@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ63: (2017-11-25 )
MTTKNQKISRRHISGVFLLNKPLGLSSNAALQKVRWLYRAQKAGHTGALDPLATGLLPICLGEATKFSHYLLDSTKRYQTTVRLGQTTTTGDVEGDILQERPIPVLSKELIEQTLEKFRGDIQQVPPMYSALKKEGKPLYELARKGIEIEREARPVTIYALELIEFTENSITLDVTCSKGTYIRVLGEDIGEALGCGGHLTMLHRIQTGHFELIPSYTIEYLESLTEEQREALLLPVYAPIYHFLKIQVPEGREKYFCNGLESNIDHSAEAEVLVFSGERCLGLAEITDKKRLVPKRILNL
Atome Classification :
(20 SA)
.........10.--.......20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....----.--.----170.......180.......190.......200.......210---------...-....220.---..--------.---------.-..230--------.........-240.......250.......260---......--------.-270-----..-------.....-.-.--280-----.......----------290.......300
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTTKN
Q
K
I
S
RRH--I
S
G
V
F
L
LNKPLGLSS
N
A
A
L
Q
K
V
R
W
L
Y
R
A
QKAGHTGA
L
D
P
L
A
T
G
L
L
P
I
CLGEA
T
K
F
S
H
Y
L
LDSTK
R
Y
Q
T
T
V
R
LG
Q
T
TTTGDVEG
D
I
LQERPI
P
V
L
S
K
E
L
I
E
Q
T
L
E
K
F
R
G
D
I
Q
QV
P
P
M
Y
S
A
L
K
KEGK
P
L
Y
E
L
A
RKG
I
E
I
EREAR
P
V
T
I
Y
A
L
E
L
IEFT----E--N----
S
I
T
L
D
V
TCSKG
T
Y
I
R
V
L
G
E
D
I
G
E
A
LGCGGH
L
T
M
L
H
R
IQTG
H
F
E
---------L
I
P
-
S
Y
T
I
E
Y
L
E
---
S
L
--------
T
---------
E
-
E
Q
R
----------
E
A
L
L
L
P
V
Y
A
-
P
I
Y
H
F
L
K
I
QVPEGR
E
K
Y
F
CNGLE---SNIDHS--------A-E-------A
E
-------
V
L
V
FS-G-E--
R
C
L-----
G
L
A
E
ITD----------KKRL
V
P
K
R
ILNL-
25
HHSearch
88.54
48%
-73
- C4 -
-
1K8W
1
TRUB_ECOLI
A:
[22-323]
----------
M
D
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
---------
V
E
R
-
M
V
T
L
E
H
L
R
---
E
L
--------
V
E
Q
A
E
Q
Q
DIP
A
A
E
L
L
----------
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
---
V
R
T
S
G
A
P-------
L
-
E
-------
G
L
-------
V
R
V
T
E
G
E
N
G
--
K
F
I
-----
G
M
G
E
I
D
D
----------
E
G
R
V
A
P
R
R
L
V
V
--
48
Fugue
86.77
48%
-70
- C4 -
-
1K8W
1
TRUB_ECOLI
A:
[22-324]
----------
M
D
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
T
-
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
---------
V
E
R
-
M
V
T
L
E
H
L
R
---
E
L
--------
V
---------
E
-
Q
A
E
Q
Q
DIP
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
V
R
T
S
G
A
P
L
E
--------
G
-
L
-------
V
R
-------
V
T
E
G
E
-
N
-
G
--
K
F
I
-----
G
M
G
E
I
D
D
----------
E
G
R
V
A
P
R
R
L
V
V
E
-
1
PsiBlast_PDB
85.89
48%
-78
- C4 -
-
1R3F
-
TRUB_ECOLI
A:
[9-309]
----------
R
D
--
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
-----------------------------
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
---------
V
E
R
-
M
V
T
L
E
H
L
R
---
E
L
--------
V
---------
E
-
Q
A
E
Q
Q
DIP
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
---
V
R
T
S
G
A
--------
P
L
E
-------
G
L
-------
V
R
V
T
E
-
G
-
E
NG
K
F
I
-----
G
M
G
E
I
D
D
----------
E
G
R
V
A
P
R
R
L
V
---
2
PsiBlast_PDB
79.82
47%
17
- C4 -
-
1K8W
1
TRUB_ECOLI
A:
[22-322]
------------M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
D
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
---------
V
E
R
-
M
V
T
L
E
H
L
R
---
E
L
--------
V
---------
E
-
Q
A
E
Q
Q
DIP
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
---
V
R
T
S
G
A
--------
P
L
E
-------
G
L
-------
V
R
V
T
E
-
G
-
E
NG
K
F
I
-----
G
M
G
E
I
D
D
----------
E
G
R
V
A
P
R
R
L
V
---
3
PsiBlast_PDB
79.57
47%
18
- C4 -
-
1ZL3
1
TRUB_ECOLI
A:
[22-322]
------------M
D
I
N
G
V
L
L
L
D
K
P
Q
G
M
S
S
N
D
A
L
Q
K
V
K
R
I
Y
N
A
N
R
A
G
H
T
G
A
L
N
P
L
A
T
G
M
L
P
I
C
L
G
E
A
T
K
F
S
Q
Y
L
L
D
S
D
K
R
Y
R
V
I
A
R
L
G
Q
R
T
D
T
S
D
A
D
G
Q
I
V
E
E
R
P
V
-
T
F
S
A
E
Q
L
A
A
A
L
D
T
F
R
G
D
I
E
Q
I
P
S
M
Y
S
A
L
K
Y
Q
G
K
K
L
Y
E
Y
A
R
Q
G
I
E
V
P
R
E
A
R
P
I
T
V
Y
E
L
L
F
I
R
H
E
----
G
--
N
----
E
L
E
L
E
I
H
C
S
K
G
T
Y
I
R
T
I
I
D
D
L
G
E
K
L
G
C
G
A
H
V
I
Y
L
R
R
L
A
V
S
K
Y
P
---------
V
E
R
-
M
V
T
L
E
H
L
R
---
E
L
--------
V
---------
E
-
Q
A
E
Q
Q
DIP
A
A
E
L
L
D
P
L
L
M
P
M
D
S
-
P
A
S
D
Y
P
V
V
N
L
P
L
T
S
S
V
Y
F
K
N
G
N
P
---
V
R
T
S
G
A
--------
P
L
E
-------
G
L
-------
V
R
V
T
E
-
G
-
E
NG
K
F
I
-----
G
M
G
E
I
D
D
----------
E
G
R
V
A
P
R
R
L
V
---
47
Fugue
76.32
31%
-90
- C4 -
-
1R3E
3
TRUB_THEMA
A:
[1-309]
-----------
M
--
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
-
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
---
V
F
---
E
A
--------
A
---------
P
-
E
E
I
----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
--------
K
-
E
WDGFKKG
E
V
-------
V
R
V
F
N
-
E
-
E
G-
R
L
L
-----
A
L
A
E
A
E
R
NSSFLETLRK
E
R
V
L
T
L
R
K
V
F
N
T
R
8
PsiBlast_PDB
73.65
32%
0
- C- -
-
2AB4
1
TRUB_THEMA
A:
[4-287]
----------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
F
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
V
T
E
E
E
-
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
--
F
E
---
A
A
--------
P
---------
E
-
E
I
-----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
--------
K
-
E
-------
W
D
G
F
K
KG
E
V
V
R
V
F
N
-
E
-
E
G-
R
L
L
-----
A
L
A
E
--------------------------
7
PsiBlast_PDB
73.65
32%
0
- C- -
-
1ZE2
2
TRUB_THEMA
A:
[4-287]
----------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
V
T
E
E
E
-
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
--
F
E
---
A
A
--------
P
---------
E
-
E
I
-----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
--------
K
-
E
-------
W
D
G
F
K
K
G
E
V
V
R
V
F
N
-
E
-
E
G-
R
L
L
-----
A
L
A
E
--------------------------
27
HHSearch
73.58
31%
-87
- C4 -
-
1R3E
3
TRUB_THEMA
A:
[1-288]
-----------
M
--
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
F
E
A
A
---
P
E
--------
E
-------------
I
----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
KEWDGFK-
K
-
G
-------
E
V
-------
V
R
V
F
N
E
E
-
G
--
R
L
L
-----
A
L
A
E
A
E
R
----------
N
S
-----------
6
PsiBlast_PDB
72.58
32%
-97
- C4 -
-
1R3E
3
TRUB_THEMA
A:
[4-283]
----------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
V
T
E
E
E
-
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
--
F
E
---
A
A
--------
P
---------
E
-
E
I
-----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
--------
K
-
E
-------
W
D
GFKKG
E
V
V
R
V
F
N
-
E
-
E
G-
R
L
L
-----
A
L
A
E
--------------------------
29
HHSearch
71.92
31%
-86
* C4 *
-
2APO
-
TRUB_METJA
A:
[57-324]
----
E
R
K
I
E
D
L
I
--
K
Y
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
------------------
D
A
S
E
E
D
I
L
R
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
----
G
--
K
----
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
---------
E
K
D
-
A
V
Y
L
Q
D
L
L
---
D
A
Y
V
F
W
K
EDG
D
---------
E
-
E
E
L
----------
R
R
V
I
K
P
M
E
Y
-
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
---
V
Y
V
R
G
I
A
K
L
S
K
GIG
K
-
G
-------
E
T
-------
V
L
V
E
T
L
K
-
G
--
E
A
V
-----
A
V
G
K
A
L
M
----------
N
------------
28
HHSearch
71.50
31%
-83
- C4 -
-
1ZE1
-
TRUB_THEMA
B:
[1-284]
-----------
M
--
K
H
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
-
C
N
V
T
E
E
E
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
F
E
A
A
---
P
E
--------
E
-------------
I
----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
K
E
W
DGFK-
K
-
G
-------
E
V
-------
V
R
V
F
N
E
E
-
G
--
R
L
L
-----
A
L
A
E
A
E
R
----------
N
S
-----------
5
PsiBlast_PDB
70.72
32%
-93
- C4 -
-
1ZE1
-
TRUB_THEMA
A:
[4-279]
----------------
G
I
L
V
A
Y
K
P
K
G
P
T
S
H
D
V
V
D
E
V
R
K
K
L
K
T
R
K
V
G
H
G
G
T
L
D
P
F
A
C
G
V
L
I
I
G
V
N
Q
G
T
R
I
L
E
F
Y
K
D
L
K
K
V
Y
W
V
K
M
R
L
G
L
I
T
E
T
F
D
I
T
G
E
V
V
E
E
R
E
C
N
V
T
E
E
E
-
I
R
E
A
I
F
S
F
V
G
E
Y
D
Q
V
P
P
A
Y
S
A
K
K
Y
K
G
E
R
L
Y
K
L
A
R
E
G
K
I
I
N
L
P
P
K
R
V
K
I
F
K
I
W
D
V
N
I
E
----
G
--
R
----
D
V
S
F
R
V
E
V
S
P
G
T
Y
I
R
S
L
C
M
D
I
G
Y
K
L
G
C
G
A
T
A
V
E
L
V
R
E
S
V
G
P
H
T
---------
I
E
E
-
S
L
N
V
--
F
E
---
A
A
--------
P
---------
E
-
E
I
-----------
E
N
R
I
I
P
L
E
K
-
C
L
E
W
L
P
R
V
V
V
H
Q
E
S
T
K
M
I
L
N
G
S
Q
---
I
H
L
E
M
L
--------
K
-
E
-------
W
D
GFKKG
E
V
V
R
V
F
N
-
E
-
E
G-
R
L
L
-----
A
L
A
E
--------------------------
32
HHSearch
69.93
28%
-98
- C4 -
-
2AUS
-
TRUB_PYRAB
C:
[37-304]
----
K
R
P
I
E
L
H
I
--
Q
Y
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
R
I
L
N
L
E
K
A
G
H
G
G
T
L
D
P
K
V
S
G
V
L
P
V
A
L
E
R
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
------------------
D
V
P
E
D
K
I
R
A
V
M
K
E
F
E
G
E
I
I
Q
R
-----------------------------
T
R
K
V
Y
Y
I
E
I
L
E
I
D
----
G
--
R
----
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
A
E
L
R
R
T
R
S
G
P
F
K
---------
E
D
E
T
L
V
T
L
H
D
L
V
---
D
Y
--------
Y
H
F
W
KEDGI-
E
-
E
Y
I
----------
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
I
W
I
K
D
S
A
V
A
A
V
A
H
G
A
N
---
L
T
V
P
G
I
V
K
L
N
A
GIK
K
-
G
-------
D
L
-------
V
A
I
M
T
L
K
-
D
--
E
L
V
-----
A
L
G
K
A
M
M
-----------------------
33
HHSearch
67.89
27%
-76
- C4 -
-
2RFK
-
TRUB_PYRFU
A:
[33-301]
----
K
R
P
I
E
M
H
I
--
Q
F
G
V
I
N
L
D
K
P
P
G
P
T
S
H
E
V
V
A
W
I
K
K
I
L
N
L
E
K
A
G
H
G
G
T
L
A
P
K
V
S
G
V
L
P
V
A
L
E
K
A
T
R
V
V
Q
A
L
L
P
A
G
K
E
Y
V
A
L
M
H
L
H
G
------------------
D
V
P
E
D
K
I
I
Q
V
M
K
E
F
E
G
E
I
I
Q
R
P
P
L
R
S
A
V
K
R
R
-----------------
L
R
T
R
K
V
Y
Y
I
E
V
L
E
I
E
----
G
--
R
----
D
V
L
F
R
V
G
V
E
A
G
T
Y
I
R
S
L
I
H
H
I
G
L
A
L
G
V
G
A
H
M
S
E
L
R
R
T
R
S
G
P
F
K
---------
E
D
E
T
L
I
T
L
H
D
L
V
---
D
Y
Y
Y
F
-----
W
K
EDGI----
E
-
E
Y
F
----------
R
K
A
I
Q
P
M
E
K
-
A
V
E
H
L
P
K
V
W
I
K
D
S
A
V
A
A
V
T
H
G
A
D
---
L
A
V
P
G
I
A
K
L
H
A
GIK
R
-
G
-------
D
L
-------
V
A
I
M
T
L
K
-
D
--
E
L
V
-----
A
L
G
K
A
M
M
----------
T
------------
26
HHSearch
67.50
35%
-57
- C4 -
-
1SGV
-
TRUB_MYCTU
B:
[3-283]
----------
A
T
--
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
----------------------------
S
V
Q
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
DQ
L
--
I
----
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
---------
L
D
Q
-
A
R
S
L
D
D
L
A
---
E
R
--------
P
-------------------------
A
L
S
L
S
L
D
E
A
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
---
L
P
A
V
G
I
----------
D
-------
G
V
-------
Y
A
A
C
D
A
D
-
G
--
R
V
I
-----
A
L
L
R
D
E
G
----------
S
R
-----------
49
Fugue
66.82
28%
-103
- C4 -
-
1SGV
-
TRUB_MYCTU
A:
[3-292]
----------
A
T
--
G
P
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
----
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
R
R
D
--------------------
Q
----
L
--
I
----
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
---------
L
D
Q
-
A
R
S
L
D
D
L
A
---
E
R
--------
P
---------
A
-
L
--------------
S
L
S
L
D
E
A
-
C
L
L
M
F
A
R
R
D
L
T
A
A
E
A
S
A
A
A
N
G
R
S
---
L
P
A
V
G
I
--------
D
-
G
-------
V
Y
-------
A
A
C
D
A
-
D
-
G
--
R
V
I
-----
A
L
L
R
D
E
G
----------
S
-
R
T
R
S
V
A
V
L
R
P
-
9
PsiBlast_PDB
63.94
29%
-74
- C4 -
-
2APO
-
TRUB_METJA
A:
[67-330]
----------------
G
V
V
V
V
D
K
P
R
G
P
T
S
H
E
V
S
T
W
V
K
K
I
L
N
L
D
K
A
G
H
G
G
T
L
D
P
K
V
T
G
V
L
P
V
A
L
E
R
A
T
K
T
I
P
M
W
H
I
P
P
K
E
Y
V
C
L
M
H
L
H
R
D
A
S
----
E
E
D
I
L
R
--------------
V
F
K
E
F
T
G
R
I
Y
Q
R
----------------------------
R
I
R
K
I
H
E
L
E
L
L
D
K
D
----
G
--
K
----
D
V
L
F
R
V
K
C
Q
S
G
T
Y
I
R
K
L
C
E
D
I
G
E
A
L
G
T
S
A
H
M
Q
E
L
R
R
T
K
S
G
C
F
E
EKDAVY
L
Q
D
L
L
D
-
A
Y
V
F
-
W
K
E
---
D
G
--------
D
---------
E
-
E
E
L
----------
R
R
V
I
K
P
M
E
Y
-
G
L
R
H
L
K
K
V
V
V
K
D
S
A
V
D
A
I
C
H
G
A
D
---
V
Y
V
R
G
I
--------
A
-
K
-------
L
S
-------
K
G
I
G
K
-
G
-
E
--
T
V
L
V
E
T
LK
G
E
A
V
A
V
G
----------
K
A
L
M
N
T
K
E
I
L
N
--
4
PsiBlast_PDB
63.34
40%
-79
- C4 -
-
1SGV
-
TRUB_MYCTU
A:
[7-234]
----------------
G
I
V
V
I
D
K
P
A
G
M
T
S
H
D
V
V
G
R
C
R
R
I
F
A
T
R
R
V
G
H
A
G
T
L
D
P
M
A
T
G
V
L
V
I
G
I
E
R
A
T
K
I
L
G
L
L
T
A
A
P
K
S
Y
A
A
T
I
R
L
G
Q
T
T
S
T
E
D
A
E
G
Q
V
L
Q
S
V
P
A
K
H
L
T
I
E
A
I
D
A
A
M
E
R
L
R
G
E
I
----------------------------
L
E
A
R
P
I
R
I
D
R
F
E
L
L
A
A
R
----
R
--
R
DQ
L
I
D
I
D
V
E
I
D
C
S
S
G
T
Y
I
R
A
L
A
R
D
L
G
D
A
L
G
V
G
G
H
V
T
A
L
R
R
T
R
V
G
R
F
E
---------
L
D
Q
-
A
R
S
L
D
D
L
A
E
R
P
A
L
--------
S
---------
L
-
S
L
D
----------
E
A
C
L
L
-----------------------------------------------------------------------------------------------------------------
30
HHSearch
56.26
28%
-
- C4 -
-
3U28
-
CBF5_YEAST
A:
[49-320]
---
L
K
R
D
L
K
S
Y
I
--
S
S
G
V
I
N
L
D
K
P
S
N
P
S
S
H
E
V
V
A
W
I
K
R
I
L
R
C
E
K
T
G
H
S
G
T
L
D
P
K
V
T
G
C
L
I
V
C
I
D
R
A
T
R
L
V
K
S
Q
Q
G
A
G
K
E
Y
V
C
I
V
R
L
H
D
A
L
-----------------
K
D
E
K
D
L
G
R
S
L
E
N
L
T
G
A
L
F
Q
R
P
P
-----
K
R
Q
-----------------
L
R
V
R
T
I
Y
E
S
N
L
I
E
F
D
----
N
KR
N
----
L
G
V
F
W
A
S
C
E
A
G
T
Y
M
R
T
L
C
V
H
L
G
M
L
L
G
V
G
G
H
M
Q
E
L
R
R
V
R
S
G
A
L
S
---------
E
N
D
N
M
V
T
L
H
D
V
M
---
D
A
Q
W
V
Y
D
N
T-
R
D--------
E
-
S
Y
L
----------
R
S
I
I
Q
P
L
E
T
-
L
L
V
G
Y
K
R
I
V
V
K
D
S
A
V
N
A
V
C
Y
G
A
K
---
L
M
I
P
G
L
L
R
Y
E
E
GIE
L
-
Y
-------
D
E
-------
I
V
L
I
T
T
K
-
G
--
E
A
I
-----
A
V
A
I
A
Q
M
-----------------------