@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQZ7: (2017-11-30 )
MTDITLAPVQPDQPTHLMATYGRQAISFVRGRGAYLYTQDGTEYLDALTGIAVCGLGHTHPTIAEAIAEQAATLVHTSNLFEIPWQTAAAQKLAEVSGMEEIFFSNSGAESNEGAIKIARKFGTQQGISLPKIIVAEQSFHGRTLATLSATGNKKVQDGFAPLVEGFIRVPFGDIEAIQEAALQHPDIVAILIEPIQGEGGINTAPQGFSYLEEVRQICNQHNWLMMLDEIQTGNGRTGKYFAYQHTNIIPDVLTTAKGLGNGFPVGAVMTQGKAVGLLGPGSHGSTYGGTVLGSRVVYTVIDTIQKENAVENAAVVGNYIVDQLRAQLSDKNVQVRGFGMMIGIQLPKDCAELVAIARDEYKLIINVTAGSVVRLLPPINMTQAQADILLECLVALITNYL
Atome Classification :
(49 SA)
.........10........20........30........40........50.......-.60........----70.......--.--80........90.....------..---.100........110.......120.-..-.-...--130.---........140.......150.......160........170..---------------------.....180-......-...190........200.......210.......220.......230.......240.......250.......260.-.-....-.270.----......280----.-.......290.......300.......310.......320--......--..330--..---.--.....340--....----.----.---.350-----------------------------.---------------------------------.-..--.....360.--......370.-.--.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTD
I
T
LAPVQPDQP
T
H
L
M
A
T
Y
G
R
Q
A
I
S
F
VRGR
G
A
Y
L
Y
TQD
G
T
E
Y
L
D
A
L
T
G
I
A
V
CGLGH-TH
P
T
I
A
E
A
I
A
E
----
Q
A
A
T
L
VHTS--N--LFEIPW
Q
T
A
A
A
Q
K
L
A
E
V------SG---
M
E
-
E
I
FFSNSGAESNEG
A
I
K
I
A
R
K
FG-TQ-Q-GIS--L--
P
---
K
I
I
V
AEQSFHG
R
T
L
A
T
L
SATGNKKVQDG
F
-
A
P
L
V
E
G
F
I
RVPFG
D
---------------------
I
E
A
I
Q
E
---
A
ALQHP-
D
I
V
A
-
I
L
I
EPIQGEGGINTAP
Q
G
F
S
Y
L
E
E
V
R
Q
I
C
N
QH
N
W
L
M
M
L
D
E
IQTGNGRTG
K
Y
F
A
Y
QHTNI
I
P
D
V
L
T
T
A
K
GLGNG-F-PV
G
A
-
V
M
TQG----
K
A
V
G
L
LGP-----G-SHGSTYGG
T
V
LG
S
R
V
V
Y
T
V
I
D
T
I
Q
K
ENAVE
N
A
A
V
V
G
N
Y
I
---
V
D
Q
L
R
A
--
Q
LSD---K
N
---
V
--
Q
V
R
G
F
G
M
M
--
I
G
I
Q----L----
P
---
K
D
-------------------------------
C
---------------------------------
A
-
E
L
--
V
A
IARD
E
Y
K
--
L
I
I
N
VTA--G-
S
--
V
V
R
LLPPIN
M
T
Q
A
Q
A
D
I
L
L
E
C
L
V
A
L
I
TNYL
2
PsiBlast_PDB
88.53
42%
-75
- C1 -
-
2E54
3
ARGD_THEMA
A:
[2-382]
---------------
Y
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
----
Q
A
E
K
L
I
H
C
S
--
N
--
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
------
T
F
---
G
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
-
K
K
-
K
-
S
E
K
--
K
--
Y
---
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
---------------------
V
E
D
L
R
R
---
K
M
S
E
---
D
V
C
A
-
V
F
L
E
P
I
Q
G
E
S
G
I
--
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
V
I
V
N
E
----
R
A
-
N
V
L
E
P
-----
G
-
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
---
M
K
K
L
Q
E
--
M
K
E
E
---
Y
D
---
V
VA
D
V
R
G
M
G
L
M
--
I
G
I
Q
----
F
----
R
---
E
E
-------------------------------
V
---------------------------------
S
-
N
R
E
-
V
A
T
K
C
F
E
N
K
--
L
L
V
V
P
A
G
--
N
-
N
--
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
----
3
PsiBlast_PDB
87.12
41%
-75
- C1 -
-
2ORD
15
ARGD_THEMA
A:
[14-394]
---------------
Y
L
M
N
T
Y
S
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
----
Q
A
E
K
L
I
H
C
S
--
N
--
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
------
T
F
---
G
G
-
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
-
K
K
-
K
-
S
E
K
--
K
--
Y
---
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
Y
Q
K
P
F
-
E
P
L
V
P
G
F
E
Y
F
E
F
N
N
---------------------
V
E
D
L
R
R
---
K
M
S
E
---
D
V
C
A
-
V
F
L
E
P
I
Q
G
E
S
G
I
--
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
V
I
V
N
E
----
R
A
-
N
V
L
E
P
-----
G
-
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
---
M
K
K
L
Q
E
--
M
K
E
E
---
Y
D
---
V
VA
D
V
R
G
M
G
L
M
--
I
G
I
Q
----
F
----
R
---
E
E
-------------------------------
V
---------------------------------
S
-
N
R
E
-
V
A
T
K
C
F
E
N
K
--
L
L
V
V
P
A
G
--
N
-
N
--
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
----
21
PsiBlast_CBE
83.32
43%
-25
- C1 -
-
2EH6
2
ARGD_AQUAE
B:
[1-375]
--------------
T
Y
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
----
Q
V
E
K
L
L
H
V
S
--
N
--
L
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
K
H
------
F
W
---
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
-
R
D
-
K
-
G
K
N
--
K
--
W
---
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
N
D
---------------------
I
D
S
V
Y
K
-----
L
L
D
E
-
E
T
A
G
-
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
--
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
I
L
A
R
E
----
E
V
A
Q
S
F
T
P
-----
G
-
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
---
K
E
K
L
K
E
--
L
G
K
G
---
K
--------
V
K
G
R
G
L
M
--
L
G
L
E
----
L
----
E
---
R
E
-------------------------------
C
---------------------------------
K
-
D
Y
--
V
L
K
A
L
-
E
K
G
--
L
L
I
N
C
T
A
--
G
-
K
--
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
----
8
PsiBlast_PDB
82.20
37%
-66
- C1 -
-
3NX3
-
ARGD_CAMJE
A:
[8-395]
-------------
Q
S
H
I
I
P
T
Y
K
R
F
D
I
V
L
E
K
G
Q
G
V
Y
L
F
D
D
K
A
K
K
Y
L
D
F
S
S
G
I
G
V
C
A
L
G
Y
-
N
H
A
K
F
N
A
K
I
K
A
----
Q
V
D
K
L
L
H
T
S
--
N
--
L
Y
Y
N
E
N
I
A
A
A
A
K
N
L
A
K
A
------
S
A
---
L
E
-
R
V
F
F
T
N
S
G
T
E
S
I
E
G
A
M
K
T
A
R
K
Y
A
-
F
N
-
K
-
G
V
K
--
G
--
G
---
Q
F
I
A
F
K
H
S
F
H
G
R
T
L
G
A
L
S
L
T
A
N
E
K
Y
Q
K
P
F
-
K
P
L
I
S
G
V
K
F
A
K
Y
N
D
---------------------
I
S
S
V
E
K
-----
L
V
N
E
-
K
T
C
A
-
I
I
L
E
S
V
Q
G
E
G
G
I
N
P
A
N
K
D
F
--
Y
K
A
L
R
K
L
C
D
E
K
D
I
L
L
I
A
D
E
I
Q
C
G
M
G
R
S
G
K
F
F
A
Y
E
H
A
Q
I
L
P
D
I
M
T
S
A
K
A
L
G
C
G
-
L
-
S
V
G
A
F
V
I
N
Q
K
----
V
A
S
N
S
L
E
A
-----
G
-
D
H
G
S
T
Y
G
G
N
P
L
V
C
A
G
V
N
A
V
F
E
I
F
K
E
E
K
I
L
E
N
V
N
K
L
T
P
Y
L
E
Q
S
L
D
E
L
I
N
--
E
F
-
D
---
F
C
---
K
--
K
R
K
G
L
G
F
M
--
Q
G
L
S
----
L
----
D
---
K
S
-------------------------------
V
---------------------------------
K
-
V
A
--
K
V
I
Q
K
C
Q
E
N
--
A
L
L
L
I
S
C
--
G
E
N
--
D
L
R
F
L
P
P
L
I
L
Q
K
E
H
I
D
E
M
S
E
K
L
R
K
A
L
K
S
F
-
1
PsiBlast_PDB
81.35
43%
-23
- C1 -
-
2EH6
2
ARGD_AQUAE
A:
[1-375]
--------------
T
Y
L
M
N
N
Y
A
R
L
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
----
Q
V
E
K
L
L
H
V
S
--
N
--
L
Y
E
N
P
W
Q
E
E
L
A
H
K
L
V
K
H
------
F
W
---
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
-
R
D
-
K
-
G
K
N
--
K
--
W
---
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
G
F
-
E
P
L
V
P
G
F
S
Y
A
K
L
N
D
---------------------
I
D
S
V
Y
K
-----
L
L
D
E
-
E
T
A
G
-
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
--
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
-
P
I
G
A
-
I
L
A
R
E
----
E
V
A
Q
S
F
T
P
-----
G
-
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
---
K
E
K
L
K
E
--
L
G
K
G
---
K
--------
V
K
G
R
G
L
M
--
L
G
L
E
----
L
----
E
---
R
E
-------------------------------
C
---------------------------------
K
-
D
Y
--
V
L
K
A
L
-
E
K
G
--
L
L
I
N
C
T
A
--
G
-
K
--
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
----
23
PsiBlast_CBE
78.60
37%
-34
- C1 -
-
4ADD
4
ASTC_ECOLI
C:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
5
PsiBlast_PDB
78.41
37%
-33
- C1 -
-
4ADC
2
ASTC_ECOLI
A:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
6
PsiBlast_PDB
78.38
37%
-34
- C1 -
-
4ADD
4
ASTC_ECOLI
A:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
25
PsiBlast_CBE
77.35
37%
-35
- C1 -
-
4ADC
2
ASTC_ECOLI
D:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
26
PsiBlast_CBE
77.17
37%
-35
- C1 -
-
4ADC
2
ASTC_ECOLI
C:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
28
PsiBlast_CBE
77.08
37%
-37
- C1 -
-
4ADB
2
ASTC_ECOLI
D:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
24
PsiBlast_CBE
76.90
37%
-33
- C1 -
-
4ADD
4
ASTC_ECOLI
B:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
4
PsiBlast_PDB
76.89
37%
-34
- C1 -
-
4ADB
2
ASTC_ECOLI
A:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
29
PsiBlast_CBE
76.62
37%
-33
- C1 -
-
4ADB
2
ASTC_ECOLI
C:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
22
PsiBlast_CBE
76.16
37%
-33
- C1 -
-
4ADD
4
ASTC_ECOLI
D:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
102
HHSearch
76.08
34%
-30
- C1 -
-
4JEV
2
ARGD_SALTY
B:
[23-418]
-------
I
T
R
A
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
H
S
P
F
--
K
--
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
--
D
-
H
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
--
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
---
I
D
E
QFD
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
---
P
K
YKG----------------------------
R
A
--------------------------------
R
-
D
F
--
L
Y
A
G
A
E
-
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
-
27
PsiBlast_CBE
75.97
37%
-35
- C1 -
-
4ADC
2
ASTC_ECOLI
B:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
30
PsiBlast_CBE
74.98
37%
-35
- C1 -
-
4ADB
2
ASTC_ECOLI
B:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
AG
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
7
PsiBlast_PDB
73.13
37%
-31
- C1 -
-
4ADE
-
ASTC_ECOLI
A:
[26-401]
----------------------------
V
R
G
E
G
S
R
L
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
N
A
L
G
H
-
A
H
P
E
L
R
E
A
L
N
E
----
Q
A
S
K
F
W
H
T
G
--
N
--
G
Y
T
N
E
P
V
L
R
L
A
K
K
L
I
D
A
------
T
F
---
A
D
-
R
V
F
F
C
N
S
G
A
E
A
N
E
A
A
L
K
L
A
R
K
F
A
-
H
D
-
R
Y
G
S
H
--
K
--
S
---
G
I
V
A
F
K
N
A
F
H
G
R
T
L
F
T
V
S
A
G
G
Q
P
A
Y
S
Q
D
F
-
A
P
L
P
A
D
I
R
H
A
A
Y
N
D
---------------------
I
N
S
A
-----
S
A
L
I
D
D
-
S
T
C
A
-
V
I
V
E
P
I
Q
G
E
G
G
V
--
V
P
A
S
N
A
F
L
Q
G
L
R
E
L
C
N
R
H
N
A
L
L
I
F
D
E
V
Q
T
G
V
G
R
T
G
E
L
Y
A
Y
M
H
Y
G
V
T
P
D
L
L
T
T
A
K
A
L
G
G
G
-
F
-
P
V
G
A
-
L
L
A
T
E
----
E
C
A
R
V
M
T
V
-----
G
-
T
H
G
T
T
Y
G
G
N
P
L
A
S
A
V
A
G
K
V
L
E
L
I
N
T
P
E
M
L
N
G
V
K
Q
R
H
D
W
F
---
V
E
R
L
N
T
--
I
N
H
R
---
Y
G
---
L
FS
E
V
R
G
L
G
L
L
--
I
G
C
V
----
L
----
N
---
A
D
-------------------------------
Y
---------------------------------
A
G
Q
A
--
K
Q
I
S
Q
E
A
A
K
A
G
V
M
V
L
I
A
G
--
G
-
N
--
V
V
R
F
A
P
A
L
N
V
S
E
E
E
V
T
T
G
L
D
R
F
A
A
A
C
E
H
F
V
47
PsiBlast_CBE
72.88
34%
-21
- C1 -
-
2BYJ
2
OAT_HUMAN
B:
[54-439]
-------------------
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
----
Q
V
D
K
L
T
L
T
S
--
R
--
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
------
F
N
---
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
I
Q
--
K
YK
A
---
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
-
E
---
R
A
L
Q
D
P
-
N
V
A
A
-
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
--
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
----
D
I
M
L
T
I
K
P
-----
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
--
L
P
S
D
---
V
V
---
T
--
A
V
R
G
K
G
L
L
NA
I
V
I
K
----
E
----
T
---
K
D
-------------------------------
W
D--------------------------------
A
-
W
K
--
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
--
G
-
D
--
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
-
48
PsiBlast_CBE
71.88
34%
-20
- C1 -
-
2BYJ
2
OAT_HUMAN
A:
[54-439]
-------------------
N
Y
H
P
L
P
V
A
L
E
R
G
K
G
I
Y
L
W
D
V
E
G
R
K
Y
F
D
F
L
S
S
I
S
A
V
N
Q
G
H
-
C
H
P
K
I
V
N
A
L
K
S
----
Q
V
D
K
L
T
L
T
S
--
R
--
A
F
Y
N
N
V
L
G
E
Y
E
E
Y
I
T
K
L
------
F
N
---
Y
H
-
K
V
L
P
M
N
T
G
V
E
A
G
E
T
A
C
K
L
A
R
K
W
G
Y
T
V
-
K
-
G
I
Q
--
K
YK
A
---
K
I
V
F
A
A
G
N
F
W
G
R
T
L
S
A
I
S
S
S
T
D
P
T
S
Y
D
G
F
-
G
P
F
M
P
G
F
D
I
I
P
Y
N
D
---------------------
L
P
A
L
-
E
---
R
A
L
Q
D
P
-
N
V
A
A
-
F
M
V
E
P
I
Q
G
E
A
G
V
V
V
P
D
P
G
--
Y
L
M
G
V
R
E
L
C
T
R
H
Q
V
L
F
I
A
D
E
I
Q
T
G
L
A
R
T
G
R
W
L
A
V
D
Y
E
N
V
R
P
D
I
V
L
L
G
K
A
L
S
G
G
L
Y
-
P
V
S
A
-
V
L
C
D
D
----
D
I
M
L
T
I
K
P
-----
G
-
E
H
G
S
T
Y
G
G
N
P
L
G
C
R
V
A
I
A
A
L
E
V
L
E
E
E
N
L
A
E
N
A
D
K
L
G
I
I
L
---
R
N
E
L
M
K
--
L
P
S
D
---
V
V
---
T
--
A
V
R
G
K
G
L
L
N
A
I
V
I
K
----
E
----
T
---
K
D
-------------------------------
W
D--------------------------------
A
-
W
K
--
V
C
L
R
L
R
D
N
G
--
L
L
A
K
P
T
H
--
G
-
D
--
I
I
R
F
A
P
P
L
V
I
K
E
D
E
L
R
E
S
I
E
I
I
N
K
T
I
L
S
F
-
98
HHSearch
70.32
33%
-30
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[27-418]
-----------
T
F
D
E
V
I
L
P
V
Y
A
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
H
S
P
F
--
K
--
T
---
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
--
D
-
H
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
--
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
---
I
D
E
Q
FD
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
---
P
K
YKG----------------------------
R
A
--------------------------------
R
-
D
F
--
L
Y
A
G
A
E
-
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
-
20
PsiBlast_PDB
69.88
34%
-10
- C1 -
-
5VIU
9
?
A:
[22-409]
------------
E
E
K
H
G
A
H
N
Y
H
P
L
P
V
V
L
D
R
G
E
G
V
F
V
W
D
V
E
G
K
K
Y
Y
D
F
L
S
A
Y
S
A
V
N
Q
G
H
-
S
H
P
K
I
V
E
A
L
V
E
----
Q
A
S
K
L
A
L
T
S
--
R
--
A
F
Y
N
S
K
L
G
E
Y
E
Q
K
I
T
S
L
------
L
G
---
F
D
-
K
V
L
P
M
N
S
G
A
E
A
V
E
T
A
V
K
L
A
R
K
W
S
-
Y
E
V
K
-
G
I
A
EN
A
--
A
---
K
I
I
V
C
E
N
N
F
H
G
R
T
T
T
I
--
F
S
N
D
P
D
------
G
P
F
T
P
G
F
I
R
I
P
Y
N
D
---------------------
I
A
A
L
E
E
---
V
L
S
K
E
A
G
N
I
A
A
-
F
L
V
E
P
I
Q
G
E
A
G
V
Y
V
P
N
E
G
F
--
L
K
Q
S
S
E
L
C
K
K
H
N
V
L
F
I
A
D
E
V
Q
T
G
I
A
R
T
G
K
L
I
A
C
H
H
E
D
V
Q
P
D
I
L
I
L
G
K
A
L
S
G
G
M
Y
-
P
V
S
A
-
V
L
A
N
N
----
N
I
M
D
V
I
K
P
-----
G
-
Q
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
M
A
A
L
D
V
V
Q
D
E
K
L
S
E
R
A
E
K
L
G
N
L
F
---
R
S
E
I
E
K
L
I
E
K
T
D
---
L
I
---
T
--
K
V
R
G
K
G
L
L
--
N
A
I
L
----
I
NDTP
D
---
S
S
-------------------------------
T
---------------------------------
A
-
W
N
--
L
C
L
A
L
K
E
N
G
--
L
L
A
K
P
T
H
--
G
-
N
--
I
I
R
L
A
P
P
L
V
I
T
E
E
Q
---
L
L
D
C
V
--------
13
PsiBlast_PDB
69.04
37%
-32
- C1 -
-
4JEV
2
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
37
PsiBlast_CBE
66.93
37%
-29
- C1 -
-
2PB0
5
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
16
PsiBlast_PDB
66.89
37%
-36
- C1 -
-
2PB2
6
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
34
PsiBlast_CBE
66.69
37%
-29
- C1 -
-
4JEW
9
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
12
PsiBlast_PDB
66.56
37%
-33
- C1 -
-
4JEW
8
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
38
PsiBlast_CBE
66.51
37%
-29
- C1 -
-
4JF1
6
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
19
PsiBlast_PDB
66.34
37%
-33
- C1 -
-
4JEY
8
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
----------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
18
PsiBlast_PDB
66.32
37%
-32
- C1 -
-
4JEZ
6
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
R
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
75
PsiBlast_CBE
66.27
31%
-21
- C1 -
-
4ZWM
2
?
A:
[44-420]
---------------
Y
V
C
Q
N
Y
A
-
V
P
V
V
I
S
K
G
K
G
A
R
V
W
D
I
N
G
N
E
Y
Y
D
F
L
A
G
V
S
S
L
S
Q
G
H
-
C
H
P
R
V
I
A
A
L
C
R
----
Q
A
E
R
L
T
L
T
L
--
R
--
A
F
G
N
D
V
T
G
P
A
C
R
F
M
A
E
M
------
F
G
---
Y
D
-
R
V
L
L
M
N
T
G
A
E
A
G
E
S
A
L
K
I
A
R
K
W
A
-
Y
E
-
V
-
K
E
I
--
P
--
P
DS
A
K
V
I
L
C
N
N
N
Y
W
G
R
T
I
T
A
C
S
S
S
T
T
F
D
C
Y
N
N
F
-
G
P
F
T
P
G
F
E
L
I
D
Y
D
D
---------------------
V
G
A
L
E
E
----
A
L
K
D
P
-
N
V
A
A
-
F
F
V
E
P
I
Q
G
E
G
G
V
N
V
P
K
P
G
--
Y
L
K
R
A
H
E
L
C
R
S
K
N
V
L
L
I
V
D
E
I
Q
T
G
L
C
R
T
G
R
L
L
A
A
D
H
D
E
V
H
P
D
I
L
L
L
G
K
S
L
S
A
G
V
V
-
P
I
S
A
-
V
M
G
R
A
----
D
V
M
D
V
L
K
P
-----
G
-
T
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
V
E
A
L
T
V
L
K
D
E
K
L
A
D
R
A
E
R
L
G
A
Q
F
---
R
D
C
L
R
R
--
E
L
Y
G
---
K
V
PWI
K
--
E
I
R
G
R
G
L
L
--
N
A
V
E
----
V
----
D
---
S
D
-------------------------------
A
---------------------------------
I
-
D
P
N
D
V
V
M
K
L
K
E
N
G
--
I
L
S
K
P
T
R
--
G
-
R
--
V
M
R
F
I
P
P
L
V
I
T
D
E
E
----------------
40
PsiBlast_CBE
66.13
37%
-29
- C1 -
-
4JEY
9
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
H
V
-----
G
-
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
15
PsiBlast_PDB
65.36
37%
-34
- C1 -
-
2PB0
5
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
39
PsiBlast_CBE
65.27
37%
-32
- C1 -
-
4JEZ
6
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
R
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
14
PsiBlast_PDB
64.43
37%
-32
- C1 -
-
4JEX
8
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
17
PsiBlast_PDB
64.30
37%
-31
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
35
PsiBlast_CBE
64.14
37%
-31
- C1 -
-
4JEX
8
ARGD_SALTY
B:
[44-402]
----------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
----
Q
G
E
T
L
W
H
T
S
--
N
--
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
------
T
F
---
A
E
-
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
-
C
V
-
R
-
H
S
P
--
F
--
K
T
--
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
G
F
-
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
---
V
M
D
D
H
---
T
C
A
-
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
--
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
-
M
L
T
T
Q
----
E
I
A
S
A
F
-----------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
---
V
Q
H
L
Q
A
I
D
E
Q
F
D
---
I
F
---
S
--
D
I
R
G
M
G
L
L
--
I
G
A
E
----
L
----
K
PKY
K
G
-------------------------------
R
---------------------------------
A
-
R
D
--
F
L
Y
A
G
A
E
A
G
--
V
M
V
L
N
A
G
--
A
-
D
--
V
M
R
F
A
P
S
L
V
V
E
E
A
-----------------
10
PsiBlast_PDB
61.61
33%
9
- C1 -
-
1WKG
2
LYSJ_THET8
A:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
33
PsiBlast_CBE
60.75
33%
11
- C1 -
-
1VEF
2
LYSJ_THET8
B:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
LP----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
9
PsiBlast_PDB
60.71
33%
11
- C1 -
-
1VEF
2
LYSJ_THET8
A:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
11
PsiBlast_PDB
60.47
33%
10
- C1 -
-
1WKH
2
LYSJ_THET8
A:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
32
PsiBlast_CBE
60.19
33%
9
- C1 -
-
1WKG
2
LYSJ_THET8
B:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
LP----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
108
HHSearch
59.17
34%
-4
- C1 -
-
4PPM
2
PIGE_SERSF
B:
[414-848]
----------------------
R
C
D
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
----
Y
L
D
A
Q
G
P
N
F
--
I
QY
I
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
R
L
------
A
P
GN-
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
--------
G
--
K
--
P
---
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
---
A
L
N
-
R
E
-
D
V
G
A
-
L
M
I
E
P
I
Q
G
E
G
G
V
H
--
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
-
P
I
G
A
-
T
L
C
R
A
----
D
L
W
Q
K
A
Y
G
TADRF
L
-
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
---
K
Q
A
L
S
E
---
I
A
A
RYP
F
V
---
S
--
E
V
R
G
R
G
L
M
--
L
G
I
Q
----
F
----
D
-------------------------------------WHTTWKFLPDPVQAHLRAAMDRMEQALGEMFCM
K
-
F
V
--
T
K
L
C
Q
D
-
H
K
--
I
L
T
F
I
T
A
NS
S
-
T
--
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
C
E
E
L
-
31
PsiBlast_CBE
59.15
33%
10
- C1 -
-
1WKH
2
LYSJ_THET8
B:
[24-394]
--------------------
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
----
Q
A
E
T
L
M
A
M
P
--
Q
--
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
LP----
P
E
---
L
N
-
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
-
G
R
-
K
-------------
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
F
-
L
P
L
V
E
P
V
E
F
I
P
Y
N
D
---------------------
V
E
A
L
K
R
---
A
V
D
E
---
E
T
A
A
-
V
I
L
E
P
V
Q
G
E
G
G
V
R
--
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
-
P
L
G
V
-
A
V
M
R
E
----
E
V
A
R
S
M
P
K
-----
G
-
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
---
M
E
K
L
R
A
--
I
P
S
P
---
K
I
---
R
--
E
V
R
G
M
G
L
M
--
V
G
L
E
----
L
----
K
---
E
K
-------------------------------
A
---------------------------------
A
-
P
Y
--
I
A
R
L
E
K
E
H
R
--
V
L
A
L
Q
A
G
--
P
-
T
--
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
----
109
HHSearch
58.98
34%
-2
- C1 -
-
4PPM
2
PIGE_SERSF
A:
[414-848]
----------------------
R
C
D
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
----
Y
L
D
A
Q
G
P
N
F
--
I
QY
I
S
I
P
E
Q
T
A
K
L
A
E
V
L
C
R
L
------
A
P
GN-
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
--------
G
--
K
--
P
---
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
---
A
L
N
-
R
E
-
D
V
G
A
-
L
M
I
E
P
I
Q
G
E
G
G
V
H
--
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
L
I
-
P
I
G
A
-
T
L
C
R
A
----
D
L
W
Q
K
A
Y
G
TADRF
L
-
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
---
K
Q
A
L
S
E
---
I
A
A
R
Y
P
F
V
---
S
--
E
V
R
G
R
G
L
M
--
L
G
I
Q
----
F
----
D
---
Q
A
--------------------------------H
T
T
W
K
F
LP
D
P
V
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
C
M
-
K
-
F
V
--
T
K
L
C
Q
D
-
H
K
--
I
L
T
F
I
T
A
NS
S
-
T
--
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
C
E
E
L
-
89
PsiBlast_CBE
48.85
33%
6
- C1 -
-
4PPM
2
PIGE_SERSF
A:
[419-835]
---------------------------
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
P
N
F
I
Q
-------
Y
I
S
I
P
E
Q
T
A
---
K
L
A
E
V
L
C
R
L
AP
G
N
---
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
-
G
K
-
P
-
G
I
A
--
Y
--
L
---
R
-----
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
---
A
-
L
N
R
E
-
D
V
G
A
-
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
--
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
-
T
L
C
R
A
D
L
W
Q
K
A
Y
G
T
A
D
R
-----
F
L
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
----
K
Q
A
L
S
--
E
I
A
A
---
R
Y
P
FV
S
--
E
V
R
G
R
G
L
M
--
L
G
I
Q
F
D
Q
A-----------H
T
T
W
K
F
LP
D
P
V
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
-
C
---------------------------------
M
-
K
F
--
V
T
K
L
C
Q
D
H
K
--
I
L
T
F
I
T
A
--
N
-
S
ST
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
--------------
90
PsiBlast_CBE
48.64
31%
-8
- C1 -
-
2EO5
2
?
A:
[31-415]
------------------------------
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
----
Q
M
Q
K
L
A
H
A
A
AN
D
--
F
Y
N
I
P
-
Q
L
E
L
A
K
K
L
V
T
Y
------
S
P
GN
F
Q
K
-
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
T
G
-
R
K
-
Y
--------------
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
P
N
PYRNPWHINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
YIF
V
N
L
V
P
P
-
E
E
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
--
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
-
P
I
G
A
-
T
I
F
R
K
----
D
L
D
--
F
K
------------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
--
D
L
L
P
H
V
N
E
I
G
K
I
F
---
A
E
E
L
Q
G
--
L
A
D
D
------------
V
R
G
I
G
L
A
--
W
G
L
E
----
Y
----
N
---
E
K
-------------------------------
K
---------------------------------
V
-
R
D
--
R
I
I
G
E
S
F
K
R
--
G
L
L
L
L
P
A
--
G
R
S
--
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
----
88
PsiBlast_CBE
46.84
33%
7
- C1 -
-
4PPM
2
PIGE_SERSF
B:
[419-835]
---------------------------
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
-
N
P
Q
P
V
V
N
A
L
K
N
YLDA
Q
G
P
N
F
I
Q
-------
Y
I
S
I
P
E
Q
T
A
---
K
L
A
E
V
LCRLAP
G
N
---
M
G
-
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
-
G
K
-
P
-
G
I
A
--
Y
--
L
---
R
-----
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
R
Y
F
-
T
P
L
L
D
A
M
V
E
V
P
F
G
D
---------------------
L
A
A
L
R
E
---
A
-
L
N
R
E
-
D
V
G
A
-
L
M
I
E
P
I
Q
G
E
G
G
V
H
I
P
P
A
G
--
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
W
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
-
T
L
C
R
A
DLWQ
K
A
Y
G
T
A
D
R
-----
F
L
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
A
E
R
M
G
A
Y
F
----
K
Q
A
L
S
--
E
I
A
A
---
R
Y
PFV
S
--
E
V
R
G
R
G
L
M
--
L
G
I
Q
FD-------------WHTTWKFLPDPVQAHLRAAMDRMEQALGEMF
C
---------------------------------
M
-
K
F
--
V
T
K
L
C
Q
D
H
K
--
I
L
T
F
I
T
A
--
N
-
S
ST
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
--------------