@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQB1: (2017-11-26 )
MPAYKAPLHDIRFLMNEVLDYPAHYKTLSNGESADPDTVDMILEGAADYCENVLSPLNQSGDEEGCHFDNGEVKTPKGFKEAYDQFVMGGWQGLSYPEEFGGQGLPMSLNLIKSEMMGTANWSFTMYPGLSSGCMNTILQFGTDEQKQTYMPKLVEGTWSGTMCLTEPQCGTDLGQVKTKAEPQADGTYKISGTKIFISAGEHDLTENIIHIVLARLPDAPAGTRGISLFIVPKFIPTAEGGVGERNTVSCGSIEHKMGIRASATAVLNFDNATGYLIGEVNKGLHAMFTFMNTARIGTAVQGIAHAELSFQGALPYAKERMSMRALSGKKDPDKVADAIIHHADVRRMLLTQKAIAEGGRSMIYYAAQLADKMTDALTRGDQAAFEDYDDKLGFYTPILKGFLTELGLEAANHGMQVYGGHGYIKEWGMEQIVRDARISTLYEGTTGVQALDLIGRKVLLSSKGKVVREYTAEILKFCAAHARNKYLRRFAWDLTKLCAQWNTLTVRIMLAARKDRDIVSSASVDFLMFSGYVMMAYFWAQQAVVASEKLEAGNGQETPEFYKAKIKVADFYFDRLLPRAQGHAESMVTTSRTLTSLPAEHFSFDY
Atome Classification :
(20 SA)
----------------.........10------.........20........30........40........50........60........70........80........90........100....----...110.....--..120.......130.--.-.-.....-140-.........150....----...160.......170....-...180...-..-.-.190.......-200.......210.......----220---........230.......240.......250.......260.......270---.---.---.---....-280.......290.......300.......310.......320.......330-........340.......350.....-..360.......370.......380.-...--...390.......400.......410.......420.......430.......440.......450.......460....--------------...470.---.---.....480-.--.----..--.....490.......500..----...-..510...-------....520.......530.......540.......550-..--.....560.......570.......580.--......590.......600.....------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------MPAYKA
P
L
H
D
-------
I
R
F
L
M
N
E
V
LDYPAH
Y
K
TLSNGESAD
P
D
T
V
D
M
I
L
E
G
A
A
D
Y
C
E
N
V
L
S
P
LNQSGDEEGCHFDNGEVKT
P
K
G
F
K
E
A
Y
D
Q
F
V
M
GGWQGLS
Y
P
E
E
FGGQGLP----
M
S
L
N
L
I
K
S
E
MM--GTANW
S
F
T
MYPGL-SS--
G
-
C
-
M
N
T
I
L
-Q---FGT
D
E
Q
K
QTY
M
P
K
L
VE----GTWSG
T
M
C
LTEPQCGTD
L
G
Q-VKTKAEPQA-D
G
-
T
-
Y
K
ISG
T
K
I
F
I
S-AGEH
D
L
T
E
N
I
I
H
I
V
L
A
RLPD----AP----AGTR
G
I
S
L
F
I
V
PKFIPTAEGGVGERNTVSCGS
I
E
H
KMGI
R
A
S
A
T
A
V
L
N
FDN---A---
T
---
G
---
Y
L
I
G
-
E
VNK
G
L
H
A
M
F
T
F
M
N
T
A
R
I
G
T
A
V
Q
G
I
A
H
A
E
L
S
FQGAL
P
Y
A
K
E
R
M
S
M
R
ALSGKK--
D
P
D
K
V
A
D
A
I
I
H
H
A
D
V
R
R
M
L
L
T
Q
K
A
I
A
-EGGR
S
M
I
Y
Y
A
A
Q
L
A
D
K
M
T
D
A
L
TRG
D
Q
-
A
A
F
--
E
D
YDDKLG
F
Y
T
P
I
L
K
G
F
L
T
E
L
G
L
E
A
A
NHG
M
Q
V
YGGH
G
Y
I
K
EW
G
M
E
Q
I
V
R
D
A
R
I
S
T
L
YEGTT
G
V
Q
A
L
D
L
I
G
R
K
V
L
LSSK
G
K
--------------
V
V
R
E
Y
T
A
---
E
---
I
L
K
F
C
A
---
A
--
H
----
A
R
--
N
K
Y
L
R
R
F
A
W
D
L
T
K
L
C
AQWN
T
----
L
T
V
-
R
I
M
L
A
ARK-------DRDIVSSAS
V
D
F
L
MFS
G
Y
V
M
M
A
Y
F
W
A
Q
Q
A
V
V
A
S
EKLE-AG--NGQET
P
E
F
Y
K
A
K
I
K
V
A
D
F
Y
F
D
R
LLPRAQG--H
A
E
S
M
VTTS
R
T
L
T
SL
P
A
E
HFSFDY------
25
HHSearch
76.75
24%
-17
- C1 -
-
2UXW
4
ACADV_HUMAN
A:
[53-577]
------------------------------------------------------------
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
--
D
A
L
E
M
V
--------
E
---
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
----
N
T
Q
Y
A
R
L
V
E
I
V
--
G
M
H
D
L
G
V
G
I
T
L
G
A
-
H
Q
--
S
I
G
-
F
K
G
I
L
-
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
C
G
K
-
Y
-
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
--
A
D
--
I
F
T
V
F
A
K
T
P
V
----
T
D
PATG
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
G
----------
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
---
S
---
E
---
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
--------------
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
-
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
A
T
------------------
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
-
V
A
L
Q
G
C
M
-
D
K
G
K
E
L
S
G
L
GS
A
L
K
N
PFG--------------------SGL
S
--
L
----
S
G
LV
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
E
-
A
K
L
I
K
H
K
K
GIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
------
V
L
S
----
R
A
S
R
S
L
S
-
E
G
-------
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
--
G
M
A
A
L
Q
S
D
P
---------------------
46
Fugue
76.34
21%
-37
- C1 -
-
2Z1Q
2
?
B:
[5-577]
-------------------
K
K
L
W
Q
K
G
-------
G
G
W
L
L
E
V
P
E
R
V
Y
T
--------
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
----------
G
E
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
----
K
V
I
S
T
V
V
A
E
E
L
--
S
G
S
G
G
F
S
V
T
Y
G
A
H
-
T
S
--
I
-
G
-
T
L
P
L
V
-
Y
---
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
----
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
-
A
K
T
R
A
T
L
S
E
-
D
G
K
H
-
Y
I
L
N
G
V
K
Q
W
I
S
-
N
A
G
F
----
A
H
L
F
T
V
F
A
K
V
-------------
D
G
E
H
F
T
A
F
L
V
E
R
D
T
P
G
----------
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
---
V
---
K
---
V
P
VE
N
V
L
G
-
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
--------------
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
-
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
G
-
K
K
G
P
E
-
A
V
M
--
A
G
I
E
E
-
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
--------------
L
E
L
H
Q
V
Q
N
L
K
K
---
L
A
L
M
V
A
---
G
--
L
----
A
V
--
Q
K
Y
G
Q
G
V
E
E
E
-
Q
E
V
L
G
A
V
A
D
----
I
L
I
-
D
A
Y
A
A
E
S
A
-------
L
L
R
A
R
R
L
G
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
-
R
-
L
V
--
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
D
L
V
A
L
R
R
Q
--
A
A
E
A
V
L
E
A
G
G
Y
P
I
P
R
---------------
24
HHSearch
75.51
24%
-11
- C1 -
-
3B96
2
ACADV_HUMAN
A:
[33-557]
------------------------------------------------------------
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
--
N
D
A
L
E
M
V
--------
E
---
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
----
N
T
Q
Y
A
R
L
V
E
I
V
--
G
M
H
D
L
G
V
G
I
T
L
G
A
-
H
Q
--
S
I
G
-
F
K
G
I
L
-
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
C
G
K
-
Y
-
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
--
A
D
--
I
F
T
V
F
A
K
T
P
V
----
T
D
PATG
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
G
----------
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
---
S
---
E
---
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
--------------
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
-
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
A
T
------------------
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
-
V
A
L
Q
G
C
M
-
D
K
G
K
E
L
S-----------------------------------LS
L
----
S
G
LV
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
E
-
A
K
L
I
K
H
K
K
GIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
------
V
L
S
----
R
A
S
R
S
L
S
-
E
G
-------
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
--
G
M
A
A
L
Q
S
D
P
---------------------
26
HHSearch
75.05
22%
-13
- C1 -
-
3OWA
8
?
C:
[33-551]
---------------------------------------------------------
F
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
H
E
F
D
R
-------
S
---
V
R
L
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
----
K
V
S
S
A
L
I
A
E
K
F
--
S
R
A
G
-
G
F
A
I
T
H
G
A
-
H
V
--
G
I
G
-
S
L
P
I
V
-
L
---
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
----
G
E
K
L
A
A
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
-
A
K
T
T
A
R
L
N
A
E
G
T
-
H
-
Y
V
L
N
G
E
K
Q
W
I
T
-
N
S
A
F
--
A
D
--
V
F
I
V
Y
A
K
I
D
G
-------------
E
H
F
S
A
F
I
V
E
K
D
Y
A
----------
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
E
D
A
L
V
P
---
K
---
E
---
N
L
L
G
-
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
--------------
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
-
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
S
R
M
S
T
L
S
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
-
I
V
P
G
T
F
L
R
-
K
A
M
K
--------------
G
E
L
P
L
L
Q
---
K
A
Q
K
L
Q
E
E
L
M
---
M
M-
M
P
E
E
V
G
D
--
E
P
-
L
-
A
L
Q
K
Y
L
V
N
N
A
K
K
I
G
L
----
M
V
A
G
L
A
A
Q
K
Y
G
K
ALDKE
Q
E
I
L
V
N
I
A
D
I
V
S
N
L
Y
A
M
E
S
------
A
V
L
----
R
T
E
K
A
I
K
T
T
G
-------
L
E
K
N
K
Q
K
V
L
Y
T
E
V
F
C
Q
E
A
F
N
E
I
E
A
--
H
A
K
E
T
L
------------------------
36
HHSearch
74.92
25%
-62
- C1 -
-
1RX0
9
ACAD8_HUMAN
C:
[18-391]
--------------------------------------------------------
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
L
F
--------
P
---
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
----
R
L
D
T
S
V
I
F
E
A
L
--
A
T
G
C
T
S
T
T
A
Y
I
S
I
-
H
N
--
M
-
C
-
A
W
M
I
D
-
S
---
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
----
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
-
L
L
T
S
A
K
K
Q
--
G
D
-
H
-
Y
I
L
N
G
S
K
A
F
I
S
-
G
A
G
E
--
S
D
--
I
Y
V
V
M
C
R
T
G
G
----------
P
G
P
K
G
I
S
C
I
V
V
E
K
G
T
P
----------
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
CAV
P
---
V
---
A
---
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
--------------
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
-
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
-
L
I
S
R
S
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.23
29%
0
- C- -
-
3B96
2
ACADV_HUMAN
A:
[75-435]
-------------------------------------------------------------------------------------------------------------------
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
----
N
T
Q
Y
A
R
L
V
E
I
V
--
G
M
H
D
L
G
V
G
I
T
L
G
A
H
Q
S
--
I
-
G
-
F
K
G
I
L
-
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
-
C
G
-
K
Y
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
--
G
L
A
D
--
I
F
T
V
F
A
K
T
P
V
----
T
D
----
P
A
T
G
A
V
K
E
K
I
T
A
F
V
V
E
R
G
F
G
G
------
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
---
V
R
V
P
S
---
E
---
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
----
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
-----------
I
H
N
F
G
-----
L
I
Q
E
K
L
A
-
R
--
M
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
--
N
M
D
Q
-
G
A
---
T
D
F
Q
----
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
73.49
25%
-62
- C1 -
-
1RX0
8
ACAD8_HUMAN
A:
[18-391]
--------------------------------------------------------
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
L
F
--------
P
---
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
----
R
L
D
T
S
V
I
F
E
A
L
--
A
T
G
C
T
S
T
T
A
Y
I
S
I
-
H
N
--
M
-
C
-
A
W
M
I
D
-
S
---
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
----
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
-
L
L
T
S
A
K
K
Q
--
G
D
-
H
-
Y
I
L
N
G
S
K
A
F
I
S
-
G
A
G
E
--
S
D
--
I
Y
V
V
M
C
R
T
G
G
----------
P
G
P
K
G
I
S
C
I
V
V
E
K
G
T
P
----------
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
---
V
---
A
---
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
--------------
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
-
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
-
L
I
S
R
S
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
72.89
22%
-5
- C1 -
-
3OWA
5
?
D:
[33-551]
---------------------------------------------------------
F
S
S
E
H
K
M
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
H
E
F
D
R
-------
S
---
V
R
L
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
----
K
V
S
S
A
L
I
A
E
K
F
--
S
R
A
G
-
G
F
A
I
T
H
G
A
-
H
V
--
G
I
G
-
S
L
P
I
V
-
L
---
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
----
G
E
K
L
A
A
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
-
A
K
T
T
A
R
L
N
A
E
G
T
-
H
-
Y
V
L
N
G
E
K
Q
W
I
T
-
N
S
A
F
--
A
D
--
V
F
I
V
Y
A
K
I
D
G
-------------
E
H
F
S
A
F
I
V
E
K
D
Y
A
----------
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
E
D
A
L
V
P
---
K
---
E
---
N
L
L
G
-
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
--------------
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
A
A
K
T
-
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
S
R
M
S
T
L
S
E
E
E
V
K
D
G
K
A
V
A
A
S
I
A
E
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
-
I
V
P
G
T
F
L
R
-
K
A
M
K
--------------
G
E
L
P
L
L
Q
---
K
A
Q
K
L
Q
E
E
L
M
---
M
---V---
G
D
--
E
P
-
L
-
A
L
Q
K
Y
L
V
N
N
A
K
K
I
G
L
----
M
V
A
G
L
A
A
Q
K
Y
G
K
ALDKE
Q
E
I
L
V
N
I
A
D
I
V
S
N
L
Y
A
M
E
S
------
A
V
L
----
R
T
E
K
A
I
K
T
T
G
-------
L
E
K
N
K
Q
K
V
L
Y
T
E
V
F
C
Q
E
A
F
N
E
I
E
A
--
H
A
K
E
T
L
------------------------
30
HHSearch
72.85
23%
-16
* C1 *
-
2Z1Q
2
?
B:
[27-526]
--------------------------------------------------------
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
-------
N
---
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
----
K
V
I
S
T
V
V
A
E
E
L
--
S
G
-
S
G
G
F
S
V
T
Y
G
A
-
H
T
S
-
I
-
G
-
T
L
P
L
V
-
Y
---
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
----
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
-
A
K
T
R
A
T
L
S
E
D
G
K
-
H
-
Y
I
L
N
G
V
K
Q
W
I
S
-
N
A
G
F
--
A
H
--
L
F
T
V
F
A
K
V
D
G
-------------
E
H
F
T
A
F
L
V
E
R
D
T
P
----------
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
---
V
---
E
---
N
V
L
G
-
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
--------------
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
-
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
G
K
K
--
G
P
-
E
A
V
--
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
-
I
P
G
M
L
L
R
-
R
A
--------------------------------------------------------
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
-
L
A
V
Q
K
Y
G
Q
GVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
------
A
L
L
----
R
A
R
R
L
G
G
-
L
--------------
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
--
G
A
L
---------------------------
5
PsiBlast_PDB
71.58
26%
-38
- C1 -
-
2JIF
6
ACDSB_HUMAN
A:
[35-400]
---------------------------------------------------------------
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
-----------
N
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
S
----
F
L
S
T
V
L
V
I
E
E
L
--
A
K
V
D
A
S
V
A
V
F
C
E
I
-
Q
N
--
T
-
L
-
I
N
T
L
I
R
K
---
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
-----
E
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
-
L
K
T
R
A
D
K
E
G
-
D
--
Y
-
Y
V
L
N
G
S
K
M
W
I
S
-
S
A
E
H
----
A
G
L
F
L
V
M
A
N
V
-
D
----
P
T
----
I
G
Y
K
G
I
T
S
F
L
V
D
R
D
T
P
G
----------
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
---
V
---
K
V
P
E
A
---
N
I
L
G
-
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
----
G
K
R
LF
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
-------
T
Q
---
L
-
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
F
I
K
E
A
S
M
-
A
K
Y
------------------
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
-
L
N
T
I
A
K
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
71.05
30%
-6
- C1 -
-
1BUC
3
ACDS_MEGEL
A:
[1-383]
-----------------------------------------------------
M
D
F
N
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
G
---------
I
Y
D
--
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
A
--
K
Y
D
A
G
V
A
I
T
L
S
A
T
-
V
S
--
L
-
C
-
A
N
P
I
W
-
Q
---
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
----
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
-
Q
Q
T
I
A
T
K
N
D
-
D
G
-
T
-
Y
T
L
N
G
S
K
I
F
I
T
-
N
G
G
A
--
A
D
I
Y
I
V
F
A
M
T
D
K
S
-----------
K
G
N
H
G
I
T
A
F
I
L
E
D
----------
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
---
V
---
K
V
P
A
E
---
N
M
L
G
-
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
----
G
K
P
----------
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
-
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
-------------------
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
-
V
T
G
G
A
L
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
69.66
19%
3
- C1 -
-
4Y9J
4
ACD11_CAEEL
A:
[1-592]
TITARHTQYSHAKTGG
F
S
Q
T
G
P
T
L
H
N
PYKDDPI
L
D
R
T
L
R
R
L
L
P
-
E
S
E
Y
M
R
V
A
A
D
L
S
K
F
G
D
R
I
T
S
E
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
-
D
A
W
G
K
R
V
D
--
K
L
I
V
C
N
E
W
H
K
L
K
Q
I
C
A
E
E
G
V
I
S
I
G
Y
E
D
S
V
D
-
P
F
V
R
----
R
I
H
Q
V
A
K
L
F
L
F
--
S
P
S
A
G
L
V
S
C
P
M
A
M
-
T
D
--
G
-
A
-
V
K
T
L
T
-
S
L
NL
Y
G
K
H
K
L
A
T
E
A
V
D
R
L
R
S
RDPS
K
A
W
T
S
G
Q
W
M
T
E
K
K
G
G
S
D
V
A
G
G
C
D
T
Y
A
V
Q
I
D
-
K
D
-
T
-
Y
R
L
H
G
Y
K
W
F
S
S
-
A
V
D
A
D
-----
V
A
L
T
L
A
R
I
V
D
SDG
N
A
L
----
E
G
S
R
G
L
S
L
F
L
L
K
--
I
R
D
E
S
G
N
L
---
N
G
I
Q
M
V
R
L
K
N
K
L
G
T
K
Q
L
P
T
A
E
L
L
L
D
G
---
A
---
I
---
A
---
E
R
I
G
-
D
Q
G
R
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
R
V
V
F
G
----------
Q
T
Q
S
K
W
P
L
H
T
T
T
L
A
K
M
----
E
V
D
T
-
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
E
A
G
K
S
S
D
V
E
-
A
M
M
--------
L
R
L
I
T
P
V
L
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
E
C
F
G
G
Q
G
Y
M
E
D
T
G
L
P
T
L
L
R
D
A
Q
V
T
P
I
W
E
G
T
T
N
V
L
S
L
D
V
L
R
---
V
F
S
G
K
E
N
--------------
I
L
L
A
F
G
K
---
R
---
V
E
Q
L
L
G
N--
T
--
K
----
T
E
--
D
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
----
L
L
V
-
K
A
S
D
S
A
I
Q
-------
G
E
T
R
I
D
S
V
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
--
S
D
S
S
V
A
-
N
Q
--
S
D
I
E
V
A
Y
R
Y
C
C
E
Q
P
L
I
D
L
R
W
E
W
F
A
S
E
R
V
K
--
A
D
R
E
I
V
F
D
N
F
T
-------------------
2
PsiBlast_PDB
68.78
29%
-25
- C1 -
-
4L1F
4
?
A:
[11-380]
---------------------------------------------------------------
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
--
A
H
I
W
D
---------
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
--
K
V
D
D
G
T
G
I
T
L
S
A
N
-
V
S
--
L
-
C
-
A
T
P
I
Y
-
M
---
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
----
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
-
Q
Q
T
T
A
V
L
K
G
-
D
--
K
-
Y
I
L
N
G
S
K
I
F
I
T
-
N
G
K
----
E
A
D
T
Y
V
V
F
A
-
M
T
D
----
K
S
----
Q
G
V
H
G
I
S
A
F
I
L
E
K
G
M
P
------
G
F
R
----
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
---
C
E
V
P
K
---
E
---
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
--------------
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
-
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
---
E
G
K
P
Y
S
E
A
-
A
A
---------------
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
--
Q
V
M
R
I
V
T
S
R
A
L
L
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.43
28%
-58
- C1 -
-
4IV6
2
?
A:
[51-372]
----------------------------------------------------------------------------------------------------------------
G
I
F
G
L
A
I
P
E
P
Y
G
F
G
A
V
S
----
M
P
C
Y
V
Q
V
A
E
E
L
--
A
R
G
W
M
S
L
A
G
A
M
G
G
-
H
T
--
V
-
V
-
S
K
L
L
L
-
L
---
F
G
T
E
E
Q
K
Q
K
Y
L
P
R
M
A
T
----
G
E
L
R
A
T
M
A
L
T
E
P
G
G
G
S
D
L
Q
A
-
M
R
T
V
A
R
R
D
G
-
D
--
D
-
Y
V
I
N
G
S
K
T
W
I
S
-
N
A
R
R
S
---
D
L
V
A
L
M
C
K
T
D
P
D
----
A
Q
----
P
A
H
K
G
V
S
I
L
L
V
E
K
-
V
P
---
G
F
D
V
S
R
D
L
-------
P
K
L
G
Y
K
G
V
E
S
C
E
L
N
F
T
D
---
A
R
V
P
V
---
S
---
S
L
L
G
D
D
E
G
R
G
F
A
Q
M
M
K
G
L
E
V
G
R
L
Q
V
A
A
R
A
T
G
V
A
R
A
A
F
E
D
A
L
R
Y
S
Q
E
R
E
S
F
----
G
K
P
----------
I
W
Q
H
Q
S
V
G
N
M
L
A
D
M
G
T
K
L
-
Y
A
A
R
S
L
L
L
S
A
A
E
----
K
F
D
A
G
Q
R
C
D
M
-
E
A
--------------
G
M
A
K
L
F
A
S
E
T
A
M
Q
I
A
L
D
A
V
R
V
H
G
G
Y
G
Y
S
T
E
Y
D
V
E
R
Y
F
R
D
A
P
L
M
I
V
G
E
G
T
N
E
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.40
28%
-51
- C1 -
-
3NF4
1
?
A:
[23-379]
----------------------------------------------------------------
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
D
E
T
Y
--------
P
E
G
V
---
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
W
G
G
G
G
Q
P
----
Y
E
V
Y
L
Q
V
L
E
E
I
--
A
A
R
W
A
S
V
A
V
A
V
S
V
-
H
S
--
L
-
S
-
S
H
P
L
L
-
V
---
F
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
----
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
A
-
L
R
C
A
A
T
P
-
T
-
D
G
-
G
-
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
-----
Y
T
L
F
A
R
T
G
-------------
S
R
G
V
S
C
F
L
V
P
A
D
Q
P
----------
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
---
A
R
I
D
A
---
D
---
R
R
I
G
-
E
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
----------
K
----------
I
I
D
H
-
G
L
-
G
F
L
L
A
D
M
A
A
A
-
V
A
T
A
R
A
T
Y
L
---------
D
A
A
R
R
R
D
Q
-
G
----
R
P
Y
S
Q
Q
----
A
S
I
A
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
67.92
20%
-7
- C1 -
-
2UXW
4
ACADV_HUMAN
A:
[21-607]
---------------Q
S
M
S
F
A
V
G
M
F
K
-------
G
Q
L
T
T
D
Q
V
F
P
Y
P
S
V
L
------
N
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
D
A
L
E
-------------
M
V
E
E
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
----
N
T
Q
Y
A
R
L
V
E
I
V
--
G
M
H
D
L
G
V
G
I
T
L
G
A
-
H
Q
--
S
-
I
G
F
K
G
I
L
-
L
---
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
----
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
-
I
R
T
S
A
V
P
S
P
-
C
G
K
Y
-
Y
T
L
N
G
S
K
L
W
I
S
-
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
P
A
----
T
G
----
A
V
K
E
K
I
T
A
F
V
V
E
----------
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
---
V
---
R
---
V
P
SE
N
V
L
G
-
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
--------------
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
Q
-
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
A
T
------------------
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
--------------
S
G
L
G
S
A
L
---
K
---
N
P
F
G
S
G
---
L
--
S
----
L
S
--
G
L
V
H
P
E
L
S
R
S
G
E
L
A
V
R
A
L
E
Q
----
F
A
T
-
V
V
E
A
K
L
I
K
-------
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
-
E
G
HP
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
S
DP
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
G
V
V
T
SNPLGF
22
PsiBlast_CBE
67.35
31%
-19
- C1 -
-
4U83
1
?
C:
[12-376]
-----------------------------------------------------------
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
-
F
P
R
A
E
L
T
E
M
G
A
L
----------
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
----
M
V
A
Y
A
L
A
L
E
E
I
--
A
A
G
D
G
A
C
S
T
I
V
S
V
-
H
S
SV
G
-
C
-
M
-
P
I
L
-
R
---
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
----
G
E
W
I
G
G
F
A
L
T
E
P
---------
L
K
T
R
A
R
L
D
G
-
D
--
H
-
Y
V
I
D
G
S
K
Q
F
I
T
-
S
G
K
N
G
---
N
V
V
-
I
V
F
A
-
V
T
D
----
P
A
----
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
----------
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
---
V
---
E
---
N
R
L
G
-
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
----
G
K
P
----------
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
-
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
-
A
------------------
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.27
31%
-18
- C1 -
-
4U83
5
?
B:
[12-376]
-----------------------------------------------------------
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
-
F
P
R
A
E
L
T
E
M
G
A
L
----------
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
----
M
V
A
Y
A
L
A
L
E
E
I
--
A
A
G
D
G
A
C
S
T
I
V
S
V
-
H
S
SV
G
-
C
-
M
-
P
I
L
-
R
---
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
----
G
E
W
I
G
G
F
A
L
T
E
P
---------
L
K
T
R
A
R
L
D
G
-
D
--
H
-
Y
V
I
D
G
S
K
Q
F
I
T
-
S
G
K
N
G
---
N
V
V
-
I
V
F
A
-
V
T
D
----
P
A
----
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
----------
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
---
V
---
E
---
N
R
L
G
-
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
----
G
K
P
----------
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
-
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
-
A
------------------
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.83
27%
-40
- C1 -
-
2VIG
5
ACADS_HUMAN
A:
[7-376]
----------------------------------------------------------
P
E
T
H
Q
M
L
L
Q
T
C
R
D
F
A
E
K
E
L
F
P
I
A
A
Q
V
D
K
E
H
L
-
F
P
A
A
Q
V
K
K
M
G
G
L
----------
G
L
L
A
M
D
V
P
E
E
L
G
G
A
G
L
D
----
Y
L
A
Y
A
I
A
M
E
E
I
S
R
G
C
A
S
T
G
V
I
M
S
V
N
--
N
S
--
L
-
Y
-
L
G
P
I
L
-
K
---
F
G
S
K
E
Q
K
Q
A
W
V
T
P
F
T
S
----
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
-
A
S
T
T
A
R
A
E
G
-
D
--
S
-
W
V
L
N
G
T
K
A
W
I
T
-----
N
A
W
E
A
S
A
A
V
V
F
A
S
-
T
D
----
R
A
----
L
Q
N
K
S
I
S
A
F
L
V
P
M
P
T
P
G
----------
L
T
L
G
K
K
E
D
K
L
G
I
R
G
S
S
T
A
N
L
I
F
E
D
---
C
R
I
P
K
---
D
---
S
I
L
G
-
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
T
A
L
D
C
A
V
N
Y
A
E
N
R
M
A
F
---------------
G
A
P
L
T
K
L
Q
V
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
I
K
E
A
A
M
-
A
------------------
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
H
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.29
31%
-18
- C1 -
-
4U83
1
?
A:
[12-376]
-----------------------------------------------------------
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
A
-
F
P
R
A
E
L
T
E
M
G
A
L
----------
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
----
M
V
A
Y
A
L
A
L
E
E
I
--
A
A
G
D
G
A
C
S
T
I
V
S
V
-
H
S
SV
G
-
C
-
M
-
P
I
L
-
R
---
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
----
G
E
W
I
G
G
F
A
L
T
E
P
---------
L
K
T
R
A
R
L
D
G
-
D
--
H
-
Y
V
I
D
G
S
K
Q
F
I
T
-
S
G
K
N
G
---
N
V
V
-
I
V
F
A
-
V
T
D
----
P
A
----
A
G
K
K
G
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
----------
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
---
V
---
E
---
N
R
L
G
-
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
----
G
K
P
----------
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
-
E
T
A
R
Q
M
V
L
H
A
A
A
L
R
E
A
G
K
P
C
L
T
E
A
S
M
-
A
------------------
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------