@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQH5: (2017-11-27 )
MTLKNAYIIDAIRTPFGRYAGGLASVRADDLGAVPIKALMQRNPNVDWEQVDDVIYGCANQAGEDNRNVGRMSALLAGLPYQVPATTINRLCGSSLDAIAIAARAIKAGEANLVIAGGVESMSRAPYVMGKSDSAFGRSQKIEDTTMGWRFINPKLKELYGVDTMPQTAENVAEQFNVNRADQDQFALVSQQRTASAQAKGFFSKEIVAVEIPQRKGDAVVIDTDEHPRASTTLEGLSKLKPVVKADGTVTAGNASGINDGAAALLIASDDAVQAYNLKPRAKIIASTAVGVEPRIMGFAPAPAIKKLFKQANLTLDQMDVIELNEAFAAQALAVTRDLGLPDNSDKVNPNGGAIALGHPLGASGARLVTTALNQLEQTGGRYALCSMCIGVGQGIALIIERV
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-...--..-.140.-.......150.......160.---------......170.......180.......190.......200.......210......-.220.......230.......240....--...--250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTLK
N
A
Y
I
I
D
A
I
R
T
P
F
G
R
YAGGLASVRADDLG
A
V
P
I
K
A
L
M
QRNPNV
D
W
E
Q
V
D
D
V
I
Y
GCANQAGEDNR
N
V
G
R
M
S
A
L
L
AGLPYQV
P
A
T
T
I
N
R
L
CGSS
L
D
A
I
A
I
A
A
R
A
IKAGEA
N
L
V
I
AGG
V
E
SMSRA
P
Y
V
MG--KSD-SAF--GR-SQ-KI-EDTTM
G
W
R
FIN
P
K
L
K
E
L
YGVD---------TM
P
Q
T
A
E
N
V
A
E
Q
FNVNRA
D
Q
D
Q
F
A
L
V
S
Q
QRTA
S
A
QAKGFFSK
E
I
V
A
V
EIPQRKG
D
-
A
V
V
I
DTDEHPRA
S
T
T
L
E
G
L
S
KL
K
P
V
VKA--D
G
T
--
V
TAGNASGINDG
A
A
A
L
L
I
ASDDA
V
Q
A
YNLKP
R
A
K
I
I
A
S
TAVGVEPRIMGFAP
A
P
A
I
K
K
L
F
K
Q
ANLTLD
Q
M
D
V
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
T
RDLGLPDNSDKVNPNG
G
A
I
A
LGHPLGAS
G
A
R
L
V
T
T
A
L
N
Q
L
E
QTGG
R
Y
A
L
C
S
M
C
I
GVGQ
G
I
A
L
I
IERV
127
HHSearch
93.94
52%
-33
- C6 -
-
1ULQ
-
?
G:
[2-400]
---
P
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
--
K
P
E
-
R
G
F
--
P
T
G
N
L
-
V
M
-
Y
D
T
T
L
G
W
R
F
V
N
P
K
M
Q
A
L
Y
G
T
E
---------
S
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
--
K
R
G
K
E
E
I
L
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
R
E
--
G
G
T
--
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
M
E
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
M
1
PsiBlast_PDB
92.19
51%
-32
- C6 -
-
1ULQ
-
?
A:
[3-398]
----
E
A
W
I
V
E
A
V
R
T
P
I
G
K
H
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
S
-
G
V
P
K
E
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
--
K
P
E
-
R
G
F
--
P
T
-
G
N
-
L
V
M
Y
D
T
T
L
G
W
R
F
V
N
P
K
M
Q
A
L
Y
G
T
E
---------
S
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
V
-
K
R
G
K
E
-
E
I
L
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
R
E
--
G
G
T
--
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
M
E
D
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
--
12
PsiBlast_PDB
91.62
45%
-82
- C6 -
-
4O9C
-
THIL_CUPNH
A:
[1-392]
--
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
35
PsiBlast_CBE
91.12
45%
-80
- C6 -
-
4O9C
1
THIL_CUPNH
C:
[1-392]
--
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
32
PsiBlast_CBE
91.05
45%
-84
- C6 -
-
4O99
1
THIL_CUPNH
C:
[2-391]
----
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
34
PsiBlast_CBE
91.00
45%
-82
- C6 -
-
4O9C
1
THIL_CUPNH
H:
[1-392]
--
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
11
PsiBlast_PDB
90.88
45%
-85
- C6 -
-
4O99
1
THIL_CUPNH
A:
[2-391]
----
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
13
PsiBlast_PDB
90.83
45%
-82
- C6 -
-
4O9A
-
THIL_CUPNH
A:
[3-392]
----
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
33
PsiBlast_CBE
89.97
45%
-84
- C6 -
-
4O99
1
THIL_CUPNH
B:
[2-391]
----
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
-
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--------
R
M
-
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
--
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
6
PsiBlast_PDB
89.17
45%
-24
- C6 -
-
4XL3
4
?
A:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
10
PsiBlast_PDB
88.09
44%
-30
- C6 -
-
4C2J
8
THIM_HUMAN
A:
[24-414]
--
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
G
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
NV
R
F
G
-
T
K
L
--
G
S
-
D
I
-
K
L
-
E
D
S
L
--
W
V
S
L
T
D
Q
H
V
Q
L
-------------
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
I
E
V
K
----
K
-
Q
T
-
M
Q
V
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
D
L
--
D
I
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
--
5
PsiBlast_PDB
88.04
45%
-26
- C6 -
-
4N45
-
?
A:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
8
PsiBlast_PDB
87.98
44%
-28
- C6 -
-
4C2K
10
THIM_HUMAN
A:
[24-414]
--
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
G
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
NV
R
F
G
-
T
K
L
--
G
S
-
D
I
-
K
L
-
E
D
S
L
--
W
V
S
L
T
D
Q
H
V
Q
L
-------------
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
I
E
V
K
T
K
K
G
K
-
Q
T
-
M
Q
V
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
D
L
--
D
I
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
--
29
PsiBlast_CBE
87.89
44%
-28
- C6 -
-
4C2K
8
THIM_HUMAN
D:
[24-414]
--
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
G
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
NV
R
F
G
-
T
K
L
--
G
S
-
D
I
-
K
L
-
E
D
S
L
--
W
V
S
L
T
D
Q
H
V
Q
L
-------------
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
I
E
V
K
T
K
K
G
K
-
Q
T
-
M
Q
V
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
D
L
--
D
I
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
--
140
HHSearch
87.84
47%
-38
- C6 -
-
4O9A
-
THIL_CUPNH
B:
[3-392]
----
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
-
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--
R
M
G
D
A
-
K
L
-
V
D
T
M
-----
I
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
--
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
88
PsiBlast_CBE
87.84
44%
-36
- C6 -
-
5F0V
11
ATOB_ECOLI
B:
[2-395]
-
S
M
K
N
C
V
I
V
S
A
V
R
T
A
I
G
S
F
N
G
S
L
A
S
T
S
A
I
D
L
G
A
T
V
I
K
A
A
I
E
R
-
A
K
I
D
S
Q
H
V
D
E
V
I
M
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
L
L
K
S
G
L
A
E
T
V
C
G
F
T
V
N
-
V
C
G
S
G
L
K
S
V
A
L
A
A
Q
A
I
Q
A
G
Q
A
Q
S
I
V
A
G
G
M
E
N
M
S
L
A
P
Y
L
L
-------
D
A
K
--
A
R
-
S
----------
G
Y
R
L
G
D
G
Q
V
Y
D
V
I
L
R
D
GLMCATHGY
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
M
Q
D
E
L
A
L
H
S
Q
R
K
A
A
A
A
I
E
S
G
A
F
T
A
E
I
V
P
V
N
V
V
T
R
--
K
-
T
F
V
F
S
Q
D
E
F
P
K
A
N
S
T
A
E
A
L
G
A
L
R
P
A
F
D
K
--
A
G
T
--
V
T
A
G
N
A
S
G
I
N
D
G
A
A
A
L
V
I
M
E
E
S
A
A
L
A
A
G
L
T
P
L
A
R
I
K
S
Y
A
S
G
G
V
P
P
A
L
M
G
M
G
P
V
P
A
T
Q
K
A
L
Q
L
A
G
L
Q
L
A
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
F
L
A
V
G
K
N
L
G
F
--
D
S
E
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
L
H
A
M
Q
A
R
D
K
T
L
G
L
A
T
L
C
I
G
G
G
Q
G
I
A
M
V
I
E
R
L
2
PsiBlast_PDB
87.84
46%
-30
- C6 -
-
4WYR
5
THLA_CLOAB
A:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
Y
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
126
HHSearch
87.56
47%
-36
- C6 -
-
4O9C
-
THIL_CUPNH
E:
[1-392]
--
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
-
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
-
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
--
G
S
R
-
D
G
F
--
R
M
G
D
A
-
K
L
-
V
D
T
M
I
-----
V
D
G
L
W
D
V
Y
N
Q
Y
---------
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
-
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
--
A
G
T
--
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
--
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
138
HHSearch
87.47
43%
-45
- C6 -
-
1WL4
4
THIC_HUMAN
A:
[4-396]
-
G
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
A
-
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
--
L
R
T
G
V
K
I
--
G
E
--
M
-
P
L
-
T
D
S
-----
I
L
C
D
G
L
T
D
A
F
H
N
C
---------
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
T
R
K
G
--
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
DG
T
G
T
--
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
P
E
--
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
30
PsiBlast_CBE
87.37
44%
-29
- C6 -
-
4C2K
10
THIM_HUMAN
C:
[24-414]
--
L
R
G
V
F
V
V
A
A
K
R
T
P
F
G
A
Y
G
G
L
L
K
D
F
T
A
T
D
L
S
E
F
A
A
K
A
A
L
S
A
G
-
K
V
S
P
E
T
V
D
S
V
I
M
G
N
V
L
Q
S
S
S
D
A
I
Y
L
A
R
H
V
G
L
R
V
G
I
P
K
E
T
P
A
L
T
I
N
R
L
C
G
S
G
F
Q
S
I
V
N
G
C
Q
E
I
C
V
K
E
A
E
V
V
L
C
G
G
T
E
S
M
S
Q
A
P
Y
C
V
R
NV
R
F
G
-
T
K
L
--
G
S
-
D
I
-
K
L
-
E
D
S
L
--
W
V
S
L
T
D
Q
H
V
Q
L
-------------
P
M
A
M
T
A
E
N
L
A
V
K
H
K
I
S
R
E
E
C
D
K
Y
A
L
Q
S
Q
Q
R
W
K
A
A
N
D
A
G
Y
F
N
D
E
M
A
P
I
E
V
K
T
--
G
K
-
Q
T
-
M
Q
V
D
E
H
A
R
P
Q
T
T
L
E
Q
L
Q
K
L
P
P
V
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
V
A
D
G
A
G
A
V
I
I
A
S
E
D
A
V
K
K
H
N
F
T
P
L
A
R
I
V
G
Y
F
V
S
G
C
D
P
S
I
M
G
I
G
P
V
P
A
I
S
G
A
L
K
K
A
G
L
S
L
K
D
M
D
L
V
E
V
N
E
A
F
A
P
Q
Y
L
A
V
E
R
S
L
D
L
--
D
I
S
K
T
N
V
N
G
G
A
I
A
L
G
H
P
L
G
G
S
G
S
R
I
T
A
H
L
V
H
E
L
R
R
R
G
G
K
Y
A
V
G
S
A
C
I
G
G
G
Q
G
I
A
V
I
I
Q
--
21
PsiBlast_CBE
87.22
46%
-29
- C6 -
-
4WYR
3
THLA_CLOAB
B:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
Y
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
7
PsiBlast_PDB
87.04
45%
-24
- C6 -
-
4XL4
7
?
A:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
24
PsiBlast_CBE
86.93
45%
-25
- C6 -
-
4XL4
4
?
B:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
25
PsiBlast_CBE
86.80
45%
-24
- C6 -
-
4XL3
3
?
B:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
16
PsiBlast_PDB
86.50
43%
-46
- C6 -
-
1WL4
4
THIC_HUMAN
A:
[10-396]
-------
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
-
A
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
---------
A
Y
--
L
R
-
T
G
V
K
I
-
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
---------
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
T
R
K
G
--
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
--
D
G
T
GT
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
--
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
17
PsiBlast_PDB
86.02
43%
-47
- C6 -
-
1WL5
2
THIC_HUMAN
A:
[10-396]
-------
I
V
S
A
A
R
T
I
I
G
S
F
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
-
A
T
V
A
P
E
D
V
S
E
V
I
F
G
H
V
L
A
A
G
-
C
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
---------
A
Y
--
L
R
-
T
G
V
K
I
-
G
E
M
P
L
T
D
S
I
L
C
D
G
L
T
D
A
F
H
N
C
---------
H
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
T
R
K
G
--
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
T
--
D
G
T
GT
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
--
N
P
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
R
S
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
-
22
PsiBlast_CBE
85.60
46%
-26
- C6 -
-
4XL2
6
THLA_CLOAB
B:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
4
PsiBlast_PDB
84.55
46%
-25
- C6 -
-
4XL2
6
THLA_CLOAB
A:
[1-391]
--
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
--
N
A
R
-
W
G
Y
RM
G
N
-
A
K
-
F
V
-
D
E
------
M
I
T
D
G
L
W
D
A
F
N
D
Y
---------
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
-
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
--
D
G
T
--
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
--
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-