@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPZ5: (2017-11-24 )
MLIHLFFRNNKKSKMHLKLNNYLISGEYMNIPRFGLGTFRLKEQAVIDSVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQDKFIPSLKESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQNHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAANKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELTAAEMQMIAELDRNSREVSPEPWAPVWD
Atome Classification :
(28 SA)
.........10........20........30........40....-...-.50.-.......60........70........80........90........100.......110.......120.....-..130---........140.......150.......160.......170.......180.......190.......200.......210.---...--...220.......230.......240-.......250..-.....260.......270.......--280....-....290...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
I
H
L
F
F
RNNKK
S
K
M
H
L
K
LN
N
Y
L
ISGEYMNIPRFGLG
T
F
R
L
K
E
Q
A
-
V
I
D
-
S
V
K
N
-
A
L
D
V
G
Y
R
AI
D
T
A
Q
I
YEN
E
A
A
I
G
Q
A
I
A
E
SGVSRQ
D
L
F
L
T
T
K
I
WVDNFAQDK
F
I
P
S
L
K
E
S
L
Q
K
L
R
TDHV
D
L
T
L
I
HWP-APDL----GV
S
I
P
E
I
M
Q
L
L
L
E
A
K
QQGL
T
K
QIGISNF
N
I
A
L
T
Q
Q
A
I
D
T
IG
V
E
HIATN
Q
I
E
L
S
P
Y
L
Q
N
H
K
L
V
N
F
L
Q
EKNI
D
V
T
S
Y
M
T
L
A
Y
G
K
---
V
LQ--D
P
V
L
A
E
I
AAANKA
T
T
A
Q
I
A
L
A
W
A
L
QR-G
F
A
VIPSS
T
K
R
E
-
N
L
I
S
NLKAQD
I
E
L
T
A
A
E
M
Q
M
I
A
E
LD--R-NSREV-SPEPWAPVWD
123
HHSearch
91.71
43%
-79
- C6 -
-
3UP8
-
?
A:
[19-297]
---------------
Y
F
Q
S
M
M
H
A
V
S
S
N
G
A
N
I
P
A
L
G
F
G
T
F
R
M
S
G
A
E
-
V
L
R
-
I
L
P
Q
-
A
L
K
L
G
F
R
H
V
D
T
A
Q
I
Y
G
N
E
A
E
V
G
E
A
I
Q
K
S
G
I
P
R
A
D
V
F
L
T
T
K
V
W
V
D
N
Y
R
H
D
A
F
I
A
S
V
D
E
S
L
R
K
L
R
T
D
H
V
D
L
L
L
L
H
W
P
-
G
S
D
V
------
P
M
A
E
R
I
G
A
L
N
E
V
R
N
A
G
K
V
R
H
I
G
I
S
N
F
N
T
T
Q
M
E
E
A
A
R
L
S
-
D
A
P
I
A
T
N
Q
V
E
Y
H
P
Y
L
D
Q
T
K
V
L
Q
T
A
R
R
L
G
M
S
L
T
S
Y
Y
A
M
A
N
G
K
---
V
P
A
--
D
P
L
L
T
E
I
G
G
R
H
G
K
T
A
A
Q
V
A
L
R
W
L
V
Q
Q
Q
D
V
I
V
L
S
K
T
A
T
E
A
-
R
L
K
E
N
F
A
I
F
D
F
A
L
T
R
E
E
M
A
A
V
R
E
L
A
R-
P
-
N
G
R
I
V
-
N
P
Q
G
L
A
P
E
W
D
1
PsiBlast_PDB
90.52
43%
-77
- C6 -
-
3UP8
-
?
A:
[18-297]
--------------
L
Y
F
Q
S
M
M
H
A
V
S
S
N
G
A
N
I
P
A
L
G
F
G
T
F
R
M
S
G
A
E
-
V
L
R
-
I
L
P
Q
-
A
L
K
L
G
F
R
H
V
D
T
A
Q
I
Y
G
N
E
A
E
V
G
E
A
I
Q
K
S
G
I
P
R
A
D
V
F
L
T
T
K
V
W
V
D
N
Y
R
H
D
A
F
I
A
S
V
D
E
S
L
R
K
L
R
T
D
H
V
D
L
L
L
L
H
W
P
-
G
S
D
------
V
P
M
A
E
R
I
G
A
L
N
E
V
R
N
A
G
K
V
R
H
I
G
I
S
N
F
N
T
T
Q
M
E
E
A
A
-
R
L
S
D
A
P
I
A
T
N
Q
V
E
Y
H
P
Y
L
D
Q
T
K
V
L
Q
T
A
R
R
L
G
M
S
L
T
S
Y
Y
A
M
A
N
G
K
---
V
P
A
--
D
P
L
L
T
E
I
G
G
R
H
G
K
T
A
A
Q
V
A
L
R
W
L
V
Q
Q
-
Q
D
V
I
V
L
S
K
T
A
T
E
A
R
L
K
E
N
F
A
I
F
D
F
A
L
T
R
E
E
M
A
A
V
R
E
L
A
--
R
P
N
G
R
I
V
-
N
P
Q
G
L
A
P
E
W
D
15
PsiBlast_PDB
87.01
37%
-92
- C6 -
-
2WZM
1
Y2407_MYCS2
A:
[22-277]
------------------------------
L
P
V
V
G
I
G
V
G
E
L
S
D
S
E
-
A
E
R
-
S
V
S
A
-
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
G
G
D
T
----
S
K
Y
V
-
D
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
-
A
E
D
L
E
T
I
V
S
L
T
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
V
G
R
---
L
L
D
--
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-
G
T
R
-
F
-
R
P
D
P
------
33
PsiBlast_CBE
86.69
37%
-92
- C6 -
-
2WZM
1
Y2407_MYCS2
B:
[22-277]
------------------------------
L
P
V
V
G
I
G
V
G
E
L
S
D
S
E
-
A
E
R
-
S
V
S
A
-
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
G
G
D
T
----
S
K
Y
V
-
D
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
-
A
E
D
L
E
T
I
V
S
L
T
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
V
G
R
---
L
L
D
--
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-
G
T
R
-
F
-
R
P
D
P
------
10
PsiBlast_PDB
86.26
37%
-99
- C6 -
-
4OTK
-
Y2971_MYCTU
A:
[57-307]
------------------------------
M
P
V
L
G
L
G
V
A
E
L
S
D
D
E
-
T
E
R
-
A
V
S
A
-
A
L
E
I
G
C
R
L
I
D
T
A
Y
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
V
A
R
E
E
L
F
V
T
T
K
L
A
T
P
D
Q
G
F
T
R
S
Q
E
A
C
R
A
S
L
D
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
A
P
P
V
----
G
K
Y
V
-
D
A
W
G
G
M
I
Q
S
R
G
E
G
H
A
R
S
I
G
V
S
N
F
T
A
E
N
I
E
N
L
I
D
L
T
F
V
T
P
-
A
V
N
Q
I
E
L
H
P
L
L
N
Q
D
E
L
R
K
A
N
A
Q
H
T
V
V
T
Q
S
Y
C
P
L
A
L
G
R
---
L
L
D
--
N
P
T
V
T
S
I
A
S
E
Y
V
K
T
P
A
Q
V
L
L
R
W
N
L
Q
L
-
G
N
A
V
V
V
R
S
A
R
P
E
-
R
I
A
S
N
F
D
V
F
D
F
E
L
A
A
E
H
M
D
A
L
G
G
L
N
--
D
-
G
T
R
-------------
125
HHSearch
85.20
34%
-91
- C6 -
-
2WZM
1
Y2407_MYCS2
B:
[10-282]
-----------------
A
I
P
T
V
T
L
N
-
D
D
N
T
L
P
V
V
G
I
G
V
G
E
L
S
D
S
E
-
A
E
R
-
S
V
S
A
-
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
G
G
D
T
-----
S
K
Y
V
D
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
A
E
D
L
E
T
I
V
S
L
T
-
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
V
G
R
---
L
L
D
--
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-
G
T
R
F
R
P
D
P
A
-
T
Y
T
G
--
122
HHSearch
84.81
35%
-93
- C6 -
-
4OTK
-
Y2971_MYCTU
A:
[48-317]
--------------------
S
I
T
L
N
-
D
E
H
T
M
P
V
L
G
L
G
V
A
E
L
S
D
D
E
-
T
E
R
-
A
V
S
A
-
A
L
E
I
G
C
R
L
I
D
T
A
Y
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
V
A
R
E
E
L
F
V
T
T
K
L
A
T
P
D
Q
G
F
T
R
S
Q
E
A
C
R
A
S
L
D
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
A
P
P
V
-----
G
K
Y
V
D
A
W
G
G
M
I
Q
S
R
G
E
G
H
A
R
S
I
G
V
S
N
F
T
A
E
N
I
E
N
L
I
D
L
T
-
F
V
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
D
E
L
R
K
A
N
A
Q
H
T
V
V
T
Q
S
Y
C
P
L
A
L
G
R
---
L
L
D
--
N
P
T
V
T
S
I
A
S
E
Y
V
K
T
P
A
Q
V
L
L
R
W
N
L
Q
L
-
G
N
A
V
V
V
R
S
A
R
P
E
-
R
I
A
S
N
F
D
V
F
D
F
E
L
A
A
E
H
M
D
A
L
G
G
L
N
--
D
-
G
T
R
V
R
E
D
P
L
-
T
Y
A
G
--
3
PsiBlast_PDB
83.79
37%
-90
- C6 -
-
3O0K
4
?
A:
[36-283]
-----------------------------
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
----
D
L
F
M
-
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
-
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
----
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
16
PsiBlast_PDB
82.99
37%
-101
- C- -
-
2WZT
-
Y2407_MYCS2
A:
[22-269]
------------------------------
L
P
V
V
G
I
G
V
G
E
L
S
D
S
E
-
A
E
R
-
S
V
S
A
-
A
L
E
A
G
Y
R
L
I
D
T
A
A
A
Y
G
N
E
A
A
V
G
R
A
I
A
A
S
G
I
P
R
D
E
I
Y
V
T
T
K
L
A
T
P
D
Q
G
F
T
S
S
Q
A
A
A
R
A
S
L
E
R
L
G
L
D
Y
V
D
L
Y
L
I
H
W
P
-
G
G
D
T
----
S
K
Y
V
-
D
S
W
G
G
L
M
K
V
K
E
D
G
I
A
R
S
I
G
V
C
N
F
G
-
A
E
D
L
E
T
I
V
S
L
T
Y
F
T
P
A
V
N
Q
I
E
L
H
P
L
L
N
Q
A
A
L
R
E
V
N
A
G
Y
N
I
V
T
E
A
Y
G
P
L
G
V
G
R
---
L
L
D
--
H
P
A
V
T
A
I
A
E
A
H
G
R
T
A
A
Q
V
L
L
R
W
S
I
Q
L
-
G
N
V
V
I
S
R
S
A
N
P
E
-
R
I
A
S
N
L
D
V
F
G
F
E
L
T
A
D
E
M
E
T
L
N
G
L
D
--
D
-----------------
22
PsiBlast_CBE
82.91
37%
-87
- C6 -
-
3O0K
3
?
D:
[36-283]
-----------------------------
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
----
D
L
F
M
-
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
-
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
--
K
---
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
24
PsiBlast_CBE
82.88
37%
-92
- C6 -
-
3O0K
4
?
B:
[36-283]
-----------------------------
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
----
D
L
F
M
-
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
-
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
26
PsiBlast_CBE
82.86
35%
-80
- C6 -
-
3WBW
1
?
B:
[25-277]
------------------------------
M
P
Q
I
G
L
G
V
W
E
T
P
P
D
E
-
T
A
E
-
V
V
K
E
-
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
----
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-
M
P
A
Q
----
G
Q
Y
V
-
E
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
G
V
V
P
V
-
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
K
G
R
---
V
L
S
--
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
--
R
-
K
D
G
R
M
-
G
A
D
P
------
18
PsiBlast_PDB
82.62
39%
-60
- C6 -
-
1M9H
1
DKGA_CORSC
A:
[13-274]
-----------------------------
S
I
P
Q
L
G
Y
G
V
Y
K
V
P
P
A
D
-
T
Q
R
-
A
V
E
E
-
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-
T
P
A
A
----
D
N
Y
V
-
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
G
V
V
-
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
G
K
YDL
F
G
A
--
E
P
V
T
A
A
A
A
A
H
G
K
-
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
G
S
V
R
R
E
-
H
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
PG
D
-
G
S
G
R
V
-
S
G
H
P
------
124
HHSearch
82.42
33%
-79
- C6 -
-
3WBW
1
?
B:
[12-280]
-----------------
E
A
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
W
E
T
P
P
D
E
-
T
A
E
-
V
V
K
E
-
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
----
D
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-
M
P
A
Q
-----
G
Q
Y
V
E
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
-
G
V
V
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
K
G
R
---
V
L
S
--
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R-
K
-
D
G
R
M
G
--
A
D
P
N
T
A
---
17
PsiBlast_PDB
82.25
39%
-57
- C6 -
-
1A80
1
DKGA_CORSC
A:
[12-273]
-----------------------------
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
A
D
-
T
Q
R
-
A
V
E
E
-
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-
T
P
A
A
----
D
N
Y
V
-
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
G
V
V
-
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
G
K
YDL
F
G
A
--
E
P
V
T
A
A
A
A
A
H
G
K
-
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
K
S
V
R
R
E
-
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
PG
D
-
G
S
G
R
V
-
S
A
H
P
------
4
PsiBlast_PDB
81.66
35%
-75
- C6 -
-
3WBW
1
?
A:
[25-277]
------------------------------
M
P
Q
I
G
L
G
V
W
E
T
P
P
D
E
-
T
A
E
-
V
V
K
E
-
A
V
K
L
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
----
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-
M
P
A
Q
----
G
Q
Y
V
-
E
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
G
V
V
P
V
-
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
K
G
R
---
V
L
S
--
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
--
R
-
K
D
G
R
M
-
G
A
D
P
------
28
PsiBlast_CBE
81.54
35%
-80
- C6 -
-
3WBY
1
?
B:
[25-277]
------------------------------
M
P
Q
I
G
L
G
V
W
E
T
P
P
D
E
-
T
A
E
-
V
V
K
E
-
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
----
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-
M
P
A
Q
----
G
Q
Y
V
-
E
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
G
V
V
P
V
-
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
K
G
R
---
V
L
S
--
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
--
R
-
K
D
G
R
M
-
G
A
D
P
------
140
HHSearch
81.21
35%
-91
- C6 -
-
3O0K
4
?
A:
[21-282]
-------------
S
M
I
M
T
V
P
T
V
K
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
-----
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
----
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
---------------------
8
PsiBlast_PDB
81.10
35%
-81
- C6 -
-
3WBY
1
?
A:
[25-277]
------------------------------
M
P
Q
I
G
L
G
V
W
E
T
P
P
D
E
-
T
A
E
-
V
V
K
E
-
A
V
K
L
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
----
H
P
E
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
-
M
P
A
Q
----
G
Q
Y
V
-
E
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
G
V
V
P
V
-
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
L
G
K
G
R
---
V
L
S
--
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
-
G
L
I
V
I
P
K
S
V
N
P
K
-
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
--
R
-
K
D
G
R
M
-
G
A
D
P
------
23
PsiBlast_CBE
80.83
37%
-92
- C6 -
-
3O0K
3
?
C:
[36-283]
-----------------------------
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
----
D
L
F
M
-
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
G
V
T
P
V
-
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
--------------------
139
HHSearch
80.67
35%
-91
- C6 -
-
3O0K
4
?
B:
[25-282]
-----------------
T
V
P
T
V
K
L
N
-
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
S
N
D
E
-
A
V
S
-
A
V
S
E
-
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
S
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
-
M
P
S
K
-----
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
-
G
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
------
L
L
E
--
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
-
G
N
I
V
I
P
K
S
I
T
P
A
-
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
---------------------
132
HHSearch
78.40
38%
-57
- C6 -
-
1A80
1
DKGA_CORSC
A:
[8-261]
-------------------------
N
D
G
N
S
I
P
Q
L
G
Y
G
V
F
K
V
P
P
A
D
-
T
Q
R
-
A
V
E
E
-
A
L
E
V
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
E
G
V
G
A
A
I
A
A
S
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
-
T
P
A
A
-----
D
N
Y
V
H
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
-
G
V
V
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
L
G
Q
G
K
---
Y
D
L
FG
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
-
G
F
V
V
F
P
K
S
V
R
R
E
-
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
--------------------
32
PsiBlast_CBE
75.04
35%
6
- C6 -
-
4F40
9
PGFS_LEIMA
B:
[19-283]
----------------------------
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
-
V
T
E
N
A
V
K
W
-
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
LSKE
G
K
K
Y
L
D
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
-
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
--
K
---
L
L
S
--
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
-
Y
-
G
P
D
P
------
12
PsiBlast_PDB
74.87
35%
10
- C6 -
-
4F40
10
PGFS_LEIMA
A:
[19-283]
----------------------------
V
K
M
P
Q
F
G
L
G
V
W
Q
S
P
A
G
E
-
V
T
E
N
A
V
K
W
-
A
L
C
A
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
S
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
R
G
K
D
I
L
S
K
E
G
K
K
Y
L
D
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
T
V
T
P
M
-
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
L
G
--
K
---
L
L
S
--
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
-
N
L
I
T
I
P
K
S
V
H
R
E
-
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
--
T
-
N
S
R
-
Y
-
G
P
D
P
------
59
PsiBlast_CBE
70.69
33%
-19
- C6 -
-
1VBJ
2
PGFS_TRYBB
A:
[12-274]
----------------
L
K
L
S
N
G
V
M
------
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
-
E
A
E
-
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-
G
K
D
K
----
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
---
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
K
V
A
P
M
-
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
G
H
---
L
V
E
--
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
-
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
-
G
H
R
-
Y
-
G
P
D
P
------
58
PsiBlast_CBE
69.90
33%
-18
- C6 -
-
1VBJ
2
PGFS_TRYBB
B:
[12-274]
----------------
L
K
L
S
N
G
V
M
------
M
P
V
L
G
F
G
M
W
K
L
Q
D
G
N
-
E
A
E
-
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
C
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
-
G
K
D
K
----
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
---
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
K
V
A
P
M
-
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
L
G
Q
G
H
---
L
V
E
--
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
-
G
V
I
T
I
P
K
S
G
N
E
A
-
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
--
A
-
G
H
R
-
Y
-
G
P
D
P
------
6
PsiBlast_PDB
69.52
33%
3
- C6 -
-
4FZI
1
PGFS_TRYCC
A:
[22-276]
----------------------------
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
-
A
V
R
W
-
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-
G
K
K
K
----
F
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
---
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
-
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
G
E
EAG
I
L
K
--
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
-
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
-
D
K
R
-------------
27
PsiBlast_CBE
68.95
33%
-15
- C6 -
-
4FZI
1
PGFS_TRYCC
B:
[22-276]
----------------------------
V
R
M
P
Q
L
G
L
G
V
W
R
A
Q
D
G
A
E
T
A
N
-
A
V
R
W
-
A
I
E
A
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
S
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
-
G
K
K
K
----
F
V
D
T
W
K
A
L
E
K
L
Y
E
E
K
K
---
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
K
I
R
P
M
-
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
L
G
S
-----
I
L
K
--
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
-
G
I
V
T
I
P
K
S
T
N
K
G
-
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
--
E
-
D
K
R
-------------