
S
K
G
F
--------
K
----
L
I
I
-----------
L
D
E
A
D
A
M
T
N
A
A
Q
N
A
L
R
R
V
I
E
R
--
Y
T
K
N
T
R
F
C
V
L
A
N
Y
A
H
K
L
T
P
A
L
L
S
Q
C
T
R
F
R
F
Q
P
L
P
Q
E
A
I
E
R
R
I
A
N
V
L
V
H
E
K
L
----------
K
L
S
P
N
A
E
K
A
L
I
E
L
S
N
G
D
M
R
R
V
L
N
V
L
Q
S
C
K
A
T
L
D
N
P
--
D
E
D
E
I
S
D
D
V
I
------------
Y
E
C
C
G
A
P
R
P
S
D
L
K
A
V
L
K
--
S
I
L
E
D
D
W
G
T
A
H
Y
T
L
-
N
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.83
26%
-28
- C1 -
-
2CHQ
1
RFCS_ARCFU
A:
[9-219]
---------------
E
K
Y
R
P
R
T
L
D
E
V
V
G
Q
D
E
V
I
Q
R
---
L
K
G
Y
V
E
R
K
-
N
I
P
-
H
L
L
F
S
G
P
P
G
T
G
K
T
A
T
A
I
A
L
A
R
D
L
FGENW
R
-----
D
-----
N
--
F
I
E
M
N
----------------------
A
S
------
D
-
E
R
G
I
D
V
-
V
R
H
K
------------------
I
---
K
E
----
F
A
R
TAPI
G
----
G
A
P
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
A
D
A
Q
A
A
L
R
R
T
M
E
M
--
Y
S
K
S
C
R
F
I
L
S
C
N
Y
V
S
R
I
I
E
P
I
Q
S
R
C
A
V
F
R
F
K
P
V
P
K
E
A
M
K
K
R
L
L
E
I
C
E
K
E
G
V
----------
K
I
T
E
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
R
K
A
I
N
A
L
Q
G
A
A
A
I
G
E
V
V
--
D
A
D
T
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.47
26%
-32
- C1 -
-
2CHV
-
RFCS_ARCFU
A:
[9-219]
---------------
E
K
Y
R
P
R
T
L
D
E
V
V
G
Q
D
E
V
I
Q
R
---
L
K
G
Y
V
E
R
K
-
N
I
P
-
H
L
L
F
S
G
P
P
G
T
G
K
T
A
T
A
I
A
L
A
R
D
L
FGENW
R
-----
D
-----
N
--
F
I
E
M
N
----------------------
A
S
------
D
-
E
R
G
I
D
V
-
V
R
H
K
------------------
I
---
K
E
----
F
A
R
TAPI
G
----
G
A
P
F
-----------
K
----
I
I
F
-----------
L
D
E
A
D
A
L
T
A
D
A
Q
A
A
L
R
R
T
M
E
M
--
Y
S
K
S
C
R
F
I
L
S
C
N
Y
V
S
R
I
I
E
P
I
Q
S
R
C
A
V
F
R
F
K
P
V
P
K
E
A
M
K
K
R
L
L
E
I
C
E
K
E
G
V
----------
K
I
T
E
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
R
K
A
I
N
A
L
Q
G
A
A
A
I
G
E
V
V
--
D
A
D
T
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
46.37
25%
-22
- C1 -
-
3GLG
3
DPO3X_ECOLI
B:
[28-311]
-------------
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
---
T
A
L
A
N
G
L
S
L
G
-
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
-----
N
-----
C
-----
E
---
T
G
I
T
----------------------
A
T
------
P
-
C
-
G
V
C
D
N
C
R
E
I
E
Q
GRFVDLIEIDAASRTK
V
---
E
D
----
T
------
R
----
D
L
L
D
N
VQYAPARGRF
K
----
V
Y
L
-----------
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
PP
E
H
V
K
F
L
L
A
T
A
D
P
Q
K
L
P
V
T
--
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
-
A
----
H
E
P
R
A
L
Q
L
-----
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
--
V
S
T
Q
A
V
S
A
M
L
G
T
-
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
-
L
G
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
46.18
24%
-19
- C1 -
-
1SXJ
2
RFC4_YEAST
B:
[7-274]
---------
L
Q
L
P
W
V
E
K
Y
R
P
Q
V
L
S
D
I
V
G
N
K
E
T
I
D
---
R
L
Q
Q
I
A
K
D
G
-
N
M
P
-
H
M
I
I
S
G
M
P
G
I
G
K
T
T
S
V
H
C
L
A
H
E
L
-----
L
-----
G
RSYAD
G
--
V
L
E
L
N
----------------------
A
S
------
D
-
D
R
G
I
D
V
-
V
R
N
Q
------------------
I
---
K
H
F
A
Q
K
K
L
H
L
---
P
----
P
G
K
H
-----------
K
----
I
V
I
-----------
L
D
E
A
D
S
M
T
A
G
A
Q
Q
A
L
R
R
T
M
E
L
Y
S
N
S
T
R
F
A
F
A
C
N
Q
--
S
N
K
I
I
E
P
L
Q
S
Q
C
A
I
L
R
Y
S
K
L
S
D
E
D
V
L
K
R
L
L
Q
I
I
K
L
E
D
----------
V
K
Y
T
N
D
G
L
E
A
I
I
F
T
A
E
G
D
M
R
Q
A
I
N
N
L
Q
S
T
V
A
G
H
G
-------
L
V
N
A
D
N
V
F
K
I
V
------------
D
S
P
H
P
L
I
V
K
K
M
-----
L
L
A
S
N
L
E
D
S
I
Q
I
L
R
T
D
L
W
-
K
K
G
Y
S
S
I
D
I
V
T
T
S
F
R
V
T
--------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.16
25%
-18
- C1 -
-
3GLI
3
DPO3X_ECOLI
B:
[28-311]
-------------
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
---
T
A
L
A
N
G
L
S
L
G
-
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
-----
N
-----
C
-----
E
---
T
G
I
T
----------------------
A
T
------
P
-
C
-
G
V
C
D
N
C
R
E
I
E
Q
GRFVD
L
I
E
I
DAASRTK
V
---
E
D
----
T
------
R
----
D
L
L
D
N
VQYAPARGRF
K
----
V
Y
L
-----------
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
PP
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
--
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
-
A
----
H
E
P
R
A
L
Q
L
-----
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
--
V
S
T
Q
A
V
S
A
M
L
G
T
-
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
-
L
G
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
45.60
45%
-200
- C2 -
-
2QW6
-
?
B:
[241-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
I
S
A
F
Q
K
--
S
I
R
G
S
D
V
D
A
A
L
H
Y
L
-
A
R
L
V
-
E
A
G
-
D
L
A
S
I
C
R
R
L
M
V
I
G
Y
E
D
I
---
N
P
A
A
A
A
R
T
V
N
A
V
L
A
A
E
K
L
G
L
P
E
A
R
I
P
L
A
D
V
V
V
D
L
C
L
S
P
-----------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.41
26%
-30
- C1 -
-
1NJF
2
DPO3X_ECOLI
A:
[13-248]
-------------
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
---
T
A
L
A
N
G
L
S
L
G
-
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
-----
N
-----
C
-----
E
---
T
G
I
T
----------------------
A
T
------
P
-
C
-
G
V
C
D
N
C
R
E
I
E
Q
GRFVD
L
I
E
I
D
AASRTK
V
---
E
D
----
T
------
R
----
D
L
L
D
-----------
N
----
V
Q
Y
APARGRFK
V
Y
L
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
PP
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
--
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
-
A
----
H
E
P
R
A
L
Q
L
-----
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
--
V
S
T
Q
A
V
S
A
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
45.27
25%
-20
- C1 -
-
3GLF
3
DPO3X_ECOLI
B:
[28-311]
-------------
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
---
T
A
L
A
N
G
L
S
L
G
-
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
-----
N
-----
C
-----
E
---
T
G
I
T
----------------------
A
T
------
P
-
C
-
G
V
C
D
N
C
R
E
I
E
Q
GRFVDLIEIDAASRTK
V
---
E
D
----
T
------
R
----
D
L
L
D
NVQYAPARGRF
K
----
V
Y
L
-----------
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
PP
E
H
V
K
F
L
L
A
T
T
D
P
Q
K
L
P
V
T
--
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
I
-
A
----
H
E
P
R
A
L
Q
L
-----
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
Q
--
V
S
T
Q
A
V
S
A
M
L
G
T
-
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
-
L
G
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.12
46%
-186
- C2 -
-
2QW6
-
?
A:
[241-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
I
S
A
F
Q
K
--
S
I
R
G
S
D
V
D
A
A
L
H
Y
L
-
A
R
L
V
-
E
A
G
-
D
L
A
S
I
C
R
R
L
M
V
I
G
Y
E
D
I
---
N
P
A
A
A
A
R
T
V
N
A
V
L
A
A
E
K
L
G
L
P
E
A
R
I
P
L
A
D
V
V
V
D
L
C
L
S
P
-----------------------------------------------------------------------------------------------
90
HHSearch
45.05
24%
-8
- C1 -
-
1XXI
-
DPO3X_ECOLI
H:
[3-288]
----------
Y
Q
V
L
A
R
K
W
R
P
Q
T
F
A
D
V
V
G
Q
E
H
V
L
T
---
A
L
A
N
G
L
S
L
G
R
I
H
H
-
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
-----
N
-----
C
-----
E
TG
I
T
A
T
P
CGVCDNCREIEQGRFVDLIEID
A
A
S-----
R
-
T
-
K
V
E
D
-
T
R
D
L
------------------
L
---
D
N
----
V
------
Q
YAPA
R
G
R
F
-----------
K
----
V
Y
L
-----------
I
D
E
V
H
M
L
S
R
H
S
F
N
A
L
L
K
T
L
E
E
PP
E
H
V
K
F
L
L
A
T
T
D
P
--
Q
K
L
P
V
T
I
L
S
R
C
L
Q
F
H
L
K
A
L
D
V
E
Q
I
R
H
Q
L
E
H
I
L
N
E
E
H
----------
I
A
H
E
P
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
------
Q
V
S
T
Q
A
V
S
A
M
L
------------
G
T
L
D
D
D
Q
A
L
S
L
V
E
--
A
M
V
E
A
N
G
E
R
V
M
A
L
I
-
N
E
A
A
-
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
---------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
45.01
45%
-186
* C2 *
-
2QW6
-
?
A:
[241-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
I
S
A
F
Q
K
--
S
I
R
G
S
D
V
D
A
A
L
H
Y
L
-
A
R
L
V
-
E
A
G
-
D
L
A
S
I
C
R
R
L
M
V
I
G
Y
E
D
I
---
N
P
A
A
A
A
R
T
V
N
A
V
L
A
A
E
K
L
G
L
P
E
A
R
I
P
L
A
D
V
V
V
D
L
C
L
S
P
-----------------------------------------------------------------------------------------------