@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQI4: (2017-11-27 )
MFMSQIVDIRAREILDSRGNPTIEADVILESGVVGRACAPSGASTGSREALELRDGDKSRYLGKGVRTAVQNVNSSIHELLVGQSVFEQKALDEKMIAFDGTENKSKLGANATLAVSLAAAHAAAAEQKLPLFQYIANLRGQTTLTMPVPMMNILNGGAHADNTVDIQEFMIEPVGFTSFAEALRAGAEVFHSLKSVLKKQGLNTAVGDEGGFAPNLRSNEEAITVILQAIEQTGYKAGSDIMLALDCASSEFYKNGQYILEGEGNKSFTSNQFADYLAGLVKQYPIISIEDGLDESDWEGWSYLTSILGDKIQLVGDDLFVTNPKILQRGIDEKVGNSILIKYNQIGTLTETLDAIYLAKANGYTTVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVSKYNQLLRIEELTKAVYRGKAEFKGLK
Atome Classification :
(69 SA)
........-.10........20........30........40........50........60........70......-..80.--..-.--.--...90........100.......110.......120.......130.......140.--.--.....150.......160.......170.......180.......190.......-200..--.-..--...210.......220.......230.......240.......250..--.--.-------...---260---..-----..-------.....270------.......280.......290.......300.......310.....---..320.......330.......340.......350.......360.......370.......380.......390.......400.......410.-.-.--.--.-..-420.........430
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
F
M
S
Q
I
V
D
-
I
R
A
R
E
I
L
DSRGNP
T
I
E
A
D
V
I
LESGVVGRACAPSGASTGSR
E
A
L
ELRDGDK
S
R
Y
L
G
K
G
V
R
T
A
V
Q
N
V
N
S
S
I
-
H
E
L
L
V
--
G
Q
-
S
--
V
--
F
E
Q
KALDE
K
M
I
A
FDGTEN
K
S
KLGAN
A
T
L
A
V
S
L
A
A
A
H
A
A
A
A
EQKL
P
L
F
Q
Y
I
A
NLRG
Q
T
--
T
--
L
TMP
V
P
M
M
N
ILNGGAHADNTV
D
I
Q
E
F
M
IEPV
G
F
T
S
F
A
E
A
L
R
A
G
A
E
V
F
H
S
L
K
S
V
L
K
-KQ-GL--N-TA--VGDEGGFAPNLRS
N
E
E
A
I
T
V
I
L
Q
A
I
E
Q
TGYKAGS
D
I
M
L
A
L
DCAS
S
E
F
Y--K--N-------G
Q
Y
---
I
-----
L
E-----GE-------GNKSFT
S
N
------
Q
F
A
D
Y
L
A
G
L
V
K
QY
P
I
I
S
IEDGLDESDWE
G
W
S
Y
L
T
S
ILGD
K
I
Q
LVG---DDLFVT
N
P
K
I
L
Q
R
GI
D
E
KVG
N
S
I
L
I
K
YNQIG
T
L
T
E
T
L
D
A
I
Y
L
AKAN
G
Y
T
T
V
I
SHRSGETEDS
T
I
A
D
L
AVGTAAGQIKTGSLC
R
S
D
R
V
S
K
Y
N
Q
L
L
R
I
-
E
-
E
--
L
--
T
-
K
A
-
V
--YRGKAEFKGLK
9
PsiBlast_PDB
92.68
64%
-63
- C1 -
-
4ROP
-
ENO_SYNP6
A:
[5-410]
-
Y
G
T
Q
I
A
E
-
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
-
S
A
I
-
E
D
A
L
I
--
G
L
-
S
--
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
G
P
L
--
A
--
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
-
D
K
-
G
L
--
A
-
T
G
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
-------
G
L
Y
---
T
-----
C
D
-----
G
----------
V
S
H
E
P
A
------
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
-
E
--------------------------
34
PsiBlast_CBE
91.91
64%
-63
- C1 -
-
5J04
1
ENO_SYNP6
A:
[1-406]
-
Y
G
T
Q
I
A
E
-
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
-
S
A
I
-
E
D
A
L
I
--
G
L
-
S
--
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
G
P
L
--
A
--
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
-
D
K
-
G
L
--
A
-
T
G
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
-------
G
L
Y
---
T
-----
C
D
-----
G
----------
V
S
H
E
P
A
------
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
-
E
--------------------------
33
PsiBlast_CBE
91.88
64%
-62
- C1 -
-
5J04
1
ENO_SYNP6
B:
[1-406]
-
Y
G
T
Q
I
A
E
-
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
-
S
A
I
-
E
D
A
L
I
--
G
L
-
S
--
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
G
P
L
--
A
--
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
-
D
K
-
G
L
--
A
-
T
G
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
-------
G
L
Y
---
T
-----
C
D
-----
G
----------
V
S
H
E
P
A
------
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
---
D
D
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
-
E
--------------------------
156
HHSearch
91.66
61%
-64
- C1 -
-
4Z17
1
ENO_CHLAA
A:
[1-425]
-
M
S
T
L
I
E
A
-
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
-
A
E
A
L
I
--
G
F
-
D
--
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
L
G
G
V
Y
A
-------
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
-
D
R
-
G
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
-------
G
K
Y
---
H
-----
L
K
-----
R
--------
E
G
R
S
L
S
S
A
------
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
E
E
--
L
--
G
-
S
A
A
R
--
Y
A
G
R
S
A
F
K
---
18
PsiBlast_PDB
90.98
59%
-67
- C1 -
-
3TQP
-
ENO_COXBU
A:
[3-423]
---
A
T
I
T
D
-
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
Y
G
C
A
A
V
P
S
G
A
---
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
-
R
D
A
L
L
--
G
Q
-
D
--
P
--
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
L
G
G
D
G
G
----
P
--
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
L
K
K
R
L
V
-
S
R
-
G
L
--
M
-
S
A
--
V
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
I
Y
L
A
L
D
A
A
S
S
E
L
Y
--
Q
--
N
-------
G
R
Y
---
D
-----
F
E
---------------
N
N
Q
L
T
S
E
------
E
M
I
D
R
L
T
E
W
T
K
K
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
---
D
D
I
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
-
E
R
E
--
L
--
N
D
Q
A
-
P
--
Y
A
G
K
E
A
F
----
164
HHSearch
88.65
61%
-52
- C1 -
-
3TQP
-
ENO_COXBU
A:
[2-423]
--
T
A
T
I
T
D
-
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
Y
G
C
A
A
V
P
S
G
A
---
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
-
R
D
A
L
L
--
G
Q
-
D
--
P
--
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
L
G
G
D
G
G
----
P
--
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
L
K
K
R
L
V
-
S
R
-
G
L
--
M
-
S
A
--
V
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
I
Y
L
A
L
D
A
A
S
S
E
L
Y
--
Q
--
N
-------
G
R
Y
---
D
-----
F
E
-----
N
----------
N
Q
L
T
S
E
------
E
M
I
D
R
L
T
E
W
T
K
K
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
--
D
I
F
-
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
-
E
R
E
--
L
--
N
-
D
Q
A
P
--
Y
A
G
K
E
A
F
----
174
HHSearch
88.20
62%
-46
- C1 -
-
4ROP
-
ENO_SYNP6
A:
[6-423]
--
G
T
Q
I
A
E
-
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
A
-
I
-
E
D
A
L
I
--
G
L
-
S
--
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
L
G
G
P
L
A
-------
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
-
D
K
-
G
L
--
A
-
T
G
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
-------
G
L
Y
---
T
-----
C
D
-----
G
----------
V
S
H
E
P
A
------
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
--
G
S
T
V
Q
L
V
G
D
D
L
F
-
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
-
E
A
A
--
L
--
G
-
E
N
A
L
--
Y
A
G
A
I
------
93
PsiBlast_CBE
87.65
55%
-64
- C1 -
-
3QN3
3
ENO_CAMJE
C:
[4-406]
--
M
L
V
I
E
D
-
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
V
G
A
A
I
V
P
S
G
A
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
-
A
D
E
I
L
--
G
L
-
D
--
A
--
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
G
A
N
--
A
--
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
-
N
S
-
G
H
--
S
-
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
--
D
-------
G
K
Y
---
H
-----
M
E
-----
G
----------
K
A
F
S
S
E
------
A
L
I
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
-
E
--------------------------
92
PsiBlast_CBE
87.63
55%
-64
- C1 -
-
3QN3
2
ENO_CAMJE
D:
[4-406]
--
M
L
V
I
E
D
-
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
V
G
A
A
I
V
P
S
G
A
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
-
A
D
E
I
L
--
G
L
-
D
--
A
--
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
G
A
N
--
A
--
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
-
N
S
-
G
H
--
S
-
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
--
D
-------
G
K
Y
---
H
-----
M
E
-----
G
----------
K
A
F
S
S
E
------
A
L
I
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
-
E
--------------------------
94
PsiBlast_CBE
87.01
55%
-64
- C1 -
-
3QN3
2
ENO_CAMJE
B:
[4-406]
--
M
L
V
I
E
D
-
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
V
G
A
A
I
V
P
S
G
A
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
-
A
D
E
I
L
--
G
L
-
D
--
A
--
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
G
A
N
--
A
--
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
-
N
S
-
G
H
--
S
-
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
--
D
-------
G
K
Y
---
H
-----
M
E
-----
G
----------
K
A
F
S
S
E
------
A
L
I
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
-
E
--------------------------
173
HHSearch
86.72
62%
-44
- C1 -
-
5J04
1
ENO_SYNP6
A:
[3-419]
---
T
Q
I
A
E
-
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
-
E
D
A
L
I
--
G
L
-
S
--
A
--
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
L
G
G
P
L
A
-------
N
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
-
D
K
-
G
L
--
A
-
T
G
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
-------
G
L
Y
---
T
-----
C
D
--------------
G
-
V
S
H
E
P
A
------
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
--
G
S
T
V
Q
L
V
G
D
D
L
F
-
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
-
E
A
A
--
L
--
G
-
E
N
A
L
--
Y
A
G
A
I
------
95
PsiBlast_CBE
86.68
55%
-64
- C1 -
-
3QN3
2
ENO_CAMJE
A:
[4-406]
--
M
L
V
I
E
D
-
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
V
G
A
A
I
V
P
S
G
A
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
-
A
D
E
I
L
--
G
L
-
D
--
A
--
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
G
A
N
--
A
--
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
-
N
S
-
G
H
--
S
-
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
--
D
-------
G
K
Y
---
H
-----
M
E
-----
G
----------
K
A
F
S
S
E
------
A
L
I
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
-
E
--------------------------
4
PsiBlast_PDB
86.09
64%
-11
- C1 -
-
4A3R
-
ENO_BACSU
A:
[1-428]
--
M
P
Y
I
V
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
-
A
P
E
L
L
--
G
F
-
D
--
V
--
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
--
S
--
K
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
-
A
K
-
G
L
--
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
-------
G
K
Y
---
H
-----
L
S
-----
G
E
-------
G
V
V
K
-
T
S
A
------
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
-
E
-
D
Q
L
A
--
E
-
T
A
-
Q
--
Y
H
G
I
N
S
F
Y
N
L
-
3
PsiBlast_PDB
85.25
67%
3
- C1 -
-
2FYM
-
ENO_ECOLI
A:
[1-429]
---
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
-
A
Q
A
L
I
--
G
K
-
D
--
A
--
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
P
G-
K
--
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
L
A
K
V
L
K
-
A
K
-
G
M
--
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
-------
G
K
Y
---
V
-----
L
A
-----
G
E
-------
G
N
K
A
F
T
S
E
------
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
-
E
-
E
--
A
L
G
E
-
K
A
-
P
--
Y
N
G
R
K
E
I
K
G
--
28
PsiBlast_CBE
85.11
64%
-8
- C1 -
-
4A3R
1
ENO_BACSU
D:
[1-428]
--
M
P
Y
I
V
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
-
A
P
E
L
L
--
G
F
-
D
--
V
--
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
G
F
N
--
S
--
K
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
-
A
K
-
G
L
--
N
-
T
A
--
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
-------
G
K
Y
---
H
-----
L
S
-----
G
E
-------
G
V
V
K
-
T
S
A
------
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
-
E
-
D
QL
A
--
E
-
T
A
-
Q
--
Y
H
G
I
N
S
F
Y
N
L
-
155
HHSearch
85.05
59%
-61
- C1 -
-
4MKS
-
ENO2_LACGA
A:
[3-428]
----
V
I
T
D
-
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
F
G
R
A
I
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
-
A
K
A
V
I
--
G
L
-
D
--
V
--
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
L
G
G
P
N
A
-------
H
V
L
P
T
P
M
M
N
V
I
N
G
G
---
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
L
K
G
L
L
Q
-
E
R
-
G
E
--
S
-
T
A
--
V
G
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
I
A
I
A
F
D
C
A
A
S
E
F
Y
--------------------------------------------------------
W
T
S
L
I
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
---
D
D
L
F
V
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
-
E
E
A
--
L
--
G
-
S
T
A
Q
--
Y
K
G
I
H
S
F
Y
N
L
-
2
PsiBlast_PDB
85.04
67%
4
- C1 -
-
1E9I
-
ENO_ECOLI
A:
[1-429]
---
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
-
A
Q
A
L
I
--
G
K
-
D
--
A
--
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
P
G-
K
--
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
L
A
K
V
L
K
-
A
K
-
G
M
--
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
-------
G
K
Y
---
V
-----
L
A
-----
G
E
-------
G
N
K
A
F
T
S
E
------
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
-
E
-
E
--
A
L
G
E
-
K
A
-
P
--
Y
N
G
R
K
E
I
K
G
--
1
PsiBlast_PDB
84.99
67%
0
- C1 -
-
3H8A
-
ENO_ECOLI
A:
[2-430]
---
S
K
I
V
K
-
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
-
A
Q
A
L
I
--
G
K
-
D
--
A
--
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
I
A
E
L
N
G
T
P
G-
K
--
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
L
A
K
V
L
K
-
A
K
-
G
M
--
N
-
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
-------
G
K
Y
---
V
-----
L
A
-----
G
E
-------
G
N
K
A
F
T
S
E
------
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
---
D
D
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
-
E
-
E
--
A
L
G
E
-
K
A
-
P
--
Y
N
G
R
K
E
I
K
G
--
35
PsiBlast_CBE
84.62
59%
-20
- C1 -
-
1W6T
1
ENO_STRPN
B:
[11-442]
--
M
S
I
I
T
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
-
A
E
A
I
I
--
G
Y
-
D
--
V
--
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
G
F
N
--
T
--
K
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
-
S
R
-
G
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
D
--
K
-------
E
R
K
---
V
YDYTK
F
E
-----
G
E
-------
G
A
A
V
R
T
S
A
------
E
Q
I
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
---
D
D
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
-
D
--
Q
--
L
-
G
E
-
V
AE
Y
R
G
L
K
S
F
Y
N
L
-
8
PsiBlast_PDB
84.52
58%
-60
- C1 -
-
4MKS
-
ENO2_LACGA
A:
[3-428]
----
V
I
T
D
-
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
F
G
R
A
I
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
-
A
K
A
V
I
--
G
L
-
D
--
V
--
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
G
P
N
--
A
--
H
V
L
P
T
P
M
M
N
V
I
N
G
G
---
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
L
K
G
L
L
Q
-
E
R
-
G
E
--
S
-
T
A
--
V
G
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
I
A
I
A
F
D
C
A
A
S
E
F
Y
--------------------------------------------------------
W
T
S
L
I
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
---
D
D
L
F
V
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
-
E
-
E
--
A
L
G
S
-
T
A
-
Q
--
Y
K
G
I
H
S
F
Y
N
L
-
15
PsiBlast_PDB
78.19
60%
-1
- C1 -
-
4Z17
1
ENO_CHLAA
A:
[1-425]
--
M
S
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
-
A
E
A
L
I
--
G
F
-
D
--
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
L
G
G
V
Y
A
H
V
-------
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
-
D
R
-
G
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
-------
G
K
Y
---
H
-----
L
K
-----
R
E
-------
G
-
R
S
L
S
S
A
------
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
-
E
--
E
L
G
S
-
A
A
-
R
--
Y
A
G
R
S
A
F
K
---
43
PsiBlast_CBE
76.51
60%
-5
- C1 -
-
4Z17
1
ENO_CHLAA
B:
[2-425]
---
S
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
-
A
E
A
L
I
--
G
F
-
D
--
A
--
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
L
G
G
V
Y
A
H
V
-------
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
-
D
R
-
G
F
--
S
-
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
-------
G
K
Y
---
H
-----
L
K
-----
R
E
-------
G
-
R
S
L
S
S
A
------
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
---
D
D
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
-
E
--
E
L
G
S
-
A
A
-
R
--
Y
A
G
R
S
A
F
K
---
166
HHSearch
76.11
52%
-5
- C1 -
-
3QTP
1
ENO1_ENTHI
A:
[4-439]
-
G
S
M
S
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
-
G
P
A
L
L
--
G
K
-
N
--
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
K
--
E
--
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
-
A
K
Y
G
Q
D-
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
EE
T
-------
K
K
Y
---
D
-----
L
G
-----
K
K
IPADKKD
P
S
L
V
K
D
V
D
------
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
-
E
E
E
--
L
--
G
-
N
I
-
P
--
Y
A
G
K
-
N
W
R
N
S
-
167
HHSearch
76.08
52%
-5
- C1 -
-
3QTP
1
ENO1_ENTHI
B:
[4-439]
-
G
S
M
S
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
-
G
P
A
L
L
--
G
K
-
N
--
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
K
--
E
--
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
-
A
K
Y
G
Q
D-
A
-
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
EE
T
-------
K
K
Y
---
D
-----
L
G
-----
K
K
IPADKKD
P
S
L
V
K
D
V
D
------
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
-
E
E
E
--
L
--
G
-
N
I
-
P
--
Y
A
G
K
-
N
W
R
N
S
-
98
PsiBlast_CBE
75.72
51%
-17
- C1 -
-
3QTP
1
ENO1_ENTHI
B:
[8-434]
-----
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
-
G
P
A
L
L
--
G
K
-
N
--
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
K
--
E
--
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y
-
G
Q
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
G
--
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
ETKKYDL
G
K
K
---
I
-----
P
A
-----
D
K
-------
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
D
Y
----
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
-
E
--
L
--
G
-
N
I
-
P
--
Y
A
G
K
-------
31
PsiBlast_CBE
75.38
60%
24
- C1 -
-
5BOE
4
ENO_STAAU
B:
[1-432]
--
M
P
I
I
T
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
E
--
G
E
F
S
--
V
--
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
L
G
G
F
N
G
K
Q
-------
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
-
K
R
-
G
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
--
N
-------
G
V
Y
DYS
K
-----
F
E
-----
G
E
-------
H
G
A
K
R
T
A
A
------
E
Q
V
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
-
D
EL
F
--
E
-
T
A
-
K
--
Y
D
G
I
K
S
F
Y
N
L
-
99
PsiBlast_CBE
75.18
51%
-16
- C1 -
-
3QTP
1
ENO1_ENTHI
A:
[8-434]
-----
I
Q
K
-
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
-
G
P
A
L
L
--
G
K
-
N
--
V
--
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
L
A
E
L
T
G
H
K
--
E
--
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y
-
G
Q
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
G
--
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
ETKKYDL
G
K
K
---
I
-----
P
A
-----
D
K
-------
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
D
Y
----
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
---
D
D
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
-
E
--
L
--
G
-
N
I
-
P
--
Y
A
G
K
-------
6
PsiBlast_PDB
74.71
60%
23
- C1 -
-
5BOE
3
ENO_STAAU
A:
[1-432]
--
M
P
I
I
T
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
E
--
G
E
F
S
--
V
--
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
L
G
G
F
N
G
K
Q
-------
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
-
K
R
-
G
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
--
N
-------
G
V
Y
DYS
K
-----
F
E
-----
G
E
-------
H
G
A
K
R
T
A
A
------
E
Q
V
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
---
D
D
L
F
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
-
D
E
L
F
--
E
-
T
A
-
K
--
Y
D
G
I
K
S
F
Y
N
L
-
158
HHSearch
73.74
60%
28
- C1 -
-
5BOE
4
ENO_STAAU
B:
[1-432]
--
M
P
I
I
T
D
-
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
F
G
R
A
L
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
-
A
P
E
I
I
--
E
G
-
E
--
F
SV
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
L
G
G
F
N
G
-------
K
Q
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
-
K
R
-
G
L
--
E
-
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
--
N
-------
G
V
Y
---
D
-----
Y
S
-----
K
F
EGE----
H
G
A
K
R
T
A
A
------
E
Q
V
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
D--
D
L
F
-
V
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
-
E
D
E
--
L
--
F
-
E
T
A
K
--
Y
D
G
I
K
S
F
Y
N
L
-
68
PsiBlast_CBE
72.48
54%
17
- C1 -
-
3UJR
1
ENOG_HUMAN
B:
[2-414]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
SS
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
96
PsiBlast_CBE
72.45
52%
18
- C1 -
-
1PDZ
1
ENO_HOMGA
A:
[3-417]
-----
I
T
K
-
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
-
V
P
E
I
I
K
S
G
L
-
K
--
V
--
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
N
Y
D
--
E
--
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
L
K
A
V
I
K
-
A
R
F
G
L
--
D
A
T
A
--
V
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
G
--
K
I
E
I
G
M
D
V
A
A
S
E
F
Y
--
K
Q-
N
-------
N
I
Y
---
D
-----
L
D
FKTAN
N
D
-------
G
S
Q
K
I
S
G
D
------
Q
L
R
D
M
Y
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
-
E
-
E
------------------------
63
PsiBlast_CBE
72.41
54%
17
- C1 -
-
4ZCW
1
ENOG_HUMAN
A:
[3-415]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
S
S
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
73
PsiBlast_CBE
71.90
54%
18
- C1 -
-
3UJE
2
ENOG_HUMAN
A:
[2-414]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
S
S
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
64
PsiBlast_CBE
71.84
54%
17
- C1 -
-
4ZA0
1
ENOG_HUMAN
B:
[3-415]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
SS
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
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I
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R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
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M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
79
PsiBlast_CBE
71.79
54%
18
- C1 -
-
3UCD
1
ENOG_HUMAN
A:
[2-414]
-----
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
S
S
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
81
PsiBlast_CBE
71.76
54%
20
- C1 -
-
3UCC
2
ENOG_HUMAN
A:
[2-414]
-----
I
Q
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
S
S
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
70
PsiBlast_CBE
71.71
54%
16
- C1 -
-
3UJF
1
ENOG_HUMAN
B:
[2-414]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
SS
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
62
PsiBlast_CBE
71.66
54%
21
- C1 -
-
4ZCW
1
ENOG_HUMAN
B:
[3-415]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
SS
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
---
D
D
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
-
E
-
E
------------------------
72
PsiBlast_CBE
71.57
54%
19
- C1 -
-
3UJE
1
ENOG_HUMAN
B:
[2-414]
-----
I
E
K
-
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
-
A
P
A
L
I
SS
G
L
-
S
--
V
--
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
G
N
S
--
D
--
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y
-
G
K
--
D
A
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
-------
G
K
Y
---
D
-----
L
D
FKSP-
T
D
-------
P
S
R
Y
I
T
G
D
------
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V