@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ68: (2017-11-25 )
MSQHLSLPKDKIRFLLLEGVHQNAVDTLNAAGYTNIDYRKTALEGEALKEAIKDAHFIGIRSRTQLTEEVFEAANKLIAVGCFCIGTNQVDLKAAMARGIPVFNAPYSNTRSVAELVLAETILLLRRVPEKSAACHRGGWDKSAVGSFETRGKTLGIVGYGSIGSQLSVLAESMGMNVIYYDAVTKLPMGNARQVGSLDELLATADVVTLHIPDVPSTRNFFTKEQFAKMKEGAIFLNAARGTCVVIEDLADAIKSGHLAGAAVDVFPKEPKANGEEFQSPLRGLDNVILTPHVGGSTMEAQANIGLEVAEKFVAYSDKGMTLSAVNFPEIALPLTAGQHRLLHIHKNVPGVLSKINNLFAEQGINISGQSLMTKGDIGYLVMDVDASASQEALDMLHEVEGTIRVRVLF
Atome Classification :
(24 SA)
.........10........20........30........40.........50........60........70........80........90........100.......110.......120.......130.......140....--...150.......160.......170.......180.......----190..--......200.......210.......220.......230...----.....240.......250.......260.......270.......280.......290.......300.......310.......320.......-----------------------------------------------330-------------------------------------------------------------------------------------------------------------------------------.----------.--------------...--------------------------------------------------------------------------------------------------------..---------------------------------------------------------------------------------.340.......350.......360.......370--..--.....380....--.--.--.--390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSQHLSL
P
K
D
K
I
R
F
L
L
L
E
G
V
HQNA
V
D
T
LNAAGYTNI
D
Y
R
K-TALE
G
E
A
L
K
E
A
I
KDA
H
F
I
GI
R
S
R
T
Q
L
T
E
E
V
F
E
A
A
N
K
L
I
A
V
G
C
F
C
IGTN
Q
V
D
L
K
A
A
M
ARGIPVFNAPYS
N
T
R
S
V
A
E
L
V
L
A
E
T
I
L
L
L
R
RVPEKSAACHRGGWDKSAVG--SFETRG
K
T
L
G
I
V
GYGSI
G
S
Q
L
S
V
L
A
E
SMG
M
N
V
I
Y
YD
A
V
TKLPM----G-NAR--QVG
S
L
D
E
L
L
ATA
D
V
V
T
L
HIPDVPSTRNFF
T
K
E
Q
F
A
K
MK-E
G
A
----
I
F
L
NAAR
G
T
C
V
V
I
E
D
L
A
D
A
I
KSGHLAG
A
A
V
DVFPKEPKAN
G
E
E
F
Q
S
P
L
R
GLD
N
V
I
L
TPHVGGST
M
E
A
QANI
G
L
E
V
A
E
K
F
V
AYSDKG
M
T
L
S
AVNFP-----------------------------------------------
E
I
--------------------------------------------------------------------------------------------------------------------------------
A
----------
L
--------------
P
LT--------------------------------------------------------------------------------------------------------AG---------------------------------------------------------------------------------
Q
H
R
L
L
H
IHKNV
P
G
V
L
S
K
I
N
N
L
F
A
EQGINISG
Q
S
L
--MT--KGD
I
G
Y
L
V
M
DVD--A--S--
A
--
S
Q
E
A
L
D
M
L
H
EVE
G
T
I
R
V
R
V
LF--
25
PsiBlast_CBE
88.21
60%
-112
- C1 -
-
2P9C
2
SERA_ECOLI
B:
[6-410]
------
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
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Q
L
K
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S
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D
A
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T
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D
V
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N
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N
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L
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A
A
A
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S
N
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A
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L
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L
L
L
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R
G
V
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E
A
N
A
K
A
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V
W
N
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L
A
A
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--
S
F
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G
K
K
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I
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T
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L
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L
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M
Y
V
Y
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I
E
N
K
L
P
L
----
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N
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--
Q
V
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L
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D
L
L
N
M
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D
V
V
S
L
H
V
P
E
N
P
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K
N
M
M
G
A
K
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L
M
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-
P
G
S
----
L
L
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N
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V
V
D
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P
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L
A
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K
H
L
A
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A
A
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F
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T
E
P
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S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
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V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
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V
L
T
A
L
N
K
I
F
A
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Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
DE
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
3
PsiBlast_PDB
88.13
60%
-113
- C1 -
-
2P9E
4
SERA_ECOLI
A:
[5-410]
-----
S
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
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L
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D
A
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L
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S
R
T
H
L
T
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D
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N
A
A
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A
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G
A
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T
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L
D
A
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A
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I
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V
F
N
A
P
F
S
N
T
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S
V
A
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L
V
I
G
E
L
L
L
L
L
R
G
V
P
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A
N
A
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A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
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L
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L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
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A
A
I
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V
F
P
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E
P
A
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N
S
D
P
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P
L
A
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F
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N
V
L
L
T
P
H
I
G
G
S
T
Q
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A
Q
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N
I
G
L
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V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
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A
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V
N
I
A
A
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Y
L
--
Q
T
--
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A
Q
M
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Y
V
V
I
D
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--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
21
PsiBlast_CBE
87.98
61%
-115
- C1 -
-
1PSD
2
SERA_ECOLI
B:
[6-409]
-------
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
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Q
L
K
E
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D
A
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C
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C
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F
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A
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L
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Y
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Y
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I
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N
K
L
P
L
----
G
-
N
A
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--
Q
V
Q
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L
S
D
L
L
N
M
S
D
V
V
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P
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N
P
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K
N
M
M
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A
K
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M
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-
P
G
S
----
L
L
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N
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T
V
V
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A
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C
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A
A
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T
E
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S
D
P
F
T
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P
L
C
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F
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N
V
L
L
T
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I
G
G
S
T
Q
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A
Q
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N
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G
L
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V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
G
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
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--
A
DE
D
--
V
--
A
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K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
6
PsiBlast_PDB
87.25
60%
-119
- C1 -
-
1YBA
5
SERA_ECOLI
A:
[5-410]
-----
S
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
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G
A
L
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V
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A
A
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E
P
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D
P
F
T
S
P
L
C
E
F
D
N
V
L
L
T
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I
G
G
S
T
Q
E
A
Q
E
N
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L
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V
A
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K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
G
G
---------------------------------------------------------------------------------
R
-
R
L
M
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I
H
E
N
R
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V
L
T
A
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N
I
A
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L
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Q
T
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Q
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V
I
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K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
1
PsiBlast_PDB
87.22
61%
-112
- C1 -
-
1PSD
2
SERA_ECOLI
A:
[6-409]
-------
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
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G
A
L
D
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A
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N
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L
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L
----
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--
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Q
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S
D
L
L
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----
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L
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L
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G
S
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S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
G
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
24
PsiBlast_CBE
86.92
60%
-113
- C1 -
-
2P9E
2
SERA_ECOLI
B:
[7-410]
-------
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
23
PsiBlast_CBE
86.83
60%
-112
- C1 -
-
2P9E
3
SERA_ECOLI
C:
[5-410]
-----
S
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
DE
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
2
PsiBlast_PDB
86.75
60%
-117
- C1 -
-
2P9C
2
SERA_ECOLI
A:
[6-410]
------
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
22
PsiBlast_CBE
86.58
60%
-118
- C1 -
-
2P9E
3
SERA_ECOLI
D:
[8-410]
--------
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
DE
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
4
PsiBlast_PDB
86.44
60%
-113
- C1 -
-
2PA3
2
SERA_ECOLI
A:
[5-410]
-----
S
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
26
PsiBlast_CBE
86.32
60%
-115
- C1 -
-
2P9G
2
SERA_ECOLI
B:
[7-410]
-------
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
V
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
DE
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
5
PsiBlast_PDB
85.69
60%
-115
- C1 -
-
2P9G
2
SERA_ECOLI
A:
[7-410]
-------
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
V
V
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
119
HHSearch
84.60
57%
-110
- C1 -
-
3K5P
4
?
A:
[12-416]
-------
S
R
D
R
I
N
V
L
L
L
E
G
I
S
Q
T
A
V
E
Y
F
K
S
S
G
Y
T
N
V
T
H
L
P
-
K
A
L
D
K
A
D
L
I
K
A
I
S
S
A
H
I
I
G
I
R
S
R
T
Q
L
T
E
E
I
F
A
A
A
N
R
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
A
G
G
W
E
K
T
A
I
G
--
S
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
Y
----
G
-
N
V
K
--
P
A
A
S
L
D
E
L
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
-
K
G
A
----
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
F
P
V
E
P
A
S
N
G
E
R
F
S
T
P
L
Q
G
L
E
N
V
I
L
T
P
H
I
G
G
S
T
E
E
A
Q
E
R
I
G
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
-----------------------------------------------
Q
V
--------------------------------------------------------------------------------------------------------------------------------
Q
----------
L
--------------
P
P
R
--------------------------------------------------------------------------------------------------------
P
T
---------------------------------------------------------------------------------
G
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
T
--
D
G
E
V
G
Y
L
V
M
E
A
D
--
G
--
V
G
E
A
--
S
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
Y
--
7
PsiBlast_PDB
84.07
60%
-116
- C1 -
-
1SC6
1
SERA_ECOLI
A:
[2-404]
--------
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
N
I
E
F
H
K
-
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
G
N
-------
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
---------
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
--------------------------------------------------------------------------------------------------------
G
G
---------------------------------------------------------------------------------
R
-
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
D
E
D
--
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
8
PsiBlast_PDB
83.94
56%
-109
- C1 -
-
3K5P
4
?
A:
[12-416]
-------
S
R
D
R
I
N
V
L
L
L
E
G
I
S
Q
T
A
V
E
Y
F
K
S
S
G
Y
T
N
V
T
H
L
P
-
K
A
L
D
K
A
D
L
I
K
A
I
S
S
A
H
I
I
G
I
R
S
R
T
Q
L
T
E
E
I
F
A
A
A
N
R
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
A
G
G
W
E
K
T
A
I
G
--
S
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
T
S
D
K
L
Q
Y
----
G
-
N
V
K
--
P
A
A
S
L
D
E
L
L
K
T
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
-
K
G
A
----
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
F
P
V
E
P
A
S
N
G
E
R
F
S
T
P
L
Q
G
L
E
N
V
I
L
T
P
H
I
G
G
S
T
E
E
A
Q
E
R
I
G
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
-----------------------------------------------
Q
V
--------------------------------------------------------------------------------------------------------------------------------
Q
----------
L
--------------
P
P
R
--------------------------------------------------------------------------------------------------------
P
T
---------------------------------------------------------------------------------
G
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
T
--
D
G
E
V
G
Y
L
V
M
E
A
D
GV
G
--
E
--
A
--
S
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
Y
--
118
HHSearch
76.22
60%
-40
- C1 -
-
2P9E
3
SERA_ECOLI
C:
[5-410]
-----
S
L
E
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
-
N
I
E
F
H
K
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
W
N
K
L
A
A
G
--
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
A
T
N
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
H
---------------------------------------------------------------------------------------------------------
V
---------------------------------------------------------------------------------
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
--
D
--
E
DV
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
120
HHSearch
72.89
61%
-45
- C1 -
-
1SC6
1
SERA_ECOLI
D:
[2-404]
--------
K
D
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
L
E
S
L
R
A
A
G
Y
T
-
N
I
E
F
H
K
G
A
L
D
D
E
Q
L
K
E
S
I
R
D
A
H
F
I
G
L
R
S
R
T
H
L
T
E
D
V
I
N
A
A
E
K
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
R
G
V
G
--------
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
P
L
----
G
-
N
A
T
--
Q
V
Q
H
L
S
D
L
L
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
-
P
G
S
----
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
----------
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
----
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
-----------------------------------------------
E
V
--------------------------------------------------------------------------------------------------------------------------------
S
----------
L
--------------
P
L
---------------------------------------------------------------------------------------------------------
H
G
---------------------------------------------------------------------------------
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
--
S
A
Q
M
G
Y
V
V
I
D
I
E
--
A
--
D
E
D
V
--
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
132
HHSearch
59.63
33%
-68
- C1 -
-
1YGY
1
SERA_MYCTU
A:
[3-526]
---------
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
-
Q
V
E
-
V
R
W
V
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
S
F
S
--
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
Q
-
L
-
G
I
E
--
L
-
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
-
P
G
V
----
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
-----
D
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
-----------------------------------------------
G
G
VVNEEV
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
----------
F
--------------
D
L
R
--------------------------------------------------------------------------------------------------------
A
Q
---------------------------------------------------------------------------------
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
--
E
G
P
G
A
T
I
L
L
R
L
D
--
Q
--
D
--
V
--
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
---
125
HHSearch
59.52
33%
-71
- C1 -
-
3DDN
2
SERA_MYCTU
A:
[3-525]
----------
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
-
Q
V
E
-
V
R
W
V
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
S
F
S
--
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
Q
-
L
-
G
I
E
--
L
-
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
-
P
G
V
----
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
-----
D
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
-----------------------------------------------
G
G
--------------------------------------------------------------------------------------------------------------------------------
V
VNEEVAPW
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDE
L
P
V
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
A
Q
---------------------------------------------------------------------------------
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
--
E
G
P
G
A
T
I
L
L
R
L
D
--
Q
--
D
--
V
--
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
---
138
Fugue
57.87
32%
-63
- C1 -
-
1YGY
1
SERA_MYCTU
A:
[3-529]
---------
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
V
A
A
L
G
D
Q
V
E
V
R
W
---
V
-
D
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
K
R
S
S
F
S
--
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
Y
V
S
P
A
R
----
A
-
A
Q
L
G
I
E
L
L
S
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
-
P
G
V
----
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
C
T
D
-----
S
P
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
GGVVNEEV
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
--------------------------------------------------------------------------------------------------------------------------------
R
----------
L
--------------
S
A
L
--------------------------------------------------------------------------------------------------------
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
AQ
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
--
S
E
D
A
E
G
P
G
A
T
I
L
L
R
L
D
--
Q
--
D
--
V
--
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
LS
116
PsiBlast_CBE
34.74
32%
-48
- C1 -
-
5BQF
4
?
A:
[100-285]
------------------------------------------------------------------------------------------------------------
S
L
T
T
R
M
S
E
W
V
V
M
Q
C
L
M
H
L
R
G
Q
Y
G
H
D
S
H
Q
R
R
R
E
W
A
K
--
L
I
--
A
P
E
A
A
E
V
T
V
G
V
M
G
L
G
I
L
G
Q
D
A
V
A
K
L
K
V
M
G
F
N
V
I
G
W
S
R
T
R
K
T
I
E
----
G
V
E
T
F
--
D
A
G
E
L
D
R
F
L
A
K
T
D
I
L
V
G
L
L
P
L
T
P
E
T
T
G
F
Y
D
S
E
L
F
K
K
L
R
R
D
G
A
LG
Q
P
V
F
I
N
A
G
R
G
K
S
Q
I
E
T
D
I
V
S
A
V
R
E
G
T
L
G
G
A
S
L
D
V
F
E
V
E
P
L
A
T
----
D
S
P
L
W
E
L
E
N
V
F
I
T
P
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
34.46
32%
-51
- C1 -
-
5TSD
2
?
B:
[100-285]
------------------------------------------------------------------------------------------------------------
S
L
T
T
R
M
S
E
W
V
V
M
Q
C
L
M
H
L
R
G
Q
Y
G
H
D
S
H
Q
R
R
R
E
W
A
K
--
L
I
--
A
P
E
A
A
E
V
T
V
G
V
M
G
L
G
I
L
G
Q
D
A
V
A
K
L
K
V
M
G
F
N
V
I
G
W
S
R
T
R
K
T
I
E
----
G
V
E
T
F
--
D
A
G
E
L
D
R
F
L
A
K
T
D
I
L
V
G
L
L
P
L
T
P
E
T
T
G
F
Y
D
S
E
L
F
K
K
L
R
R
D
G
A
LGQP
V
F
I
N
A
G
R
G
K
S
Q
I
E
T
D
I
V
S
A
V
R
E
G
T
L
G
G
A
S
L
D
V
F
E
V
E
P
L
A
T
----
D
S
P
L
W
E
L
E
N
V
F
I
T
P
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
PsiBlast_CBE
34.29
32%
-49
- C1 -
-
5TSD
2
?
A:
[100-285]
------------------------------------------------------------------------------------------------------------
S
L
T
T
R
M
S
E
W
V
V
M
Q
C
L
M
H
L
R
G
Q
Y
G
H
D
S
H
Q
R
R
R
E
W
A
K
--
L
I
--
A
P
E
A
A
E
V
T
V
G
V
M
G
L
G
I
L
G
Q
D
A
V
A
K
L
K
V
M
G
F
N
V
I
G
W
S
R
T
R
K
T
I
E
----
G
V
E
T
F
--
D
A
G
E
L
D
R
F
L
A
K
T
D
I
L
V
G
L
L
P
L
T
P
E
T
T
G
F
Y
D
S
E
L
F
K
K
L
R
R
D
G
A
LG
Q
P
V
F
I
N
A
G
R
G
K
S
Q
I
E
T
D
I
V
S
A
V
R
E
G
T
L
G
G
A
S
L
D
V
F
E
V
E
P
L
A
T
----
D
S
P
L
W
E
L
E
N
V
F
I
T
P
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
31.33
33%
-10
- C1 -
-
3JTM
8
FDH_ARATH
A:
[95-314]
-------------------------------------------------------------------------------------
I
G
S
D
H
I
D
L
Q
A
A
A
A
A
G
L
T
V
A
E
V
T
G
S
N
V
V
S
V
A
E
D
E
L
M
R
I
L
I
L
M
R
N
F
V
P
G
Y
N
Q
V
V
K
G
E
W
N
V
A
G
I
A
Y
R
A
Y
D
L
E
G
K
T
I
G
T
V
G
A
G
R
I
G
K
L
L
L
Q
R
L
K
P
F
G
C
N
L
L
Y
H
D
R
L
Q
M
A
P
E
L
E
K
E
T
-
G
A
K
--
F
V
E
D
L
N
E
M
L
P
K
C
D
V
I
V
I
N
M
P
L
T
E
K
T
R
G
M
F
N
K
E
L
I
G
K
L
K
-
K
G
V
----
L
I
V
N
N
A
R
G
A
I
M
E
R
Q
A
V
V
D
A
V
E
S
G
H
I
G
G
Y
S
G
D
V
W
D
P
Q
P
A
P
K
----
D
H
P
W
R
Y
M
P
N
Q
A
M
T
P
H
T
S
G
T
T
I
D
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------