@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQB5: (2017-11-26 )
MTKQFAVIGNPIEQSRSPELHHAFAEKTGVDLNYQKRLAPLDGFESSMRSFFAEGGSGMNVTVPFKEQAFALCNVLTERAQIAKAVNTLWMENGKLHGDNTDGQGLVAAIQALEWNLENTTILILGAGGATRGVIYPLVQAGAKKIVIANRTLARAEQLVDDLKTAVPQAQLQAISLNDLEGDFDIVINATSASLSGDALQLPEKLKFKYAYEMAYGKPSSFLDQAKQRNVPYAEGFGMLVGQAIEAFSIWNGVRPQLKDFL
Atome Classification :
(44 SA)
.........10........20..----......30.----.......40..-......50.........60........70........80........-90.........100.......110-.......120.......130.......140......--.150.......160.......170......-.-180.---.......190.....-..-200-..----..---.-----.------.--210.....--..-.--220...-..-..230.-.-.-.....240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
K
Q
F
A
VIGNPIEQSRSP
E
L
H
H
A
----
F
A
E
KTGVDL----N
Y
Q
KRLAPLD
G
-
F
E
S
S
M
R
S
-
F
F
AEGGSG
M
N
V
T
V
P
F
K
E
Q
A
F
A
L
C
N
V
L
T
E
R
A
Q
I
A
K
A
V
N
T
L
-
W
-MENGKLHGDNTDG
Q
G
L
V
A
A
I
Q
A
-
L
EWNLEN
T
T
I
L
I
L
GAGGATR
G
V
I
Y
P
L
V
QAGA
K
K
I
V
I
--AN
R
T
L
A
R
A
E
Q
L
V
D
D
L
K
T
AV
P
Q
A
Q
L
Q
A
I
S
LN-D-LE-G---
D
F
D
I
V
I
N
ATSASLSG-DA-LQL-
P
E
----K
L
---
K
-----
F
------
K
--
Y
A
-
Y
EMAY--GK-
P
--
S
S
F
L
D
Q
-
A
K
-QRNV-P-
Y
-
A
-
E
G
F
G
M
L
V
G
Q
A
I
E
A
F
S
I
WNGV
R
P
Q
L
K
DFL
5
PsiBlast_PDB
79.78
47%
-35
- C4 -
-
4OMU
-
?
A:
[3-258]
---
Q
Y
V
V
F
G
N
P
I
G
H
S
K
S
P
L
I
H
R
L
----
F
A
E
Q
T
G
Q
D
L
----
E
Y
A
T
L
L
A
P
L
D
E
-
F
S
D
C
A
R
G
-
F
F
K
Q
-
G
S
G
G
N
V
T
V
P
F
K
E
E
A
F
R
L
C
D
S
L
T
P
R
A
R
R
A
G
A
V
N
T
L
-
S
K
L
A
D
G
T
L
Q
G
D
N
T
D
G
A
G
L
V
R
D
L
T
V
N
A
G
V
E
L
A
G
K
R
I
L
I
L
G
A
G
G
A
V
R
G
V
L
E
P
I
L
A
H
K
P
Q
S
L
V
I
--
A
N
R
T
V
E
K
A
E
Q
L
A
R
E
F
D
E
L
G
P
---
V
V
A
S
G
F
A
-
W
-
L
Q
-
E
---
P
V
D
V
I
I
N
A
T
S
A
S
L
A
G
-
E
L
-
P
P
I
-
A
D
----
S
L
VEA
G
-----
R
------
T
--
V
C
-
Y
D
M
M
Y
--
G
K
E
P
--
T
P
F
C
Q
W
-
A
T
-
K
L
G
A
-
A
-
K
-
V
L
D
G
L
G
M
L
A
E
Q
A
A
E
A
F
F
I
W
R
G
V
R
P
------
6
PsiBlast_PDB
79.62
44%
-43
- C4 -
-
3PWZ
-
?
A:
[2-261]
-
S
D
R
Y
A
V
I
G
R
P
I
N
H
T
K
S
P
L
I
H
G
L
----
F
A
Q
A
S
N
Q
Q
L
----
E
Y
G
A
I
E
G
S
L
D
D
-
F
E
A
Q
V
L
Q
-
F
R
S
E
G
G
K
G
M
N
I
T
A
P
F
K
L
R
A
F
E
L
A
D
R
R
S
E
R
A
Q
L
A
R
A
A
N
A
L
-
K
-
F
E
D
G
R
I
V
A
E
N
F
D
G
I
G
L
L
R
D
I
E
E
N
L
G
E
P
L
R
N
R
R
V
L
L
L
G
A
G
G
A
V
R
G
A
L
L
P
F
L
Q
A
G
P
S
E
L
V
I
--
A
N
R
D
M
A
K
A
L
A
L
R
N
E
L
D
----
H
S
R
L
R
I
S
R
Y
E
-
A
-
L
E
-
G
Q--
S
F
D
I
V
V
N
A
T
S
A
S
L
T
A
-
D
L
-
P
P
L
-
P
A
----
D
V
LG-
E
-----
A
------
A
--
L
A
-
Y
E
L
A
Y
--
G
K
-
G
L-
T
P
F
L
R
L
-
A
R
E
Q
G
Q
A
-
R
-
L
-
A
-
D
G
V
G
M
L
V
E
Q
A
A
E
A
F
A
W
W
R
G
V
R
P
D
T
R
---
70
HHSearch
79.15
44%
-43
- C4 -
-
3PWZ
-
?
A:
[2-263]
-
S
D
R
Y
A
V
I
G
R
P
I
N
H
T
K
S
P
L
I
H
G
L
----
F
A
Q
A
S
N
Q
Q
L
----
E
Y
G
A
I
E
G
S
L
D
D
-
F
E
A
Q
V
L
Q
-
F
R
S
E
G
G
K
G
M
N
I
T
A
P
F
K
L
R
A
F
E
L
A
D
R
R
S
E
R
A
Q
L
A
R
A
A
N
A
L
-
K
-
F
E
D
G
R
I
V
A
E
N
F
D
G
I
G
L
L
R
D
I
E
E
N
L
G
E
P
L
R
N
R
R
V
L
L
L
G
A
G
G
A
V
R
G
A
L
L
P
F
L
Q
A
G
P
S
E
L
V
I
--
A
N
R
D
M
A
K
A
L
A
L
R
N
E
L
D
H
S
R
----
L
R
I
S
R
Y
E
A
L
-
E
G
-
Q
---
S
F
D
I
V
V
N
A
T
S
A
S
L
T
A
-
D
L
-
P
P
L
-
P
A
----
D
V
---
L
GE---
A
------
A
--
L
A
-
Y
E
L
A
Y
--
G
K
G
L
--
T
P
F
L
R
L
-
A
R
-
E
Q
G
Q
A
R
-
L
-
A
-
D
G
V
G
M
L
V
E
Q
A
A
E
A
F
A
W
W
R
G
V
R
P
D
T
R
A
V
-
4
PsiBlast_PDB
78.91
44%
-46
- C4 -
-
1NYT
2
AROE_ECOLI
A:
[2-260]
--
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
---
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
-
E
-
L
E
-
G
H--
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
-----
H
------
P
G
I
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
-
R
N
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
---
74
HHSearch
78.82
45%
-39
- C4 -
-
1NYT
1
AROE_ECOLI
C:
[1-261]
-
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
S
---
I
Q
A
L
S
M
D
-
E
L
E
G
-
H
---
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
HP---
G
------
I
--
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
R
N
-
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
--
26
PsiBlast_CBE
78.48
44%
-44
- C4 -
-
1NYT
1
AROE_ECOLI
D:
[2-260]
--
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
---
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
-
E
-
L
E
-
G
H--
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
-----
H
------
P
GI
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
-
R
N
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
---
28
PsiBlast_CBE
77.69
44%
-40
- C4 -
-
1NYT
1
AROE_ECOLI
B:
[2-260]
--
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
---
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
-
E
-
L
E
-
G
H--
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
-----
H
------
P
GI
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
-
R
N
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
---
27
PsiBlast_CBE
77.26
44%
-40
- C4 -
-
1NYT
1
AROE_ECOLI
C:
[2-260]
--
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
---
K
L
F
A
H
T
G
S
I
Q
A
L
S
M
D
-
E
-
L
E
-
G
H--
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
-----
H
------
P
GI
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
-
R
N
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
---
75
HHSearch
77.03
45%
-39
- C4 -
-
1NYT
1
AROE_ECOLI
B:
[1-261]
-
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
Q
----
F
A
Q
Q
L
N
I
E
H
----
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
-
F
F
S
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
-
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
-
A
V
T
I
--
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
S
---
I
Q
A
L
S
M
D
-
E
L
E
G
-
H
---
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
-
D
I
-
P
A
I
-
P
S
----
S
L
---
I
HP---
G
------
I
--
Y
C
-
Y
D
M
F
Y
--
Q
K
G
K
--
T
P
F
L
A
W
-
C
E
-
Q
R
G
S
-
K
R
N
-
A
-
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
--
8
PsiBlast_PDB
76.72
43%
-44
- C4 -
-
1P77
1
AROE_HAEIN
A:
[4-258]
----
Y
A
V
W
G
N
P
I
A
Q
S
K
S
P
L
I
Q
N
K
----
L
A
A
Q
T
H
Q
T
M
----
E
Y
I
A
K
L
G
D
L
D
A
-
F
E
Q
Q
L
L
A
-
F
F
E
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
-
L
D
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
Q
R
-
L
N
W
L
R
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
K
G
V
L
L
P
L
L
Q
A
-
Q
Q
N
I
V
L
--
A
N
R
T
F
S
K
T
K
E
L
A
E
R
F
Q
---
P
Y
G
N
I
Q
A
V
S
M
D
-
S
-
I
P
L
Q
---
T
Y
D
L
V
I
N
A
T
S
A
---------
S
V
D
A
E
----
I
L
---
K
-----
L
------
G
--
S
A
F
Y
D
M
Q
Y
AK
G
T
-
D
--
T
P
F
I
A
L
-
C
K
-
S
L
G
L
-
T
N
V
-
S
-
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
------
7
PsiBlast_PDB
75.85
43%
-50
- C4 -
-
1P74
-
AROE_HAEIN
A:
[4-258]
----
Y
A
V
W
G
N
P
I
A
Q
S
K
S
P
L
I
Q
N
K
----
L
A
A
Q
T
H
Q
T
M
----
E
Y
I
A
K
L
G
D
L
D
A
-
F
E
Q
Q
L
L
A
-
F
F
E
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
-
L
D
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
Q
R
-
L
N
W
L
R
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
K
G
V
L
L
P
L
L
Q
A
-
Q
Q
N
I
V
L
--
A
N
R
T
F
S
K
T
K
E
L
A
E
R
F
Q
---
P
Y
G
N
I
Q
A
V
S
M
D
-
S
-
I
P
L
Q
---
T
Y
D
L
V
I
N
A
T
S
A
G
-------
A
S
V
D
A
E
----
I
L
---
K
-----
L
------
G
--
S
A
F
Y
D
M
Q
Y
A
K
G
T
-
D
--
T
P
F
I
A
L
-
C
K
-
S
L
G
L
-
T
N
V
-
S
-
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
------
23
PsiBlast_CBE
75.04
45%
-34
- C4 -
-
3PGJ
1
AROE_VIBCH
D:
[31-291]
---
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
-
E
--
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
3
PsiBlast_PDB
74.67
45%
-31
- C4 -
-
3O8Q
1
?
A:
[10-270]
---
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
-------
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
24
PsiBlast_CBE
74.63
45%
-35
- C4 -
-
3PGJ
1
AROE_VIBCH
C:
[31-291]
---
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
----------
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
1
PsiBlast_PDB
73.98
45%
-33
- C4 -
-
3PGJ
1
AROE_VIBCH
A:
[31-291]
---
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
-
E
--
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
2
PsiBlast_PDB
72.91
45%
-32
- C4 -
-
3SEF
1
AROE_VIBCH
A:
[31-291]
---
Q
Y
A
V
F
G
N
P
---
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
-
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
-
E
--
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
25
PsiBlast_CBE
72.83
45%
-30
- C4 -
-
3PGJ
1
AROE_VIBCH
B:
[31-291]
---
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
-
E
--
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
22
PsiBlast_CBE
72.68
45%
-34
- C4 -
-
3SEF
2
AROE_VIBCH
B:
[31-291]
---
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
-
E
--
L
P
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
K
-
G
--
Y
T
V
F
N
Q
W
A
R
-
Q
H
G
C
-
A
-
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
11
PsiBlast_PDB
72.34
32%
-92
- C4 -
-
2HK7
-
AROE_AQUAE
A:
[6-252]
-
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
N
A
----
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
--
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
V
V
N
S
P
E
E
V
I
D
------------
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-
E
D
-----
P
E
----
I
F
---
N
-----
Y
DLIKKD
H
--
V
V
-
V
D
I
I
Y
---
K
-
E
--
T
K
L
L
K
K
-
A
K
-
E
K
G
A
-
K
-
L
-
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
---------
13
PsiBlast_PDB
72.26
32%
-94
- C4 -
-
2HK9
3
AROE_AQUAE
A:
[12-258]
-
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
N
A
----
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
--
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
V
V
N
S
P
E
E
V
I
D
------------
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-
E
D
-----
P
E
----
I
F
---
N
-----
Y
DLIKKD
H
--
V
V
-
V
D
I
I
Y
---
K
-
E
--
T
K
L
L
K
K
-
A
K
-
E
K
G
A
-
K
-
L
-
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
---------
33
PsiBlast_CBE
72.05
32%
-91
- C4 -
-
2HK9
2
AROE_AQUAE
B:
[12-258]
-
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
N
A
----
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
--
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
V
V
N
S
P
E
E
V
I
D
------------
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-
E
D
-----
P
E
----
I
F
---
N
-----
Y
DLIKKD
H
--
V
V
-
V
D
I
I
Y
---
K
-
E
--
T
K
L
L
K
K
-
A
K
-
E
K
G
A
-
K
-
L
-
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
---------
31
PsiBlast_CBE
71.97
32%
-87
- C4 -
-
2HK9
2
AROE_AQUAE
D:
[12-258]
-
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
N
A
----
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
--
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
V
V
N
S
P
E
E
V
I
D
------------
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-
E
D
-----
P
E
----
I
F
---
N
-----
Y
DLIKKD
H
--
V
V
-
V
D
I
I
Y
---
K
-
E
--
T
K
L
L
K
K
-
A
K
-
E
K
G
A
-
K
-
L
-
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
---------
32
PsiBlast_CBE
71.49
32%
-88
- C4 -
-
2HK9
2
AROE_AQUAE
C:
[12-258]
-
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
A
----
L
I
R
Y
A
G
L
N
A
----
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
-
F
K
A
L
K
V
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
-
K
-
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
E
G
A
-
K
V
F
L
--
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
V
V
N
S
P
E
E
V
I
D
------------
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
-
E
D
-----
P
E
----
I
F
---
N
-----
Y
DLIKKD
H
--
V
V
-
V
D
I
I
Y
---
K
-
E
--
T
K
L
L
K
K
-
A
K
-
E
K
G
A
-
K
-
L
-
L
-
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
---------
21
PsiBlast_CBE
71.15
45%
-38
- C4 -
-
3SEF
1
AROE_VIBCH
C:
[31-291]
---
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
L
----
F
A
R
Q
T
Q
Q
S
M
----
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
-
F
F
A
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
--
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
Q
Q
P
A
S
I
T
V
--
T
N
R
T
F
A
K
A
E
Q
L
A
-
E
L
V
A
A
Y
G
E
V
K
A
Q
A
--
F
E
-
Q
-
L
K
-
Q
---
S
Y
D
V
I
I
N
S
T
S
-----------
A
-
I
D
----
P
V
---
I
-----
F
SSR---
S
--
V
C
-
Y
D
M
M
Y
--
G
-------------------------I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
47
PsiBlast_CBE
69.40
32%
-95
- C4 -
-
2D5C
1
AROE_THET8
B:
[3-248]
---
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
-
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
G
P
A
-
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-------
L
R
A
V
P
L
E
-
K
-
A
R
-----
E
A
R
L
L
V
N
A
T
R
V
G
L
----
A
-
S
P
L
-
P
A
----
E
L
FP-
E
-----
E
------
G
--
A
A
-
V
D
L
V
Y
---
R
-
P
LW
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
------
48
PsiBlast_CBE
67.72
32%
-80
- C4 -
-
2D5C
1
AROE_THET8
A:
[3-248]
---
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
-
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
G
P
A
-
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-------
L
R
A
V
P
L
E
-
K
-
A
R
-----
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
-
S
P
L
-
P
A
----
E
L
FP-
E
-----
E
------
G
--
A
A
-
V
D
L
V
Y
---
R
-
P
LW
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
------
45
PsiBlast_CBE
67.20
32%
-82
- C4 -
-
2EV9
1
AROE_THET8
B:
[3-248]
---
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
-
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
G
P
A
-
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-------
L
R
A
V
P
L
E
-
K
-
A
R
-----
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
-
S
P
L
-
P
A
----
E
L
FP-
E
-----
E
------
G
--
A
A
-
V
D
L
V
Y
---
R
-
P
LW
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
------
81
HHSearch
66.99
32%
-79
* C4 *
-
2D5C
1
AROE_THET8
A:
[1-253]
-
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
-
L
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
L
R
-------
A
V
P
L
--
E
-
K
A
-
R
---
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
-
P
S
A
S
P
L
-
P
A
----
E
L
---
F
PE---
E
------
G
--
A
A
-
V
D
L
V
Y
--
R
P
L
W
--
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
-
46
PsiBlast_CBE
66.83
32%
-78
- C4 -
-
2EV9
2
AROE_THET8
A:
[3-248]
---
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
-
R
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
G
P
A
-
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
L
-
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-------
L
R
A
V
P
L
E
-
K
-
A
R
-----
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A
-
S
P
L
-
P
A
----
E
L
FP-
E
-----
E
------
G
--
A
A
-
V
D
L
V
Y
---
R
-
P
LW
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
------
82
HHSearch
66.63
32%
-81
- C4 -
-
2EV9
1
AROE_THET8
B:
[1-253]
-
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
F
----
A
L
E
S
L
G
L
E
G
----
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
-
V
R
-
R
A
F
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
-
L
-
Q
V
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
G
I
P
L
K
-
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
A
G
-
L
E
V
W
V
--
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
L
R
-------
A
V
P
L
--
E
-
K
A
-
R
---
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
-
P
S
A
S
P
L
-
P
A
----
E
L
---
F
PE---
E
------
G
--
A
A
-
V
D
L
V
Y
--
R
P
L
W
--
T
R
F
L
R
E
-
A
K
-
A
K
G
L
-
K
-
V
-
Q
-
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
-
10
PsiBlast_PDB
65.79
31%
-56
- C4 -
-
3DOO
1
AROE_STAEQ
A:
[2-255]
---
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
A
----
N
F
Q
S
L
N
L
E
N
----
T
Y
E
A
I
N
V
P
V
N
Q
-
F
Q
D
I
K
K
I
-
I
S
E
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
-
L
-
V
K
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
-
I
Y
E
G
I
E
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
E
L
Y
K
I
V
R
P
T
L
T
V
--
A
N
R
T
M
S
R
F
N
N
W
---------
S
L
N
I
N
K
I
N
L
S
-
H
-
A
E
-
S
H
LD
E
F
D
I
I
I
N
T
T
P
--------V
I
S
L
-
N
R
----
L
A
---
S
-----
H
------
T
--
L
V
-
S
D
I
V
Y
--
N
P
Y
K
--
T
P
I
L
I
E
-
A
E
-
Q
R
G
N
-
P
-
I
-
Y
-
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
---
76
HHSearch
57.29
35%
4
- C4 -
-
4FQ8
1
AROE_HELPY
B:
[2-255]
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
----
C
F
L
T
F
Q
K
E
L
RFLG
H
Y
H
P
I
L
L
P
L
E
S
H
I
K
S
E
F
----
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
----
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
-
Q
V
S
V
--
L
N
R
S
S
R
G
L
D
-
F
F
Q
R
L
G
C
D
--------
C
F
M
E
-
P
-
P
K
-
S
---
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
--
L
P
L
-
N
K
EVLK
G
Y
---
F
KE---
G
------
K
--
L
A
-
Y
D
L
A
A
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
-
80
HHSearch
56.07
35%
-2
- C4 -
-
3PHH
1
AROE_HELPY
A:
[2-255]
K
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
----
C
F
L
T
F
Q
K
E
L
R
F
L
G
H
Y
H
P
I
L
L
P
L
E
S
H
I
K
S
E
F
----
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
--------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
-
Q
V
S
V
--
L
N
R
S
S
R
G
L
D
-
F
F
Q
R
L
G
C
D
--------
C
F
M
E
-
P
-
P
K
-
S
---
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
--
L
P
L
-
N
K
E
V
L
K
G
Y
---
F
K
E
---
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
-
40
PsiBlast_CBE
54.91
35%
9
- C4 -
-
4FQ8
1
AROE_HELPY
B:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
CFLT
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
Q
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
NR
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
GYFKE
G
------
K
--
L
A
-
Y
D
L
A
A
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
37
PsiBlast_CBE
54.05
35%
8
- C4 -
-
4FOS
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
Q
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
A
A
A
L
S
F
E
K
F
S
----------
38
PsiBlast_CBE
54.02
35%
8
- C4 -
-
4FR5
1
AROE_HELPY
B:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
CFLT
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
Q
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
NR
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
GYFKE
G
------
K
--
L
A
-
Y
D
L
A
S
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
41
PsiBlast_CBE
53.99
35%
10
- C4 -
-
4FQ8
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
Q
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
A
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
39
PsiBlast_CBE
53.85
35%
8
- C4 -
-
4FR5
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
Q
K
N
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
S
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
14
PsiBlast_PDB
53.52
35%
8
- C4 -
-
4FSH
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
K
L
G
F
L
G
----
H
Y
R
P
I
L
L
P
L
----
E
S
H
I
K
N
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
A
S
I
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
---
H
Q
N
Y
Q
N
A
--
L
I
L
G
S
G
G
S
A
K
A
L
A
C
G
L
K
K
Q
G
L
K
V
S
V
L
N
R
S
P
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
N
-----
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
KE
A
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
A
L
-
A
K
-
E
L
K
I
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
----------
17
PsiBlast_PDB
53.08
36%
5
- C4 -
-
3PHI
2
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
36
PsiBlast_CBE
52.89
36%
4
- C4 -
-
3PHI
2
AROE_HELPY
B:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
CFLT
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
NR
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
GYFKE
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
16
PsiBlast_PDB
52.20
36%
6
- C4 -
-
3PHH
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
A
S
L
H
N
-
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
18
PsiBlast_PDB
52.17
36%
5
- C4 -
-
3PHJ
1
AROE_HELPY
A:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
------
E
L
-
P
L
N
-
K
E
----
V
L
---
K
G
Y
F
K
E
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------
35
PsiBlast_CBE
50.54
36%
4
- C4 -
-
3PHJ
1
AROE_HELPY
B:
[4-246]
--
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
CFLT
F
Q
K
E
L
R
F
L
G
----
H
Y
H
P
I
L
L
P
L
----
E
S
H
I
K
S
E
F
L
H
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
-
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
------
Y
Q
N
A
--
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
Q
G
L
Q
V
S
V
L
NR
S
S
R
G
L
D
F
F
Q
R
L
G
C
D
C
F
M
E
P
P
K
S
A
------------------
F
D
L
I
I
N
A
T
S
------
E
L
-
P
L
N
-
K
E
----
V
L
---
K
GYFKE
G
------
K
--
L
A
-
Y
D
L
A
Y
--
G
F
-
L
--
T
P
F
L
S
L
-
A
K
-
E
L
K
T
-
P
-
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
----------