@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQH4: (2017-11-27 )
MSQLYASLFYQKDVTEIFSDSSLITYMIQVEVALAQAQAQVGVIPQNAANTIAQVAEHALDKFDFSALAVATSLAGNIAIPFVKQLTAIVKDIDEDASRYVHWGATSQDILDTACILQCRDALNMVEGQLQQCYATALQQAKQYRHQVMIGRTWLQQALPITLGHKLARWASAFKRDLDRIQAMKSRVLTAQLGGAVGSLASLQDQGSLVVSAFAKQLNLTVPTSTWHGERDRIVEIASVLGMIVGNTGKMARDWSLMMQTEIAELFEPTAKGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQSMVQEHERSLGAWHAEWLAVPEIFQLCAGALTRTGEVLQGFEVNAEHMQQNLECTNGLIMAEAVMMTLAPKIGRLNAHHLVEAACKTAVAQNQHLFDVVSQLDEVKGQFSQEEIRNIFKPENYLGNIQQQIDAVLKEAQGESK
Atome Classification :
(20 SA)
.........10........20........30........40..-......-------50.....-...60........70........80........90--.........100.......110.......120.......130.......140.......150.......160.......170.......180.......-190.......200..----.----.---...210.......220.-.-.-.-....230.......240.......250.......260.......270.......280.......290.......300.......310........320.......330.......340.......350.......360.......370.....-..-380..--......390.......400----.........410.........420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
Q
L
Y
A
S
L
F
Y
Q
K
D
V
T
E
I
FSDS
S
L
I
T
Y
M
I
Q
V
E
V
A
L
A
QAQAQVGV-IPQ
N
A
A
-------
N
T
I
A
Q
V
A
-
E
H
A
L
D
K
F
D
F
S
A
L
A
V
A
T
S
LAGN
I
A
I
P
F
V
K
Q
L
T
A
I
V
---
K
D
I
D
E
D
A
S
R
Y
V
HWGA
T
S
Q
D
I
L
D
T
A
C
I
L
Q
C
R
D
A
L
N
M
V
E
G
Q
L
Q
Q
C
Y
A
T
A
L
Q
Q
A
K
Q
Y
R
H
Q
V
M
I
G
R
T
W
L
Q
QAL
P
I
T
L
G
H
K
L
A
R
W
A
S
A
F
K
R
D
L
D
R
I
Q
A
M
K
S
R
V
L
-
T
A
Q
LGGAV
G
S
L
A
S
L
Q----D----Q---G
S
L
V
V
S
A
F
A
K
QLNL-TV-P-T-S-TWHGE
R
D
R
I
V
E
I
A
S
V
L
G
M
I
VGNTGKMA
R
D
W
S
L
M
M
Q
T
E
I
A
E
L
FEPTAKGRGGSSTMPHKRN
P
V
A
A
A
S
V
L
A
A
A
N
R
V
P
A
L
M
S
S
I
Y
Q
S
M
-
V
Q
E
H
E
R
S
LG
A
W
H
A
E
W
L
A
V
P
E
I
F
Q
L
C
A
G
A
L
TR
T
G
E
V
L
QGFEV
N
A
E
H
M
Q
Q
N
LECTN
G
L
I
M
A
E
A
V
M
M
T
L
A
-PK-IG-RL--
N
A
H
H
L
V
E
A
A
C
K
T
A
VAQ
N
------
Q
H
L
F
D
V
V
S
Q
L
--
D
E
V
KGQF
S
Q
E
E
I
R
N
IFKP
E
N
Y
L
G
N
I
Q
Q
Q
I
D
A
V
L
K
E
AQGESK
1
PsiBlast_PDB
98.99
80%
-137
- C3 -
-
1Q5N
-
PCAB_ACIAD
A:
[3-446]
--
Q
L
Y
A
S
L
F
Y
Q
R
D
V
T
E
I
F
S
D
R
A
L
V
S
Y
M
V
E
A
E
V
A
L
A
Q
A
Q
A
Q
V
G
V
-
I
P
Q
S
A
A
-------
T
V
I
Q
R
A
A
-
K
T
A
I
D
K
I
D
F
D
A
L
A
T
A
T
G
L
A
G
N
I
A
I
P
F
V
K
Q
L
T
A
I
V
---
K
D
A
D
E
D
A
A
R
Y
V
H
W
G
A
T
S
Q
D
I
L
D
T
A
C
I
L
Q
C
R
D
A
L
A
I
V
Q
N
Q
V
Q
Q
C
Y
E
T
A
L
S
Q
A
Q
T
Y
R
H
Q
V
M
M
G
R
T
W
L
Q
Q
A
L
P
I
T
L
G
H
K
L
A
R
W
A
S
A
F
K
R
D
L
D
R
I
N
A
I
K
A
R
V
L
-
V
A
Q
L
G
G
A
V
G
S
L
A
S
L
Q
----
D
----
Q
---
G
S
I
V
V
E
A
Y
A
K
Q
L
K
L
-
G
Q
-
T
-
A
-
C
-
T
W
H
G
E
R
D
R
I
V
E
I
A
S
V
L
G
I
I
T
G
N
V
G
K
M
A
R
D
W
S
L
M
M
Q
T
E
I
A
E
V
F
E
P
T
-------------
R
N
P
V
A
A
A
S
V
L
A
A
A
N
R
V
P
A
L
M
S
S
I
Y
Q
S
M
-
V
Q
E
H
E
R
S
L
G
A
W
H
A
E
W
L
S
L
P
E
I
F
Q
L
T
A
G
A
L
E
R
T
L
D
V
L
K
G
M
E
V
N
A
E
N
M
H
Q
N
I
E
C
T
H
G
L
I
M
A
E
A
V
M
M
A
L
A
-
P
H
-
M
G
-
R
L
--
N
A
H
H
V
V
E
A
A
C
K
T
A
V
A
E
Q
------
K
H
L
K
D
I
I
S
Q
V
--
D
E
V
K
Q
Y
F
N
P
S
Q
L
D
E
I
F
K
P
E
S
Y
L
G
N
I
Q
D
Q
I
D
A
V
L
Q
E
A
-----
45
HHSearch
88.62
81%
-47
- C3 -
-
1Q5N
-
PCAB_ACIAD
A:
[3-446]
--
Q
L
Y
A
S
L
F
Y
Q
R
D
V
T
E
I
F
S
D
R
A
L
V
S
Y
M
V
E
A
E
V
A
L
A
Q
A
Q
A
Q
V
G
V
-
I
P
Q
S
A
A
-------
T
V
I
Q
R
A
A
K
T
A
I
-
D
K
I
D
F
D
A
L
A
T
A
T
G
L
A
G
N
I
A
I
P
F
V
K
Q
L
T
A
I
V
---
K
D
A
D
E
D
A
A
R
Y
V
H
W
G
A
T
S
Q
D
I
L
D
T
A
C
I
L
Q
C
R
D
A
L
A
I
V
Q
N
Q
V
Q
Q
C
Y
E
T
A
L
S
Q
A
Q
T
Y
R
H
Q
V
M
M
G
R
T
W
L
Q
Q
A
L
P
I
T
L
G
H
K
L
A
R
W
A
S
A
F
K
R
D
L
D
R
I
N
A
I
K
A
R
V
L
-
V
A
Q
L
G
G
A
V
G
S
L
A
S
L
Q
----
D
----
Q
---
G
S
I
V
V
E
A
Y
A
K
Q
L
K
L
-
G
Q
-
T
-
A
-
C
-
T
W
H
G
E
R
D
R
I
V
E
I
A
S
V
L
G
I
I
T
G
N
V
G
K
M
A
R
D
W
S
L
M
M
Q
T
E
I
A
E
V
F
E
P
T
-------------
R
N
P
V
A
A
A
S
V
L
A
A
A
N
R
V
P
A
L
M
S
S
I
Y
Q
S
M
-
V
Q
E
H
E
R
S
L
G
A
W
H
A
E
W
L
S
L
P
E
I
F
Q
L
T
A
G
A
L
E
R
T
L
D
V
L
K
G
M
E
V
N
A
E
N
M
H
Q
N
I
E
C
T
H
G
L
I
M
A
E
A
V
M
M
A
L
A
-
P
H
-
M
G
-
R
L
--
N
A
H
H
V
V
E
A
A
C
K
T
A
V
A
E
Q
------
K
H
L
K
D
I
I
S
Q
V
--
D
E
V
K
Q
Y
F
N
P
S
Q
L
D
E
I
F
K
P
E
S
Y
L
G
N
I
Q
D
Q
I
D
A
V
L
Q
E
A
-----
22
PsiBlast_CBE
86.79
46%
-129
- C3 -
-
1RE5
3
?
C:
[3-446]
-
N
Q
L
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
-------
A
A
I
E
A
A
C
-
Q
--
A
E
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
I
---
A
T
G
V
P
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
-
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
----
K
---
A
M
P
V
A
E
A
L
A
E
Q
L
K
L
-
T
L
-
P
-
E
-
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
--------
S
T
M
P
H
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
-
L
G
-
R
D
--
R
A
H
H
L
L
E
Q
C
C
Q
R
A
V
A
E
Q
------
R
H
L
R
A
V
L
G
D
E
--
P
Q
V
S
A
E
L
S
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
Q
----
23
PsiBlast_CBE
86.18
46%
-130
- C3 -
-
1RE5
3
?
B:
[3-446]
-
N
Q
L
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
-------
A
A
I
E
A
A
C
-
Q
--
A
E
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
I
---
A
T
G
V
P
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
-
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
----
K
---
A
M
P
V
A
E
A
L
A
E
Q
L
K
L
-
T
L
-
P
-
E
-
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
-------
M
P
H
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
-
L
G
-
R
D
--
R
A
H
H
L
L
E
Q
C
C
Q
R
A
V
A
E
Q
------
R
H
L
R
A
V
L
G
D
E
--
P
Q
V
S
A
E
L
S
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
Q
----
2
PsiBlast_PDB
85.25
46%
-127
- C3 -
-
1RE5
2
?
A:
[3-446]
-
N
Q
L
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
-------
A
A
I
E
A
A
C
-
Q
--
A
E
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
I
---
A
T
G
V
P
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
-
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
----
K
---
A
M
P
V
A
E
A
L
A
E
Q
L
K
L
-
T
L
-
P
-
E
-
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
----------
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
-
L
G
-
R
D
--
R
A
H
H
L
L
E
Q
C
C
Q
R
A
V
A
E
Q
------
R
H
L
R
A
V
L
G
D
E
--
P
Q
V
S
A
E
L
S
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
Q
----
21
PsiBlast_CBE
85.20
46%
-121
- C3 -
-
1RE5
3
?
D:
[3-446]
-
N
Q
L
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
-------
A
A
I
E
A
A
C
-
Q
--
A
E
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
I
---
A
T
G
V
P
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
-
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
----
K
---
A
M
P
V
A
E
A
L
A
E
Q
L
K
L
-
T
L
-
P
-
E
-
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
G
K
G
G
S
S
T
M
P
H
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
-
L
G
-
R
D
--
R
A
H
H
L
L
E
Q
C
C
Q
R
A
V
A
E
Q
------
R
H
L
R
A
V
L
G
D
E
--
P
Q
V
S
A
E
L
S
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
Q
----
46
HHSearch
77.66
47%
-51
- C3 -
-
1RE5
3
?
D:
[3-448]
-
N
Q
L
F
D
A
Y
F
T
A
P
A
M
R
E
I
F
S
D
R
G
R
L
Q
G
M
L
D
F
E
A
A
L
A
R
A
E
A
S
A
G
L
-
V
P
H
S
A
V
-------
A
A
I
E
A
A
C
Q
A
---
E
R
Y
D
T
G
A
L
A
N
A
I
A
T
A
G
N
S
A
I
P
L
V
K
A
L
G
K
V
I
A
T
G
V
P
---
E
A
E
R
Y
V
H
L
G
A
T
S
Q
D
A
M
D
T
G
L
V
L
Q
L
R
D
A
L
D
L
I
E
A
D
L
G
K
L
A
D
T
L
S
Q
Q
A
L
K
H
A
D
T
P
L
V
G
R
T
W
L
Q
H
A
T
P
V
T
L
G
M
K
L
A
G
V
L
G
A
L
T
R
H
R
Q
R
L
Q
E
L
R
P
R
L
L
-
V
L
Q
F
G
G
A
S
G
S
L
A
A
L
G
----
S
----
K
---
A
M
P
V
A
E
A
L
A
E
Q
L
K
L
-
T
L
-
P
-
E
-
Q
-
P
W
H
T
Q
R
D
R
L
V
E
F
A
S
V
L
G
L
V
A
G
S
L
G
K
F
G
R
D
I
S
L
L
M
Q
T
E
A
G
E
V
F
E
P
S
A
P
G
K
G
G
S
S
T
M
P
H
K
R
N
P
V
G
A
A
V
L
I
G
A
A
T
R
V
P
G
L
L
S
T
L
F
A
A
M
-
P
Q
E
H
E
R
S
L
G
L
W
H
A
E
W
E
T
L
P
D
I
C
C
L
V
S
G
A
L
R
Q
A
Q
V
I
A
E
G
M
E
V
D
A
A
R
M
R
R
N
L
D
L
T
Q
G
L
V
L
A
E
A
V
S
I
V
L
A
-
Q
R
-
L
G
-
R
D
--
R
A
H
H
L
L
E
Q
C
C
Q
R
A
V
A
E
Q
------
R
H
L
R
A
V
L
G
D
E
--
P
Q
V
S
A
E
L
S
G
E
E
L
D
R
L
L
D
P
A
H
Y
L
G
Q
A
R
V
W
V
A
R
A
V
S
E
H
Q
R
F
--
48
HHSearch
70.31
41%
-48
- C- -
-
3C8T
-
?
A:
[19-456]
--
P
L
Y
G
R
S
F
A
D
D
K
M
R
E
L
F
S
A
Q
S
F
I
S
R
C
V
E
T
E
V
A
L
A
R
A
Q
A
R
L
G
I
-
I
P
E
D
A
A
-------
A
G
I
T
A
A
A
R
T
F
---
A
P
E
M
E
R
L
R
D
D
T
E
I
V
G
Y
P
I
L
P
L
V
E
Q
L
S
A
H
A
---
G
----
E
A
G
K
Y
L
H
W
G
A
T
T
Q
D
I
M
D
T
A
T
V
L
Q
I
R
D
G
L
A
L
I
S
R
R
I
E
S
V
R
K
A
L
A
A
L
A
R
N
H
R
D
T
P
M
A
G
R
T
H
L
Q
H
A
L
P
V
T
F
G
Y
K
A
A
V
W
L
S
A
F
D
R
H
A
A
R
L
E
E
I
S
P
R
V
L
-
V
V
E
F
S
G
A
S
G
T
L
A
S
L
G
----
T
----
R
---
G
L
D
V
Q
R
E
L
A
R
E
L
N
L
-
G
V
-
P
-
S
-
I
-
T
W
H
S
A
R
D
A
V
A
E
T
V
Q
F
L
A
L
V
S
G
S
L
G
K
L
A
M
D
I
S
I
M
M
T
T
E
L
G
E
V
A
E
P
---------------
N
P
V
S
C
E
L
I
L
A
G
A
R
I
V
R
N
H
A
T
S
M
L
D
A
M
-
I
H
D
F
E
R
A
T
G
P
W
H
L
E
W
S
A
V
P
E
G
F
A
V
A
S
G
I
L
Y
Q
A
E
F
M
L
G
G
L
Q
V
F
P
D
R
M
R
E
N
L
D
H
S
R
G
L
I
V
A
E
A
V
M
M
A
L
A
-
P
H
-
T
G
-
R
K
--
E
A
H
D
I
V
Y
L
G
C
R
R
A
V
E
D
K
------
T
G
L
F
E
V
L
R
T
M
--
P
E
V
A
K
P
L
G
E
E
A
L
R
D
L
T
D
P
R
N
Y
L
G
S
A
G
A
M
V
D
N
V
L
G
G
R
-----
3
PsiBlast_PDB
68.97
40%
-50
- C- -
-
3C8T
-
?
A:
[19-456]
--
P
L
Y
G
R
S
F
A
D
D
K
M
R
E
L
F
S
A
Q
S
F
I
S
R
C
V
E
T
E
V
A
L
A
R
A
Q
A
R
L
G
I
-
I
P
E
D
A
A
A
G
I
T
A
A
A
R
T
F
A
P
E
M
-
E
R
L
R
D
D
---------
T
E
I
V
G
Y
P
I
L
P
L
V
E
Q
L
S
A
H
A
---
G
E
----
A
G
K
Y
L
H
W
G
A
T
T
Q
D
I
M
D
T
A
T
V
L
Q
I
R
D
G
L
A
L
I
S
R
R
I
E
S
V
R
K
A
L
A
A
L
A
R
N
H
R
D
T
P
M
A
G
R
T
H
L
Q
H
A
L
P
V
T
F
G
Y
K
A
A
V
W
L
S
A
F
D
R
H
A
A
R
L
E
E
I
S
P
R
V
L
-
V
V
E
F
S
G
A
S
G
T
L
A
S
L
G
----
T
----
R
---
G
L
D
V
Q
R
E
L
A
R
E
L
N
L
-
G
V
-
P
-
S
-
I
-
T
W
H
S
A
R
D
A
V
A
E
T
V
Q
F
L
A
L
V
S
G
S
L
G
K
L
A
M
D
I
S
I
M
M
T
T
E
L
G
E
V
A
E
P
---------------
N
P
V
S
C
E
L
I
L
A
G
A
R
I
V
R
N
H
A
T
S
M
L
D
A
M
-
I
H
D
F
E
R
A
T
G
P
W
H
L
E
W
S
A
V
P
E
G
F
A
V
A
S
G
I
L
Y
Q
A
E
F
M
L
G
G
L
Q
V
F
P
D
R
M
R
E
N
L
D
H
S
R
G
L
I
V
A
E
A
V
M
M
A
L
A
-
P
H
-
T
G
-
R
K
--
E
A
H
D
I
V
Y
L
G
C
R
R
A
V
E
D
K
------
T
G
L
F
E
V
L
R
T
M
--
P
E
V
A
K
P
L
G
E
E
A
L
R
D
L
T
D
P
R
N
Y
L
G
S
A
G
A
M
V
D
N
V
L
G
G
R
-----
7
PsiBlast_PDB
66.76
27%
-38
- C3 -
-
2PFM
-
?
A:
[12-437]
------
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
D
-
I
P
K
E
----------
D
V
K
K
I
R
-
E
H
A
--
S
F
D
I
D
R
I
Y
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
P
---
A
L
G
E
E
--
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
A
A
N
T
V
R
-
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
D
--------------
P
F
V
E
K
Y
V
C
E
N
L
G
L
E
A
A
-
P
-
I
-
S
-
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
-
D
K
G
M
V
-
R
E
--
E
A
Y
D
I
V
Q
P
K
A
M
E
A
W
E
T
Q
------
V
Q
F
K
E
L
V
E
A
D
--
E
R
I
T
S
K
L
T
Q
E
E
I
N
E
C
F
N
Y
E
H
H
M
----
Q
H
V
D
T
I
F
E
-------
50
HHSearch
65.54
26%
-39
- C3 -
-
2PFM
-
?
A:
[11-441]
-----
I
S
R
Y
T
R
P
E
M
G
A
I
W
T
E
E
N
K
F
K
A
W
L
E
V
E
I
L
A
C
E
A
W
A
E
L
G
D
-
I
P
K
E
D
V
-------
K
K
I
R
E
H
A
------
S
F
D
I
D
R
I
Y
E
I
E
K
E
T
R
H
D
V
V
A
F
T
R
A
V
S
E
T
P
---
A
L
--
G
E
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
Y
I
L
K
Q
A
N
E
I
I
L
K
D
L
E
N
F
V
S
I
L
A
N
K
A
K
E
H
K
Y
T
I
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
L
K
L
G
L
W
Y
E
E
M
K
R
N
V
E
R
F
K
Q
A
A
N
T
V
R
-
V
G
K
L
S
G
A
V
G
T
Y
A
N
I
D
--------------
P
F
V
E
K
Y
V
C
E
N
L
G
L
-
E
A
-
A
-
P
-
I
S
T
Q
T
L
Q
R
D
R
H
A
H
Y
M
S
T
L
A
L
I
A
T
S
I
E
K
M
A
V
E
I
R
G
L
Q
K
S
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
M
T
G
L
A
R
V
I
R
G
Y
M
M
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
V
I
L
P
D
A
T
I
A
L
N
Y
M
L
N
R
F
G
N
I
V
K
N
L
T
V
Y
P
E
N
M
K
R
N
M
T
R
T
Y
G
L
I
Y
S
Q
R
V
M
L
T
L
I
D
K
G
-
M
V
-
R
E
--
E
A
Y
D
I
V
Q
P
K
A
M
E
A
W
E
T
Q
------
V
Q
F
K
E
L
V
E
A
D
--
E
R
I
T
S
K
L
T
Q
E
E
I
N
E
C
F
N
Y
E
H
H
M
Q
H
V
D
T
I
F
E
R
L
G
L
-------
9
PsiBlast_PDB
64.67
26%
-38
- C3 -
-
1C3U
-
PUR8_THEMA
A:
[24-430]
---------------------------
L
E
V
E
L
A
V
T
R
A
Y
E
E
L
G
M
-
I
P
K
G
V
T
-------
E
R
I
R
N
N
A
------
K
I
D
V
E
L
F
K
K
I
E
E
K
T
N
H
D
V
V
A
F
V
E
G
I
G
S
M
------
I
G
E
D
-
S
R
F
F
H
Y
G
L
T
S
S
D
V
L
D
T
A
N
S
L
A
L
V
E
A
G
K
I
L
L
E
S
L
K
E
F
C
D
V
L
W
E
V
A
N
R
Y
K
H
T
P
T
I
G
R
T
H
G
V
H
A
E
P
T
S
F
G
L
K
V
L
G
W
Y
S
E
M
K
R
N
V
Q
R
L
E
R
A
I
E
E
V
S
-
Y
G
K
I
S
G
A
V
G
N
Y
A
N
V
P
----
P
----
E
------
V
E
E
K
A
L
S
Y
L
G
L
-
K
P
E
P
-
V
-
S
-
T
Q
V
V
P
R
D
R
H
A
F
Y
L
S
T
L
A
I
V
A
A
G
I
E
R
I
A
V
E
I
R
H
L
Q
R
T
E
V
L
E
V
E
E
P
F
R
------
S
A
M
P
H
K
K
N
P
I
T
C
E
R
L
T
G
L
S
R
M
M
R
A
Y
V
D
P
S
L
E
N
I
-
A
L
W
H
E
R
D
I
S
H
S
S
V
E
R
Y
V
F
P
D
A
T
Q
T
L
Y
Y
M
I
V
T
A
T
N
V
V
R
N
M
K
V
N
E
E
R
M
K
K
N
I
D
L
T
K
G
L
V
F
S
Q
R
V
L
L
K
L
I
-
E
K
G
L
T
-
R
K
--
E
A
Y
D
I
V
Q
R
N
A
L
K
T
W
N
S
E
------
K
H
F
L
E
Y
L
L
E
D
--
E
E
V
K
K
L
V
T
K
E
E
L
E
E
L
F
D
I
S
Y
Y
L
K
H
V
D
H
I
F
E
R
F
E
K
-------
6
PsiBlast_PDB
63.57
25%
-40
- C3 -
-
2X75
2
PUR8_STAAW
A:
[5-428]
--------
Y
S
R
E
E
M
S
N
I
W
T
D
Q
N
R
Y
E
A
W
L
E
V
E
I
L
A
C
E
A
W
S
E
L
G
H
-
I
P
K
A
D
V
-------
Q
K
I
R
Q
N
A
-
K
V
N
V
E
R
----
A
Q
E
I
E
Q
E
T
R
H
D
V
-
V
A
F
T
R
Q
V
S
E
T
L
---
G
E
----
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
F
V
I
K
Q
A
N
D
I
I
E
K
D
L
E
R
F
I
D
V
L
A
E
K
A
K
N
Y
K
Y
T
L
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
V
K
M
A
L
W
Y
T
E
M
Q
R
N
L
Q
R
F
K
Q
V
R
E
E
I
E
-
V
G
K
M
S
G
A
V
G
T
F
A
N
I
P
----
P
----
E
------
I
E
S
Y
V
C
K
H
L
G
I
G
T
A
-
P
-
V
-
S
-
T
Q
T
L
Q
R
D
R
H
A
Y
Y
I
A
T
L
A
L
I
A
T
S
L
E
K
F
A
V
E
I
R
N
L
Q
K
T
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
I
T
G
I
S
R
V
I
R
G
Y
I
T
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
I
M
L
P
D
V
T
I
A
L
D
Y
A
L
N
R
F
T
N
I
V
D
R
L
T
V
F
E
D
N
M
R
N
N
I
D
K
T
F
G
L
I
F
S
Q
R
V
L
L
A
L
I
-
N
K
G
M
V
-
R
E
--
E
A
Y
D
K
V
Q
P
K
A
M
I
S
W
E
T
K
------
T
P
F
R
E
L
I
E
Q
D
--
E
S
I
T
---
T
K
E
E
L
D
E
C
F
D
P
K
H
H
L
N
----
Q
V
D
T
I
F
E
R
A
-----
47
HHSearch
62.48
24%
-43
- C3 -
-
2X75
2
PUR8_STAAW
A:
[2-428]
-----
I
E
R
Y
S
R
E
E
M
S
N
I
W
T
D
Q
N
R
Y
E
A
W
L
E
V
E
I
L
A
C
E
A
W
S
E
L
G
H
-
I
P
K
A
D
V
-------
Q
K
I
R
Q
N
A
------
K
V
N
V
E
R
A
Q
E
I
E
Q
E
T
R
H
D
V
V
A
F
T
R
Q
V
S
E
T
L
---
G
E
----
E
R
K
W
V
H
Y
G
L
T
S
T
D
V
V
D
T
A
L
S
F
V
I
K
Q
A
N
D
I
I
E
K
D
L
E
R
F
I
D
V
L
A
E
K
A
K
N
Y
K
Y
T
L
M
M
G
R
T
H
G
V
H
A
E
P
T
T
F
G
V
K
M
A
L
W
Y
T
E
M
Q
R
N
L
Q
R
F
K
Q
V
R
E
E
I
E
-
V
G
K
M
S
G
A
V
G
T
F
A
N
I
P
----
P
----------
E
I
E
S
Y
V
C
K
H
L
G
I
-
G
T
-
A
-
P
-
V
S
T
Q
T
L
Q
R
D
R
H
A
Y
Y
I
A
T
L
A
L
I
A
T
S
L
E
K
F
A
V
E
I
R
N
L
Q
K
T
E
T
R
E
V
E
E
A
F
A
K
G
Q
K
G
S
S
A
M
P
H
K
R
N
P
I
G
S
E
N
I
T
G
I
S
R
V
I
R
G
Y
I
T
T
A
Y
E
N
V
-
P
L
W
H
E
R
D
I
S
H
S
S
A
E
R
I
M
L
P
D
V
T
I
A
L
D
Y
A
L
N
R
F
T
N
I
V
D
R
L
T
V
F
E
D
N
M
R
N
N
I
D
K
T
F
G
L
I
F
S
Q
R
V
L
L
A
L
I
N
K
G
-
M
V
-
R
E
--
E
A
Y
D
K
V
Q
P
K
A
M
I
S
W
E
T
K
------
T
P
F
R
E
L
I
E
Q
D
--
E
S
I
T
---
T
K
E
E
L
D
E
C
F
D
P
K
H
H
L
N
Q
V
D
T
I
F
E
R
A
---------
55
HHSearch
61.64
22%
-35
- C3 -
-
5EYT
1
?
A:
[25-480]
-
R
N
P
L
T
K
R
Y
A
S
R
E
M
V
C
N
F
G
E
K
R
K
V
I
L
W
R
Q
L
W
I
W
L
A
E
T
Q
K
E
L
G
F
D
I
T
D
E
Q
I
-------
N
E
M
K
S
Q
R
-----
D
S
V
D
F
G
T
A
A
A
E
E
K
A
R
R
H
D
V
M
A
H
V
Y
T
F
A
L
A
C
---
P
----
K
A
A
P
I
I
H
L
G
A
T
S
C
F
V
G
D
N
A
D
L
I
M
L
K
D
G
L
N
I
L
L
P
K
V
A
R
C
I
D
R
L
A
K
K
A
M
L
H
K
S
L
I
C
L
A
R
T
H
L
Q
P
A
Q
P
T
T
M
G
R
R
I
C
M
W
I
Q
D
L
L
L
D
L
E
N
L
E
R
L
K
N
H
T
I
R
F
R
G
A
K
G
A
V
G
T
Q
A
S
F
M
----
D
L
F
QG
D
H
Q
K
V
I
K
L
D
E
I
L
T
K
K
S
G
F
-
Q
R
-
S
W
C
-
V
T
G
Q
T
Y
P
R
K
V
D
I
E
I
T
N
A
L
S
N
I
G
A
T
V
H
K
I
C
T
D
I
R
L
L
S
S
--
F
H
E
V
E
E
P
F
E
T
K
------
M
P
Y
K
R
N
P
I
R
S
E
R
A
C
S
L
A
R
Y
L
M
H
I
S
T
S
M
V
S
T
V
S
V
Q
W
L
E
R
S
L
D
D
S
A
I
R
R
I
V
L
P
E
A
F
L
A
A
D
A
C
L
T
L
L
Q
N
I
A
E
G
L
I
V
Y
P
M
V
M
E
A
N
L
N
S
E
L
P
F
L
V
V
E
R
I
L
V
K
M
V
S
E
G
-
A
A
N
R
Q
--
E
C
H
E
R
L
R
K
H
S
H
E
A
A
A
E
I
KLKGLK
N
S
L
M
D
K
L
L
N
D
--
Y
Y
F
A
P
I
--
H
S
L
L
P
T
V
L
D
P
S
Y
M
I
G
R
A
V
E
Q
V
E
V
F
L
N
T
E
V
D
P
--
58
HHSearch
59.85
23%
-72
- C3 -
-
4EEI
13
?
B:
[2-421]
-----
I
K
R
Y
D
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
M
-
V
P
K
G
T
A
-------
A
E
I
R
A
R
A
------
Q
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
E
Q
F
---
T
A
---
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
-
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
T
----
T
----------
E
D
E
K
K
A
A
D
I
L
G
L
-
P
V
-
E
-
E
-
V
S
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
F
------------
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
--
N
-
T
P
-
F
M
RE
D
C
Y
K
I
V
Q
Q
V
A
F
D
L
----------
E
S
F
S
K
K
L
Q
K
V
MH
D
E
H
N
I
I
L
D
I
P
E
M
D
F
E
G
I
K
K
T
Y
L
K
E
-----------------
56
HHSearch
58.52
20%
-37
- C3 -
-
2J91
4
PUR8_HUMAN
C:
[36-489]
-
R
S
P
L
A
S
R
Y
A
S
P
E
M
C
F
V
F
S
D
R
Y
K
F
R
T
W
R
Q
L
W
L
W
L
A
E
A
E
Q
T
L
G
L
P
I
T
D
E
Q
I
-------
R
E
M
K
S
N
L
-----
E
N
I
D
F
K
M
A
A
E
E
E
K
R
L
R
H
D
V
M
A
H
V
H
T
F
G
H
C
C
---
P
----
K
A
A
G
I
I
H
L
G
A
T
S
C
Y
V
G
D
N
T
D
L
I
I
L
R
N
A
L
D
L
L
L
P
K
L
A
R
V
I
S
R
L
A
D
F
A
K
E
R
A
S
L
P
T
L
G
F
T
H
F
Q
P
A
Q
L
T
T
V
G
K
R
C
C
L
W
I
Q
D
L
C
M
D
L
Q
N
L
K
R
V
R
D
D
L
R
-
F
R
G
V
K
G
T
T
G
T
Q
A
S
F
L
Q
L
F
E
G
----
D
D
H
K
V
E
Q
L
D
K
M
V
T
E
K
A
G
F
-
K
R
-
A
-
F
I
I
T
G
Q
T
Y
T
R
K
V
D
I
E
V
L
S
V
L
A
S
L
G
A
S
V
H
K
I
C
T
D
I
R
L
L
A
N
--
L
K
E
M
E
E
P
------------
Y
K
R
N
P
M
R
S
E
R
C
C
S
L
A
R
H
L
M
T
L
V
M
D
P
L
Q
T
A
S
V
Q
W
F
E
R
T
L
D
D
S
A
N
R
R
I
C
L
A
E
A
F
L
T
A
D
T
I
L
N
T
L
Q
N
I
S
E
G
L
V
V
Y
P
K
V
I
E
R
R
I
R
Q
E
L
P
F
M
A
T
E
N
I
I
M
A
M
V
K
A
G
-
G
S
-
R
Q
--
D
C
H
E
K
I
R
V
L
S
Q
Q
A
A
S
V
V
KQEGGD
N
D
L
I
E
R
I
Q
V
D
--
A
-
Y
F
S
P
I
-
H
S
Q
L
D
H
L
L
D
P
S
S
F
T
G
R
A
S
Q
Q
V
Q
R
F
L
E
E
E
V
Y
P
--
69
Fugue
58.21
22%
-50
- C3 -
-
4EEI
10
?
A:
[1-433]
M
I
K
R
Y
D
----
V
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
V
E
L
A
I
L
E
A
L
E
D
-
R
M
-
V
P
K
G
T
A
-------
A
E
I
R
A
R
A
-
Q
-----
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
I
I
A
F
C
T
S
I
A
------
E
Q
F
T
A
E
T
G
K
F
F
H
F
G
V
T
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
E
A
L
C
D
S
L
L
T
K
A
E
E
T
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
L
K
D
F
Q
K
D
G
L
-
T
V
Q
F
S
G
A
V
G
N
Y
C
I
L
T
--------------
T
E
D
E
K
K
A
A
D
I
L
G
L
-
P
V
E
E
-
V
-
S
-
T
Q
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
S
D
V
F
E
V
Y
E
G
------------
F
K
K
N
P
I
S
T
E
N
L
T
G
M
A
R
M
L
R
S
H
V
S
I
A
L
E
N
C
-
V
L
W
H
E
R
D
I
S
H
S
S
A
E
R
F
Y
L
P
D
N
F
G
I
M
V
Y
A
L
R
R
M
K
N
T
I
D
N
L
V
V
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
A
N
T
P
-
F
M
-
R
E
--
D
C
Y
K
I
V
Q
Q
V
E
S
F
S
K
K
L
Q
------
K
V
M
H
D
--------
E
H
N
I
I
L
D
I
P
E
M
D
F
E
G
I
K
K
T
Y
L
K
E
I
D
H
V
F
D
R
S
V
K
A
R
-----
66
HHSearch
57.84
26%
-80
- C3 -
-
1DOF
-
?
A:
[3-396]
-
V
S
P
F
D
W
R
Y
G
S
E
E
I
R
R
L
F
T
N
E
A
I
I
N
A
Y
L
E
V
E
R
A
L
V
C
A
L
E
E
L
G
V
-
A
E
R
G
C
C
-------
E
K
V
N
K
A
S
-----
V
S
A
D
--
E
V
--------
H
D
I
L
S
L
V
L
L
L
E
Q
K
S
---
G
------
C
R
Y
V
H
Y
G
A
T
S
N
D
I
I
D
T
A
W
A
L
L
I
R
R
A
L
A
A
V
K
E
K
A
R
A
V
G
D
Q
L
A
S
M
A
R
K
Y
K
T
L
E
M
V
G
R
T
H
G
Q
W
A
E
P
I
T
L
G
F
K
F
A
N
Y
Y
Y
E
L
Y
I
A
C
R
Q
L
A
L
A
E
E
F
I
--
R
A
K
I
G
G
A
V
G
T
M
A
S
W
G
----
E
----
L
---
G
L
E
V
R
R
R
V
A
E
R
L
G
L
-
P
H
-
H
-
V
-
I
T
T
Q
V
A
P
R
E
S
F
A
V
L
A
S
A
L
A
L
M
A
A
V
F
E
R
L
A
V
E
I
R
E
L
S
R
P
E
I
G
E
V
V
E
G
----
G
---------
A
N
P
T
A
S
E
R
I
V
S
L
A
R
Y
V
R
A
L
T
H
V
A
F
E
N
V
-
A
L
W
H
E
R
D
L
T
N
S
A
N
E
R
V
W
I
P
E
A
L
L
A
L
D
E
I
L
T
S
A
L
R
V
L
K
N
V
Y
I
D
E
E
R
I
T
E
N
L
Q
K
A
L
P
Y
I
L
T
E
F
H
M
N
R
M
I
K
E
G
-
A
S
-
R
A
--
E
A
Y
K
K
A
K
E
V
K
A
L
T
F
E
Y
Q
------
K
W
P
V
E
R
L
I
E
D
-------------------------------------------
54
HHSearch
56.52
22%
-36
- C3 -
-
5EYV
-
?
B:
[25-480]
-
R
N
P
L
T
K
R
Y
A
S
R
E
M
V
C
N
F
G
E
K
R
K
V
I
L
W
R
Q
L
W
I
W
L
A
E
T
Q
K
E
L
G
F
D
I
T
D
E
Q
I
-------
N
E
M
K
S
Q
R
-----
D
S
V
D
F
G
T
A
A
A
E
E
K
A
R
R
H
D
V
M
A
H
V
Y
T
F
A
L
A
C
---
P
----
K
A
A
P
I
I
H
L
G
A
T
S
C
F
V
G
D
N
A
D
L
I
M
L
K
D
G
L
N
I
L
L
P
K
V
A
R
C
I
D
R
L
A
K
K
A
M
L
H
K
S
L
I
C
L
A
R
T
H
L
Q
P
A
Q
P
T
T
M
G
R
R
I
C
M
W
I
Q
D
L
L
L
D
L
E
N
L
E
R
L
K
N
H
T
I
R
F
R
G
A
K
G
A
V
G
T
Q
A
S
F
M
----
D
L
F
QG
D
H
Q
K
V
I
K
L
D
E
I
L
T
K
K
S
G
F
-
Q
R
-
S
W
C
-
V
T
G
Q
T
Y
P
R
K
V
D
I
E
I
T
N
A
L
S
N
I
G
A
T
V
H
K
I
C
T
D
I
R
L
L
S
S
--
F
H
E
V
E
E
P
F
E
-----------
K
R
N
P
I
R
S
E
R
A
C
S
L
A
R
Y
L
M
H
I
S
T
S
M
V
S
T
V
S
V
Q
W
L
E
R
S
L
D
D
S
A
I
R
R
I
V
L
P
E
A
F
L
A
A
D
A
C
L
T
L
L
Q
N
I
A
E
G
L
I
V
Y
P
M
V
M
E
A
N
L
N
S
E
L
P
F
L
V
V
E
R
I
L
V
K
M
V
S
E
G
-
A
A
---------------------------------------------------
L
P
T
V
L
D
P
S
Y
M
I
G
R
A
V
E
Q
V
E
V
F
L
N
T
E
V
D
P
--