@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ85: (2017-11-25 )
MEQPISVTRSNFNDWMVPVFAPANFIPVRGEGSRIWDQENKEYIDFAGGIAVNALGHAHPVAVNALTEQAKKLWHVGNGYTNEPVLRLAKQLTENTFADKVFFCNSGAEANEAALKLARKVGLDSGVAGKSGIVAFNNAFHGRTLFTVSAGGQPKYSQDFAPLPNGISHVAYNDLEAAKAVINEQTCAVIVEPVQGEGGVIPADIEFLKGLRELCDQFGALLIFDEVQTGVGRTGALYAYMNYGVVPDVLTTAKALGGGFPVGAMLTTDKFAPHFSVGTHGTTYGGNPLASAVAGAVFEFINTPEVLEGVKHRHQYFLDALNALNAEYQVFDEIRGQGLLIGCVLKAEYAGKAKDITTWAGEEGLLALIAGPNVVRFTPSLIIPEQDIDEGIARLKRALAKLAK
Atome Classification :
(49 SA)
.........10........20.......---.30........40........50......-..60........70......-..80........90.---..--.....-100.......110.......120..-...--..-130-.......140.......150.......160........170----------.....-..180.-----------------...---...190.......200.......210.......220.......230.......240.......250.......-260.......270.......280.......290.......300.......310.......320.......330.......340....-...---350...-....360.......370.......380.......390.......400..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEQPISVTRSNFND
W
M
V
P
V
FAPA
N
F
I
PV---RGEGSRIWDQENK
E
Y
I
DFAG
G
I
A
V
NALGH-AH
P
V
A
V
N
A
L
T
E
Q
A
K
K
L
W
HVG-NGYTN
E
P
V
L
R
L
A
K
Q
L
---TE--NTFA
D
-
K
V
F
F
CNSGAE
A
N
E
A
A
L
K
L
A
R
K
VGLD-SGV--AG-KS
G
-
I
V
A
FNNAFHG
R
T
L
F
T
VSAGGQPKYSQDFA-PLPNG
I
S
H
V
A
Y
----------
N
D
L
E
A
-
A
K
A
V
IN-----------------EQ
T
---
C
A
V
I
V
E
PVQGEG
G
V
IP
A
D
I
E
F
L
K
G
L
R
E
L
C
D
QFG
A
L
L
I
F
D
E
V
Q
TGVGRTG
A
L
Y
A
Y
MNYGVV
P
D
V
L
T
T
A
K
ALGGG-FPV
G
A
M
L
TTDKFAPHFSVGTHGTTYGG
N
P
L
A
S
A
V
A
G
A
V
F
E
FIN
T
P
E
V
L
E
G
V
K
H
R
H
Q
Y
F
L
D
A
L
N
ALN
A
E
Y
Q
V
F
D
E
IRGQ
G
L
L
I
G
C
V
L
K-AEY---AGKAKD-
I
T
TWAGEE
G
L
L
A
L
I
AGP
N
V
V
R
FTPSLII
P
E
Q
D
I
D
E
G
I
A
R
L
K
R
A
L
A
K
LAK
4
PsiBlast_PDB
95.10
70%
-104
- C1 -
-
4ADE
-
ASTC_ECOLI
A:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
25
PsiBlast_CBE
95.08
70%
-107
- C1 -
-
4ADC
2
ASTC_ECOLI
C:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
24
PsiBlast_CBE
95.07
70%
-104
- C1 -
-
4ADC
2
ASTC_ECOLI
D:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
2
PsiBlast_PDB
94.87
70%
-105
- C1 -
-
4ADC
2
ASTC_ECOLI
A:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
29
PsiBlast_CBE
94.65
70%
-103
- C1 -
-
4ADB
2
ASTC_ECOLI
B:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
26
PsiBlast_CBE
94.06
70%
-106
- C1 -
-
4ADC
2
ASTC_ECOLI
B:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
28
PsiBlast_CBE
94.01
70%
-103
- C1 -
-
4ADB
2
ASTC_ECOLI
C:
[4-396]
---
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
1
PsiBlast_PDB
93.92
70%
-102
- C1 -
-
4ADB
2
ASTC_ECOLI
A:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
23
PsiBlast_CBE
93.55
70%
-103
- C1 -
-
4ADD
4
ASTC_ECOLI
B:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
22
PsiBlast_CBE
93.48
70%
-102
- C1 -
-
4ADD
4
ASTC_ECOLI
C:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
27
PsiBlast_CBE
93.47
70%
-104
- C1 -
-
4ADB
2
ASTC_ECOLI
D:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
21
PsiBlast_CBE
92.92
70%
-102
- C1 -
-
4ADD
4
ASTC_ECOLI
D:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
6
PsiBlast_PDB
92.88
58%
-105
- C1 -
-
4JEV
2
ARGD_SALTY
A:
[22-418]
-----
A
I
T
R
A
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
30
PsiBlast_CBE
92.54
58%
-106
- C1 -
-
4JEW
9
ARGD_SALTY
B:
[31-418]
--------------
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
35
PsiBlast_CBE
92.14
58%
-106
- C1 -
-
4JEY
9
ARGD_SALTY
B:
[33-418]
----------------
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
3
PsiBlast_PDB
92.10
70%
-99
- C1 -
-
4ADD
4
ASTC_ECOLI
A:
[3-396]
--
Q
P
I
--
T
R
E
N
F
D
E
W
M
I
P
V
Y
A
P
A
P
F
I
P
V
---
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
Q
A
S
K
F
W
H
T
G
-
N
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
---
I
D
--
A
T
F
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
H
D
-
R
Y
G
--
S
H
-
K
S
G
-
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
A
-
P
L
P
A
D
I
R
H
A
A
Y
----------
N
D
I
N
S
-
A
S
A
L
I
D
-----------------
D
S
T
---
C
A
V
I
V
E
P
I
Q
G
E
G
G
V
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
P
V
G
A
L
L
A
T
E
E
C
A
R
V
M
T
V
G
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
V
E
R
L
N
T
I
N
H
R
Y
G
L
F
S
E
V
R
G
L
G
L
L
I
G
C
V
L
N
-
A
D
Y
---
A
G
Q
A
K
Q
-
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
G
N
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
------
33
PsiBlast_CBE
91.97
58%
-105
- C1 -
-
4JF1
6
ARGD_SALTY
B:
[33-418]
----------------
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
5
PsiBlast_PDB
91.12
58%
-109
- C1 -
-
4JEW
9
ARGD_SALTY
A:
[22-418]
-----
A
I
T
R
A
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
8
PsiBlast_PDB
90.71
58%
-109
- C1 -
-
2PB2
6
ARGD_SALTY
A:
[39-418]
----------------------
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
----
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
32
PsiBlast_CBE
90.66
58%
-107
- C1 -
-
2PB0
5
ARGD_SALTY
B:
[33-418]
----------------
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
10
PsiBlast_PDB
89.97
58%
-108
- C1 -
-
4JEZ
6
ARGD_SALTY
A:
[39-418]
----------------------
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
9
PsiBlast_PDB
89.93
58%
-108
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[27-418]
----------
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
11
PsiBlast_PDB
89.91
58%
-108
- C1 -
-
4JEX
8
ARGD_SALTY
A:
[39-418]
----------------------
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
36
PsiBlast_CBE
89.11
58%
-107
- C1 -
-
4JEX
8
ARGD_SALTY
B:
[33-418]
----------------
L
P
V
K
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
34
PsiBlast_CBE
89.07
58%
-106
- C1 -
-
4JEZ
6
ARGD_SALTY
B:
[33-418]
----------------
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
7
PsiBlast_PDB
88.77
58%
-109
- C1 -
-
2PB0
5
ARGD_SALTY
A:
[27-418]
----------
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
---
K
G
R
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
--
105
HHSearch
87.33
59%
-84
- C1 -
-
4JEV
2
ARGD_SALTY
B:
[21-419]
----
T
A
I
T
R
A
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
KG-
R
--
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
-
104
HHSearch
85.23
58%
-86
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[27-419]
----------
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
---
I
D
--
A
T
F
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
-
R
H
S
--
P
F
-
K
T
K
-
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
G
-
P
K
P
A
D
I
I
H
V
P
F
----------
N
D
L
H
A
-
V
K
A
V
M
D
-----------------
D
H
T
---
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
-
P
K
Y
KG-
R
--
A
R
D
-
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
G
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
-
12
PsiBlast_PDB
80.45
45%
-102
- C1 -
-
2E54
3
ARGD_THEMA
A:
[11-382]
---------------------
P
A
T
F
--
V
---
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
---
S
K
--
N
T
F
G
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
S
E
--
K
K
-
Y
R
--
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
E
-
P
L
V
P
G
F
E
Y
F
E
F
----------
N
N
V
E
D
-
L
R
R
K
M
S
-----------------
E
D
V
---
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
-
A
N
V
L
E
P
G
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
-
E
E
V
---
S
N
--
R
E
-
V
A
T
K
C
F
E
N
K
L
L
V
V
P
A
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
-----
13
PsiBlast_PDB
79.71
45%
-102
- C1 -
-
2ORD
14
ARGD_THEMA
A:
[23-394]
---------------------
P
A
T
F
--
V
---
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
---
S
K
--
N
T
F
G
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
K
K
-
K
S
E
--
K
K
-
Y
R
--
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
E
-
P
L
V
P
G
F
E
Y
F
E
F
----------
N
N
V
E
D
-
L
R
R
K
M
S
-----------------
E
D
V
---
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
-
A
N
V
L
E
P
G
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
-
E
E
V
---
S
N
--
R
E
-
V
A
T
K
C
F
E
N
K
L
L
V
V
P
A
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
-----
14
PsiBlast_PDB
66.94
43%
-17
- C1 -
-
2EH6
2
ARGD_AQUAE
A:
[11-375]
---------------------
P
V
K
F
--
V
---
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
S
-
N
L
Y
E
N
P
W
Q
E
E
L
A
H
K
L
---
V
K
--
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
G
---
K
N
-
K
W
K
-
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
E
-
P
L
V
P
G
F
S
Y
A
K
L
----------
N
D
I
D
S
-
V
Y
K
L
L
D
-----------------
E
E
T
---
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
--
E
V
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
E
-
R
E
-------
C
K
D
-
Y
V
L
K
A
L
E
K
G
L
L
I
N
C
T
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
-----
37
PsiBlast_CBE
66.73
43%
-20
- C1 -
-
2EH6
2
ARGD_AQUAE
B:
[11-375]
---------------------
P
V
K
F
--
V
---
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
S
-
N
L
Y
E
N
P
W
Q
E
E
L
A
H
K
L
---
V
K
--
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
-
K
G
---
K
N
-
K
W
K
-
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
E
-
P
L
V
P
G
F
S
Y
A
K
L
----------
N
D
I
D
S
-
V
Y
K
L
L
D
-----------------
E
E
T
---
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
--
E
V
E
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
E
-
R
E
-------
C
K
D
-
Y
V
L
K
A
L
E
K
G
L
L
I
N
C
T
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
-----
59
PsiBlast_CBE
58.98
35%
-29
- C1 -
-
1OAT
2
OAT_HUMAN
B:
[64-436]
-------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
60
PsiBlast_CBE
58.81
35%
-30
- C1 -
-
1OAT
2
OAT_HUMAN
A:
[64-436]
-------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
18
PsiBlast_PDB
58.16
40%
11
- C1 -
-
1WKH
2
LYSJ_THET8
A:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
I
L
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
48
PsiBlast_CBE
58.04
36%
-31
- C1 -
-
2BYJ
2
OAT_HUMAN
A:
[64-436]
-------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
39
PsiBlast_CBE
57.86
40%
9
- C1 -
-
1WKG
2
LYSJ_THET8
B:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
IL
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
56
PsiBlast_CBE
57.65
35%
-30
- C1 -
-
2OAT
2
OAT_HUMAN
B:
[64-436]
-------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
Y
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
40
PsiBlast_CBE
57.40
40%
12
- C1 -
-
1VEF
2
LYSJ_THET8
B:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
IL
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
16
PsiBlast_PDB
57.34
40%
13
- C1 -
-
1VEF
2
LYSJ_THET8
A:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
I
L
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
47
PsiBlast_CBE
57.33
36%
-31
- C1 -
-
2BYJ
2
OAT_HUMAN
B:
[64-436]
-------------------------------
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
38
PsiBlast_CBE
57.14
40%
11
- C1 -
-
1WKH
2
LYSJ_THET8
B:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
IL
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
63
PsiBlast_CBE
56.08
35%
-3
- C1 -
-
2BYL
2
OAT_HUMAN
A:
[55-436]
----------------------
A
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
17
PsiBlast_PDB
56.01
40%
10
- C1 -
-
1WKG
2
LYSJ_THET8
A:
[23-395]
------------------
V
Y
N
K
H
D
L
L
I
V
---
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
-
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
---
T
A
I
L
P
P
E
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
-------
A
H
--
T
G
-
R
K
K
-
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
L
-
P
L
V
E
P
V
E
F
I
P
Y
----------
N
D
V
E
A
-
L
K
R
A
V
D
-----------------
E
E
T
---
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
-
E
K
------
A
A
P
Y
-
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
----
112
HHSearch
55.91
34%
-14
- C1 -
-
5VIU
9
?
A:
[15-419]
----
S
E
Y
F
I
E
L
E
E
K
H
G
A
H
N
Y
H
P
L
P
V
V
L
D
---
R
G
E
G
V
F
V
W
D
V
E
G
K
K
Y
Y
D
F
L
S
A
Y
S
A
V
N
Q
G
H
-
S
H
P
K
I
V
E
A
L
V
E
Q
A
S
K
L
A
L
T
S
-
R
A
F
Y
N
S
K
L
G
E
Y
E
Q
K
I
---
T
S
--
L
L
G
F
D
-
K
V
L
P
M
N
S
G
A
E
A
V
E
T
A
V
K
L
A
R
K
W
S
Y
E
-
V
K
G
IA
E
N
-
A
A
K
-
I
I
V
C
E
N
N
F
H
G
R
T
T
T
I
--
F
S
N
D
P
D
-----
G
-
P
F
T
P
G
F
I
R
I
P
Y
----------
N
D
I
A
A
-
L
E
E
V
L
S
K
EA--------------
G
N
I
---
A
A
F
L
V
E
P
I
Q
G
E
A
G
V
Y
V
P
N
E
G
F
L
K
Q
S
S
E
L
C
K
K
H
N
V
L
F
I
A
D
E
V
Q
T
G
I
A
R
T
G
K
L
I
A
C
H
H
E
D
V
Q
P
D
I
L
I
L
G
K
A
L
S
G
G
M
Y
P
V
S
A
V
L
A
N
N
N
I
M
D
V
I
K
P
G
Q
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
M
A
A
L
D
V
V
Q
D
E
K
L
S
E
R
A
E
K
L
G
N
L
F
R
S
E
I
E
K
L
I
E
K
T
D
L
I
T
K
V
R
G
K
G
L
L
N
A
I
L
I
N
-
D
T
P
DSS
T
--
A
W
N
-
L
C
L
A
L
K
E
N
G
L
L
A
K
P
T
H
G
N
I
I
R
L
A
P
P
L
V
I
T
E
E
Q
L
L
D
C
V
K
I
I
E
K
T
I
L
E
F
--
45
PsiBlast_CBE
55.79
35%
-10
- C1 -
-
5VIU
9
?
A:
[30-416]
-------------------
Y
H
P
L
P
V
V
L
D
---
R
G
E
G
V
F
V
W
D
V
E
G
K
K
Y
Y
D
F
L
S
A
Y
S
A
V
N
Q
G
H
-
S
H
P
K
I
V
E
A
L
V
E
Q
A
S
K
L
A
L
T
S
-
R
A
F
Y
N
S
K
L
G
E
Y
E
Q
K
I
---
T
S
--
L
L
G
F
D
-
K
V
L
P
M
N
S
G
A
E
A
V
E
T
A
V
K
L
A
R
K
W
S
Y
E
V
K
G
I
--
A
E
-
N
A
A
K
I
I
V
C
E
N
N
F
H
G
R
T
T
T
I
--
F
S
N
D
P
D
-----
G
-
P
F
T
P
G
F
I
R
I
P
Y
----------
N
D
I
A
A
-
L
E
E
V
L
S
-----------------
K
E
A
GNI
A
A
F
L
V
E
P
I
Q
G
E
A
G
V
Y
V
P
N
E
G
F
L
K
Q
S
S
E
L
C
K
K
H
N
V
L
F
I
A
D
E
V
Q
T
G
I
A
R
T
G
K
L
I
A
C
H
H
E
D
V
Q
P
D
I
L
I
L
G
K
A
L
S
G
G
M
Y
P
V
S
A
V
L
A
N
N
N
I
M
D
V
I
K
P
G
Q
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
M
A
A
L
D
V
V
Q
D
E
K
L
S
E
R
A
E
K
L
G
N
L
F
R
S
E
I
E
K
L
I
E
K
T
D
L
I
T
K
V
R
G
K
G
L
L
N
A
I
L
I
N
D
T
P
D
---
S
S
T
A
W
N
-
L
C
L
A
L
K
E
N
G
L
L
A
K
P
T
H
G
N
I
I
R
L
A
P
P
L
V
I
T
E
E
Q
L
L
D
C
V
K
I
I
E
K
T
I
-----
62
PsiBlast_CBE
54.52
35%
-2
- C1 -
-
2BYL
2
OAT_HUMAN
B:
[55-436]
----------------------
A
H
P
L
P
V
ALE
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
Q
V
D
K
L
T
L
T
S
-
R
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
---
T
K
--
L
F
N
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
K
G
I
--
Q
K
Y
K
A
K
-
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
G
-
P
F
M
P
G
F
D
I
I
P
Y
----------
N
D
L
P
A
L
E
R
A
L
Q
D
-----------------
P
N
V
---
A
A
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
P
V
S
A
V
L
C
D
D
D
I
M
L
T
I
K
P
G
E
H
F
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
R
N
E
L
M
K
L
P
S
D
--
V
V
T
A
V
R
G
K
G
L
L
N
A
I
V
I
K
-
E
T
K
---
D
W
D
A
W
K
-
V
C
L
R
L
R
D
N
G
L
L
A
K
P
T
H
G
D
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
-----
111
HHSearch
53.05
34%
-15
- C1 -
-
5VIU
4
?
B:
[15-419]
----
S
E
Y
F
I
E
L
E
E
K
H
G
A
H
N
Y
H
P
L
P
V
V
L
D
---
R
G
E
G
V
F
V
W
D
V
E
G
K
K
Y
Y
D
F
L
S
A
Y
S
A
V
N
Q
G
H
-
S
H
P
K
I
V
E
A
L
V
E
Q
A
S
K
L
A
L
T
S
-
R
A
F
Y
N
S
K
L
G
E
Y
E
Q
K
I
---
T
S
--
L
L
G
F
D
-
K
V
L
P
M
N
S
G
A
E
A
V
E
T
A
V
K
L
A
R
K
W
S
Y
E
-
V
K
G
IA
E
N
-
A
A
K
-
I
I
V
C
E
N
--------------------------
T
P
G
F
I
R
I
P
Y
----------
N
D
I
A
A
-
L
E
E
V
L
S
K
EA--------------
G
N
I
---
A
A
F
L
V
E
P
I
Q
G
E
A
G
V
Y
V
P
N
E
G
F
L
K
Q
S
S
E
L
C
K
K
H
N
V
L
F
I
A
D
E
V
Q
T
G
I
A
R
T
G
K
L
I
A
C
H
H
E
D
V
Q
P
D
I
L
I
L
G
K
A
L
S
G
G
M
Y
P
V
S
A
V
L
A
N
N
N
I
M
D
V
I
K
P
G
Q
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
M
A
A
L
D
V
V
Q
D
E
K
L
S
E
R
A
E
K
L
G
N
L
F
R
S
E
I
E
K
L
I
E
K
T
D
L
I
T
K
V
R
G
K
G
L
L
N
A
I
L
I
N
-
D
T
P
DSS
T
--
A
W
N
-
L
C
L
A
L
K
E
N
G
L
L
A
K
P
T
H
G
N
I
I
R
L
A
P
P
L
V
I
T
E
E
Q
L
L
D
C
V
K
I
I
E
K
T
I
L
E
F
--
92
PsiBlast_CBE
42.37
34%
13
- C1 -
-
2EO5
2
?
A:
[30-415]
-------------------------------
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
A
N
D
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
S
P
--
G
N
F
Q
K
-
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
----------
T
G
-
R
K
Y
-
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
PNPYRNPWHI
N
G
Y
E
N
-
P
S
E
L
V
N
R
V
I
E
F
I
E
DYIFVNLVPP
E
E
V
---
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
F
R
K
D
L
--
D
F
K
------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
L
A
------
D
D
V
R
G
I
G
L
A
W
G
L
-----
E
Y
N--
E
K
K
V
R
D
R
I
I
G
E
S
F
K
R
G
L
L
L
L
P
A
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
-----